For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
LRWQLLLGVLAVVTIVLVAVGGVSVLSLRGYVTAMNDAEVVESMHAFSHAYARYRNGEHTSIHTGTPPLS QALLEFTGQTPGNLIAVMRDGVVIGSAVFSEDAPRPAPPDVIHAIETQHWTDEPSRVETLGSLGSYQVDS RAAGSDRLIVGVSLSIADRIITRKQITTSVLVATALVITAALTVWVVGITLRPLRRVAATAATVAAMPLA GDDHQISVRVRPEDTDPDNEVGIVGHTLNRLLDNVDSALQHRVASDLRMRQFITDASHELRTPLAAIQGY AELTRQDSSDLPPTTEYALARIESEARRMASLVDELLLLSRLGEGEDLETEHLDLTDLVMNAVNDAAVAA PTHRWIKDLPDEPVWVNGDHARLHQLVSNLLTNAWVHTPPGVTVKTGITNYPDDPNGPYTELTVSNDGPD IDPEVLPHLFERFVRSSKSRSSAPGHGLGLAIVNSIVKAHDGSVTAESAAGQTVFRIRLPLIDAPLNASA PGRPRQPSDY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4625 | trcS | - | 100% (500) | two component sensor histidine kinase TrcS |
| M. ulcerans Agy99 | MUL_0464 | phoR | 1e-45 | 32.40% (500) | two component system response phosphate sensor kinase, PhoR |
| M. ulcerans Agy99 | MUL_1502 | - | 2e-25 | 32.20% (323) | two component regulator - sensor kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1061c | trcS | 0.0 | 80.20% (490) | two component sensor histidine kinase TRCS |
| M. gilvum PYR-GCK | Mflv_2267 | - | 3e-71 | 39.58% (432) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv1032c | trcS | 0.0 | 80.20% (490) | two component sensor histidine kinase TRCS |
| M. leprae Br4923 | MLBr_00175 | - | 5e-22 | 27.72% (368) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_2582 | - | 1e-68 | 38.98% (413) | putative two component sensor kinase |
| M. marinum M | MMAR_4456 | trcS | 0.0 | 98.80% (500) | two-component sensor histidine kinase TrcS |
| M. avium 104 | MAV_1175 | - | 0.0 | 73.78% (492) | two component sensor histidine kinase trcs |
| M. smegmatis MC2 155 | MSMEG_2915 | - | 1e-125 | 51.55% (485) | sensor histidine kinase |
| M. thermoresistible (build 8) | TH_2452 | - | 4e-29 | 27.59% (511) | PUTATIVE putative sensor histidine kinase PhoR |
| M. vanbaalenii PYR-1 | Mvan_2295 | - | 1e-129 | 51.63% (490) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2267|M.gilvum_PYR-GCK MSSSPRAERTPAPVLRPPRTWSLRTRLILTQLLLLAVVCAGVGVATEFAL
MAB_2582|M.abscessus_ATCC_1997 -------------------------------------------------M
MUL_4625|M.ulcerans_Agy99 ----------------------MRWQLLLGVLAVVTIVLVAVGGVSVLSL
