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MGCSREDVLGAFDALDAVVESILALDYDALSAAERVRLEARLERNLRRIPTVEHELLASVIAETEPARLG EGSWKKVLTTALRISGAEAGRRLKRAKTLGPRRGLTGTPLPPLWESTAAAQAQGLLSEEHVAVIAAFHKR LPAWVDIETRAEADRQLAHAGSGLDPEGLDEAAGVLLAMINPDGAQPCDKERARKRGIRISKQHPDGTAT ISGTLTPEALAIWQAIFAKEAAPGANNPESEHTEDSTSGGAADDASDAPGDHAGAASSAASGASDAAEHD PQPERCGSDTRTQAQRNHDAFLAVGRRLLESGELGTHNGLPVTVIVSTTLQELEKGAGVAVTGGGSLLPM PDLIRLAARAHHYLYVYDQHSGKSLYLGRAKRLANAAQRIVLHARDRGCTRPGCTAPGYWCQAHHASADF VDGGLTNIDDLTLACPCDHRMLDNTGWRTRKNGKNQTEWLPPPDLDTGQHRVNGHHHPERYLLPEDDLPE DDQGP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3050 | - | - | 100% (495) | hypothetical protein Mvan_3050 |
| M. vanbaalenii PYR-1 | Mvan_3851 | - | 0.0 | 85.19% (513) | hypothetical protein Mvan_3851 |
| M. vanbaalenii PYR-1 | Mvan_4451 | - | 0.0 | 85.94% (505) | hypothetical protein Mvan_4451 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1159c | - | 1e-105 | 43.35% (489) | hypothetical protein Mb1159c |
| M. gilvum PYR-GCK | Mflv_4014 | - | 1e-164 | 60.83% (480) | hypothetical protein Mflv_4014 |
| M. tuberculosis H37Rv | Rv1128c | - | 1e-105 | 43.35% (489) | hypothetical protein Rv1128c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0394c | - | 1e-102 | 45.40% (467) | hypothetical protein MAB_0394c |
| M. marinum M | MMAR_3121 | - | 1e-113 | 46.36% (494) | hypothetical protein MMAR_3121 |
| M. avium 104 | MAV_2999 | - | 1e-114 | 45.93% (492) | hypothetical protein MAV_2999 |
| M. smegmatis MC2 155 | MSMEG_6573 | - | 1e-103 | 43.42% (479) | hypothetical protein MSMEG_6573 |
| M. thermoresistible (build 8) | TH_3287 | - | 2e-73 | 37.33% (509) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_2371 | - | 1e-112 | 45.95% (494) | hypothetical protein MUL_2371 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3050|M.vanbaalenii_PYR-1 -------MGCSREDVLGAFDALDAV-----VESILALDYDALSAAERVRL
Mflv_4014|M.gilvum_PYR-GCK ----MAGLSVGRTSVRCMDGVAEAVGVIGEQLAVLAKAAEDLSHRELIGL
MSMEG_6573|M.smegmatis_MC2_155 ----------MDDGVQDAVAALDAA-----LNTLLTLPHSALTDAELLTI
Mb1159c|M.bovis_AF2122/97 -------MCSTREEITEAFASLATA-----LSRVLGLTFDALTTPERLAL
