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TDTVTDTAPGALTERRGNVLIITINRPEARNAVNASVSIGVGNALQAAQDDPEIRAVILTGAGDKSFCAG ADLKAISRGENLFHPEHTEWGFAGYVRHFIDKPTIAAVNGTALGGGTELALASDLVVAEERAKFGLPEVK RGLIAGAGGVFRIVEQLPRKVALELIYTGEPISSADALRWGLINQVVPDGTVVDAALALAERITCNAPLA VQASKRVSYGAVDGVVGSEEPFWKQTFGEFSTLLKTEDAMEGPLAFAQKREPVWKAK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4588 | - | - | 100% (268) | enoyl-CoA hydratase/isomerase |
| M. vanbaalenii PYR-1 | Mvan_1990 | - | 3e-56 | 46.30% (257) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_5216 | - | 6e-48 | 43.73% (263) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3545 | echA19 | 3e-43 | 41.67% (264) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2117 | - | 1e-142 | 95.77% (260) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv0222 | echA1 | 4e-57 | 46.33% (259) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 6e-33 | 36.33% (245) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_4588c | - | 2e-57 | 49.43% (261) | enoyl-CoA hydratase/isomerase |
| M. marinum M | MMAR_4317 | echA1_1 | 1e-114 | 73.51% (268) | enoyl-CoA hydratase, EchA1_1 |
| M. avium 104 | MAV_2597 | - | 1e-119 | 76.95% (269) | carnitinyl-CoA dehydratase |
| M. smegmatis MC2 155 | MSMEG_5198 | - | 1e-131 | 87.12% (264) | carnitinyl-CoA dehydratase |
| M. thermoresistible (build 8) | TH_4237 | - | 1e-100 | 83.89% (211) | PUTATIVE carnitinyl-CoA dehydratase |
| M. ulcerans Agy99 | MUL_0972 | echA1_1 | 1e-110 | 71.27% (268) | enoyl-CoA hydratase, EchA1_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4588|M.vanbaalenii_PYR-1 -MTDTVTDTA-PGALTERRGNVLIITINRPEARNAVNASVSIGVGNALQA
Mflv_2117|M.gilvum_PYR-GCK --------MA-PGALTERRGNVLIITINRPEARNAINASVSIAVGDALQA
MSMEG_5198|M.smegmatis_MC2_155 -----MTETA-PGALTERRGNVLLITINRPEARNAINSSVSQAVGDALAE
TH_4237|M.thermoresistible__bu --------------------------------------------------
MAV_2597|M.avium_104 -MAETLTEVTRQAAVVERRGNVALITIDRPDARNAVNGAVSTAVGDALEE
MMAR_4317|M.marinum_M ---MTDAGDDQPAGLVEHRGNVMVITINRPEARNAINGAVSVAVGDALES
MUL_0972|M.ulcerans_Agy99 ---MTDAGDDQPAGLVEHRGNVMVITINRPEARNAINGAVSVAVGGALES
