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RSDLPGVAARLGLFTMACAAGTFALIMIFAQLRFAPSNHYDAQFVNVSGLKAGEFVRIAGVEVGKVKRIA VNEDGTATVTFGADDSVLLTEGTRALIRYDNLIGDRYLELQEGAGAVQALEPGGTIPVARTQPALDLDAL VGGFRPLFKALDPTQVNALSAQLVQAFQGQGTTINSFLAQTAEMTAALADRDALIGEVITNLNTVLGSLA DESDNFDEAVTSLSQLVEGLAARKTDIGESVSHSNAAAASITDLLADIRPPFAETVAQSDRMNSVVLSDH EYVDDLLATLPDAYRVLGRQGIYGDFFAFYLCDLVLKVNGKGGQPVYVKVAGQDSGRCAPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4398 | - | - | 100% (342) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0364 | - | e-128 | 64.33% (342) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_4603 | - | e-126 | 65.97% (335) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0605 | mce2B | 3e-82 | 47.35% (340) | MCE-family protein MCE2B |
| M. gilvum PYR-GCK | Mflv_2102 | - | 1e-127 | 65.97% (335) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1967 | mce3B | 1e-123 | 63.16% (342) | MCE-family protein MCE3B |
| M. leprae Br4923 | MLBr_02590 | mce1B | 5e-76 | 43.31% (344) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4152c | - | 2e-64 | 39.09% (330) | MCE-family protein |
| M. marinum M | MMAR_2883 | mce3B | 1e-124 | 62.57% (342) | MCE-family protein Mce3B |
| M. avium 104 | MAV_2533 | - | 1e-116 | 60.53% (342) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0347 | - | 1e-117 | 61.75% (332) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3222 | - | 1e-120 | 63.45% (342) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_2869 | mce3B | 1e-123 | 61.99% (342) | MCE-family protein Mce3B |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0605|M.bovis_AF2122/97 --MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHT-TGYSAVFTHVS
MLBr_02590|M.leprae_Br4923 --MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRT-NGYTAEFTNIS
MAV_2533|M.avium_104 MKENLTGTLWRLAIYVVVSVLGMFTLVAVFGQLRFQSE-KTYKAQFANVS
TH_3222|M.thermoresistible__bu LRKNLSGLVLRLTVFVVVCALGAFGLIAIFAQLRFQEE-DTYHAIFTSVT
Mflv_2102|M.gilvum_PYR-GCK MSVSIRRDATRLGAFLAVCLLGVFGLFAVFGQMRFGEKTQQYRAEFVNVT
MMAR_2883|M.marinum_M MREDLRGVVIRLGVFLTVCALTAFLLVAVFGQVRFGDG-NTYYAEFSNVS
MUL_2869|M.ulcerans_Agy99 MREDLRGVVIRLGVFLTVCALTAFLLVAVFGQVRFGDG-NTYYAEFSNVS
Rv1967|M.tuberculosis_H37Rv MRENLGGVVVRLGVFLAVCLLTAFLLIAVFGEVRFGDG-KTYYAEFANVS
Mvan_4398|M.vanbaalenii_PYR-1 MRSDLPGVAARLGLFTMACAAGTFALIMIFAQLRFAPS-NHYDAQFVNVS
MSMEG_0347|M.smegmatis_MC2_155 MNKEVLSTLIRVSAFLTVCAVGVFALFSIFADLRFGER-KQYTAQFSDIS
MAB_4152c|M.abscessus_ATCC_199 ---MKRATQIKVIVFTVVMLLVAAGLIITFGEFRFGSG-KRYHAMFSTAS
:: . :. *.:.** * * * :
Mb0605|M.bovis_AF2122/97 GLRAGQFVRAAGVEVGKVAKVTLIDGDKQVLVDFTVDRSLSLDQATTASI
MLBr_02590|M.leprae_Br4923 GLRTGQFVRASGVEVGKVNSVALINGGTRVRVKFNVDRSVPLYQSTTAQI
MAV_2533|M.avium_104 GLEGGNFVRIAGVEVGKVKNITVEP-DSTVLVEFTAAEKVVLTEGTRAAI
TH_3222|M.thermoresistible__bu GLENGNFVRIAGVEVGKVKHVSVRD-DSTVLVKFSADRSVVLTEGSRAII
Mflv_2102|M.gilvum_PYR-GCK GLETNDFVRIAGVEVGKVENVEIQP-DTTAVVEFTADDSVVLTQGSRAVI
MMAR_2883|M.marinum_M NLREGKLVRIAGVEVGKVEKISINP-DSTVKVGFTADNSVTLTQGTQAVI
MUL_2869|M.ulcerans_Agy99 NLREGKLVRIAGVEVGKVEKISINP-DATVKVEFTADNSVTLTQGTQAVI