MMAR_4456|M.marinum_M --------MTGHRNTPRWLPRSLRWQLLLGVLAVVTIVLVAVGGVSVLSL
Mb1061c|M.bovis_AF2122/97 ---MIPDRNTRSRKAPCWRPRSLRQQLLLGVLAVVTVVLVAVGVVSVLSL
Rv1032c|M.tuberculosis_H37Rv ---MIPDRNTRSRKAPCWRPRSLRQQLLLGVLAVVTVVLVAVGVVSVLSL
MAV_1175|M.avium_104 ---MTRDRDTASGGFPRWFPSSLRRQLLFGVLAVVSVVLVTVGFVSVLSL
MSMEG_2915|M.smegmatis_MC2_155 --------------MRTPKSWSLRRQLVVGVSAVVMIALATIGTLSVFTL
Mvan_2295|M.vanbaalenii_PYR-1 --------------MRAWKSWTLLRQLVVGVSVVVMVALVSVGAMTVMTL
TH_2452|M.thermoresistible__bu -MTSEPPSPSGRPRWRRLLPSAARTRIIGWVLLLVMVALGVVTLTTWRLM
MLBr_00175|M.leprae_Br4923 ---MVRFAWRRRASLRATSSLSLRWRVMLLAMSMVAMVVVLMAFAVYVVI
:
Mflv_2267|M.gilvum_PYR-GCK QRFLMNQLDEQVIEAGRRSSMIFEFGPPPPPGMGMPPPPGVGMPPPPGVG
MAB_2582|M.abscessus_ATCC_1997 NRFLNTQLDEQVRDAGNRSVVLFELGPPPP--LSLPRPLANGWRP-----
MUL_4625|M.ulcerans_Agy99 RGYVTAMNDAEVVESMHAFSHAYARYRNGE-----HTSIHTGTPP-----
MMAR_4456|M.marinum_M RGYVTAMNDAEVVESMHAFSHAYARYRNGE-----HTSIHTGTPP-----
Mb1061c|M.bovis_AF2122/97 SGYVTAMNDAELVESLHALNHSYTRYRDSA-----QTSTPTGNLP-----
Rv1032c|M.tuberculosis_H37Rv SGYVTAMNDAELVESLHALNHSYTRYRDSA-----QTSTPTGNLP-----
MAV_1175|M.avium_104 RGYVNAMSDADVAESLDAFSHQYTKYRNGE-----HVSPHPGTPP-----
MSMEG_2915|M.smegmatis_MC2_155 RSSMVGLIDAQLAGAADGFSKTVTKYRTTP-----LPGEDEVPPPG----
Mvan_2295|M.vanbaalenii_PYR-1 RSSVLGIIDTQLSVAADATISSVAKYRSTP-----GPG-GQMPAPG----
TH_2452|M.thermoresistible__bu VSSIDARMDEALHIEVDEFEELTASGLNPR-----TGAPFTGVAE-----
MLBr_00175|M.leprae_Br4923 SAALYSDIDNQLQSRAQLLIASGSLAADPG--------------------
: * :
Mflv_2267|M.gilvum_PYR-GCK MPVPPVGPPPRRGHHMMIRDEGPGPAFLNAPGQAILTVGAVVSDGRADDA
MAB_2582|M.abscessus_ATCC_1997 -------------------TDGPGPAFLDAPGQSIGMVGAVAVNGHVTEA
MUL_4625|M.ulcerans_Agy99 ----------------------LSQALLEFTGQTPGNLIAVMRDGVVIGS
MMAR_4456|M.marinum_M ----------------------VSQALLEFTGQTPGNLIAVVRDGVVIGS
Mb1061c|M.bovis_AF2122/97 ----------------------MSQAVLEFTGQTPGNLIAVLHDGVVIGS
Rv1032c|M.tuberculosis_H37Rv ----------------------MSQAVLEFTGQTPGNLIAVLHDGVVIGS
MAV_1175|M.avium_104 ----------------------IQQAILEFTGQTPGNLIAVLRNGAVIGS
MSMEG_2915|M.smegmatis_MC2_155 ----------------------SMKPLIHVLGQAEGNVIALIQDGEVVDS
Mvan_2295|M.vanbaalenii_PYR-1 ----------------------AMKPLTHLIGQAPGNIVVLIQNGEVVDS
TH_2452|M.thermoresistible__bu ----------------------VIREAIAYNLARPNEKFLGYVDGEYHTQ
MLBr_00175|M.leprae_Br4923 ---------------------------KAIEGTAYSDVNAMLVNPGHSIY
:
Mflv_2267|M.gilvum_PYR-GCK GMIATDGSRTEISDVAARQLATVAVGGRPHTVDLDGLGRYRVVAFPSHM-
MAB_2582|M.abscessus_ATCC_1997 ARITADGSRERLSPQACREVEGLLQQS-TSTVDLDHAGLYRLVTMPTN--
MUL_4625|M.ulcerans_Agy99 AVFSEDAPRPAPPDVIHAIETQHWTDEPSRVETLGSLGSYQVDSRAA---
MMAR_4456|M.marinum_M AVFSEDAPRPAPPDVIHAIETQHWTDEPSRVETLGSLGSYQVDSRAA---
Mb1061c|M.bovis_AF2122/97 AVFSEDGARPAPPDVIRAIEAQVWDGGPPRVESLGSLGAYQVDSSAA---
Rv1032c|M.tuberculosis_H37Rv AVFSEDGARPAPPDVIRAIEAQVWDGGPPRVESLGSLGAYQVDSSAA---
MAV_1175|M.avium_104 AVFSEDEPRPAPPDVVRDLAAQSWKDSPPRTEILGRLGPYRVNSTVN---
MSMEG_2915|M.smegmatis_MC2_155 AFFSDGDAQAAPPAAVDTLRDLATTGPTPRNVDIPGLGWYRVVSHPGD--
Mvan_2295|M.vanbaalenii_PYR-1 AFFGDGDAQVAPAAAVETIADQSWTDPQPRTVELPGLGWYRMESRAGD--
TH_2452|M.thermoresistible__bu SRQEPGFPEVLAGDDAFTERVATVTEPVEGSYDHPEVGEVRYLAIPVTMA
MLBr_00175|M.leprae_Br4923 TANQPGQTLPVGTAEKAVIRGELFMSQRTASD-------QRILAIHLP--
. . : :
Mflv_2267|M.gilvum_PYR-GCK ---EGEAVVAGLPTTDVDDTLFWVAVIFGVVAVVALMAAGTAGAVIVRRQ
MAB_2582|M.abscessus_ATCC_1997 ---GGAVIVTGLPAEGVGQTLSSVFGIICVVGAAALITAIGAGIVIIRRQ
MUL_4625|M.ulcerans_Agy99 ---GSDRLIVGVSLSIADRIITRKQITTSVLVATALVITAALTVWVVGIT
MMAR_4456|M.marinum_M ---GSDRLIVGVSLSIADRIITRKQITTSVLVATALVITAALTVWVVGIT
Mb1061c|M.bovis_AF2122/97 ---GADRLFVGVSLSLANQIIARKKVTTVALVGAALVVTAALTVWVVGYA
Rv1032c|M.tuberculosis_H37Rv ---GADRLFVGVSLSLANQIIARKKVTTVALVGAALVVTAALTVWVVGYA
MAV_1175|M.avium_104 ---GSDVLVVGVSHNLADRIIARKQLTTVALTASALLLTAGLTVWVVGYT
MSMEG_2915|M.smegmatis_MC2_155 ---GDESLVTAVSYTPAWEAMMRVTGIVSAMTVVALILTAISTIAIVGFA
Mvan_2295|M.vanbaalenii_PYR-1 ---GDEVLVTGVSRTPAWNVMVRETAIVSGITAIALVVTALSTVAIVRFA
TH_2452|M.thermoresistible__bu GDPAQGVIVAAYLGDAERAAADDAARLMLLVGAATLFGAIGAAWLVAGRI
MLBr_00175|M.leprae_Br4923 ---NDSSLLISKSLRPTEAVMTKLRWVLLIVGSLGVAVAAVAGGMVTRAG
:. . : : : :
Mflv_2267|M.gilvum_PYR-GCK LAPLARVSEAAQQVADLELDRGEVRLPTPIVKVDPAAAQTEVGQLGSALN
MAB_2582|M.abscessus_ATCC_1997 LDPLSQVATAAQEVAELELHRGEVNLPTPIIDVASNRTHTELGQLGAALN
