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ALATWVSAINFWAWNMIGPLSTTYAGDMSLSSSEASILVATPILVGALGRIVVGPLTDRYGGRVMFMAVT LASIVPVLAVGIAGSSGSYPLLVVFGFFLGVAGTVFAVGIPFANHWYEASRRGFATGVFGMGMVGTALSA FFTPRFVKWFGLFTTHVIIAAALAVTAALCLFIMRDSPNFTPNHDAVVPKLKAAARLPVTWEMSFLYAVV FGGFVAFSNYLPTYIKTIYGFSAVDAGARTAGFALAAVLARPVGGALADRFAPKYVVLASFAGTAAMAFV AIFQPPPDIWSAATFITLALFLGIGTGGVFAWVARRAPAKSVGSVTGIVAAAGGLGGYFPPLVMGASYDS IENDYTIGLTLLVATALLAFLYTALRLHAREPQQKEAAT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4547 | - | - | 100% (390) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_3492 | - | 5e-20 | 26.39% (360) | nitrite transporter |
| M. vanbaalenii PYR-1 | Mvan_4266 | - | 7e-11 | 24.09% (357) | general substrate transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1766c | narK2 | 0.0 | 79.18% (389) | nitrate/nitrite transporter NarK2 |
| M. gilvum PYR-GCK | Mflv_2155 | - | 0.0 | 89.06% (384) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv1737c | narK2 | 0.0 | 79.18% (389) | nitrate/nitrite transporter NarK2 |
| M. leprae Br4923 | MLBr_00844 | narK | 7e-15 | 26.42% (371) | putative nitrite extrusion protein |
| M. abscessus ATCC 19977 | MAB_3523c | - | 1e-14 | 25.61% (371) | integral membrane nitrite extrusion protein NarK3 |
| M. marinum M | MMAR_0526 | narU | 3e-22 | 27.70% (361) | integral membrane nitrite extrusion protein NarU |
| M. avium 104 | MAV_4892 | narK | 6e-24 | 28.25% (361) | nitrite transporter |
| M. smegmatis MC2 155 | MSMEG_5141 | - | 0.0 | 84.33% (383) | nitrate/nitrite transporter protein |
| M. thermoresistible (build 8) | TH_0644 | narK2 | 6e-99 | 83.73% (209) | POSSIBLE NITRATE/NITRITE TRANSPORTER NARK2 |
| M. ulcerans Agy99 | MUL_1189 | narU | 2e-22 | 27.98% (361) | integral membrane nitrite extrusion protein NarU |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1766c|M.bovis_AF2122/97 --------------------------------------------------
Rv1737c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_4547|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2155|M.gilvum_PYR-GCK ----------------------------------------MEVVGQTCLS
MSMEG_5141|M.smegmatis_MC2_155 --------------------------------------------------
TH_0644|M.thermoresistible__bu --------------------------------------------------
MLBr_00844|M.leprae_Br4923 MDQLVLLQAEESLYGPGRRSKTVPIDHRHSLKSSFFRLRLRRACRISHWD
MAB_3523c|M.abscessus_ATCC_199 ---------------MANNTATAPIAR--------------RGRWIENWD
MMAR_0526|M.marinum_M -------------------MTITPVRQHTAPRE-----QHVGRHWIHDWR
MUL_1189|M.ulcerans_Agy99 -------------------MTITPVRQHTAPRE-----QHVGRHWIHDWR
MAV_4892|M.avium_104 -----------------MTTTITPVPQPAAAPE-----RHKGRHWIDDWR
Mb1766c|M.bovis_AF2122/97 -----------MRGQAANLVLATWISVVNFWAWNLIGPLSTSYARD----
Rv1737c|M.tuberculosis_H37Rv -----------MRGQAANLVLATWISVVNFWAWNLIGPLSTSYARD----
Mvan_4547|M.vanbaalenii_PYR-1 ------------------MALATWVSAINFWAWNMIGPLSTTYAGD----
Mflv_2155|M.gilvum_PYR-GCK GRVSTATTPDIGARRGLNLALATWVSAINFWAWNMIGPLSTTYAGD----
MSMEG_5141|M.smegmatis_MC2_155 --MSTATTPYT--RQGVNLALATWVSAINFWAWNMIGPLSTTYAGD----
TH_0644|M.thermoresistible__bu ----------------------------------MIGPLSTTYAVD----
MLBr_00844|M.leprae_Br4923 PEDQAAWEAGNKTIARLNLLWSVLTVHLGYSVWTLWPVMELFMPKD----
MAB_3523c|M.abscessus_ATCC_199 PEDVVAWDNGGAKIARRNLIWSVVAEHVGFSVWSIWSVMVLFMPQN----
MMAR_0526|M.marinum_M PEDPEFWDTIGRPIARRNLVFSIFAEHIGFSVWMLWSIVVVQMMAVGAPG
MUL_1189|M.ulcerans_Agy99 PEDPEFWDTIGRPIARRNLVFSIFAEHIGFTVWMLWSIVVVQMMAVGAPG
MAV_4892|M.avium_104 PEDPEFWETTGKAIARRNLIFSIFAEHVGFSVWMLWSIVVVHMTAG----
: :
Mb1766c|M.bovis_AF2122/97 ---------MSLSSAEASLLVATPILVGALGRIVTGPLTDRFGGRAMLIA
Rv1737c|M.tuberculosis_H37Rv ---------MSLSSAEASLLVATPILVGALGRIVTGPLTDRFGGRAMLIA
Mvan_4547|M.vanbaalenii_PYR-1 ---------MSLSSSEASILVATPILVGALGRIVVGPLTDRYGGRVMFMA
Mflv_2155|M.gilvum_PYR-GCK ---------MSLSSSQASVLVATPILVGALGRIVVGPLTDRFGGRVMFIG
MSMEG_5141|M.smegmatis_MC2_155 ---------MRLSSTEASMLVATPILVGSLGRIVIGSLTDRFGGRTMFIA
TH_0644|M.thermoresistible__bu ---------ISLSSAEASMLVATPILVGAVGRIVVGSLTDRYGGRAMFIA
MLBr_00844|M.leprae_Br4923 --------VYGFSAGDKFLLATTATLVGACLRVPYSLATALFGGRNWAIF
MAB_3523c|M.abscessus_ATCC_199 --------VYHIDAAGKFFLVAMPTLVGAVLRLPYTFATAWFGGRNWTVF
MMAR_0526|M.marinum_M HPSHPAASGWALSPSQALCLVAVPSGVGALLRLPYTFAIPVFGGRNWTTI
MUL_1189|M.ulcerans_Agy99 HPSHPAASGWALSPSQALCLVAVPSGVGALLRLPYTFAIPVFGGRNWTTI
MAV_4892|M.avium_104 PHGHPSASGWALTASQALCLVAVPSGVGAFLRLPYTFAVPVFGGRNWTTI
: . *.: . **: *: :***
Mb1766c|M.bovis_AF2122/97 VTLASILPVLAVGVAATMG--SYALLVFFGLFLGVAGTIFAVGIPFANNW
Rv1737c|M.tuberculosis_H37Rv VTLASILPVLAVGVAATMG--SYALLVFFGLFLGVAGTIFAVGIPFANNW
Mvan_4547|M.vanbaalenii_PYR-1 VTLASIVPVLAVGIAGSSG--SYPLLVVFGFFLGVAGTVFAVGIPFANHW
Mflv_2155|M.gilvum_PYR-GCK VTVASIVPVLAVGVAGTQG--SYPLLVVFGLFLGIAGTVFAVGIPFANHW
MSMEG_5141|M.smegmatis_MC2_155 VTVASILPVLAVGAAGSAG--SYPLLLVCGFFLGVAGTIFAVGIPFSNNW
TH_0644|M.thermoresistible__bu ITLASIVPVLAVGAAGAAG--SYPLLLVFGFFLGIAGTIFAVGIPFANNW
MLBr_00844|M.leprae_Br4923 SVMVLLIPTIATMVLLAHPGLPLWPYLACAALTGLGGGNFAASMTNANAF
MAB_3523c|M.abscessus_ATCC_199 SALVLAVPTALTLYFMAHPETSYTTFMIVAAVAGFGGGNFASSMTNINAF
MMAR_0526|M.marinum_M SASLLVIPCLLLSWAVSHPGIPFVLLTLIAATAGVGGGNFASSMANISFF
MUL_1189|M.ulcerans_Agy99 SASLLVIPCLLLSWAVSHPGIPFVLLTLIAATAGVGGGNFASSMANISFF
MAV_4892|M.avium_104 SAALLLIPCLLLAWAVSHPGIPFGVLVAIAATAGFGGGNFASSMANISFF
. :* : . . *..* ** .:. . :
Mb1766c|M.bovis_AF2122/97 YQPARRGFSTGVFG-MGMVGTALSAFFTPRFVRWFG---LFTTHAIVAAA
Rv1737c|M.tuberculosis_H37Rv YQPARRGFSTGVFG-MGMVGTALSAFFTPRFVRWFG---LFTTHAIVAAA
Mvan_4547|M.vanbaalenii_PYR-1 YEASRRGFATGVFG-MGMVGTALSAFFTPRFVKWFG---LFTTHVIIAAA
Mflv_2155|M.gilvum_PYR-GCK YDASRRGFATGVFG-MGMVGTAMSAFFTPRFVNWFG---LFTTHVIIAVA
MSMEG_5141|M.smegmatis_MC2_155 YDVSRRGFATGVFG-MGMVGTALSAFFTPRFVNWFG---LFTTHLIVAIA
TH_0644|M.thermoresistible__bu YAPSRRGFATGVFG-MGMVGTALSAFFTPRFVESFG---LFTTHVIIAVA
MLBr_00844|M.leprae_Br4923 YPHRLKGAAFGLAGGAGNLGVSVIQVVGMLVIASVGDRKPYIVCGLYVVL
MAB_3523c|M.abscessus_ATCC_199 YPQRFKGWALGLNAGGGNIGVPVIQVIGLLVIATVGNRSPHWVAAIYLVL
MMAR_0526|M.marinum_M YPEKDKGWALGLNAAGGNIGVAVVQKIIPPIVVAGGGMALARAGLFYVPL
MUL_1189|M.ulcerans_Agy99 YPEKDKGWALGLNAAGGNVGVAVVQKIIPPIVVAGGGMALARAGLFYVPL
MAV_4892|M.avium_104 YPEKDKGWALGLNAAGGNIGVAVVQKVIPPVVIAGGGVALSRAGLFYVPL
* :* : *: . * :*..: . .: * . :
Mb1766c|M.bovis_AF2122/97 LASTAVVAMVVLRDAPYFRPNADPVLPRLKAAARLPVTWEMSFLYAIVFG
Rv1737c|M.tuberculosis_H37Rv LASTAVVAMVVLRDAPYFRPNADPVLPRLKAAARLPVTWEMSFLYAIVFG
Mvan_4547|M.vanbaalenii_PYR-1 LAVTAALCLFIMRDSPNFTPNHDAVVPKLKAAARLPVTWEMSFLYAVVFG
Mflv_2155|M.gilvum_PYR-GCK LALTAVLCLVVMRDSPQFTPNHDAVMPKLRAAAKLPVTWEMSFLYAVVFG
MSMEG_5141|M.smegmatis_MC2_155 LALTAVLCVVMMRDAPSFRPNTDPVVPKLKAAAKLPVTWEMSFLYAVVFG