Rv1967|M.tuberculosis_H37Rv NLRTGKLVRIAGVEVGKVTRISINP-DATVRVQFTADNSVTLTRGTRAVI
Mvan_4398|M.vanbaalenii_PYR-1 GLKAGEFVRIAGVEVGKVKRIAVNE-DGTATVTFGADDSVLLTEGTRALI
MSMEG_0347|M.smegmatis_MC2_155 GLKEGDFVRIAGVEVGQVQKVSMDE-NALVLVEFAMEDSVELTSTSTAVI
MAB_4152c|M.abscessus_ATCC_199 DLRSGQKVRIAGVPVGRVKNVSLNR-DNSVEVTFDVDSKYQLYSSSRAII
.*. .. ** :** **:* : : . . * * . * : * *
Mb0605|M.bovis_AF2122/97 RYLNLIGDRYLELGRG---HSGQRLAPGATIPLEHTHPALDLDALLGGFR
MLBr_02590|M.leprae_Br4923 RYLDLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLDALIGGFK
MAV_2533|M.avium_104 RFADLTGGRYVALEEGA--GNIRRLSPGATIPLARTEPALDLDALIGGFR
TH_3222|M.thermoresistible__bu RYDNLIGGRYLALEEGA--GGTTKLAPGETIPLDRTAPALDLDALIGGFR
Mflv_2102|M.gilvum_PYR-GCK RYDDLIGGRYLALEEGA--GGTQKLNPGGTIPLARTSPALDLDALIGGFR
MMAR_2883|M.marinum_M RYDNLFGDRYLALEEGA--GGLTILKPGQTIPLANTKPALDLDALIGGFR
MUL_2869|M.ulcerans_Agy99 RYDNLFGDRYLALEEGA--GGLTILKPGQTIPLANTKPALDFDDLIDGFR
Rv1967|M.tuberculosis_H37Rv RYDNLFGDRYLALEEGA--GGLAVLRPGHTIPLARTQPALDLDALIGGFK
Mvan_4398|M.vanbaalenii_PYR-1 RYDNLIGDRYLELQEGA--GAVQALEPGGTIPVARTQPALDLDALVGGFR
MSMEG_0347|M.smegmatis_MC2_155 RYDNLIGGRYLELKQGE--EPGAVLQAGATIPLARTRPALDLDELIGGFR
MAB_4152c|M.abscessus_ATCC_199 RYENLVGDRYLEITAGP--GELHKLPDGGTLDKEHTQPALDLDALLGGLR
*: :* *.**: : * : * : .* ****:* *:.*::
Mb0605|M.bovis_AF2122/97 PLFQTLDPDKVNSIASSIITVFQGQGATINDILDQTASLTATLADRDHAI
MLBr_02590|M.leprae_Br4923 PLFRALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERDQAI
MAV_2533|M.avium_104 PLFRALDPDQVNKLTGQLIAAFQGQGGTIGSFLTQAAALTNTLADRDHLI
TH_3222|M.thermoresistible__bu PLFHALDPAHVNALSGQLIAAFQGQGPTIGSILEQTATLTNTLADRDELI
Mflv_2102|M.gilvum_PYR-GCK PLFRALDPDQINALSGQLISALQGQGGTINSFLAQTAALTSTLADRDQLI
MMAR_2883|M.marinum_M PLFRALDPHQVNALSDQLLQAFQGQGPTIGTFLDQAAAVTNTLADRDQLI
MUL_2869|M.ulcerans_Agy99 PLFRALDPHQVNALSDQLLQAFQGQGPTIGTFLDQAAAVTNTLADRDQLI
Rv1967|M.tuberculosis_H37Rv PLFRALNPEQVNALSEQLLHAFAGQGPTIGSLLAQSAAVTNTLADRDRLI
Mvan_4398|M.vanbaalenii_PYR-1 PLFKALDPTQVNALSAQLVQAFQGQGTTINSFLAQTAEMTAALADRDALI
MSMEG_0347|M.smegmatis_MC2_155 PLFKALDPDQVNALSTQLVQVFQGQGATISSFLDQTAAMTSTLADRDQLI
MAB_4152c|M.abscessus_ATCC_199 PVLKGFDAAKVNEISNAFIQILQGQGGTLSQLLGDTSSFTSGLAERDQLI
*::: ::. ::* :: :: : *** *:. :* ::: .* :.:** *
Mb0605|M.bovis_AF2122/97 GEVVNNLNTVLATTVKHQTEFDRTVDKLEVLITGLKNRADPLAAAAAHIS
MLBr_02590|M.leprae_Br4923 GEVVKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFAHIS
MAV_2533|M.avium_104 GQVIVNLNTVLGSLGGQSGQFARAVDSLSELVAGLEARKQDISNGMAYAN
TH_3222|M.thermoresistible__bu GQVVVNLNTVLASLGGHSDQFAEAVDSLSDLIHGLQGRKETISAGLAKAG
Mflv_2102|M.gilvum_PYR-GCK GEVIINLNTVLGSLGDQSDQFAKAVDSLSQLVEGLSDRRQEISDGLAYTN
MMAR_2883|M.marinum_M GQVVTNLNVVLGSLGGQSDRLDKAVASLSQLIAGLSERRTDISNAVAYTN
MUL_2869|M.ulcerans_Agy99 GQVVTNLNVVLGSLGGQSDRLDKAVASLSQLIAGLSERRTDISNAVAYTN
Rv1967|M.tuberculosis_H37Rv GQVITNLNVVLGSLGAHTDRLDQAVTSLSALIHRLAQRKTDISNAVAYTN
Mvan_4398|M.vanbaalenii_PYR-1 GEVITNLNTVLGSLADESDNFDEAVTSLSQLVEGLAARKTDIGESVSHSN
MSMEG_0347|M.smegmatis_MC2_155 GEVIGNLDVLLGSLGEQSHQFDKAVNSLSELVAGLSARRTDITNAIANSD
MAB_4152c|M.abscessus_ATCC_199 GDVINHLNEVLATVDSKSTQFSSSVDQLQQLISGLAQQRDVVAGALPPLA
*:*: :*: :* : . .: :* .*. *: * : : . .
