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RGQAANLVLATWISVVNFWAWNLIGPLSTSYARDMSLSSAEASLLVATPILVGALGRIVTGPLTDRFGGR AMLIAVTLASILPVLAVGVAATMGSYALLVFFGLFLGVAGTIFAVGIPFANNWYQPARRGFSTGVFGMGM VGTALSAFFTPRFVRWFGLFTTHAIVAAALASTAVVAMVVLRDAPYFRPNADPVLPRLKAAARLPVTWEM SFLYAIVFGGFVAFSNYLPTYITTIYGFSTVDAGARTAGFALAAVLARPVGGWLSDRIAPRHVVLASLAG TALLAFAAALQPPPEVWSAATFITLAVCLGVGTGGVFAWVARRAPAASVGSVTGIVAAAGGLGGYFPPLV MGATYDPVDNDYTVGLLLLVATALVACTYTALHAREPVSEEASR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1737c | narK2 | - | 100% (395) | POSSIBLE NITRATE/NITRITE TRANSPORTER NARK2 |
| M. tuberculosis H37Rv | Rv0267 | narU | 1e-20 | 26.22% (389) | integral membrane nitrite extrusion protein NarU |
| M. tuberculosis H37Rv | Rv0261c | narK3 | 5e-14 | 25.58% (434) | integral membrane nitrite extrusion protein NarK3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1766c | narK2 | 0.0 | 100.00% (395) | nitrate/nitrite transporter NarK2 |
| M. gilvum PYR-GCK | Mflv_2155 | - | 1e-179 | 79.17% (384) | major facilitator transporter |
| M. leprae Br4923 | MLBr_00844 | narK | 3e-17 | 25.44% (401) | putative nitrite extrusion protein |
| M. abscessus ATCC 19977 | MAB_3523c | - | 2e-17 | 25.06% (439) | integral membrane nitrite extrusion protein NarK3 |
| M. marinum M | MMAR_0526 | narU | 1e-19 | 26.60% (376) | integral membrane nitrite extrusion protein NarU |
| M. avium 104 | MAV_4892 | narK | 2e-21 | 25.71% (420) | nitrite transporter |
| M. smegmatis MC2 155 | MSMEG_5141 | - | 1e-180 | 80.88% (387) | nitrate/nitrite transporter protein |
| M. thermoresistible (build 8) | TH_0644 | narK2 | 4e-92 | 68.70% (246) | POSSIBLE NITRATE/NITRITE TRANSPORTER NARK2 |
| M. ulcerans Agy99 | MUL_1189 | narU | 2e-19 | 26.60% (376) | integral membrane nitrite extrusion protein NarU |
| M. vanbaalenii PYR-1 | Mvan_4547 | - | 0.0 | 79.18% (389) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1737c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1766c|M.bovis_AF2122/97 --------------------------------------------------
Mflv_2155|M.gilvum_PYR-GCK ----------------------------------------MEVVGQTCLS
Mvan_4547|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5141|M.smegmatis_MC2_155 --------------------------------------------------