Rv1128c|M.tuberculosis_H37Rv -------MCSTREEITEAFASLATA-----LSRVLGLTFDALTTPERLAL
MAV_2999|M.avium_104 ----MRGMSSDREAVSAAFDAIDAA-----LDDLLDCDYAALATREKLAL
MMAR_3121|M.marinum_M ---MHSNGCSDRESVVATLDRLDRA-----VDALVEVSFEALTTPERLRV
MUL_2371|M.ulcerans_Agy99 ---MHSNGCSDRESVVATLDRLDRA-----VDALVEVSFEALTTPERLRV
MAB_0394c|M.abscessus_ATCC_199 ---------------MSPIDDLLTT-----ATAVVESSFDELNNPELLSA
TH_3287|M.thermoresistible__bu MGQQFVTAGAARARVGELLAAVDAA-----YAEMRALCLDEVGTGFRLEL
. : : :
Mvan_3050|M.vanbaalenii_PYR-1 EARLERNLRRIPTVEHELLASVIAETEPARLGEGSWKKVLTTALRISGAE
Mflv_4014|M.gilvum_PYR-GCK LSELTTVLRSAPAVEHAVLARLLDETEPHHLGEASWKKVLTTSLRMSSAE
MSMEG_6573|M.smegmatis_MC2_155 CAGLQDARNRIPAVEHRAIAALSQQTTPAAIGAKSWPLVLATRLGISSKE
Mb1159c|M.bovis_AF2122/97 LEHCETARRQLPSVEHTLINQIGEQSTEEELGG-KLGLTLADRLRITRSE
Rv1128c|M.tuberculosis_H37Rv LEHCETARRQLPSVEHTLINQIGEQSTEEELGG-KLGLTLADRLRITRSE
MAV_2999|M.avium_104 LNRCERLRRRLPAIEHPLINALARDATPAELGG-RLSHAIAEATLISRAE
MMAR_3121|M.marinum_M LERLEVVARRLPVAQYALLNQLDEQAGEAELGG-RLAAVVASRLRITRSE
MUL_2371|M.ulcerans_Agy99 LERLEVVARRLPAAQYALVNQLDEQPGEAELGG-RLAAVVASRLRITRSE
MAB_0394c|M.abscessus_ATCC_199 LRQLEIAQRKITAASHTLTARLVQRGSPVALGGTSFAEVLARYLSITTAT
TH_3287|M.thermoresistible__bu AERLETQCRINRGLMYRVFAQLADPPDEPAMVP-AVRDRLWARLRITPGE
. : : : : ::
Mvan_3050|M.vanbaalenii_PYR-1 AGRRLKRAKTLGPRRGLTGTPLPPLWESTAAAQAQGLLSEEHVAVIAAFH
Mflv_4014|M.gilvum_PYR-GCK AGRRLQRAKNLGPRRAMTGEPLAPVWESTAAAQAQGHLGEEHVEIIAKFH
MSMEG_6573|M.smegmatis_MC2_155 ARRRCTDAAELGPRVSMTGEALAPKREHIAAAQADGTLTPDHVAELFKFF
Mb1159c|M.bovis_AF2122/97 AKRRVAEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFV
Rv1128c|M.tuberculosis_H37Rv AKRRVAEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFV
MAV_2999|M.avium_104 AARRVHTAADLGPRVGLTGEPLPPLLAATAAAQREGSLGLEQVAVIRKFC
MMAR_3121|M.marinum_M AGRRVAEAADVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFF
MUL_2371|M.ulcerans_Agy99 AGRRVAEAAEVGPRRALSGQPVGPVLTATAAALRQGVVGEGHVRVIRDFF
MAB_0394c|M.abscessus_ATCC_199 ARRRLADAAHLGPRRALTGEPLRPALPYVAHALREGRLGDEHVRIIRRFF
TH_3287|M.thermoresistible__bu VKRRLRVAALLRPRRRLSGPPLPPVLARVAGAVESGLLGEEHLRVITTVM
. ** * : * ::* .: * * * * : :: : .
Mvan_3050|M.vanbaalenii_PYR-1 KRLPAWVDIETRAEADRQLAHAGSGLDPEGLDEAAGVLLAMINPDGAQPC
Mflv_4014|M.gilvum_PYR-GCK KKLPSWVDVDTRAAADAQLAHTGSGLGPEELAQVADRLLMMIDQDGPEPS
MSMEG_6573|M.smegmatis_MC2_155 TKCPDWVTYAEQCRLEEKLVTGAIGADPETVRQAVDHAVFLLDQDGPAPT
Mb1159c|M.bovis_AF2122/97 HRLPSWVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDG-DYT
Rv1128c|M.tuberculosis_H37Rv HRLPSWVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDG-DYT
MAV_2999|M.avium_104 HQLPGWIDQATRERAEADLANQGTRYRPEQLAALAGTLADCLNPDG-LYR
MMAR_3121|M.marinum_M RRLPAGVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDG-RHS
MUL_2371|M.ulcerans_Agy99 RQLPAGVDVGTRDRAEAHLAKLATQFRPDQLARLAGRLMDCLNPDG-RHS
MAB_0394c|M.abscessus_ATCC_199 DVLPDAVDADTREAAEKQLASMGTEFGPEQLRAGADRIAALVNPDG-RFS
TH_3287|M.thermoresistible__bu AALPSAVSVTDREAVEASLIAEAARSDAGIVRQVGRRIEEIFNPDG-HYD
* : : * . . : .: **
Mvan_3050|M.vanbaalenii_PYR-1 DKERARKRGIRISKQHPDGTATISGTLTPEALAIWQAIFAKEAAPGANNP
Mflv_4014|M.gilvum_PYR-GCK EKEKATRFWVKLGTQQRDGGRTISGYVDAETSAYWEAVLAKEAAPGANMA
MSMEG_6573|M.smegmatis_MC2_155 DNPPTKPFGITFGPQQPDGSYHLRGKVSAEFKATFDPIDEKLAAPGMCNP
Mb1159c|M.bovis_AF2122/97 DEDRARRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAPGMCNP
Rv1128c|M.tuberculosis_H37Rv DEDRARRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAPGMCNP
MAV_2999|M.avium_104 DEDRARRRSLTLGNQHADGMSELRGLLTPELRATLEAVLAKLAAPGMCNP
MMAR_3121|M.marinum_M DEDRARRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAPGMCNP
MUL_2371|M.ulcerans_Agy99 DEDRARRRGLSLGRQGLDGMSRISGWLTPEARAGLEAVWAKLAAPGMCNP
MAB_0394c|M.abscessus_ATCC_199 DIDRARRRGISIGRQGADGMSALSGLLDPETRAYFDAVLSKLAAPGMCDP
TH_3287|M.thermoresistible__bu DQDRARRRGIHLGDQQRDGMSAISGWIDPQLRAYLEAVTAAVR-PGRHLP
: : : :. * ** : * : .: * :.: ** .
Mvan_3050|M.vanbaalenii_PYR-1 ESEHTEDSTSGGAADDASDAPGDHAGAASSAASGASDAAEHDPQPERCGS
Mflv_4014|M.gilvum_PYR-GCK EQ-------------------------------------------EKAG-
MSMEG_6573|M.smegmatis_MC2_155 TDQTPCISG--------------------------------TPSQQQIDS
Mb1159c|M.bovis_AF2122/97 EQKAPCVNG--------------------------------APSKEQARR
Rv1128c|M.tuberculosis_H37Rv EQKAPCVNG--------------------------------APSKEQARR
MAV_2999|M.avium_104 LDESPCVDG--------------------------------TPTEQAIEG
MMAR_3121|M.marinum_M EDEAAVVDG--------------------------------PVSPDAADR
MUL_2371|M.ulcerans_Agy99 EDEAAVVDG--------------------------------PVSRDAADR
MAB_0394c|M.abscessus_ATCC_199 RDESPMTEG--------------------------------EPDSAAAER
TH_3287|M.thermoresistible__bu HTTTDTTGTTG------TTETTGTAGTAGTAATAADTAADGVGDIDTGGV
Mvan_3050|M.vanbaalenii_PYR-1 DTRTQAQRNHDAFLAVGRRLLESGELGTHNGLPVTVIVSTTLQELEKGA-