Mb0605|M.bovis_AF2122/97 SAAGTLADLLGADRPLLHSSFGHLEGIQQPLIDELAELDHVLGKLPDAYR
MLBr_02590|M.leprae_Br4923 NAAGTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQLEDYLHKLPTVLN
MAV_2533|M.avium_104 AAAGSITDLLAQARPPVKKVVHEADRTAGTMLADREWLEKYLDHWPDAFK
TH_3222|M.thermoresistible__bu EGARTLAELLSQAREPLTKTVRETDRAAGVVLGDHEYFDDLLNTLPDAYR
Mflv_2102|M.gilvum_PYR-GCK AAAGSIADFLTEARPPLKKTIDETDRAAGIVVADHEYFDNLINTLPDAYQ
MMAR_2883|M.marinum_M AAAGSVADLLSQARAPLSKALHETDRVATIALADHDYLDNLLNTLPDRYQ
MUL_2869|M.ulcerans_Agy99 AAAGSVADLLSKARAPFSKALHETDRVATIALADHDYLDNLLNTLPDRYQ
Rv1967|M.tuberculosis_H37Rv AAAGSVADLLSQARAPLAKVVRETDRVAGIAAADHDYLDNLLNTLPDKYQ
Mvan_4398|M.vanbaalenii_PYR-1 AAAASITDLLADIRPPFAETVAQSDRMNSVVLSDHEYVDDLLATLPDAYR
MSMEG_0347|M.smegmatis_MC2_155 NAATEIADLLAQARPPLQNVVTQADRAAAIAVADHEYLDNILNTLPDKYR
MAB_4152c|M.abscessus_ATCC_199 STASSLESVLKDTRPYIKGTIEQARQLATRVDERKADVNVVVENLAENYL
* : ..* : . . .: : .
Mb0605|M.bovis_AF2122/97 IIGRAGGIYGDFFNFYLCDISLKVNGLQPGGPVRTVKLFGQP---TGRCT
MLBr_02590|M.leprae_Br4923 QIGRTIGSYGDFVNFYSCDITLKINGLQPGGPVRTVRLFQQP---TGRCT
MAV_2533|M.avium_104 ILNRQ-GLYGDFFSFYLCDIVLKLNGK--GGQPVYVKVAGQA---SGRCT
TH_3222|M.thermoresistible__bu VLGRQ-AMSGDFFNFYLCDLVLKMNGK--GGQPVYVKVAGQD---TGRCA
Mflv_2102|M.gilvum_PYR-GCK VLARQ-GIYGDFFSFYLCDIVLKLNGK--GGQPVYVKVAGQS---SGRCA
MMAR_2883|M.marinum_M ALVRQ-GMYGDFFAFYLCDVVLKVNGK--GGQPVYIKVAGQA---TGRCT
MUL_2869|M.ulcerans_Agy99 ALVRQ-GMYGDFFAFYLCDVVLKVNGK--GGQPVYIKVAGQA---TGRCT
Rv1967|M.tuberculosis_H37Rv ALVRQ-GMYGDFFAFYLCDVVLKVNGK--GGQPVYIKLAGQD---SGRCA
Mvan_4398|M.vanbaalenii_PYR-1 VLGRQ-GIYGDFFAFYLCDLVLKVNGK--GGQPVYVKVAGQD---SGRCA
MSMEG_0347|M.smegmatis_MC2_155 VLGRQ-AMYGDYFSFYLCDLILKLNGK--GGQPVYVKLAEQV---TGRCA
MAB_4152c|M.abscessus_ATCC_199 RLNAL-GAYGSFFNIYYCSIRIKVNGP--VGTDWLIPFGGPPDPSKGRCA
: . *.:. :* *.: :*:** * : . .***:
Mb0605|M.bovis_AF2122/97 PQ--
MLBr_02590|M.leprae_Br4923 PQ--
MAV_2533|M.avium_104 PR--
TH_3222|M.thermoresistible__bu PR--
Mflv_2102|M.gilvum_PYR-GCK PR--
MMAR_2883|M.marinum_M PK--
MUL_2869|M.ulcerans_Agy99 PK--
Rv1967|M.tuberculosis_H37Rv PK--
Mvan_4398|M.vanbaalenii_PYR-1 PR--
MSMEG_0347|M.smegmatis_MC2_155 PK--
MAB_4152c|M.abscessus_ATCC_199 FKNE
: