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TVTDSESTGALATAAPAPERHRGKHWIDDWRPEDPEFWATTGKPVARRNLIFSIFAEHIGFSVWLLWSIV VVQMTAGADGSPAASGFALTTTQALWLVAVPSGVGAFLRLPYTFAVPVFGGRNWTVISALLLLIPCLGLA WAVSNPDINFAVLLLIAATAGFGGGNFASSMANISFFYPESEKGWALGLNAAGGNIGVAVAQKIIPVVVT LGAGVALSLAGLFYIPFTVAAAVCAFLFMNNLTEAKADVKPVWESLRHADTWIMSLLYIGTFGSFIGYSA AFPTLLKAVFDRGDIALMWAFLGAGIGSVARPLGGKLSDRVGGARITAVSFAMLAIGAAGALWSVQAKNM PVFFIAFMFLFVATGIGNGSTYRMISKIFRVKGEDAGGDPLTMLHMRRQAAGALGIISSVGAFGGFIVPL AYAWSKSQFGNIQPALQFYVGFFIVLLGVTWFFYMRKGTRMAQAGV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3492 | - | - | 100% (467) | nitrite transporter |
| M. vanbaalenii PYR-1 | Mvan_4547 | - | 6e-20 | 26.39% (360) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_1951 | - | 5e-06 | 22.70% (348) | major facilitator superfamily transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0273 | narU | 0.0 | 79.13% (460) | putative integral membrane nitrite extrusion protein NARU |
| M. gilvum PYR-GCK | Mflv_3015 | - | 2e-90 | 43.19% (470) | nitrite extrusion protein |
| M. tuberculosis H37Rv | Rv0267 | narU | 0.0 | 79.13% (460) | integral membrane nitrite extrusion protein NarU |
| M. leprae Br4923 | MLBr_00844 | narK | 9e-70 | 34.66% (453) | putative nitrite extrusion protein |
| M. abscessus ATCC 19977 | MAB_3523c | - | 6e-93 | 41.06% (470) | integral membrane nitrite extrusion protein NarK3 |
| M. marinum M | MMAR_0526 | narU | 0.0 | 79.42% (452) | integral membrane nitrite extrusion protein NarU |
| M. avium 104 | MAV_4892 | narK | 0.0 | 81.42% (452) | nitrite transporter |
| M. smegmatis MC2 155 | MSMEG_0433 | - | 1e-88 | 41.39% (459) | nitrite extrusion protein |
| M. thermoresistible (build 8) | TH_0644 | narK2 | 4e-09 | 27.14% (210) | POSSIBLE NITRATE/NITRITE TRANSPORTER NARK2 |
| M. ulcerans Agy99 | MUL_1189 | narU | 0.0 | 78.76% (452) | integral membrane nitrite extrusion protein NarU |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3015|M.gilvum_PYR-GCK ------------------------------MTWAFTGVMAKRTRDIDTWD
MAB_3523c|M.abscessus_ATCC_199 -----------------------------MANNTATAPIARRGRWIENWD
MLBr_00844|M.leprae_Br4923 MDQLVLLQAEESLYGPGRRSKTVPIDHRHSLKSSFFRLRLRRACRISHWD
MSMEG_0433|M.smegmatis_MC2_155 ------------------------------------MPTLLKPKRITNWD
Mb0273|M.bovis_AF2122/97 ------------------MALT----TAPAIDYALPRQQDEGDHWIDDWR
Rv0267|M.tuberculosis_H37Rv ------------------MALT----TAPAIDYALPRQQDEGDHWIDDWR
MMAR_0526|M.marinum_M --------------------MT----ITPVRQHTAPREQHVGRHWIHDWR
MUL_1189|M.ulcerans_Agy99 --------------------MT----ITPVRQHTAPREQHVGRHWIHDWR
MAV_4892|M.avium_104 ------------------MTTT----ITPVPQPAAAPERHKGRHWIDDWR
Mvan_3492|M.vanbaalenii_PYR-1 ------------------MTVTDSESTGALATAAPAPERHRGKHWIDDWR
