For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VRTLVTGASGYIGSRLVTALLDDGHQVVAASRDPSRLADFGWYHDVSTVTLDAHDEISAQQAFTEAGPID VVYYLVHGIGQPDFREADNRAAANVAAAAKAAGVRRIVYLGGFVPDEDSLSEHLTSRAEVAAALTIDDGP DVVWLGAAIVIGAGSTSFEMLRYVADRFLLLPMPEWSVNPIDPIAISDVLHYLVASADPDVPAGAYDIRG PETTTYGDLLRAYARIAGIWRAPVAVYGIDTSLVSKVTGLILPVPGGLAADLVESLDFPMIASANGLREF VADPPDGPVSVDDAIRRAVGTPPRRPVNELIDPHHLADTDPDWAGGDVLRLRQLAGAVTPPLVHPVLGLI GFVPRPVAAAVRTGLDTFLGMVPRVIPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2122 | - | - | 100% (378) | NAD-dependent epimerase/dehydratase |
| M. gilvum PYR-GCK | Mflv_1635 | - | 7e-57 | 44.33% (300) | NAD-dependent epimerase/dehydratase |
| M. gilvum PYR-GCK | Mflv_2075 | - | 2e-05 | 31.86% (113) | 3-beta hydroxysteroid dehydrogenase/isomerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3658c | galE1 | 1e-07 | 36.07% (122) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. tuberculosis H37Rv | Rv3634c | galE1 | 1e-07 | 36.07% (122) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 1e-07 | 36.07% (122) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 6e-08 | 37.70% (122) | UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_4312 | - | 1e-131 | 61.05% (380) | hypothetical protein MMAR_4312 |
| M. avium 104 | MAV_1281 | - | 1e-138 | 64.40% (382) | hypothetical protein MAV_1281 |
| M. smegmatis MC2 155 | MSMEG_5189 | - | 1e-139 | 65.33% (375) | oxidoreductase |
| M. thermoresistible (build 8) | TH_4331 | - | 1e-155 | 70.42% (382) | PUTATIVE NAD-dependent epimerase/dehydratase |
| M. ulcerans Agy99 | MUL_0982 | - | 7e-92 | 65.86% (249) | hypothetical protein MUL_0982 |
| M. vanbaalenii PYR-1 | Mvan_4583 | - | 0.0 | 83.64% (379) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2122|M.gilvum_PYR-GCK -------------------------------------MRTLVTGASGYIG
Mvan_4583|M.vanbaalenii_PYR-1 ----------------------------------MKPVRTLVAGATGYIG
TH_4331|M.thermoresistible__bu ----------------------------------VKNLRVLVTGATGYVG
MSMEG_5189|M.smegmatis_MC2_155 -------------------------------------MRMMVTGATGYVG
MAV_1281|M.avium_104 -------------------------------------MRVLVTGATGYVG
MMAR_4312|M.marinum_M -------------------------------------MRILVTGATGYVG
MUL_0982|M.ulcerans_Agy99 MCSCGQSRCRFRIGSDRLLPDGPASPRPHRLGSSVETMRILVTGATGYVG
Mb3658c|M.bovis_AF2122/97 -------------------------------------MRALVTGAAGFIG
Rv3634c|M.tuberculosis_H37Rv -------------------------------------MRALVTGAAGFIG
MLBr_00204|M.leprae_Br4923 --------------------------------MYGEPVRALVTGAAGFIG
MAB_0503|M.abscessus_ATCC_1997 -------------------------------------MRAMVTGAAGFIG
:* :*:**:*::*
Mflv_2122|M.gilvum_PYR-GCK SRLVTALLDDGHQVVAASRDPS-RLADFGWYHDVSTVTLDAHDEISAQQA
