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MKISVIGATGLIGSKVVDLLQRDGHHVVAASRASGADVLTGEGLTDALAGADVLVDVTNSPSFDDDAVMD FFTRSSANLVSAAEESGVRHYVALSIVGADGLPESGYMRAKVVQEKTIAGSDVPHSIVRATQFHEFADAI VGTLEADDEVRVPDARIQPIAADDVAAEVFRAAVGSPVDGVINIGGPDKISFADLARAVLARRGADKTVV IDPQATYFGTPLDQNSLVTGDGAVLGAVRFADHH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2101 | - | - | 100% (244) | dTDP-4-dehydrorhamnose reductase |
| M. vanbaalenii PYR-1 | Mvan_5001 | - | 9e-58 | 48.96% (241) | NmrA family protein |
| M. vanbaalenii PYR-1 | Mvan_5113 | - | 1e-09 | 28.51% (221) | NAD-dependent epimerase/dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2073c | - | 2e-05 | 24.42% (217) | hypothetical protein Mb2073c |
| M. gilvum PYR-GCK | Mflv_1635 | - | 3e-09 | 25.65% (230) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv2047c | - | 2e-05 | 24.42% (217) | hypothetical protein Rv2047c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3360c | - | 5e-89 | 69.01% (242) | hypothetical protein MAB_3360c |
| M. marinum M | MMAR_4766 | - | 9e-64 | 56.22% (233) | hypothetical protein MMAR_4766 |
| M. avium 104 | MAV_4078 | - | 1e-24 | 34.45% (238) | hypothetical protein MAV_4078 |
| M. smegmatis MC2 155 | MSMEG_2353 | - | 6e-90 | 69.01% (242) | secreted protein |
| M. thermoresistible (build 8) | TH_3570 | - | 1e-79 | 63.90% (241) | PUTATIVE secreted protein |
| M. ulcerans Agy99 | MUL_0982 | - | 2e-07 | 26.50% (234) | hypothetical protein MUL_0982 |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_3360c|M.abscessus_ATCC_199 -------------------------------------MKITVVGATGQIG
MSMEG_2353|M.smegmatis_MC2_155 -------------------------------------MKITVFGATGLIG
Mvan_2101|M.vanbaalenii_PYR-1 -------------------------------------MKISVIGATGLIG
TH_3570|M.thermoresistible__bu --------------------------------VEGAVMRITVFGATGRIG
MMAR_4766|M.marinum_M -------------------------------------MKILVIGGSGLIG
Mflv_1635|M.gilvum_PYR-GCK ------------------MPG--------------NDVRCVVTGATGYIG
MUL_0982|M.ulcerans_Agy99 MCSCGQSRCRFRIGSDRLLPDGPASPRPHRLGSSVETMRILVTGATGYVG
Mb2073c|M.bovis_AF2122/97 -------------------------------------MRIAVTGASGVLG
Rv2047c|M.tuberculosis_H37Rv -------------------------------------MRIAVTGASGVLG
MAV_4078|M.avium_104 ---------------------------------MRALTTIAVIGATGTAG
* *.:* *
MAB_3360c|M.abscessus_ATCC_199 SRVVSLLIADGHDVVAASLSSG--------------ANVLTGEGLVDALT