MUL_4625|M.ulcerans_Agy99 LRPLRRVAATAATVAAMPLAG-DDHQISVRVRPEDTDPDNEVGIVGHTLN
MMAR_4456|M.marinum_M LRPLRRVAATAATVAAMPLAG-DDHQISVRVRPEDTDPDNEVGIVGHTLN
Mb1061c|M.bovis_AF2122/97 LRPLRRVAATAAEVATMPLTD-DDHQISVRVRPGDTDPDNEVGIVGHTLN
Rv1032c|M.tuberculosis_H37Rv LRPLRRVAATAAEVATMPLTD-DDHQISVRVRPGDTDPDNEVGIVGHTLN
MAV_1175|M.avium_104 LRPLRRLAAIAAHVAAMPLTD-DDHRITVRVQPQDTDPQNEVGIVGHALN
MSMEG_2915|M.smegmatis_MC2_155 LRPLRRVAATAAEVATLPLDR-ENHAITPRVPACDTDPRTEVGRVGDTLN
Mvan_2295|M.vanbaalenii_PYR-1 LRPLRRVAATAAEVAGLPLDR-DNHAITPRVPAGDTDPSTEVGLVGDTLN
TH_2452|M.thermoresistible__bu LRPLRDVADTARTITDTDLSR----------RIPSRGEGDEMDSLVRTIN
MLBr_00175|M.leprae_Br4923 LRPVGRLTEAAERVARTDDLR-----------PIPVFGSDELARLTEAFN
* *: :: * :: *: : ::*
Mflv_2267|M.gilvum_PYR-GCK RMLDRIAGALSARHASETRVRQFVADASHELRTPLAAIRG-----YTELA
MAB_2582|M.abscessus_ATCC_1997 RMLERIDDALSARHVSETRVRQFVADASHELRTPLAAISG-----YAELA
MUL_4625|M.ulcerans_Agy99 RLLDNVDSALQHRVASDLRMRQFITDASHELRTPLAAIQG-----YAELT
MMAR_4456|M.marinum_M RLLDNVDSALQHRVDSDLRMRQFITDASHELRTPLAAIQG-----YAELT
Mb1061c|M.bovis_AF2122/97 RLLDNVDGALAHRVDSDLRMRQFITDASHELRTPLAAIQG-----YAELT
Rv1032c|M.tuberculosis_H37Rv RLLDNVDGALAHRVDSDLRMRQFITDASHELRTPLAAIQG-----YAELT
MAV_1175|M.avium_104 RLLDNVDSALAHRVDSDLRMRQFITDASHELRTPLAAIQG-----YAELT
MSMEG_2915|M.smegmatis_MC2_155 QLLDHVERALADVAASDRRMRQFITDASHELRTPLAAIHG-----YAELT
Mvan_2295|M.vanbaalenii_PYR-1 RLLDHVEHALADVAASDRRMRQFITDASHELRTPLAAIHG-----YAELT
TH_2452|M.thermoresistible__bu GMLDRIEAGVS-------AQRRFIDDAGHELRTPITIVRG-----HLEVL
MLBr_00175|M.leprae_Br4923 LMLRALAESRE-------RQARLVTDAGHELRTPLTSLRTNVELLIASMA
:* : . ::: **.******:: : .:
Mflv_2267|M.gilvum_PYR-GCK QRKQAELPDDVAHAMSRVESETARMTQLVEDMLLLARLDTGRPLDRDSVD
MAB_2582|M.abscessus_ATCC_1997 RRNHDALPTDVAHAMSRVQSEAARMTELVEDLLLLARLDSGRPLAQEPVD
MUL_4625|M.ulcerans_Agy99 RQDSSDLPPTTEYALARIESEARRMASLVDELLLLSRLGEGEDLETEHLD
MMAR_4456|M.marinum_M RQDSSDLPPTTEYALARIESEARRMASLVDELLLLSRLGEGEDLETEHLD
Mb1061c|M.bovis_AF2122/97 RQDSSDLPPTTEYALARIESEARRMTLLVDELLLLSRLSEGEDLETEDLD
Rv1032c|M.tuberculosis_H37Rv RQDSSDLPPTTEYALARIESEARRMTLLVDELLLLSRLSEGEDLETEDLD
MAV_1175|M.avium_104 RQDSSALPPTTEYALARIESEARRMALLVDELLLLSRLGEGQDLQSEDVD
