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PTPEFQTLLYSTAGPVATITLNRPEHLNTIVPPMPDEIEAAVGLAERDQGIKVIVLRGAGRAFSGGYDFG GGFQHWGETMMTDGQWDPGKDFAMVTARETAPTQKFMAIWRASKPVIAQIHGWCVGGASDYALCADIVIA SDDAVIGTPYSRMWGAYLSGMWLYRLSFAKAKWHSLTGRPLSGVQAAQIELINEAVPFERLEARVAEVAA ELAQIPLSQLQAQKLIVNQAYENMGLASTQTLGGILDGLMRNTPDALDFIKTAENQGVRAAVERRDGPFG DYSQAPPELRPNPNHVIVPDRDR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1414 | echA2 | - | 100% (304) | enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_0754 | echA4 | 2e-44 | 35.23% (298) | enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_0210 | echA8 | 6e-19 | 26.41% (284) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0464c | echA2 | 1e-164 | 90.70% (301) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2433 | - | 2e-22 | 31.14% (228) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv0456c | echA2 | 1e-164 | 90.70% (301) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 1e-15 | 25.00% (284) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_3859c | - | 3e-48 | 36.96% (303) | enoyl-CoA hydratase |
| M. marinum M | MMAR_0778 | echA2 | 1e-178 | 100.00% (304) | enoyl-CoA hydratase EchA2 |
| M. avium 104 | MAV_4694 | - | 1e-162 | 90.43% (303) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_1388 | - | 1e-47 | 36.58% (298) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_3498 | - | 7e-28 | 26.69% (266) | PUTATIVE enoyl-CoA hydratase/isomerase |
| M. vanbaalenii PYR-1 | Mvan_0780 | - | 1e-149 | 84.00% (300) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1414|M.ulcerans_Agy99 -------MPTPEFQTLLYSTAGPVATITLNRPEHLNTIVPPMPDEIEAAV
MMAR_0778|M.marinum_M -------MPTPEFQTLLYSTAGPVATITLNRPEHLNTIVPPMPDEIEAAV
Mb0464c|M.bovis_AF2122/97 -------MPTPDFQTLLYTTAGPVATITLNRPEQLNTIVPPMPDEIEAAI
Rv0456c|M.tuberculosis_H37Rv -------MPTPDFQTLLYTTAGPVATITLNRPEQLNTIVPPMPDEIEAAI
MAV_4694|M.avium_104 -------MPS-DFETLLYTTAGPVATITLNRPDQLNTIVPPMPDEIEAAV
Mvan_0780|M.vanbaalenii_PYR-1 -------MPEPEFETLLYRADSAVATITLNRPEQLNTIVPPMPDEIEAAV
MAB_3859c|M.abscessus_ATCC_199 --------MVDTLKTMTYEVTDRVARITFNRPEQGNAIIADTPLELAALV
MSMEG_1388|M.smegmatis_MC2_155 MTHAIRPVDFDNLKTMTYEVTDRVARITFNRPEKGNAIVADTPLELSALV
Mflv_2433|M.gilvum_PYR-GCK -------------MYIDYEVSDRIATITLNRPEAANAQNPELLDELDAAW
TH_3498|M.thermoresistible__bu -------LETRTLEHVIYEKDGPIARIILNNPDRANAQTSEMVHSVNTAL
MLBr_02402|M.leprae_Br4923 ----------MKYDTILVDGYQRVGIITLNRPQALNALNSQMMNEITNAA
: :. * :*.*: *: . .:
MUL_1414|M.ulcerans_Agy99 GLAERDQGIKVIVLRGAGRAFSG-------GYDF----------GGGFQH
MMAR_0778|M.marinum_M GLAERDQGIKVIVLRGAGRAFSG-------GYDF----------GGGFQH
Mb0464c|M.bovis_AF2122/97 GLAERDQDIKVIVLRGAGRAFSG-------GYDF----------GGGFQH
Rv0456c|M.tuberculosis_H37Rv GLAERDQDIKVIVLRGAGRAFSG-------GYDF----------GGGFQH
MAV_4694|M.avium_104 GRAERDPAIKVIVLRGAGRAFSG-------GYDF----------GGGFQH
Mvan_0780|M.vanbaalenii_PYR-1 GLAERDPQVKVIVLRGAGRAFSG-------GYDF----------GGGFAH
MAB_3859c|M.abscessus_ATCC_199 ERADLDPQVHVILVSGRGDGFCG-------GFDLSAYAEAND--EGSVRY
MSMEG_1388|M.smegmatis_MC2_155 ERADLDPDVHVILVSGRGEGFCA-------GFDLSAYAEGSSSAGGGSPY
Mflv_2433|M.gilvum_PYR-GCK TRAAEDNDVSVIVLRANGKHFSA-------GHDLR---------------
TH_3498|M.thermoresistible__bu DDAQYDYDIKVVIIKANGKGFCSGHIPDGS--------------------
MLBr_02402|M.leprae_Br4923 KELDIDPDVGAILITGSPKVFAA---------------------------
* : .::: . *..
MUL_1414|M.ulcerans_Agy99 WGETMM---------TDGQWDPGKDFAMVTARETAPTQKFMAIWR-ASKP
MMAR_0778|M.marinum_M WGETMM---------TDGQWDPGKDFAMVTARETAPTQKFMAIWR-ASKP
Mb0464c|M.bovis_AF2122/97 WGDAMM---------TDGRWDPGKDFAMVTARETGPTQKFMAIWR-ASKP
Rv0456c|M.tuberculosis_H37Rv WGDAMM---------TDGRWDPGKDFAMVTARETGPTQKFMAIWR-ASKP
MAV_4694|M.avium_104 WGEAMM---------TDGRWDPGKDFAMVSARETGPTQKFMAIWR-ASKP
Mvan_0780|M.vanbaalenii_PYR-1 WGEAMN---------TDGRWDPGKDFAMVSARETGPTQKFMAIWR-ASKP
MAB_3859c|M.abscessus_ATCC_199 SGTALDGQVQLRNHLPNINWDPMLDYQMMSRFTRG----FSSLLH-ANKP
MSMEG_1388|M.smegmatis_MC2_155 EGTVLSGKTQALNHLPDEPWDPMVDYQMMSRFVRG----FASLMH-CDKP
Mflv_2433|M.gilvum_PYR-GCK ---------------GGGPVPDKITLEFIIQHEAKRYLEYTLRWRNVPKP
TH_3498|M.thermoresistible__bu ---------------YPEFKAEIEASGKVWRSAAQLFLWPVLKLWEFPKP
MLBr_02402|M.leprae_Br4923 ----------------GADIKEMASLTFTDAFDADFFSAWGKLAA-VRTP
.*
MUL_1414|M.ulcerans_Agy99 VIAQIHGWCVGGASDYALCADIVIASDDAVIGTPYSRM---WGAYLSGMW
MMAR_0778|M.marinum_M VIAQIHGWCVGGASDYALCADIVIASDDAVIGTPYSRM---WGAYLSGMW
Mb0464c|M.bovis_AF2122/97 VIAQVHGWCVGGASDYALCADIVIASEDAVIGTPYSRM---WGAYLTGMW
Rv0456c|M.tuberculosis_H37Rv VIAQVHGWCVGGASDYALCADIVIASEDAVIGTPYSRM---WGAYLTGMW
MAV_4694|M.avium_104 VIAQVHGWCVGGASDYALCADLVIASEDAVIGTPYSRM---WGAYLTGMW
Mvan_0780|M.vanbaalenii_PYR-1 VIAQVHGWCVGGASDYALCADIVIASDDAVIGTPYARM---WGAYLTGMW
MAB_3859c|M.abscessus_ATCC_199 TVVKVHGYCVAGGTDIALHADQLIVAADAKIGYPPTRV---WGVPATGLW
MSMEG_1388|M.smegmatis_MC2_155 TVVKIHGYCVAGGTDIALHADQVIAAADAKIGYPPMRV---WGVPAAGLW
Mflv_2433|M.gilvum_PYR-GCK SIAAVQGRCISGGLLLCWPCDLIVAADDAQFSDPVVLMG--IGGVEYHGH
TH_3498|M.thermoresistible__bu VIAQVHGYAIGGGTTWALIPEITVCSEDAWFQMPLVPGFGLPGSETMFEP
MLBr_02402|M.leprae_Br4923 MIAAVAGYALGGGCELAMMCDLLIAADTAKFGQPEIKLGVLPGMGGSQRL
:. : * .:.*. . : : : * : * *
MUL_1414|M.ulcerans_Agy99 LYRLSFAKAKWHSLTGRPLSGVQAAQIELINEAVPFERLEARVAEVAAEL
MMAR_0778|M.marinum_M LYRLSFAKAKWHSLTGRPLSGVQAAQIELINEAVPFERLEARVAEVAAEL
Mb0464c|M.bovis_AF2122/97 LYRLSLAKVKWHSLTGRPLTGVQAAEAELINEAVPFERLEARVAEIATEL
Rv0456c|M.tuberculosis_H37Rv LYRLSLAKVKWHSLTGRPLTGVQAAEAELINEAVPFERLEARVAEIATEL
MAV_4694|M.avium_104 LYRLSLAKAKWHALTGRPLTGVQAAEIELINEAVPFERLEARVAEVAAEL