Mflv_4014|M.gilvum_PYR-GCK DTRTQGQRNHDGLKAVLRRTLESGQLGSHNGLPVTVIVSTTLQELEKGA-
MSMEG_6573|M.smegmatis_MC2_155 DQRGAPERRHDAMLTAMRLLLAHKDLGQINGLPATLLVTTTLQELEKAA-
Mb1159c|M.bovis_AF2122/97 DTRSCPQRNHDALNAGLRSLLTSGNLGQHNGLPASIIVTTTLKDLEAAA-
Rv1128c|M.tuberculosis_H37Rv DTRSCPQRNHDALNAELRSLLTSGNLGQHNGLPASIIVTTTLKDLEAAA-
MAV_2999|M.avium_104 DTRSAAQRNHDGLLAGLRALLASGNLGQHNGLPASIIVTTTLADLETAA-
MMAR_3121|M.marinum_M DSRSVGQRQHDGFNAALRAVLASGELGQHNGLPASIIVSTTLKELEAAA-
MUL_2371|M.ulcerans_Agy99 DSRSVSQRQHDGFNAALRAVLASGELGQHNGLPASIIVSTTLKELEAAA-
MAB_0394c|M.abscessus_ATCC_199 DTRTSAQRNHDGLRACLRSTLASGKLGAHRGLPVTVVVSTTLRELQSAA-
TH_3287|M.thermoresistible__bu DLRSAAQRRHDGLTLGLKIAVASGRLGSHRGHPVTVIVRTTLGELNQAAH
* * :*.**.: : : ** .* *.:::* *** :*: .*
Mvan_3050|M.vanbaalenii_PYR-1 ----------GVAVTGGGSLLPMPDLIRLAARAHHYLYVYDQHSGKSLYL
Mflv_4014|M.gilvum_PYR-GCK ----------GVAVTGGGSLLPIPELIRLAADAHHYLYVYDGHTGQSLYL
MSMEG_6573|M.smegmatis_MC2_155 ----------GVAITAGGTKLSIPDLIRLASQALHYLAVYDEHTGIPLYL
Mb1159c|M.bovis_AF2122/97 ----------GAGLTGGGTILPISDVIRLARHANHYLAIF--DRGKALAL
Rv1128c|M.tuberculosis_H37Rv ----------GAGLTGGGTILPISDVIRLARHANHYLAIF--DRGKALAL
MAV_2999|M.avium_104 ----------GKGLTGGGTLLPMSDVIRLSRHAHHYLAIF--DKGKALAL
MMAR_3121|M.marinum_M ----------GRGLTGGGTLLPMSDVIRLARHAHHYLAVF--DRGEAIGL
MUL_2371|M.ulcerans_Agy99 ----------GRGLTGGGTLLPMSDVIRLARHAHHYLAVF--DRGEAIGL
MAB_0394c|M.abscessus_ATCC_199 ----------GRAISGSGNLVPIPDLIRMATHAFHYLTIFG-DDGRPLHL
TH_3287|M.thermoresistible__bu AVADPRVSMPGPARTGGTGVLPMRELIRMAADAIHYLAVFDDHTERPLYL
* . :.. :.: ::**:: * *** :: . .: *
Mvan_3050|M.vanbaalenii_PYR-1 GRAKRLANAAQRIVLHARDRGCTRPGCTAPGYWCQAHHASADFVDGGLTN
Mflv_4014|M.gilvum_PYR-GCK GRAKRLANAAQRIVMHARDRGCTRPGCTVPGYWCQAHHASADWKDDGHTD
MSMEG_6573|M.smegmatis_MC2_155 GRARRTASAGQRLAIWARDRGCTRPGCTANGYRCQAHHATTDYAKGGLTD
Mb1159c|M.bovis_AF2122/97 YHTKRLASPAQRIMLYAKDSGCSAPGCDVPGYYCEVHHVT-PYAQCRNTD
Rv1128c|M.tuberculosis_H37Rv YHTKRLASPAQRIMLYAKDSGCSAPGCDVPGYYCEVHHVT-PYAQCRNTD
MAV_2999|M.avium_104 YHTKRLASPGQRIVLYAKDRGCTAPGCTVPGYYAEVHHCT-DYATCHTTD
MMAR_3121|M.marinum_M YHAKRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHVA-AWAISGRTD
MUL_2371|M.ulcerans_Agy99 YHAKRLATPGQRIVLYAKDRGCTRPGCDVAGYQCEVHHVA-AWAISGRTD
MAB_0394c|M.abscessus_ATCC_199 GRSKRIATPDQRIVLHAKDRGCSAPGCTVPGYLCQVHHVD-DWRDDGPTD
TH_3287|M.thermoresistible__bu GRQKRIATADQRLICYARDGGCTAPGCGEPGYHAETHHQP-AWEDGGLTD
: :* *.. **: *:* **: *** ** .:.** : *:
Mvan_3050|M.vanbaalenii_PYR-1 IDDLTLACPCDHRMLDNTG--WRTRKN-GKNQTEWLPPPDLDTGQHRVNG
Mflv_4014|M.gilvum_PYR-GCK IDDLTFACGPENRMIENTG--WTTAKN-SRNQTEWIPPPDLETGQHRVNG