Rv0222|M.tuberculosis_H37Rv MSSESDAANTEPEVLVEQRDRILIITINRPKAKNAVNAAVSRGLADAMDQ
MAB_4588c|M.abscessus_ATCC_199 ---------MADEVLIEQRDRVLLITINRPDARNAVNRAVSQGLAAAADQ
Mb3545|M.bovis_AF2122/97 -------MESGPDALVERRGHTLIVTMNRPAARNALSTEMMRIMVQAWDR
MLBr_02402|M.leprae_Br4923 --------MKYDTILVDGYQRVGIITLNRPQALNALNSQMMNEITNAAKE
Mvan_4588|M.vanbaalenii_PYR-1 AQDDPEIRAVILTGAGDKSFCAGADLKAISR---GENLFHPEHTEWGFAG
Mflv_2117|M.gilvum_PYR-GCK AQEDPDVRAVILTGAGDKSFCAGADLKAISR---GENLFHPEHSEWGFAG
MSMEG_5198|M.smegmatis_MC2_155 AQNDPEVRAVVLTGAGDKSFCAGADLKAISR---GENLFHPEHPEYGFAG
TH_4237|M.thermoresistible__bu ---------VVLTGSGDKSFCAGADLKAIAR---GENLFHPDHPEWGFAG
MAV_2597|M.avium_104 AQRDPEVWAVVITGAGDKSFCAGADLKAISR---GENLYHAEHPEWGFAG
MMAR_4317|M.marinum_M AQNDPEVRAVVITGAGDKSFCAGADLLAISR---RENIYHPDHNEWGFAG
MUL_0972|M.ulcerans_Agy99 AQNDAEVRAVVITGAGDKSFCAGADLLAISR---RENIYHPDHNEWGFAG
Rv0222|M.tuberculosis_H37Rv LDGDAGLSVAILTGGGG-SFCAGMDLKAFAR---GENVVVEG----RGLG
MAB_4588c|M.abscessus_ATCC_199 LDSSADLSVAIITGAGG-NFCAGMDLKAFVS---GEAVLSE-----RGLG
Mb3545|M.bovis_AF2122/97 VDNDPDIRCCILTGAGG-YFCAGMDLKAATQKPPGDSFKDGSYDPSRIDA
MLBr_02402|M.leprae_Br4923 LDIDPDVGAILITGSPK-VFAAGADIKEMAS-----LTFTDAFDADFFSA
::**. *.** *: .
Mvan_4588|M.vanbaalenii_PYR-1 YVR-HFIDKPTIAAVNGTALGGGTELALASDLVVAEERAKFGLPEVKRGL
Mflv_2117|M.gilvum_PYR-GCK YVR-HFIDKPTIAAVNGTALGGGTELALASDLVVAEERAKFGLPEVKRGL
MSMEG_5198|M.smegmatis_MC2_155 YVS-HFIDKPTIAAVNGTALGGGTELALASDLVVAEERAMFGLPEVKRGL
TH_4237|M.thermoresistible__bu YVR-HFMDKPTIAAVNGTALGGGTELALASDLVVARESAVFGLPEVKRGL
MAV_2597|M.avium_104 YVH-HFIDKPTIAAVNGTALGGGSELALASDLVIACESASFGLPEVKRGL
MMAR_4317|M.marinum_M YVH-HFIDKPTIAAVNGTALGGGTELALASDLVVADERAKFGLPEVKRGL
MUL_0972|M.ulcerans_Agy99 YVH-HFIDKPTIAAVNGTALCGGTELALASDLVVADERAKFGLPEAKRGF
Rv0222|M.tuberculosis_H37Rv FTE-RPPTKPLIAAVEGYALAGGTELALAADLIVAARDSAFGIPEVKRGL
MAB_4588c|M.abscessus_ATCC_199 FTN-VPPRKPIIAAVEGFALAGGTELVLSCDLVVAGRSAKFGIPEVKRGL
Mb3545|M.bovis_AF2122/97 LLKGRRLTKPLIAAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSL
MLBr_02402|M.leprae_Br4923 WGKLAAVRTPMIAAVAGYALGGGCELAMMCDLLIAADTAKFGQPEIKLGV
.* **** * *: ** *: *: :* : ** .* * ..