MSMEG_2915|M.smegmatis_MC2_155 RQDSSVLPETTEYSLARIEAEAQRMNSLVSDLLLLARLDEGQELDTTEVD
Mvan_2295|M.vanbaalenii_PYR-1 RQDSSVLPQTTEYSLARIEAEAQRMHALVADLLLLARLDEGQDRQTTEVD
TH_2452|M.thermoresistible__bu DPDD---PDDVRSTVALVDDELVRMNRMVTDLLLLARSEQPTFLTPEPTD
MLBr_00175|M.leprae_Br4923 PEAPRLPDQEMADLRADVLAQIEELSTLVGDLVDLTRDDAG-QVVHEPID
: : : .: :* ::: *:* *
Mflv_2267|M.gilvum_PYR-GCK LTRLVVDAVSDAHVAAPDHVWELDLPDEPLTVCGDEARLHQVLANLLANA
MAB_2582|M.abscessus_ATCC_1997 LSRLVVDAASDAHIAASEHRWLLNLPEDPVIVCGDTPRLHQVVANLLSNC
MUL_4625|M.ulcerans_Agy99 LTDLVMNAVNDAAVAAPTHRWIKDLPDEPVWVNGDHARLHQLVSNLLTNA
MMAR_4456|M.marinum_M LTDLVMNAVNDAAVAAPTHRWIKDLPDEPVWINGDHARLHQLVSNLLTNA
Mb1061c|M.bovis_AF2122/97 LTDLVINAVNDAAVAAPTHRWVKNLPDEPVWVNGDHARLHQLVSNLLTNA
Rv1032c|M.tuberculosis_H37Rv LTDLVINAVNDAAVAAPTHRWVKNLPDEPVWVNGDHARLHQLVSNLLTNA
MAV_1175|M.avium_104 LTEVVSDAVNDAMVAAPAHHWVKDLPDEPVWVRGDQARLHQLVSNLLGNA
MSMEG_2915|M.smegmatis_MC2_155 LTELVADAVNDAAVSAPTHHWSVRVPDDPVWVRADHARLHQTLANLLSNA
Mvan_2295|M.vanbaalenii_PYR-1 LADLVVDAVNDATVCAPEHRWLTSVPDELVNVLGDRAQLHQMLANLLSNA
TH_2452|M.thermoresistible__bu IGALTR-AIFDKVVQLGDRDYQLQSVAEVTAVL-DAQRITQALIALADNA
MLBr_00175|M.leprae_Br4923 MSEVLYRSLERVRRRRNDIHFDVQAIG--WQIYGDAAGLSRAVLNLMDNA
: : : : : * : : : * *.
Mflv_2267|M.gilvum_PYR-GCK GIHTPAGTTVTTSLTAT----DTGDVLVRVVDDGPGIPARLQPDVFERFA
MAB_2582|M.abscessus_ATCC_1997 RIHTPPGTTVTVTLRS-----DGNSTYLTVADDGPGIPAGQQNEIFERFA
MUL_4625|M.ulcerans_Agy99 WVHTPPGVTVKTGITNYPDDPNGPYTELTVSNDGPDIDPEVLPHLFERFV
MMAR_4456|M.marinum_M WVHTPPGVTVKTGITSYPDDPSGPYTELTVSNDGPDIDPEVLPHLFERFV
Mb1061c|M.bovis_AF2122/97 WVHTQPGVTVTIGITCHRTGPNAPCVELSVTDDGPDIDPEILPHLFDRFV
Rv1032c|M.tuberculosis_H37Rv WVHTQPGVTVTIGITCHRTGPNAPCVELSVTDDGPDIDPEILPHLFDRFV
MAV_1175|M.avium_104 RVHTPPGVTVTTAIRCHRGGREAPFAELTVTDDGPGIDADLLPNLFERFV
MSMEG_2915|M.smegmatis_MC2_155 RVHTPEGTSVQTTLVVHGNGD-TSHAEVTVSDNGPGINPDLLPHLFERFV
Mvan_2295|M.vanbaalenii_PYR-1 RVHTPAGTTVTTTVSKGTAADGTGYVELTVTDDGPGIDPQLLPHLFERFV
TH_2452|M.thermoresistible__bu CRYTRDGDWIAVGSGLY-----DGWLRFWVSDSGPGVSDADRDRIFERFA
MLBr_00175|M.leprae_Br4923 AKWSPSGGRVVVTMRQF----DPSHVELVVSDYGPGIPPQERRLVFERFY
: * : . * : **.: :*:**