Mvan_4583|M.vanbaalenii_PYR-1 SRLVTALLHDGHQVVAASRDPA-RLTEFGWYKDVSTVTLDAHDEISARQA
TH_4331|M.thermoresistible__bu SRLVTSLLAAGHDVVAASRNPR-RLTDFGWYDRVTPVALDAHDEDSVSAA
MSMEG_5189|M.smegmatis_MC2_155 SRLVTALLAHDHDVVVASRNTV-RLTDFGWFPDVRAVRLDAGDADSVRDA
MAV_1281|M.avium_104 SRLVTALLAGGHDVLAATRNPL-RLKRFGWFDEITPVPLDAADPASLRSA
MMAR_4312|M.marinum_M SRLVTALLADGHEVLAATRNMA-RLSRLAWFDDVTPVILDATDRASAQAA
MUL_0982|M.ulcerans_Agy99 SRLVTALLADGHEVLAATRNMA-RLSRLAWFDDVTPVILDATDRASAQAA
Mb3658c|M.bovis_AF2122/97 STLVDRLLADGHSVVGLDNFATGRATNLEHLADNSAHVFVEADIVTADLH
Rv3634c|M.tuberculosis_H37Rv STLVDRLLADGHSVVGLDNFATGRATNLEHLADNSAHVFVEADIVTADLH
MLBr_00204|M.leprae_Br4923 STLVDRLLADGHTVVGLDNFATGHAANLEHLASTPALAFVEADIVTADLQ
MAB_0503|M.abscessus_ATCC_1997 STLVDRLLADGHEVTGLDNLATGKVANLEAAEANAKFTFVKDDIVEADLD
* ** ** .* * . : : : *
Mflv_2122|M.gilvum_PYR-GCK FTEAG----PIDVVYYLVHGIGQ------PDFREADNRAAAN-VAAAAKA
Mvan_4583|M.vanbaalenii_PYR-1 FTDAG----PVDVVYYLVHGIGQ------PGFREADNRAAAN-VASAAKA
TH_4331|M.thermoresistible__bu LARAGSGARPVDVIYYLVHGIGQ------DGFREADNRAAAN-VAAAAKY
MSMEG_5189|M.smegmatis_MC2_155 FGAAG----PVDVVYYLLHGIGE------PGFREADNRAATN-LATAARD
MAV_1281|M.avium_104 FAGCG----PVEVVYYLVHAIGQ------PGFRDADKAAAAN-LAAAAKD
MMAR_4312|M.marinum_M MNAAG----QIDVVYYLVHGIGQ------PDFRDRDKTAAAN-LAVAARD
MUL_0982|M.ulcerans_Agy99 MNAAG----QIDVVYYLVHGIGQ------PDFRDRDKTAAAN-LAVAARD
Mb3658c|M.bovis_AF2122/97 AILEQH---RPEVVFHLAAQIDVRRSVADPQFDAAVNVIGTVRLAEAARQ
Rv3634c|M.tuberculosis_H37Rv AILEQH---RPEVVFHLAAQIDVRRSVADPQFDAAVNVIGTVRLAEAARQ
MLBr_00204|M.leprae_Br4923 TILDEH---RPEVVFHLAAQIDVRHSVVDPQFDASVNVIGTVRLAEAARH
MAB_0503|M.abscessus_ATCC_1997 AVVAEY---SPEVIFHLAAQIDVRHSVADPQFDSSVNVVGTVRLAEAARK
:*:::* *. * : .: :* **:
Mflv_2122|M.gilvum_PYR-GCK AGVRRIVYLGGFVPDEDSLSEHLTSRAEVAAALTIDDGPDVVWLGAAIVI
Mvan_4583|M.vanbaalenii_PYR-1 AGVRRIVYLGGFVPDDDSLSEHLTSRAEVAAALTVDGGPDVVWLGAAIVI
TH_4331|M.thermoresistible__bu AGVRRIVYLGGFVPDGEALSEHLSSRAEVAHALHVDGGADVVWLGAAMII
MSMEG_5189|M.smegmatis_MC2_155 AGVRRIVYLGGFVPEDDTLSDHLAGRAEVAHALGVDGGPEVVWLGAAMII
MAV_1281|M.avium_104 AGVRRIVYLGGFVPAGEVLSEHLTSRAEVAEALAVPDGPELVWLGAAMII
MMAR_4312|M.marinum_M TGVRRIVYLGGFVPECEALSQHLSSRAEVAEALAVDDGAELVWLGAAMII
MUL_0982|M.ulcerans_Agy99 TGVRRIVYLGGFVPECEALSQHLSSRAVVAEALAVDDGAELVWLGAAMII
Mb3658c|M.bovis_AF2122/97 TGVRKIVHTS-------SGGSIYGTPPEYPTPETAPTDPASPYAAGKVAG
Rv3634c|M.tuberculosis_H37Rv TGVRKIVHTS-------SGGSIYGTPPEYPTPETAPTDPASPYAAGKVAG
MLBr_00204|M.leprae_Br4923 TGVRKIVHTS-------SGGSIYGTPSQYPTPETVPTDPTSPYAAGKVAG
MAB_0503|M.abscessus_ATCC_1997 AGVRKIVHTS-------SGGSIYGTPKQIPTSETVPTDPHSPYAAGKVAG
:***:**: . .. . . .. : .. :
Mflv_2122|M.gilvum_PYR-GCK GAGSTSFEMLR-YVADRFLLLPMPEWSVNPIDPIAISDVLHYLVASADPD