TH_0644|M.thermoresistible__bu --------------------------------------------------
Mflv_3015|M.gilvum_PYR-GCK PEDVQAWEGTGGKAPGKEIAKRNLIWSIVAEHVGFSVWSIWSVMVLFMPQ
MAB_3523c|M.abscessus_ATCC_199 PEDVVAWD-NG----GAKIARRNLIWSVVAEHVGFSVWSIWSVMVLFMPQ
MLBr_00844|M.leprae_Br4923 PEDQAAWEAGN-----KTIARLNLLWSVLTVHLGYSVWTLWPVMELFMPK
MSMEG_0433|M.smegmatis_MC2_155 PEDVAAWEAGN-----KYVARRNLIWSVVAEHIGFSIWSIWSVMVLFMPE
Mb0273|M.bovis_AF2122/97 PEDPVFWETIG-----RPIARRNLIFSIFAEHVGFSVWMLWSIVVVQMTA
Rv0267|M.tuberculosis_H37Rv PEDPVFWETIG-----RPIARRNLIFSIFAEHVGFSVWMLWSIVVVQMTA
MMAR_0526|M.marinum_M PEDPEFWDTIG-----RPIARRNLVFSIFAEHIGFSVWMLWSIVVVQMMA
MUL_1189|M.ulcerans_Agy99 PEDPEFWDTIG-----RPIARRNLVFSIFAEHIGFTVWMLWSIVVVQMMA
MAV_4892|M.avium_104 PEDPEFWETTG-----KAIARRNLIFSIFAEHVGFSVWMLWSIVVVHMTA
Mvan_3492|M.vanbaalenii_PYR-1 PEDPEFWATTG-----KPVARRNLIFSIFAEHIGFSVWLLWSIVVVQMTA
TH_0644|M.thermoresistible__bu --------------------MIGPLSTTYAVDISLS--------------
. : : : .:. :
Mflv_3015|M.gilvum_PYR-GCK D------------VYGIDAAGKFYLVAVPTLVGAFMRIPYTIAPARFGGR
MAB_3523c|M.abscessus_ATCC_199 N------------VYHIDAAGKFFLVAMPTLVGAVLRLPYTFATAWFGGR
MLBr_00844|M.leprae_Br4923 D------------VYGFSAGDKFLLATTATLVGACLRVPYSLATALFGGR
MSMEG_0433|M.smegmatis_MC2_155 A------------VYGFSAGDKFLLGATATLVGSCLRIPYTLATATFGGR
Mb0273|M.bovis_AF2122/97 A-APGHP---AASGWALSASQALCLVAVPSGVGAFLRLPYTFAIPIFGGR
Rv0267|M.tuberculosis_H37Rv A-APGHP---AASGWALSASQALCLVAVPSGVGAFLRLPYTFAIPIFGGR
MMAR_0526|M.marinum_M VGAPGHPSHPAASGWALSPSQALCLVAVPSGVGALLRLPYTFAIPVFGGR
MUL_1189|M.ulcerans_Agy99 VGAPGHPSHPAASGWALSPSQALCLVAVPSGVGALLRLPYTFAIPVFGGR
MAV_4892|M.avium_104 G-PHGHP---SASGWALTASQALCLVAVPSGVGAFLRLPYTFAVPVFGGR
Mvan_3492|M.vanbaalenii_PYR-1 G-ADGSP---AASGFALTTTQALWLVAVPSGVGAFLRLPYTFAVPVFGGR
TH_0644|M.thermoresistible__bu ------------------SAEASMLVATPILVGAVGRIVVGSLTDRYGGR
. * : . **: *: :***
Mflv_3015|M.gilvum_PYR-GCK NWTIVSALLLLIPTVLAYYYMKNPAS-YTTYMVIAAFAGLGGGNFASSMT
MAB_3523c|M.abscessus_ATCC_199 NWTVFSALVLAVPTALTLYFMAHPETSYTTFMIVAAVAGFGGGNFASSMT
MLBr_00844|M.leprae_Br4923 NWAIFSVMVLLIPTIATMVLLAHPGLPLWPYLACAALTGLGGGNFAASMT
MSMEG_0433|M.smegmatis_MC2_155 NWTVFSALVLLIPTVMTVVLMANPGLPLWPYLVCAALAGFGGGNFASSMT
Mb0273|M.bovis_AF2122/97 NWTTVSAALLVIPCLLLAWAVSHPSLPFAVLVVIAATAGFGGGNFASSMA
Rv0267|M.tuberculosis_H37Rv NWTTVSAALLVIPCLLLAWAVSHPSLPFAVLVVIAATAGFGGGNFASSMA
MMAR_0526|M.marinum_M NWTTISASLLVIPCLLLSWAVSHPGIPFVLLTLIAATAGVGGGNFASSMA
MUL_1189|M.ulcerans_Agy99 NWTTISASLLVIPCLLLSWAVSHPGIPFVLLTLIAATAGVGGGNFASSMA
MAV_4892|M.avium_104 NWTTISAALLLIPCLLLAWAVSHPGIPFGVLVAIAATAGFGGGNFASSMA
Mvan_3492|M.vanbaalenii_PYR-1 NWTVISALLLLIPCLGLAWAVSNPDINFAVLLLIAATAGFGGGNFASSMA
TH_0644|M.thermoresistible__bu --AMFIAITLASIVPVLAVGAAGAAGSYPLLLVFGFFLGIAGTIFAVGIP
: . . * . . *..* ** .:.