MSMEG_2353|M.smegmatis_MC2_155 SKVVAALNEAGHDVVAAARDTG--------------ADVLTGEGLADALT
Mvan_2101|M.vanbaalenii_PYR-1 SKVVDLLQRDGHHVVAASRASG--------------ADVLTGEGLTDALA
TH_3570|M.thermoresistible__bu SEVVALLRADGHDVVPASLSTG--------------ADVVTGAGLADSLS
MMAR_4766|M.marinum_M SQVVAQLTGLAHQAVAASPRSG--------------VNALTGEGLADAVA
Mflv_1635|M.gilvum_PYR-GCK GRLVPELLARGLQVRAMARTPSKLDRTEWRDRVEVVRGDLTEADSLTAAF
MUL_0982|M.ulcerans_Agy99 SRLVTALLADGHEVLAATRNMARLSRLAWFDDVTPVILDATDRASAQAAM
Mb2073c|M.bovis_AF2122/97 RGLTARLLSQGHEVVGIARHRPD-------SWPSSADFIAADIRDATAVE
Rv2047c|M.tuberculosis_H37Rv RGLTARLLSQGHEVVGIARHRPD-------SWPSSADFIAADIRDATAVE
MAV_4078|M.avium_104 SRVVARLRPRDVAVVEISRAQG--------------VDVFDAPGLTRALE
:. * . : :
MAB_3360c|M.abscessus_ATCC_199 GSAVVIDVVNSPSFEDGPVMDFFT---ASARNLVDAAKATGVGHYVALS-
MSMEG_2353|M.smegmatis_MC2_155 GAEVLVDVVNSPSFADDDVMNFFT---TSTRNLTEAATKTGTGHYVALS-
Mvan_2101|M.vanbaalenii_PYR-1 GADVLVDVTNSPSFDDDAVMDFFT---RSSANLVSAAEESGVRHYVALS-
TH_3570|M.thermoresistible__bu GADVLVDVVNSPSFADGPVSEFFT---AAALNLTAAARAAGVGHHVALS-
MMAR_4766|M.marinum_M GADAVVDVSNSPSFADDDVLHFFT---TSTKNLLAAEQTAGVRHHVALS-
Mflv_1635|M.gilvum_PYR-GCK NGA---DVVYYLVHSMGTSRDFVAEERRSAHNVVEAAKKAGVRRIVYLS-
MUL_0982|M.ulcerans_Agy99 NAAGQIDVVYYLVHGIGQP-DFRDRDKTAAANLAVAARDTGVRRIVYLG-
Mb2073c|M.bovis_AF2122/97 SAMTGADVVAHCAWVRGRNDHINID---GTANVLKAMAETGTGRIVFTSS
Rv2047c|M.tuberculosis_H37Rv SAMTGADVVAHCAWVRGRNDHINID---GTANVLKAMAETGTGRIVFTSS
MAV_4078|M.avium_104 GVDVVIDVSN--PVPPDGRSDIRQTLATAARNIMGACATQEVQRLVVLTI
. ** . .: .: *: * . : *
MAB_3360c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2353|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2101|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3570|M.thermoresistible__bu --------------------------------------------------
MMAR_4766|M.marinum_M --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0982|M.ulcerans_Agy99 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 GHQPRVEQMLADCGLEWVAVRCALIFGRNVDNWVQRLFALPVLPAGYADR
Rv2047c|M.tuberculosis_H37Rv GHQPRVEQMLADCGLEWVAVRCALIFGRNVDNWVQRLFALPVLPAGYADR
MAV_4078|M.avium_104 AG------------------------------------------------
MAB_3360c|M.abscessus_ATCC_199 IVGADGLPESGYMRAKVAQEKIIVGS--------GLPYTIVRATQ-----
MSMEG_2353|M.smegmatis_MC2_155 IVGCDALPDSGYMRAKVAQEKAIAAS--------GIDHTIVRATQ-----
Mvan_2101|M.vanbaalenii_PYR-1 IVGADGLPESGYMRAKVVQEKTIAGS--------DVPHSIVRATQ-----
TH_3570|M.thermoresistible__bu IVGCDELPDSGYMRAKAAQERIIAES--------GLPYTIVRATQ-----