Mvan_4583|M.vanbaalenii_PYR-1 GAGSTSFEMLR-YVGDRFLLLPMPEWSANPIDPIAISDALHYLVAAADAD
TH_4331|M.thermoresistible__bu GAGSTSFEMLR-YVGDRFLVLPLPEWSANPIDPISISDVLYYLVAAADAD
MSMEG_5189|M.smegmatis_MC2_155 GAGSTSFEILR-YVADRFPVMPLPSWLSNPMDPISIRDVLHYLVAAADTD
MAV_1281|M.avium_104 GAGSTSFEMMR-YVGDRFPLMPIPSWMDNPIDPISIRDVLHYLLAAADRD
MMAR_4312|M.marinum_M GAGSTSFEMLR-YVGDRFPVLPMPDWMYNPIDPISIRDVLHYLVAAADVD
MUL_0982|M.ulcerans_Agy99 GAGSTLFEMLR-YVGDRFPVLPMPDWMYNPIDPISIRDVLHYLVAAADVD
Mb3658c|M.bovis_AF2122/97 EIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAGVVAIFAQALLSGKPT
Rv3634c|M.tuberculosis_H37Rv EIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAGVVAIFAQALLSGKPT
MLBr_00204|M.leprae_Br4923 EIYLNTFRHLCGLDCSHIAPANVYGPRQDPYGEAGVVAIFVQALLSDRPT
MAB_0503|M.abscessus_ATCC_1997 EIYLNTFRHLYGLECSHIAPANVYGPRQDPHGEAGVVAIFAQALLSGRST
. *. : .:: : :* . .: : : :
Mflv_2122|M.gilvum_PYR-GCK -VPAGAYDIRGPETTTYGDLLRAYARIAGIWRAPVAVYGIDTSLVSKVTG
Mvan_4583|M.vanbaalenii_PYR-1 TVPPGAYDISGPETTTYGDLLRTYARVAGVWRAPVAVYGVDIATVSKLTG
TH_4331|M.thermoresistible__bu SVPAGAYDICGPDTTTYGDLLHTYARIAGKWRADLPIRGVDTAVVSRLSA
MSMEG_5189|M.smegmatis_MC2_155 KVPAGAYDICGPETTTYRGVLAAYSRLAGKRRFGVPVCGVATGLASRVSA
MAV_1281|M.avium_104 LVPAGAYDIAGPDTTSYRRLLKTYARLSGRWHTGLPVGRVDTGLASLVTG
MMAR_4312|M.marinum_M QVPAGAYDICGPDTTSYRELLKTYARIRGRWHAALPVGRLDTAVASRITA
MUL_0982|M.ulcerans_Agy99 QVPAGAYDICGPDTTSYRELLKTYARIRGRWHAALPVGRLDTAVASRITA
Mb3658c|M.bovis_AF2122/97 RVFGDGTNTR--DYVFVDDVVDAFVRVSADVGGGLRFN-IGTGKET----
Rv3634c|M.tuberculosis_H37Rv RVFGDGTNTR--DYVFVDDVVDAFVRVSADVGGGLRFN-IGTGKET----
MLBr_00204|M.leprae_Br4923 KVFGDGTHTR--DYVFVDDVVDAFIKASGDAGGGQRFN-IGTGIET----
MAB_0503|M.abscessus_ATCC_1997 KVFGDGGNTR--DYVFVDDVVEAFVRASGPDGGGQRFN-VGTGVET----
* .. . : . :: :: : . . : . :
Mflv_2122|M.gilvum_PYR-GCK LILPVPGGLAADLVESLDFPMIASANGLREFVADPPDGPVSVDDAIRRAV
Mvan_4583|M.vanbaalenii_PYR-1 VVLPVPAGLASDLVESLDYPMMASAEGLRGRVPDPPGGLVGVEDAIRRAA
TH_4331|M.thermoresistible__bu AMLPVPGGLAADLVESLDYPMVASADRLHGLVPDPPGGLVGVDDAIARAL
MSMEG_5189|M.smegmatis_MC2_155 VALPVPDGLTADLTVSLEYPMTADGDGIRHVVPDPPGGLLGVDDAIRRAL
MAV_1281|M.avium_104 VALPVPPGLAGDLVESLDHPMVASGSDLRQRVPDPPGGLLGVDDAIARAL
MMAR_4312|M.marinum_M VTLPVPHGLVADLVESLDHPMRASGAGLQDKVPEPPGGLLSIEDAITLAL
MUL_0982|M.ulcerans_Agy99 G-----------------HPAGPAWSGRR------PGGIAGSPD------
Mb3658c|M.bovis_AF2122/97 -----------------------SDRQLHSAVAAAVGG------------
Rv3634c|M.tuberculosis_H37Rv -----------------------SDRQLHSAVAAAVGG------------
MLBr_00204|M.leprae_Br4923 -----------------------SDRQLHTAVSAAVGG------------
MAB_0503|M.abscessus_ATCC_1997 -----------------------SDRQLHSLVAAAAGA------------
: ..