TH_0644|M.thermoresistible__bu LGLTALLCLVAMHDSPDFTPNTERVLPKLKAAARLPVTWEMSILYAIVFG
MLBr_00844|M.leprae_Br4923 LIIAGIGAMLFMNDIEHHRIGVNTIRPVLFVVVSTRDSWVLALLYLASFG
MAB_3523c|M.abscessus_ATCC_199 IAFAAVGAALFMDNLADQKTDG----RSLIDVMKYRDSWIIAFLYIGTFG
MMAR_0526|M.marinum_M AVVAAVCAFAFMNNLAEAKADVKP----VWQSLRHADTWILALLYIGTFG
MUL_1189|M.ulcerans_Agy99 AVVAAVCAFAFMNNLAEAKADVKP----VWQSLRHVDTWILALLYIGTFG
MAV_4892|M.avium_104 AVVAAVCAFLFMNNLTEIKADVKP----VWQSLRHADTWIMSLLYIGTFG
:. . : : . : :* :::** **
Mb1766c|M.bovis_AF2122/97 GFVAFSNYLPTYIT-----TIYGFS---------------TVDAGARTAG
Rv1737c|M.tuberculosis_H37Rv GFVAFSNYLPTYIT-----TIYGFS---------------TVDAGARTAG
Mvan_4547|M.vanbaalenii_PYR-1 GFVAFSNYLPTYIK-----TIYGFS---------------AVDAGARTAG
Mflv_2155|M.gilvum_PYR-GCK GFVAFSNYLPTYIK-----TIYDFS---------------AVDAGARTAA
MSMEG_5141|M.smegmatis_MC2_155 GFVAFSNYLPTYIK-----TIYDFS---------------AVEAGSRTAG
TH_0644|M.thermoresistible__bu GFVAFSNYLPTYXPSSPACTITTCT---------------STPPPRHSTR
MLBr_00844|M.leprae_Br4923 SFIGFSFAFGQVLE-----TNFVAG--------GQSTAQAALHAAELAFI
MAB_3523c|M.abscessus_ATCC_199 SFIGFSFAFGQVLQ-----LNFLAGLAHSGVTPAQAAAQASLHAAQIAFI
MMAR_0526|M.marinum_M SFIGYSAAFPTLLK-----TVFDRG----------------DIALGWAFL
MUL_1189|M.ulcerans_Agy99 SFIGYSAAFPTLLK-----TVFDRG----------------DIALGWAFL
MAV_4892|M.avium_104 SFIGYSAAFPTLLK-----TVFGRG----------------DIALAWAFL
.*:.:* : . :
Mb1766c|M.bovis_AF2122/97 FALAAVLARPVGGWLSDRIAPRHVVLASLAGTALLA------------FA
Rv1737c|M.tuberculosis_H37Rv FALAAVLARPVGGWLSDRIAPRHVVLASLAGTALLA------------FA
Mvan_4547|M.vanbaalenii_PYR-1 FALAAVLARPVGGALADRFAPKYVVLASFAGTAAMA------------FV
Mflv_2155|M.gilvum_PYR-GCK FALAAVLARPVGGMLADRIPPKYVVLGSFAGTAAAA------------FV
MSMEG_5141|M.smegmatis_MC2_155 FAVAAVLARPVGGALSDRIPPKYVVLASFAGTALLA------------FV
TH_0644|M.thermoresistible__bu FGSGPGRSGPAG-SWPMCSPPRNPVTTAGSG-------------------
MLBr_00844|M.leprae_Br4923 GPTLAAVARFWGGRLADRLGGSRVTLVVFGAMVFAAGLLGVLGIIEGSRV
MAB_3523c|M.abscessus_ATCC_199 GPLLGSLARPFGGWLSDRTGGGKISLYAFIAMIFGAGILVAAGTISDRGA
MMAR_0526|M.marinum_M GAGIGSVIRPLGGRLADRVGGARVTAVSFLMLAIGA----------AAAL
MUL_1189|M.ulcerans_Agy99 GAGIGSVIRPLGGRLADRVGGARVTAVSFLMLAIGA----------AAAL
MAV_4892|M.avium_104 GAAIGSVIRPLGGKLADRVGGARITAASFVMLAVGA----------AAAL
* .