MMAR_4766|M.marinum_M IVGTDRVPNSGYLRAKCAQEKLIKES--------DLPYSIVRATQ-----
Mflv_1635|M.gilvum_PYR-GCK GLHPDRKELSRHLASRVEVGEILMQS-GIETVVLQAGIVIGSGSA-----
MUL_0982|M.ulcerans_Agy99 GFVPECEALSQHLSSRAVVAEALAVDDGAELVWLGAAMIIGAGST-----
Mb2073c|M.bovis_AF2122/97 VVQVVHSDDAQRLLVRALLDTVIDSGPVNLAAPGELTFRRIAAALGRPMV
Rv2047c|M.tuberculosis_H37Rv VVQVVHSDDAQRLLVRALLDTVIDSGPVNLAAPGELTFRRIAAALGRPMV
MAV_4078|M.avium_104 -IEDPVFDEFPYYQAKREAKEILLDG--------PVPTTVVKSTQ-----
. : : . .:
MAB_3360c|M.abscessus_ATCC_199 ---------------------------------------------FQEFA
MSMEG_2353|M.smegmatis_MC2_155 ---------------------------------------------FHEFA
Mvan_2101|M.vanbaalenii_PYR-1 ---------------------------------------------FHEFA
TH_3570|M.thermoresistible__bu ---------------------------------------------FDEFA
MMAR_4766|M.marinum_M ---------------------------------------------FFEFV
Mflv_1635|M.gilvum_PYR-GCK ---------------------------------------------SFEMV
MUL_0982|M.ulcerans_Agy99 ---------------------------------------------LFEML
Mb2073c|M.bovis_AF2122/97 PIGSPVLRRVTSFAELELLHSAPLMDVTLLRDRWGFQPAWNAEECLEDFT
Rv2047c|M.tuberculosis_H37Rv PIGSPVLRRVTSFAELELLHSAPLMDVTLLRDRWGFQPAWNAEECLEDFT
MAV_4078|M.avium_104 ---------------------------------------------WYEFA
::
MAB_3360c|M.abscessus_ATCC_199 EAITDTLVVGD--------EVRVPD-ARIQLIAVDDVSTQVAHAAAAAPR
MSMEG_2353|M.smegmatis_MC2_155 ESITQTLVAGD--------EVRVPD-GRIQLIASDEVAAEVARAAQAAAV
Mvan_2101|M.vanbaalenii_PYR-1 DAIVGTLEADD--------EVRVPD-ARIQPIAADDVAAEVFRAAVGSPV
TH_3570|M.thermoresistible__bu EAIVESLIVGA--------EVRVPD-GSIQPIAAADVAAEVAARAVAEPA
MMAR_4766|M.marinum_M IGIADSATDGD--------TVRLSHTAAIQPIAASDVATGVTRAAISDPL
Mflv_1635|M.gilvum_PYR-GCK RHLTDRLPVMT--------TPKWVH-NKIQPISISDVLHYLAEAATAEFG
MUL_0982|M.ulcerans_Agy99 RYVGDRFPVLP--------MPDWMY-NPIDPISIRDVLHYLVAAADVDQV
Mb2073c|M.bovis_AF2122/97 LAVRGRIGLGKRTFSLPWRLANIQDLPAVDSPADDGVAPRLAGPEGANGE
Rv2047c|M.tuberculosis_H37Rv LAVRGRIGLGKRTFSLPWRLANIQDLPAVDSPADDGVAPRLAGPEGANGE
MAV_4078|M.avium_104 TNHDAVSCDDN---------EVIVEDWLIQPIAADTVADVLVETALAQTH
:: : * :
MAB_3360c|M.abscessus_ATCC_199 -NGIIN--------------IGGPEKFSFADMAGAVLAARGDDRPVVVDS
MSMEG_2353|M.smegmatis_MC2_155 -NGIVN--------------IGGPEKLSFADMARAVLAKHGDDKPVVVDA
Mvan_2101|M.vanbaalenii_PYR-1 -DGVIN--------------IGGPDKISFADLARAVLARRGADKTVVIDP
TH_3570|M.thermoresistible__bu -GGVVN--------------IGGPDRMSFADLARTVLAHQHRRTPVVIDP