Mvan_4588|M.vanbaalenii_PYR-1 IAGAGGVFRIVEQLPRKVALELIYTGEPISSADALRWGLINQVVPDGTVV
Mflv_2117|M.gilvum_PYR-GCK IAGAGGVFRIVEQLPRKVALELIYTGEPISSADALRWGLINQVVPDGTVV
MSMEG_5198|M.smegmatis_MC2_155 IAGAGGVFRIIEQLPRKVALELVYTGDPISAADALKWGLINQVVPDGTVV
TH_4237|M.thermoresistible__bu IAGAGGVFRIVEQLPRKVALELLFTGEPITAAEALRWGLINEVVPDGAEL
MAV_2597|M.avium_104 IAGAGGVFRIVEQLPRKVALELVLTGEPMTASDALRWGLINEVVPDGTVV
MMAR_4317|M.marinum_M IAAAGGVFRIVNQLPRKVAMEMLLTGEPITASDAYEWGLINQVVKQGAVL
MUL_0972|M.ulcerans_Agy99 IAAAGGVFRIVNQLPRKVAMEMLLTGEPITASDAYEWGLINQVVKQGAVL
Rv0222|M.tuberculosis_H37Rv VAGGGGLLRLPERIPYAIAMELALTGDNLPAERAHELGLVNVLAEPGTAL
MAB_4588c|M.abscessus_ATCC_199 VAGAGGLLRLPNRIPYQVAMELALTGESFTAEDAAKYGFINRLVDDGQAL
Mb3545|M.bovis_AF2122/97 YPMGGSAVRLVRQIPYTLACDLLLTGRHITAAEAKEMGLIGHVVPDGQAL
MLBr_02402|M.leprae_Br4923 LPGMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRVVLADDLL
. *. *: . : * :: ** : : * . *::. :. . :
Mvan_4588|M.vanbaalenii_PYR-1 DAALALAERITCNAPLAVQASKRVSYGAVDGVVGSEEPFWKQTFGEFSTL
Mflv_2117|M.gilvum_PYR-GCK DAALALAERITCNAPLAVRASKRVSYGAIDGVVGSDEPFWKQTFSEFSTL
MSMEG_5198|M.smegmatis_MC2_155 DAALALAERITCNAPLAVQASKRVAYGAEEGTVPAEQPSWKRTNREFVTL
TH_4237|M.thermoresistible__bu DAALALAERITVNAPLAVQASKRVAYGAENGTVPGDENGWKLTNREFSTL
MAV_2597|M.avium_104 EAALALAERITCNAPLSVQASKRVAYGADDGIIGAEEPKWERTIREFTEL
MMAR_4317|M.marinum_M DAALALAARVTVNAPLSVRASKRIAYGVDDGVVADEERGWERTMREMRSL
MUL_0972|M.ulcerans_Agy99 DAALALAARVTVNAPLSVRASKRIAYGVDDGVVADEERGWERTMREMRSL
Rv0222|M.tuberculosis_H37Rv DAAIALAEKITANGPLAVVATKRIITESRG---WSPDTMFAEQMKILVPV
MAB_4588c|M.abscessus_ATCC_199 DTALELAAKITANGPLAVAATKRIIIESAS---WAPEEAFAKQGEILMPI
Mb3545|M.bovis_AF2122/97 TKALELADAISANGPLAVQAILRSIRETEC---MPENEAFKIDTQIGIKV
MLBr_02402|M.leprae_Br4923 PEAKAVATTISQMSRSATRMAKEAVNRSFES---TLAEGLLHERRLFHST
* :* :: . :. .
Mvan_4588|M.vanbaalenii_PYR-1 LKTEDAMEGPLAFAQKREPVWKAK
Mflv_2117|M.gilvum_PYR-GCK LKTEDAMEGPLAFAQKREPVWKAK
MSMEG_5198|M.smegmatis_MC2_155 LKTEDAMEGPLAFAQKRQPVWKAK
TH_4237|M.thermoresistible__bu LKTEDAKEGPLAFAEKREPVWKAR
MAV_2597|M.avium_104 LKSEDAKEGPLAFAEKRQPVWKAR
MMAR_4317|M.marinum_M IRSEDAKEGPLAFAQKREPVWKAR
MUL_0972|M.ulcerans_Agy99 IRSEDAKEGPLAFAEKREPVWKTR
Rv0222|M.tuberculosis_H37Rv FTSNDAKEGAIAFAERRRPRWTGT
MAB_4588c|M.abscessus_ATCC_199 FVSEDAKEGAKAFAEKRAPVWQGK
Mb3545|M.bovis_AF2122/97 FLSDDAKEGPRAFAEKRAPNFQNR
MLBr_02402|M.leprae_Br4923 FVTDDQSEGMAAFIEKRAPQFTHR
: ::* ** ** ::* * :