MSMEG_6573|M.smegmatis_MC2_155 ADALALACGCDNRLVGEAPNKWTTRIN-NHGQCEWIPPDLLDRGQHRTNT
Mb1159c|M.bovis_AF2122/97 VNDLTLGCGGHHPLAERG---WTTRKN-AHGDTEWLPPPHLDHGQPRVNT
Rv1128c|M.tuberculosis_H37Rv VNDLTLGCGGHHPLAERG---WTTRKN-AHGDTEWLPPPHLDHGQPRVNT
MAV_2999|M.avium_104 INDLTFACGPHHRLLQPGA--WTTHKN-ARGETQWLPPPHLDRNQPRTNT
MMAR_3121|M.marinum_M INQLTLACGPDHKLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQPRTNT
MUL_2371|M.ulcerans_Agy99 INQLTLACGPDHKLLEQG---WRTRKN-AHGDTEWLPPPHLDHGQPRTNS
MAB_0394c|M.abscessus_ATCC_199 IDNLTFACGPHHRLLQQG---WTTRKRRSDGITEWIPPPHLDTGQSRTND
TH_3287|M.thermoresistible__bu ADHLFFACGPHHSGLTEGR--WQATIT-PTGRLAWTN----DHHPPTVNH
: * :.* .: * : . * : .*
Mvan_3050|M.vanbaalenii_PYR-1 HHHPERYLLPEDD-------------------------------------
Mflv_4014|M.gilvum_PYR-GCK YHHPERHLLPHEEGEDS---------------------------------
MSMEG_6573|M.smegmatis_MC2_155 YHHPETLLADINRDQKTDGDNREQHHTDTGADTGTVHVNGHGEKPAIPPE
Mb1159c|M.bovis_AF2122/97 FHHPEKLL------ADDEGDP-----------------------------
Rv1128c|M.tuberculosis_H37Rv FHHPEKLL------ADDEGDP-----------------------------
MAV_2999|M.avium_104 FHHPEKLLRGEDGGEDDDGDDDEAA-------------------------
MMAR_3121|M.marinum_M YHHPEKLLR---DSADDDDEGHGAA-------------------------
MUL_2371|M.ulcerans_Agy99 YHHPEKLLR---DSADDDDEGHGAA-------------------------
MAB_0394c|M.abscessus_ATCC_199 HHHPERFIRRF---------------------------------------
TH_3287|M.thermoresistible__bu AHHPEELLRAHTDPPEDPG-------------------------------
**** :
Mvan_3050|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4014|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6573|M.smegmatis_MC2_155 LLDQGQQRTAPYHQAEVPPVNTRDTRSSTTTRDANRHNGNGDRNSAENRN
Mb1159c|M.bovis_AF2122/97 --------------------------------------------------
Rv1128c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2999|M.avium_104 --------------------------------------------------
MMAR_3121|M.marinum_M --------------------------------------------------
MUL_2371|M.ulcerans_Agy99 --------------------------------------------------
MAB_0394c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3287|M.thermoresistible__bu --------------------------------------------------
Mvan_3050|M.vanbaalenii_PYR-1 -----LPEDDQGP-
Mflv_4014|M.gilvum_PYR-GCK ----STSRDCDDP-
MSMEG_6573|M.smegmatis_MC2_155 GPSKNAAGDDDEPR
Mb1159c|M.bovis_AF2122/97 --------------
Rv1128c|M.tuberculosis_H37Rv --------------
MAV_2999|M.avium_104 --------------
MMAR_3121|M.marinum_M --------------
MUL_2371|M.ulcerans_Agy99 --------------
MAB_0394c|M.abscessus_ATCC_199 --------------
TH_3287|M.thermoresistible__bu --------------