MMAR_4766|M.marinum_M -NGTTN--------------IAGPDKFGMDDFVRMGLAAHGDSRQVRTDP
Mflv_1635|M.gilvum_PYR-GCK ESRTWD--------------IGGPDVMEYGDAMQGYADVAGLRRRVMVVL
MUL_0982|M.ulcerans_Agy99 PAGAYD--------------ICGPDTTSYRELLKTYARIRG-RWHAALPV
Mb2073c|M.bovis_AF2122/97 FDTPIDPRFPTYLATNLSEALPGPFSPSSASVTVRGLRAGGVGIAERLRP
Rv2047c|M.tuberculosis_H37Rv FDTPIDPRFPTYLATNLSEALPGPFSPSSASVTVRGLRAGGVGIAERLRP
MAV_4078|M.avium_104 TPRTIT----------------GPDAIRLPELTSKLLVRQGDRRAVRSVE
** .
MAB_3360c|M.abscessus_ATCC_199 --------------------------------------------GATYFG
MSMEG_2353|M.smegmatis_MC2_155 --------------------------------------------QATYFG
Mvan_2101|M.vanbaalenii_PYR-1 --------------------------------------------QATYFG
TH_3570|M.thermoresistible__bu --------------------------------------------QATYFG
MMAR_4766|M.marinum_M --------------------------------------------NARYFG
Mflv_1635|M.gilvum_PYR-GCK P---------------------------FLTPTIASWWVG--LVTPIPSG
MUL_0982|M.ulcerans_Agy99 G---------------------------RLDTAVASRITAGHPAGPAWSG
Mb2073c|M.bovis_AF2122/97 SGVIQREIAMRTVAVFAHRLYGAITSAHFMAATVPFAKPATIVSNSGFFG
Rv2047c|M.tuberculosis_H37Rv SGVIQREIAMRTVAVFAHRLYGAITSAHFMAATVPFAKPATIVSNSGFFG
MAV_4078|M.avium_104 P-------------------------------------------AVSALG
*
MAB_3360c|M.abscessus_ATCC_199 --------------------------------------------TPVDDF
MSMEG_2353|M.smegmatis_MC2_155 --------------------------------------------TAVDDD
Mvan_2101|M.vanbaalenii_PYR-1 --------------------------------------------TPLDQN
TH_3570|M.thermoresistible__bu --------------------------------------------TRIDDT
MMAR_4766|M.marinum_M --------------------------------------------AVLDGH
Mflv_1635|M.gilvum_PYR-GCK LARPLV--------------------------------------ESLECD
MUL_0982|M.ulcerans_Agy99 RRPGGI--------------------------------------AGSPDG
Mb2073c|M.bovis_AF2122/97 PSMASLPIFGAQRPPSESSRARRWLRTLRNIGVFGVNLVGLSAGSPRDTD
Rv2047c|M.tuberculosis_H37Rv PSMASLPIFGAQRPPSESSRARRWLRTLRNIGVFGVNLVGLSAGSPRDTD
MAV_4078|M.avium_104 AG-----------------------------------------ALLASGH
MAB_3360c|M.abscessus_ATCC_199 SLVT--GDDGVLTQTRFADWMARR--------------------------
MSMEG_2353|M.smegmatis_MC2_155 SLVT--GDDGKLATIRFADWLAGR--------------------------
Mvan_2101|M.vanbaalenii_PYR-1 SLVT--GDGAVLGAVRFADHH-----------------------------
TH_3570|M.thermoresistible__bu SLVT--GAGAVIAGTPLAAVLAPPASD-----------------------
MMAR_4766|M.marinum_M SIVPTDGEDVTIYPTHFSDWLAAG--------------------------
Mflv_1635|M.gilvum_PYR-GCK AICHEHDIDAVIPPPKGGLIGYREAVAKELRSEGGSSAGRR----HLLRF
MUL_0982|M.ulcerans_Agy99 GIRGRPARQGPRATRRTTEYRRCHYVGAGRPRERAPVARRRPDRSPPTRI
Mb2073c|M.bovis_AF2122/97 AYVADVDRLERLAFDNLATHDDRRLLSLILLARDHVVHGWVLASGSFMLC
Rv2047c|M.tuberculosis_H37Rv AYVADVDRLERLAFDNLATHDDRRLLSLILLARDHVVHGWVLASGSFMLC
MAV_4078|M.avium_104 AVVVGPDVDTWLQTLAPPGGDGHRGRDGDGHRGADGDHRGADGDGKPRRG
.