Mflv_3015|M.gilvum_PYR-GCK NINAFYPQRLKGWALGLNAGGGNIGVPVIQLIGLMVIAAVGNTRPEIVCA
MAB_3523c|M.abscessus_ATCC_199 NINAFYPQRFKGWALGLNAGGGNIGVPVIQVIGLLVIATVGNRSPHWVAA
MLBr_00844|M.leprae_Br4923 NANAFYPHRLKGAAFGLAGGAGNLGVSVIQVVGMLVIASVGDRKPYIVCG
MSMEG_0433|M.smegmatis_MC2_155 NINAFYPQRLKGWALGLNAGGGNIGVPMIQLVGLFVIATAGNRAPYWVCA
Mb0273|M.bovis_AF2122/97 NISFFYPEKDKGWALGLNAAGGNIGVAVVQKIIPPIVVAGSGVALSRAGL
Rv0267|M.tuberculosis_H37Rv NISFFYPEKDKGWALGLNAAGGNIGVAVVQKIIPPIVVAGSGVALSRAGL
MMAR_0526|M.marinum_M NISFFYPEKDKGWALGLNAAGGNIGVAVVQKIIPPIVVAGGGMALARAGL
MUL_1189|M.ulcerans_Agy99 NISFFYPEKDKGWALGLNAAGGNVGVAVVQKIIPPIVVAGGGMALARAGL
MAV_4892|M.avium_104 NISFFYPEKDKGWALGLNAAGGNIGVAVVQKVIPPVVIAGGGVALSRAGL
Mvan_3492|M.vanbaalenii_PYR-1 NISFFYPESEKGWALGLNAAGGNIGVAVAQKIIPVVVTLGAGVALSLAGL
TH_0644|M.thermoresistible__bu FANNWYAPSRRGFATGVFGMG-MVGTALSAFFTPRFVESFG---LFTTHV
. :*. :* * *: . . :*..: . .: . .
Mflv_3015|M.gilvum_PYR-GCK IYLVAISGAAVGAALFMDNLRNQKSNFGALVE----AMRFKHSWVMSFLY
MAB_3523c|M.abscessus_ATCC_199 IYLVLIAFAAVGAALFMDNLADQKTDGRSLID----VMKYRDSWIIAFLY
MLBr_00844|M.leprae_Br4923 LYVVLLIIAGIGAMLFMNDIEHHRIGVNTIRPVLFVVVSTRDSWVLALLY
MSMEG_0433|M.smegmatis_MC2_155 VYLVALAVAGLGAALYMDNLEHHKIDLGAMK----AILGERDTWIISLLY
Mb0273|M.bovis_AF2122/97 FFVPLAVAAAVCAFLFMNNLTEAKADVKPVWQS----LRHADTWIMSLLY
Rv0267|M.tuberculosis_H37Rv FFVPLAVAAAVCAFLFMNNLTEAKADVKPVWQS----LRHADTWIMSLLY
MMAR_0526|M.marinum_M FYVPLAVVAAVCAFAFMNNLAEAKADVKPVWQS----LRHADTWILALLY
MUL_1189|M.ulcerans_Agy99 FYVPLAVVAAVCAFAFMNNLAEAKADVKPVWQS----LRHVDTWILALLY
MAV_4892|M.avium_104 FYVPLAVVAAVCAFLFMNNLTEIKADVKPVWQS----LRHADTWIMSLLY
Mvan_3492|M.vanbaalenii_PYR-1 FYIPFTVAAAVCAFLFMNNLTEAKADVKPVWES----LRHADTWIMSLLY
TH_0644|M.thermoresistible__bu IIAVALGLTALLCLVAMHDSPDFTPNTERVLPKLKAAARLPVTWEMSILY