TH_0644|M.thermoresistible__bu --------------------------------------------------
MLBr_00844|M.leprae_Br4923 MDQLVLLQAEESLYGPGRRSKTVPIDHRHSLKSSFFRLRLRRACRISHWD
MAB_3523c|M.abscessus_ATCC_199 ---------------MANNTATAPIAR--------------RGRWIENWD
MMAR_0526|M.marinum_M -------------------MTITPVRQHTAPRE-----QHVGRHWIHDWR
MUL_1189|M.ulcerans_Agy99 -------------------MTITPVRQHTAPRE-----QHVGRHWIHDWR
MAV_4892|M.avium_104 -----------------MTTTITPVPQPAAAPE-----RHKGRHWIDDWR
Rv1737c|M.tuberculosis_H37Rv -----------MRGQAANLVLATWISVVNFWAWNLIGPLSTSYARD----
Mb1766c|M.bovis_AF2122/97 -----------MRGQAANLVLATWISVVNFWAWNLIGPLSTSYARD----
Mflv_2155|M.gilvum_PYR-GCK GRVSTATTPDIGARRGLNLALATWVSAINFWAWNMIGPLSTTYAGD----
Mvan_4547|M.vanbaalenii_PYR-1 ------------------MALATWVSAINFWAWNMIGPLSTTYAGD----
MSMEG_5141|M.smegmatis_MC2_155 --MSTATTPYT--RQGVNLALATWVSAINFWAWNMIGPLSTTYAGD----
TH_0644|M.thermoresistible__bu ----------------------------------MIGPLSTTYAVD----
MLBr_00844|M.leprae_Br4923 PEDQAAWEAGNKTIARLNLLWSVLTVHLGYSVWTLWPVMELFMPKD----
MAB_3523c|M.abscessus_ATCC_199 PEDVVAWDNGGAKIARRNLIWSVVAEHVGFSVWSIWSVMVLFMPQN----
MMAR_0526|M.marinum_M PEDPEFWDTIGRPIARRNLVFSIFAEHIGFSVWMLWSIVVVQMMAVGAPG
MUL_1189|M.ulcerans_Agy99 PEDPEFWDTIGRPIARRNLVFSIFAEHIGFTVWMLWSIVVVQMMAVGAPG
MAV_4892|M.avium_104 PEDPEFWETTGKAIARRNLIFSIFAEHVGFSVWMLWSIVVVHMTAG----
: :
Rv1737c|M.tuberculosis_H37Rv ---------MSLSSAEASLLVATPILVGALGRIVTGPLTDRFGGRAMLIA
Mb1766c|M.bovis_AF2122/97 ---------MSLSSAEASLLVATPILVGALGRIVTGPLTDRFGGRAMLIA
Mflv_2155|M.gilvum_PYR-GCK ---------MSLSSSQASVLVATPILVGALGRIVVGPLTDRFGGRVMFIG
Mvan_4547|M.vanbaalenii_PYR-1 ---------MSLSSSEASILVATPILVGALGRIVVGPLTDRYGGRVMFMA
MSMEG_5141|M.smegmatis_MC2_155 ---------MRLSSTEASMLVATPILVGSLGRIVIGSLTDRFGGRTMFIA
TH_0644|M.thermoresistible__bu ---------ISLSSAEASMLVATPILVGAVGRIVVGSLTDRYGGRAMFIA
MLBr_00844|M.leprae_Br4923 --------VYGFSAGDKFLLATTATLVGACLRVPYSLATALFGGRNWAIF
MAB_3523c|M.abscessus_ATCC_199 --------VYHIDAAGKFFLVAMPTLVGAVLRLPYTFATAWFGGRNWTVF
MMAR_0526|M.marinum_M HPSHPAASGWALSPSQALCLVAVPSGVGALLRLPYTFAIPVFGGRNWTTI
MUL_1189|M.ulcerans_Agy99 HPSHPAASGWALSPSQALCLVAVPSGVGALLRLPYTFAIPVFGGRNWTTI
MAV_4892|M.avium_104 PHGHPSASGWALTASQALCLVAVPSGVGAFLRLPYTFAVPVFGGRNWTTI