Mflv_2122|M.gilvum_PYR-GCK GTP---PRRPVNELIDPHHLADTDPDWAGGDVLRLRQLAGAVTPPLVHPV
Mvan_4583|M.vanbaalenii_PYR-1 ASP---ARRPVDELTDPHHLADTDPDWAGGDALRLRQLAGAVTPPVARPF
TH_4331|M.thermoresistible__bu SSR---EARPVDDLLDPHHLATTDPQWAGGDALRIQRLARSVTPSVIHPA
MSMEG_5189|M.smegmatis_MC2_155 AGG---RRKPVNMLPDPHHLADTDPVWAGGDPARLRQLAGAVLPSVTRPA
MAV_1281|M.avium_104 DDRSYRRPRPVNALADPHHLADTDPGWAGGDARRIRQLAGRVTPAIARPT
MMAR_4312|M.marinum_M AGHANGPPLPVDALTDPHQLAATDPVWAGGDALRIRRIAEAMTPPIARPT
MUL_0982|M.ulcerans_Agy99 -GGIRGRPARQGPRATRRTTEYRRCHYVGAGRPRER-------APVARRR
Mb3658c|M.bovis_AF2122/97 ---------PDDPEFHPPRLGDLKRSCLDIG--------------LAERV
Rv3634c|M.tuberculosis_H37Rv ---------PDDPEFHPPRLGDLKRSCLDIG--------------LAERV
MLBr_00204|M.leprae_Br4923 ---------PDDPEFHPPRLGDLKRSCLDIG--------------LATTV
MAB_0503|M.abscessus_ATCC_1997 ---------PDDPEFHPPRLGDLRQSCLDVG--------------LAKRV
. . . :
Mflv_2122|M.gilvum_PYR-GCK LGLIGFVPRPVAAAVRTGLDTFLGMVPRVIPA
Mvan_4583|M.vanbaalenii_PYR-1 LGLIGFVPGPVAAAVRTGLDAVIGLVPKVIPA
TH_4331|M.thermoresistible__bu LGMIDVVPGPVAGAVRTGLDTVLGLAPRVLP-
MSMEG_5189|M.smegmatis_MC2_155 LALLGLLPGPVAGAVRTGLDTMIGLVPKGAR-
MAV_1281|M.avium_104 LGLVNKVPGPVAGAVRTGLDILIALTPKVRPA
MMAR_4312|M.marinum_M LRWVNIVPGPLAGALRSSLDILIALTPKVLFA
MUL_0982|M.ulcerans_Agy99 PDRS-----PPTRIHRSGVGRR----------
Mb3658c|M.bovis_AF2122/97 LGWRP--QIELADGVRRTVEYFRHKHTD----
Rv3634c|M.tuberculosis_H37Rv LGWRP--QIELADGVRRTVEYFRHKHTD----
MLBr_00204|M.leprae_Br4923 LGWSP--QVQLDDGVRRTVEYFRAAQRS----
MAB_0503|M.abscessus_ATCC_1997 LGWEP--RVPLADGIRRTVDFFRS--------
* :