. :.: . *.: . . : :* :::**
Mflv_3015|M.gilvum_PYR-GCK IGTFGSFIGFSFAFGQVLQINYLAG--------GDTPAQASLHAAQIAFL
MAB_3523c|M.abscessus_ATCC_199 IGTFGSFIGFSFAFGQVLQLNFLAGLAHSGVTPAQAAAQASLHAAQIAFI
MLBr_00844|M.leprae_Br4923 LASFGSFIGFSFAFGQVLETNFVAG--------GQSTAQAALHAAELAFI
MSMEG_0433|M.smegmatis_MC2_155 IGTFGSFIGFAFAFGQVLQINFISG--------GQTPAQASLHAAQIAFI
Mb0273|M.bovis_AF2122/97 IGTFGSFIGYSAAFPTLLKTVFGRG----------------DIALGWAFL
Rv0267|M.tuberculosis_H37Rv IGTFGSFIGYSAAFPTLLKTVFGRG----------------DIALGWAFL
MMAR_0526|M.marinum_M IGTFGSFIGYSAAFPTLLKTVFDRG----------------DIALGWAFL
MUL_1189|M.ulcerans_Agy99 IGTFGSFIGYSAAFPTLLKTVFDRG----------------DIALGWAFL
MAV_4892|M.avium_104 IGTFGSFIGYSAAFPTLLKTVFGRG----------------DIALAWAFL
Mvan_3492|M.vanbaalenii_PYR-1 IGTFGSFIGYSAAFPTLLKAVFDRG----------------DIALMWAFL
TH_0644|M.thermoresistible__bu AIVFGGFVAFSNYLPTYXPSSPACT-------------------------
**.*:.:: :
Mflv_3015|M.gilvum_PYR-GCK GPLLGSISRPFGGKLADRVGGGRITLYVFVAMIFAAGVLVATGVMDDAAA
MAB_3523c|M.abscessus_ATCC_199 GPLLGSLARPFGGWLSDRTGGGKISLYAFIAMIFGAGILVAAGTISDRGA
MLBr_00844|M.leprae_Br4923 GPTLAAVARFWGGRLADRLGGSRVTLVVFGAMVFAAGLLGVLGIIEGSRV
MSMEG_0433|M.smegmatis_MC2_155 GPLLGSLSRVYGGKLADRIGGGRVTLAVFAGMILGAGLLVAVSTVSDGSS
Mb0273|M.bovis_AF2122/97 GAGIGSLVRPLGGKLADRIGGARITAASFVMLAAGA----------AAAL
Rv0267|M.tuberculosis_H37Rv GAGIGSLVRPLGGKLADRIGGARITAASFVMLAAGA----------AAAL
MMAR_0526|M.marinum_M GAGIGSVIRPLGGRLADRVGGARVTAVSFLMLAIGA----------AAAL
MUL_1189|M.ulcerans_Agy99 GAGIGSVIRPLGGRLADRVGGARVTAVSFLMLAIGA----------AAAL
MAV_4892|M.avium_104 GAAIGSVIRPLGGKLADRVGGARITAASFVMLAVGA----------AAAL
Mvan_3492|M.vanbaalenii_PYR-1 GAGIGSVARPLGGKLSDRVGGARITAVSFAMLAIGA----------AGAL
TH_0644|M.thermoresistible__bu ---ITTCTSTPPPRHSTRFGSG----------------------------
: : : * *..