: . *.: . **: *: :***
Rv1737c|M.tuberculosis_H37Rv VTLASILPVLAVGVAATMG--SYALLVFFGLFLGVAGTIFAVGIPFANNW
Mb1766c|M.bovis_AF2122/97 VTLASILPVLAVGVAATMG--SYALLVFFGLFLGVAGTIFAVGIPFANNW
Mflv_2155|M.gilvum_PYR-GCK VTVASIVPVLAVGVAGTQG--SYPLLVVFGLFLGIAGTVFAVGIPFANHW
Mvan_4547|M.vanbaalenii_PYR-1 VTLASIVPVLAVGIAGSSG--SYPLLVVFGFFLGVAGTVFAVGIPFANHW
MSMEG_5141|M.smegmatis_MC2_155 VTVASILPVLAVGAAGSAG--SYPLLLVCGFFLGVAGTIFAVGIPFSNNW
TH_0644|M.thermoresistible__bu ITLASIVPVLAVGAAGAAG--SYPLLLVFGFFLGIAGTIFAVGIPFANNW
MLBr_00844|M.leprae_Br4923 SVMVLLIPTIATMVLLAHPGLPLWPYLACAALTGLGGGNFAASMTNANAF
MAB_3523c|M.abscessus_ATCC_199 SALVLAVPTALTLYFMAHPETSYTTFMIVAAVAGFGGGNFASSMTNINAF
MMAR_0526|M.marinum_M SASLLVIPCLLLSWAVSHPGIPFVLLTLIAATAGVGGGNFASSMANISFF
MUL_1189|M.ulcerans_Agy99 SASLLVIPCLLLSWAVSHPGIPFVLLTLIAATAGVGGGNFASSMANISFF
MAV_4892|M.avium_104 SAALLLIPCLLLAWAVSHPGIPFGVLVAIAATAGFGGGNFASSMANISFF
. :* : . . *..* ** .:. . :
Rv1737c|M.tuberculosis_H37Rv YQPARRGFSTGVFG-MGMVGTALSAFFTPRFVRWFG---LFTTHAIVAAA
Mb1766c|M.bovis_AF2122/97 YQPARRGFSTGVFG-MGMVGTALSAFFTPRFVRWFG---LFTTHAIVAAA
Mflv_2155|M.gilvum_PYR-GCK YDASRRGFATGVFG-MGMVGTAMSAFFTPRFVNWFG---LFTTHVIIAVA
Mvan_4547|M.vanbaalenii_PYR-1 YEASRRGFATGVFG-MGMVGTALSAFFTPRFVKWFG---LFTTHVIIAAA
MSMEG_5141|M.smegmatis_MC2_155 YDVSRRGFATGVFG-MGMVGTALSAFFTPRFVNWFG---LFTTHLIVAIA
TH_0644|M.thermoresistible__bu YAPSRRGFATGVFG-MGMVGTALSAFFTPRFVESFG---LFTTHVIIAVA
MLBr_00844|M.leprae_Br4923 YPHRLKGAAFGLAGGAGNLGVSVIQVVGMLVIASVGDRKPYIVCGLYVVL
MAB_3523c|M.abscessus_ATCC_199 YPQRFKGWALGLNAGGGNIGVPVIQVIGLLVIATVGNRSPHWVAAIYLVL
MMAR_0526|M.marinum_M YPEKDKGWALGLNAAGGNIGVAVVQKIIPPIVVAGGGMALARAGLFYVPL
MUL_1189|M.ulcerans_Agy99 YPEKDKGWALGLNAAGGNVGVAVVQKIIPPIVVAGGGMALARAGLFYVPL
MAV_4892|M.avium_104 YPEKDKGWALGLNAAGGNIGVAVVQKVIPPVVIAGGGVALSRAGLFYVPL
* :* : *: . * :*..: . .: * . :
Rv1737c|M.tuberculosis_H37Rv LASTAVVAMVVLRDAPYFRPNADPVLPRLKAAARLPVTWEMSFLYAIVFG
Mb1766c|M.bovis_AF2122/97 LASTAVVAMVVLRDAPYFRPNADPVLPRLKAAARLPVTWEMSFLYAIVFG
Mflv_2155|M.gilvum_PYR-GCK LALTAVLCLVVMRDSPQFTPNHDAVMPKLRAAAKLPVTWEMSFLYAVVFG
Mvan_4547|M.vanbaalenii_PYR-1 LAVTAALCLFIMRDSPNFTPNHDAVVPKLKAAARLPVTWEMSFLYAVVFG
MSMEG_5141|M.smegmatis_MC2_155 LALTAVLCVVMMRDAPSFRPNTDPVVPKLKAAAKLPVTWEMSFLYAVVFG