Mb1766c|M.bovis_AF2122/97 AALQPPPEVWSAATFITLAVCLGVGTGGVFAWVARRAPAAS---------
Rv1737c|M.tuberculosis_H37Rv AALQPPPEVWSAATFITLAVCLGVGTGGVFAWVARRAPAAS---------
Mvan_4547|M.vanbaalenii_PYR-1 AIFQPPPDIWSAATFITLALFLGIGTGGVFAWVARRAPAKS---------
Mflv_2155|M.gilvum_PYR-GCK AIFQPPPDLWSAVTFITLALFLGIGTGGVFAWVARRAPASS---------
MSMEG_5141|M.smegmatis_MC2_155 AVFQPPPDVWSATTFITLAIFLGVGTGGVFAWVARRSPAQS---------
TH_0644|M.thermoresistible__bu ---------RSAITRRSRGHWIGVRS-------TRSHPMCR---------
MLBr_00844|M.leprae_Br4923 CPIRGVMMASYFAGFITLFILSGLGNGSVYKMIPTIFEACSHSLGINDDE
MAB_3523c|M.abscessus_ATCC_199 GAPSGSIMTAYVIGFIILFVVSGIGNGSVYKMIPSVFAAKARSAGLDET-
MMAR_0526|M.marinum_M WSVQIVNLPLFFASFMFLFVATGIGNGSTYRMISRIFKVKGELAGGDPDT
MUL_1189|M.ulcerans_Agy99 WSVQNVNLPLFFASFMFLFVATGIGNGSTYRMISRIFKVKGELAGGDPDT
MAV_4892|M.avium_104 WSVKAVNLPAFFASFMFLFVATGIGNGSTYRMISRIFKIKGELAGGDPDT
*: . .
Mb1766c|M.bovis_AF2122/97 --------VGSVTGIVAAAGGLGGYFPPLVMGATYDPVDNDYTVGLLLLV
Rv1737c|M.tuberculosis_H37Rv --------VGSVTGIVAAAGGLGGYFPPLVMGATYDPVDNDYTVGLLLLV
Mvan_4547|M.vanbaalenii_PYR-1 --------VGSVTGIVAAAGGLGGYFPPLVMGASYDSIENDYTIGLTLLV
Mflv_2155|M.gilvum_PYR-GCK --------VGSVTGIVAAAGGLGGYFPPLVMGGTYDSVDNDYTIGLSLLV
MSMEG_5141|M.smegmatis_MC2_155 --------VGSVTGIVAAAGGLGGYFPPLVMGATYDADDNDYTVGLLLLV
TH_0644|M.thermoresistible__bu --------CGCST--AAACCGR----------------------------
MLBr_00844|M.leprae_Br4923 CRDWSRVISGVVIGFVAEVGALGGVGIDLALRESYLNTGG-VTAAFWIFM
MAB_3523c|M.abscessus_ATCC_199 ---WSRTMSGALIGVAGAIGALGGVAINLVLRASYLSAAKSATMAFWVFL
MMAR_0526|M.marinum_M MVQMRRQAAG-ALGVISAVGAFGGFLVPLAYAWSKAQFGN-IEPALRFYV
MUL_1189|M.ulcerans_Agy99 MVQMRRQAAG-ALGVISAVGAFGGFLVPLAYAWSKAQFGN-IEPALRFYV
MAV_4892|M.avium_104 MVTMRRQAAG-ALGVISAVGAFGGFIVPLAYAWSKSQFGS-IEPALRFYV
* . .
Mb1766c|M.bovis_AF2122/97 ATALVACTYTAL--HAREP-----VSEEASR------------
Rv1737c|M.tuberculosis_H37Rv ATALVACTYTAL--HAREP-----VSEEASR------------
Mvan_4547|M.vanbaalenii_PYR-1 ATALLAFLYTALRLHAREP-----QQKEAAT------------
Mflv_2155|M.gilvum_PYR-GCK ATALIALLYTALRLHAHEP-----KPTQEVR------------
MSMEG_5141|M.smegmatis_MC2_155 ATALVAFAYTALRLHAHEPGRGGVRSDQIDR------------
TH_0644|M.thermoresistible__bu -------------------------------------------
MLBr_00844|M.leprae_Br4923 LCYAAAGVLTWKMYVCRPLPGNLHDEAANAFAASVGASRTHRG
MAB_3523c|M.abscessus_ATCC_199 VFYVICAAVTWYAYVRRPMTVSVPAISSSKNEVAV--------
MMAR_0526|M.marinum_M VFFLALLFVTWHCYLRSKTPMAQLGV-----------------
MUL_1189|M.ulcerans_Agy99 VFFLALLFVTWHCYLRSKTPMAQLGV-----------------
MAV_4892|M.avium_104 VFFLGLLAVTWYCYLRKHNAITRVGI-----------------