Mflv_2267|M.gilvum_PYR-GCK RGDTSRSRRGGSTGLGLAIVAAVVRAHHGTISLHSVPGR-----TEFAVV
MAB_2582|M.abscessus_ATCC_1997 RGDTSRSRRAGSTGLGLAIAAAVIKAHHGEIRVNSVAGE-----TVFTIT
MUL_4625|M.ulcerans_Agy99 RSSKSRSSAPG-HGLGLAIVNSIVKAHDGSVTAESAAGQ-----TVFRIR
MMAR_4456|M.marinum_M RSSKSRSSAPG-HGLGLAIVNSIVKAHDGSVTAESAAGQ-----TVFRIR
Mb1061c|M.bovis_AF2122/97 RASKSRSNGSG-HGLGLAIVSSIVKAHRGSVTAESGNGQ-----TVFRVR
Rv1032c|M.tuberculosis_H37Rv RASKSRSNGSG-HGLGLAIVSSIVKAHRGSVTAESGNGQ-----TVFRVR
MAV_1175|M.avium_104 RADKSRSDGSG-HGLGLAIVSSIVKAHHGSVGVESTAGR-----TVFRVR
MSMEG_2915|M.smegmatis_MC2_155 RADKSRSRAAGSFGLGLSIAASIVEAHGGTISAQSGSGK-----TSFVIR
Mvan_2295|M.vanbaalenii_PYR-1 RADRSRSRQNGSFGLGLAIVASIVESHGGTIDATSGSGT-----TAFRVR
TH_2452|M.thermoresistible__bu RGSAGGQRSDG-AGLGLSIVRAIAGAHGGHVDLDTVVGRG----STFTIT
MLBr_00175|M.leprae_Br4923 RSTTARSLPGS--GLGLAIVKQVVINHGGLLRVEDTAPGVQPPGTSIYVL
*. . . . ****:*. : * * : : : :
Mflv_2267|M.gilvum_PYR-GCK LPGDTQAVHSVGPR------------------------------------
MAB_2582|M.abscessus_ATCC_1997 LPTAGTQHGAFTEKLP----------------------------------
MUL_4625|M.ulcerans_Agy99 LPLIDAPLNASAPGRPRQPSDY----------------------------
MMAR_4456|M.marinum_M LPLIDAPLNASAPGRPRQPSDY----------------------------
Mb1061c|M.bovis_AF2122/97 LPMIEQQIATTA--------------------------------------
Rv1032c|M.tuberculosis_H37Rv LPMIEQQIATTA--------------------------------------
MAV_1175|M.avium_104 LPLIDGPGTLGAAGL-----------------------------------
MSMEG_2915|M.smegmatis_MC2_155 LPSIPVTAPHKTSV------------------------------------
Mvan_2295|M.vanbaalenii_PYR-1 LPTAAVGAAQPVSA------------------------------------
TH_2452|M.thermoresistible__bu IPAVLEAPWPAS--------------------------------------
MLBr_00175|M.leprae_Br4923 LPGRPMPVSAYSTLADQDMGEANFQDKIGPAVQVSGKSANFRDSAHVISV
:*
Mflv_2267|M.gilvum_PYR-GCK --------
MAB_2582|M.abscessus_ATCC_1997 --------
MUL_4625|M.ulcerans_Agy99 --------
MMAR_4456|M.marinum_M --------
Mb1061c|M.bovis_AF2122/97 --------
Rv1032c|M.tuberculosis_H37Rv --------
MAV_1175|M.avium_104 --------
MSMEG_2915|M.smegmatis_MC2_155 --------
Mvan_2295|M.vanbaalenii_PYR-1 --------
TH_2452|M.thermoresistible__bu --------
MLBr_00175|M.leprae_Br4923 DYQSARAR