Mflv_3015|M.gilvum_PYR-GCK GAPTSAQMIGYVAGFILLFILSGLGNGSTYKMIPSIFEAKAQGRDDLDKE
MAB_3523c|M.abscessus_ATCC_199 GAPSGSIMTAYVIGFIILFVVSGIGNGSVYKMIPSVFAAKARSAG-LDET
MLBr_00844|M.leprae_Br4923 CPIRGVMMASYFAGFITLFILSGLGNGSVYKMIPTIFEACSHSLGINDDE
MSMEG_0433|M.smegmatis_MC2_155 EAATGLMMSGYVVGFIALFLLSGIGNGSVYKMIPSIFEARSHSLDVSEDE
Mb0273|M.bovis_AF2122/97 WSVQSVNLPVFFVSFMFLFVATGIGNGSSYRMISRIFQVKGEVAG-GDPE
Rv0267|M.tuberculosis_H37Rv WSVQSVNLPVFFVSFMFLFVATGIGNGSSYRMISRIFQVKGEVAG-GDPE
MMAR_0526|M.marinum_M WSVQIVNLPLFFASFMFLFVATGIGNGSTYRMISRIFKVKGELAG-GDPD
MUL_1189|M.ulcerans_Agy99 WSVQNVNLPLFFASFMFLFVATGIGNGSTYRMISRIFKVKGELAG-GDPD
MAV_4892|M.avium_104 WSVKAVNLPAFFASFMFLFVATGIGNGSTYRMISRIFKIKGELAG-GDPD
Mvan_3492|M.vanbaalenii_PYR-1 WSVQAKNMPVFFIAFMFLFVATGIGNGSTYRMISKIFRVKGEDAG-GDPL
TH_0644|M.thermoresistible__bu --------------------PGRSGPAGSWPMCSPPRNPVTTAGS-----
* .. : * . .
Mflv_3015|M.gilvum_PYR-GCK GKAAWSRAMSGALIGFAGAVGALGGVFINVVLRASYVGDAKSATAAFWVF
MAB_3523c|M.abscessus_ATCC_199 ----WSRTMSGALIGVAGAIGALGGVAINLVLRASYLSAAKSATMAFWVF
MLBr_00844|M.leprae_Br4923 CR-DWSRVISGVVIGFVAEVGALGGVGIDLALRESYLNTG-GVTAAFWIF
MSMEG_0433|M.smegmatis_MC2_155 RR-HWSRSMSGALIGFAGAVGALGGVGINMALRQSYLSSG-SATTAFWTF
Mb0273|M.bovis_AF2122/97 TMVNMRRQAAG-ALGIISSIGAFGGFVVPLAYAWSKVHFG-NIEPALHFY
Rv0267|M.tuberculosis_H37Rv TMVNMRRQAAG-ALGIISSIGAFGGFVVPLAYAWSKVHFG-NIEPALHFY
MMAR_0526|M.marinum_M TMVQMRRQAAG-ALGVISAVGAFGGFLVPLAYAWSKAQFG-NIEPALRFY
MUL_1189|M.ulcerans_Agy99 TMVQMRRQAAG-ALGVISAVGAFGGFLVPLAYAWSKAQFG-NIEPALRFY
MAV_4892|M.avium_104 TMVTMRRQAAG-ALGVISAVGAFGGFIVPLAYAWSKSQFG-SIEPALRFY
Mvan_3492|M.vanbaalenii_PYR-1 TMLHMRRQAAG-ALGIISSVGAFGGFIVPLAYAWSKSQFG-NIQPALQFY
TH_0644|M.thermoresistible__bu GRSAITRRSRGHWIGVRSTR------------SHPMCRCGCSTAAACCGR
* * :*. . . . . *
Mflv_3015|M.gilvum_PYR-GCK LAFYVVCAFVTWFVFLRLQEHRAHSGEHIGRTSAPVPVG-----
MAB_3523c|M.abscessus_ATCC_199 LVFYVICAAVTWYAYVRRPMTVSVP--AISSSKNEVAV------
MLBr_00844|M.leprae_Br4923 MLCYAAAGVLTWKMYVCRPLPGNLHDEAANAFAASVGASRTHRG
MSMEG_0433|M.smegmatis_MC2_155 LAFYVLASVVTWFCYVRR--PAAMPVTGTERHAPAIAG------
Mb0273|M.bovis_AF2122/97 VAFFLALLVVTWYCYLRRTTPMGQVGV-----------------
Rv0267|M.tuberculosis_H37Rv VAFFLALLVVTWYCYLRRTTPMGQVGV-----------------
MMAR_0526|M.marinum_M VVFFLALLFVTWHCYLRSKTPMAQLGV-----------------
MUL_1189|M.ulcerans_Agy99 VVFFLALLFVTWHCYLRSKTPMAQLGV-----------------
MAV_4892|M.avium_104 VVFFLGLLAVTWYCYLRKHNAITRVGI-----------------
Mvan_3492|M.vanbaalenii_PYR-1 VGFFIVLLGVTWFFYMRKGTRMAQAGV-----------------
TH_0644|M.thermoresistible__bu --------------------------------------------