TH_0644|M.thermoresistible__bu LGLTALLCLVAMHDSPDFTPNTERVLPKLKAAARLPVTWEMSILYAIVFG
MLBr_00844|M.leprae_Br4923 LIIAGIGAMLFMNDIEHHRIGVNTIRPVLFVVVSTRDSWVLALLYLASFG
MAB_3523c|M.abscessus_ATCC_199 IAFAAVGAALFMDNLADQKTDG----RSLIDVMKYRDSWIIAFLYIGTFG
MMAR_0526|M.marinum_M AVVAAVCAFAFMNNLAEAKADVKP----VWQSLRHADTWILALLYIGTFG
MUL_1189|M.ulcerans_Agy99 AVVAAVCAFAFMNNLAEAKADVKP----VWQSLRHVDTWILALLYIGTFG
MAV_4892|M.avium_104 AVVAAVCAFLFMNNLTEIKADVKP----VWQSLRHADTWIMSLLYIGTFG
:. . : : . : :* :::** **
Rv1737c|M.tuberculosis_H37Rv GFVAFSNYLPTYIT-----TIYGFS---------------TVDAGARTAG
Mb1766c|M.bovis_AF2122/97 GFVAFSNYLPTYIT-----TIYGFS---------------TVDAGARTAG
Mflv_2155|M.gilvum_PYR-GCK GFVAFSNYLPTYIK-----TIYDFS---------------AVDAGARTAA
Mvan_4547|M.vanbaalenii_PYR-1 GFVAFSNYLPTYIK-----TIYGFS---------------AVDAGARTAG
MSMEG_5141|M.smegmatis_MC2_155 GFVAFSNYLPTYIK-----TIYDFS---------------AVEAGSRTAG
TH_0644|M.thermoresistible__bu GFVAFSNYLPTYXPSSPACTITTCT---------------STPPPRHSTR
MLBr_00844|M.leprae_Br4923 SFIGFSFAFGQVLE-----TNFVAG--------GQSTAQAALHAAELAFI
MAB_3523c|M.abscessus_ATCC_199 SFIGFSFAFGQVLQ-----LNFLAGLAHSGVTPAQAAAQASLHAAQIAFI
MMAR_0526|M.marinum_M SFIGYSAAFPTLLK-----TVFDRG----------------DIALGWAFL
MUL_1189|M.ulcerans_Agy99 SFIGYSAAFPTLLK-----TVFDRG----------------DIALGWAFL
MAV_4892|M.avium_104 SFIGYSAAFPTLLK-----TVFGRG----------------DIALAWAFL
.*:.:* : . :
Rv1737c|M.tuberculosis_H37Rv FALAAVLARPVGGWLSDRIAPRHVVLASLAGTALLA------------FA
Mb1766c|M.bovis_AF2122/97 FALAAVLARPVGGWLSDRIAPRHVVLASLAGTALLA------------FA
Mflv_2155|M.gilvum_PYR-GCK FALAAVLARPVGGMLADRIPPKYVVLGSFAGTAAAA------------FV
Mvan_4547|M.vanbaalenii_PYR-1 FALAAVLARPVGGALADRFAPKYVVLASFAGTAAMA------------FV
MSMEG_5141|M.smegmatis_MC2_155 FAVAAVLARPVGGALSDRIPPKYVVLASFAGTALLA------------FV
TH_0644|M.thermoresistible__bu FGSGPGRSGPAG-SWPMCSPPRNPVTTAGSG-------------------
MLBr_00844|M.leprae_Br4923 GPTLAAVARFWGGRLADRLGGSRVTLVVFGAMVFAAGLLGVLGIIEGSRV
MAB_3523c|M.abscessus_ATCC_199 GPLLGSLARPFGGWLSDRTGGGKISLYAFIAMIFGAGILVAAGTISDRGA
MMAR_0526|M.marinum_M GAGIGSVIRPLGGRLADRVGGARVTAVSFLMLAIGA----------AAAL
MUL_1189|M.ulcerans_Agy99 GAGIGSVIRPLGGRLADRVGGARVTAVSFLMLAIGA----------AAAL
MAV_4892|M.avium_104 GAAIGSVIRPLGGKLADRVGGARITAASFVMLAVGA----------AAAL
* .