MAB_3360c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2353|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2101|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3570|M.thermoresistible__bu --------------------------------------------------
MMAR_4766|M.marinum_M --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK SPAASD--------------------------------------------
MUL_0982|M.ulcerans_Agy99 HRSGVGRR------------------------------------------
Mb2073c|M.bovis_AF2122/97 AAFNVLLRGLCGRDTAPAAGPELVSARSVEAVQRLVAAARRDPVVIRLLA
Rv2047c|M.tuberculosis_H37Rv AAFNVLLRGLCGRDTAPAAGPELVSARSVEAVQRLVAAARRDPVVIRLLA
MAV_4078|M.avium_104 --------------------------------------------------
MAB_3360c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2353|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2101|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3570|M.thermoresistible__bu --------------------------------------------------
MMAR_4766|M.marinum_M --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0982|M.ulcerans_Agy99 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 EPGERLDKLAVEAPEFHSAVLAELTLIGHRGPAEVEMAATSYADNPELLV
Rv2047c|M.tuberculosis_H37Rv EPGERLDKLAVEAPEFHSAVLAELTLIGHRGPAEVEMAATSYADNPELLV
MAV_4078|M.avium_104 --------------------------------------------------
MAB_3360c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2353|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2101|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3570|M.thermoresistible__bu --------------------------------------------------
MMAR_4766|M.marinum_M --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0982|M.ulcerans_Agy99 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 RMVAKTLRAVPAPQPPTPVIPLRAKPVALLAARQLRDREVRRDRMVRAIW
Rv2047c|M.tuberculosis_H37Rv RMVAKTLRAVPAPQPPTPVIPLRAKPVALLAARQLRDREVRRDRMVRAIW
MAV_4078|M.avium_104 --------------------------------------------------
MAB_3360c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2353|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2101|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3570|M.thermoresistible__bu --------------------------------------------------
MMAR_4766|M.marinum_M --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0982|M.ulcerans_Agy99 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 VLRALLREYGRRLTEAGVFDTPDDVFYLLVDEIDALPADVSGLVARRRAE
Rv2047c|M.tuberculosis_H37Rv VLRALLREYGRRLTEAGVFDTPDDVFYLLVDEIDALPADVSGLVARRRAE
MAV_4078|M.avium_104 --------------------------------------------------
MAB_3360c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2353|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2101|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3570|M.thermoresistible__bu --------------------------------------------------
MMAR_4766|M.marinum_M --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0982|M.ulcerans_Agy99 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 QRRLAGIVPPTVFSGSWEPSPSSAAALAAGDTLRGVGVCGGRVRGRVRIV
Rv2047c|M.tuberculosis_H37Rv QRRLAGIVPPTVFSGSWEPSPSSAAALAAGDTLRGVGVCGGRVRGRVRIV
MAV_4078|M.avium_104 --------------------------------------------------
MAB_3360c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2353|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2101|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3570|M.thermoresistible__bu --------------------------------------------------
MMAR_4766|M.marinum_M --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0982|M.ulcerans_Agy99 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 RPETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVARE
Rv2047c|M.tuberculosis_H37Rv RPETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVARE
MAV_4078|M.avium_104 --------------------------------------------------
MAB_3360c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2353|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2101|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3570|M.thermoresistible__bu --------------------------------------------------
MMAR_4766|M.marinum_M --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0982|M.ulcerans_Agy99 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 FGFPCVVDAQGATRFLPPGALVEVDGATGEIHVVELASEDGPALPGSDLS
Rv2047c|M.tuberculosis_H37Rv FGFPCVVDAQGATRFLPPGALVEVDGATGEIHVVELASEDGPALPGSDLS
MAV_4078|M.avium_104 --------------------------------------------------
MAB_3360c|M.abscessus_ATCC_199 -
MSMEG_2353|M.smegmatis_MC2_155 -
Mvan_2101|M.vanbaalenii_PYR-1 -
TH_3570|M.thermoresistible__bu -
MMAR_4766|M.marinum_M -
Mflv_1635|M.gilvum_PYR-GCK -
MUL_0982|M.ulcerans_Agy99 -
Mb2073c|M.bovis_AF2122/97 R
Rv2047c|M.tuberculosis_H37Rv R
MAV_4078|M.avium_104 -