Mvan_0780|M.vanbaalenii_PYR-1 IYRLSLAKVKWHSLTGEPLTGKEAAAVELINESVPFEQLEARVAEVAQKL
MAB_3859c|M.abscessus_ATCC_199 AHKLGDQRAKRLLLTGDCLSGRQAYDWGLAVEAPEPDELDERTERLVERI
MSMEG_1388|M.smegmatis_MC2_155 AHRLGDQRAKRLLFTGDCITGAQAAEWGLAVEAPDPADLDARTERLVERI
Mflv_2433|M.gilvum_PYR-GCK TWELGPRKAKEILFTGRAMTADEVAATGMVNKVVPRAELDAETRALAEQI
TH_3498|M.thermoresistible__bu WVFMNYKRAAEYLYTAQKITAQQALEFGLVNRVVPADELESTVEELAAKI
MLBr_02402|M.leprae_Br4923 TRAIGKAKAMDLILTGRTIDAAEAERSGLVSRVVLADDLLPEAKAVATTI
:. :. *. : . :. : . * . :. :
MUL_1414|M.ulcerans_Agy99 AQIPLSQLQAQKLIVNQAYENMGLASTQTLGGILDGLMRNTPDALDFIKT
MMAR_0778|M.marinum_M AQIPLSQLQAQKLIVNQAYENMGLASTQTLGGILDGLMRNTPDALDFIKT
Mb0464c|M.bovis_AF2122/97 ARIPLSQLQAQKLIVNQAYENMGLASTQLLGGILDGLMRNTPDALEFIRT
Rv0456c|M.tuberculosis_H37Rv ARIPLSQLQAQKLIVNQAYENMGLASTQLLGGILDGLMRNTPDALEFIRT
MAV_4694|M.avium_104 ARIPLSQLQAQKLIVNQAYENMGLASTQTLGGILDGLMRNTPDALEFIKI
Mvan_0780|M.vanbaalenii_PYR-1 AGIPLSQLQAQKLIVNQAFENMGLASTQTLGGILDGLMRNTPDALGFIDT
MAB_3859c|M.abscessus_ATCC_199 AAMPLNQLMMIKLACNSVLINQGIANSAMIGTVFDGISRHTPEAHAFTAD
MSMEG_1388|M.smegmatis_MC2_155 AAMPVNQLIMAKLACNTALLNQGVATSQMVSTVFDGIARHTPEGHAFVAT
Mflv_2433|M.gilvum_PYR-GCK AKMPPFALRQAKRAVNQTLDVQGFY--AAIQSVFDVHQTGHGNALSVGGW
TH_3498|M.thermoresistible__bu AKAPLITLQATKAGILRAWETMGFRTHQQASNDLQAVVTGSREFQEYMAE
MLBr_02402|M.leprae_Br4923 SQMSRSATRMAKEAVNRSFESTLAEGLLHERRLFHSTFVTDDQSEGMAAF
: . * :. :
MUL_1414|M.ulcerans_Agy99 AENQGVRAAVERRDGPFGDYSQAPPELRPNPNHVIVPDRDR
MMAR_0778|M.marinum_M AENQGVRAAVERRDGPFGDYSQAPPELRPNPNHVIVPDRDR
Mb0464c|M.bovis_AF2122/97 AQTQGVRAAVERRDGPFGDYSQAPPELRPDPTHVITPDGSM
Rv0456c|M.tuberculosis_H37Rv AQTQGVRAAVERRDGPFGDYSQAPPELRPDPTHVITPDGSM
MAV_4694|M.avium_104 AETRGVRAAVERRDGPFGDYSQAPPELRPDPSHVIVPDRDG
Mvan_0780|M.vanbaalenii_PYR-1 AAADGVRAAVEQRDGPWGDYSQAPPHRRPDPSHVIEP----
MAB_3859c|M.abscessus_ATCC_199 AIANGYRQAVRHRDEPFGDYGRKPTEL--------------
MSMEG_1388|M.smegmatis_MC2_155 AREHGFREAVRRRDEPMGDHGRRASDV--------------
Mflv_2433|M.gilvum_PYR-GCK PVLVNLEEMKANIK---------------------------
TH_3498|M.thermoresistible__bu LMKRASKPADRV-----------------------------
MLBr_02402|M.leprae_Br4923 IEKRAPQFTHR------------------------------
.