Rv1737c|M.tuberculosis_H37Rv AALQPPPEVWSAATFITLAVCLGVGTGGVFAWVARRAPAAS---------
Mb1766c|M.bovis_AF2122/97 AALQPPPEVWSAATFITLAVCLGVGTGGVFAWVARRAPAAS---------
Mflv_2155|M.gilvum_PYR-GCK AIFQPPPDLWSAVTFITLALFLGIGTGGVFAWVARRAPASS---------
Mvan_4547|M.vanbaalenii_PYR-1 AIFQPPPDIWSAATFITLALFLGIGTGGVFAWVARRAPAKS---------
MSMEG_5141|M.smegmatis_MC2_155 AVFQPPPDVWSATTFITLAIFLGVGTGGVFAWVARRSPAQS---------
TH_0644|M.thermoresistible__bu ---------RSAITRRSRGHWIGVRS-------TRSHPMCR---------
MLBr_00844|M.leprae_Br4923 CPIRGVMMASYFAGFITLFILSGLGNGSVYKMIPTIFEACSHSLGINDDE
MAB_3523c|M.abscessus_ATCC_199 GAPSGSIMTAYVIGFIILFVVSGIGNGSVYKMIPSVFAAKARSAGLDET-
MMAR_0526|M.marinum_M WSVQIVNLPLFFASFMFLFVATGIGNGSTYRMISRIFKVKGELAGGDPDT
MUL_1189|M.ulcerans_Agy99 WSVQNVNLPLFFASFMFLFVATGIGNGSTYRMISRIFKVKGELAGGDPDT
MAV_4892|M.avium_104 WSVKAVNLPAFFASFMFLFVATGIGNGSTYRMISRIFKIKGELAGGDPDT
*: . .
Rv1737c|M.tuberculosis_H37Rv --------VGSVTGIVAAAGGLGGYFPPLVMGATYDPVDNDYTVGLLLLV
Mb1766c|M.bovis_AF2122/97 --------VGSVTGIVAAAGGLGGYFPPLVMGATYDPVDNDYTVGLLLLV
Mflv_2155|M.gilvum_PYR-GCK --------VGSVTGIVAAAGGLGGYFPPLVMGGTYDSVDNDYTIGLSLLV
Mvan_4547|M.vanbaalenii_PYR-1 --------VGSVTGIVAAAGGLGGYFPPLVMGASYDSIENDYTIGLTLLV
MSMEG_5141|M.smegmatis_MC2_155 --------VGSVTGIVAAAGGLGGYFPPLVMGATYDADDNDYTVGLLLLV
TH_0644|M.thermoresistible__bu --------CGCST--AAACCGR----------------------------
MLBr_00844|M.leprae_Br4923 CRDWSRVISGVVIGFVAEVGALGGVGIDLALRESYLNTGG-VTAAFWIFM
MAB_3523c|M.abscessus_ATCC_199 ---WSRTMSGALIGVAGAIGALGGVAINLVLRASYLSAAKSATMAFWVFL
MMAR_0526|M.marinum_M MVQMRRQAAG-ALGVISAVGAFGGFLVPLAYAWSKAQFGN-IEPALRFYV
MUL_1189|M.ulcerans_Agy99 MVQMRRQAAG-ALGVISAVGAFGGFLVPLAYAWSKAQFGN-IEPALRFYV
MAV_4892|M.avium_104 MVTMRRQAAG-ALGVISAVGAFGGFIVPLAYAWSKSQFGS-IEPALRFYV
* . .
Rv1737c|M.tuberculosis_H37Rv ATALVACTYTAL--HAREP-----VSEEASR------------
Mb1766c|M.bovis_AF2122/97 ATALVACTYTAL--HAREP-----VSEEASR------------
Mflv_2155|M.gilvum_PYR-GCK ATALIALLYTALRLHAHEP-----KPTQEVR------------
Mvan_4547|M.vanbaalenii_PYR-1 ATALLAFLYTALRLHAREP-----QQKEAAT------------
MSMEG_5141|M.smegmatis_MC2_155 ATALVAFAYTALRLHAHEPGRGGVRSDQIDR------------
TH_0644|M.thermoresistible__bu -------------------------------------------
MLBr_00844|M.leprae_Br4923 LCYAAAGVLTWKMYVCRPLPGNLHDEAANAFAASVGASRTHRG
MAB_3523c|M.abscessus_ATCC_199 VFYVICAAVTWYAYVRRPMTVSVPAISSSKNEVAV--------
MMAR_0526|M.marinum_M VFFLALLFVTWHCYLRSKTPMAQLGV-----------------
MUL_1189|M.ulcerans_Agy99 VFFLALLFVTWHCYLRSKTPMAQLGV-----------------
MAV_4892|M.avium_104 VFFLGLLAVTWYCYLRKHNAITRVGI-----------------