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VTISADDSDVQNADTAAELYYDPYNVDLNMDPHGVFARLREEAPLYYNDKHDFYALSRYEDVNKGVIDHQ TFISGRGALLEIIKSGMEIPPGTLIFEDPPIHNIHRNLLSRVFTPRKVQALEPQIREFTARCLDPLTGTN RFDFVRDLGAQMPMRVIGMLLGIPEEDQRRVTDHGEATLQSDSVDLMATGEVFAEFIDHRTEHPSDDIMT DLLNAEFEDETGTRRRLRRDELLMYLTVIATAGSETTTRLIGWAGKTLADYPEQRAQLVADPALIPQAIE EILRWEPPALQIARYVTRDVEYYGQVVPEGSAMLMLVGSANRDHRRFPPNGDVFDIHRELRSHMTFGAGT HFCMGNALARLEGKIALEEILKRFPTWEVDWPNAVPSQTTAVRGWESMPTIVS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4221 | - | - | 100% (403) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_3187 | - | e-116 | 50.38% (395) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_2001 | - | 1e-66 | 36.83% (391) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 7e-63 | 35.50% (400) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_2431 | - | 0.0 | 90.30% (402) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 8e-63 | 35.50% (400) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-36 | 30.70% (342) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 8e-59 | 34.23% (409) | cytochrome P450 |
| M. marinum M | MMAR_4753 | cyp189A7 | 1e-158 | 66.16% (393) | cytochrome P450 189A7 Cyp189A7 |
| M. avium 104 | MAV_2984 | - | 1e-147 | 62.22% (397) | cytochrome P450 |
| M. smegmatis MC2 155 | MSMEG_4829 | - | 0.0 | 82.86% (385) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3021 | - | 1e-175 | 73.71% (388) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0324 | cyp189A7 | 1e-156 | 65.39% (393) | cytochrome P450 189A7 Cyp189A7 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0789c|M.bovis_AF2122/97 --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
Mvan_4221|M.vanbaalenii_PYR-1 ------------------MTISADDSDVQNADTAAELYYDPYNVDLNMDP
Mflv_2431|M.gilvum_PYR-GCK ------MSYVRLIQREGAVTISAENSDVHDAET-DELYYDTQSVELNMDP
MSMEG_4829|M.smegmatis_MC2_155 ---------------------MAQPS----TSATPDLYYDPYSVQLNMEP
TH_3021|M.thermoresistible__bu ----------------------------VTVSAPNDVHYDPYDVELNADP
MMAR_4753|M.marinum_M ----------------------------MTVTAASDVYFDPYDVELNADP
MUL_0324|M.ulcerans_Agy99 ----------------------------MTVTAASDVYFDPYDVELNADP
MAV_2984|M.avium_104 ----------------------------MTASTDSDVRFDPYDVGLIADP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: . :*
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVSMDK
Mvan_4221|M.vanbaalenii_PYR-1 HGVFARLREEAPLYYNDKHDFYALSRYEDVNKGVIDHQTFISGRGALLEI
Mflv_2431|M.gilvum_PYR-GCK YAVFARLREEAPLYYNAKHDFYALSRYEDVNKAVIDHETFISGRGALLEI
MSMEG_4829|M.smegmatis_MC2_155 HEVFARIREEAPLYYNEQHDFYALSRYHDVNKAVIDHETFISGRGALLEL
TH_3021|M.thermoresistible__bu YPMFKRIREEAPLYYNPTHDFYALSRFDDVNSAILDHETFSSARGAVLEI
MMAR_4753|M.marinum_M YPMFRRLREEAPLYYNAQHGFYALSRFADVDRAIVDYQTFSSARGAILEI
MUL_0324|M.ulcerans_Agy99 YPMFRRLREEAPLYYNAQHGFYALSRFADVDRAIVDYQTFSSARGAILEF
MAV_2984|M.avium_104 YPMFARLREEAPLYYNAEYDFYAVSRYADVSKALVDHETYSSARGAILEL
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
. : : : .*: : ..* . * .. . : . . :
Mb0789c|M.bovis_AF2122/97 SSRTS----EAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
Rv0766c|M.tuberculosis_H37Rv SSRTS----EAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
MAB_1216c|M.abscessus_ATCC_199 ASFGP----HAKLVMSFLAMDDPEHLRLRALVSKGFTPRRIRELEGQVVA
Mvan_4221|M.vanbaalenii_PYR-1 IKSG-----MEIPPGTLIFEDPPIHNIHRNLLSRVFTPRKVQALEPQIRE
Mflv_2431|M.gilvum_PYR-GCK IKSG-----MEIPPGTLIFEDPPIHNIHRNLLSRVFTPRKVLALEPQIRE
MSMEG_4829|M.smegmatis_MC2_155 IKSG-----MEIPPGTLIFEDPPIHNIHRNLLSRMFTPRKVLALEPQIRE
TH_3021|M.thermoresistible__bu IKSG-----MEIPPGTLIFEDPPIHNIHRKLLSRMFTPRKIAALEPRIRE
MMAR_4753|M.marinum_M IKAN-----IDIPAGVLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKIRE
MUL_0324|M.ulcerans_Agy99 IKAN-----IDIPAGVLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKIRE
MAV_2984|M.avium_104 IKAN-----LDIPSGMLIFEDPPIHDVHRKLLSRMFTPRRIAALEPMIRD
MLBr_02088|M.leprae_Br4923 QAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAA
:: * * * * *:*: *:*: : ** :
Mb0789c|M.bovis_AF2122/97 LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRAL
Rv0766c|M.tuberculosis_H37Rv LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRAL
MAB_1216c|M.abscessus_ATCC_199 LARTHLDRALANASDRSFDFIAEYAGKLPMDVISELMGVPESDRARIREL
Mvan_4221|M.vanbaalenii_PYR-1 FTARCLDPLTGTNR---FDFVRDLGAQMPMRVIGMLLGIPEEDQRRVTDH
Mflv_2431|M.gilvum_PYR-GCK FTARCLDPVVGTGK---FDFVKDLGNQMPMRVIGMLLGIPEEDQRRVTDH
MSMEG_4829|M.smegmatis_MC2_155 FTTRCLDAVAGSDT---FDFVNDLGEQMPMRVIGMLLGIPEDRQRAITDH
TH_3021|M.thermoresistible__bu FTARCLDPLVGTGR---FDFVQDLGEQMPMRVIGMLLGIPEEDQRHVVDH
MMAR_4753|M.marinum_M FCARSLDPLIGSGR---FDFVADLGAQMPMRVIGMLLGVPEEDQEAARDF
MUL_0324|M.ulcerans_Agy99 FCARSLDPLIGSGR---FDFVADLGAQMPMRVIGMLLGVPEEDQEAARDF
MAV_2984|M.avium_104 FCAQCLDPLVGTGH---FDFVTDLGAQMPMKVISMLLGIPEDDQEYIRDR
MLBr_02088|M.leprae_Br4923 LVDSLLDKGAAAGQ---FDVIADLAFPLAVAVICRLLGVPYEDAPEFGRV
: ** **.: : . :.: ** *:*:*
Mb0789c|M.bovis_AF2122/97 ADAVLHRED------GVADVPPPAMAASIELMRYYADLIAEFRR-RPANN
Rv0766c|M.tuberculosis_H37Rv ADAVLHRED------GVADVPPPAMAASIELMRYYADLIAEFRR-RPANN
MAB_1216c|M.abscessus_ATCC_199 ADGVMHRED------GLADVPPEAIQASFDLMTYYIEMVRERRR-RPTED
Mvan_4221|M.vanbaalenii_PYR-1 GEATLQSD-------------SVDLMATGEVFAEFIDHRTE----HPSDD
Mflv_2431|M.gilvum_PYR-GCK GEATLQSD-------------SVDLMATGEVFAEFIDYRTE----HPSND
MSMEG_4829|M.smegmatis_MC2_155 GEETLQGT-------------TVDSLATGEVFAEFIDWRAD----NPSDD
TH_3021|M.thermoresistible__bu GEATIRTER----------GGKMSGLATGEVFAEYIDYRAK----HPSDD
MMAR_4753|M.marinum_M ATAQLRTEA------GKPMKASADGMVSGDFFAHYIDWRAE----HPSSD
MUL_0324|M.ulcerans_Agy99 ATAQLRTEA------GKPMKASADGMVSGDFFAHYIDWRAE----HPSSD
MAV_2984|M.avium_104 GNAQLRTEA------GKPMKAAEQGLSVGEQFEAYIDWRAE----HPSDD
MLBr_02088|M.leprae_Br4923 SALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGED
. :: : : : . * .:
Mb0789c|M.bovis_AF2122/97 LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
Rv0766c|M.tuberculosis_H37Rv LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
MAB_1216c|M.abscessus_ATCC_199 LTSALLQAEIDGD-----RLTDEEVLAFLFLMVIAGNETTTKLLANAVYW
Mvan_4221|M.vanbaalenii_PYR-1 IMTDLLNAEFEDETGTRRRLRRDELLMYLTVIATAGSETTTRLIGWAGKT
Mflv_2431|M.gilvum_PYR-GCK IMTDLLNAEFEDETGTRRKLRREELLMYLTVISTAGSETTTRLIGWAGKT
MSMEG_4829|M.smegmatis_MC2_155 IMTDLLNAEFEDETGTVRKLRRDELLLYLTVIATAGSETTTRALGWAGKT
TH_3021|M.thermoresistible__bu IMTELMNAEFEDETGTVRKLGREELLLYLTVIATAGSETTTRLIGWTGKL
MMAR_4753|M.marinum_M IMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGKV
MUL_0324|M.ulcerans_Agy99 IMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGKV
MAV_2984|M.avium_104 IMTELLNVEFVDETGTTRRLTREEILVYLNVVAGAGNETTTRLIGWTGKV
MLBr_02088|M.leprae_Br4923 LISRLIELDESGD-----QLTEEEIIATCGLLLVAGHETTVNLIANAVLA
: : *: : .: :* :*:: :: ** ***.. :. :
Mb0789c|M.bovis_AF2122/97 AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
Rv0766c|M.tuberculosis_H37Rv AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
MAB_1216c|M.abscessus_ATCC_199 GHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAEDITVYDTKI
Mvan_4221|M.vanbaalenii_PYR-1 LADYPEQRAQLVADPALIPQAIEEILRWEPPALQIARYVTRDVEYYGQVV
Mflv_2431|M.gilvum_PYR-GCK LADYPDQRAELAADHSLIPQAIEEILRWEPPALQIARYVTRDVEYYGQTV
MSMEG_4829|M.smegmatis_MC2_155 LADHPDQRRDLVENPALIPQAIEELLRWEPPALQIARYVTRDVEYYGKTV
TH_3021|M.thermoresistible__bu LSEHPDQRAELVADRSLLPQAIEEILRFEPPAPHMCRYVTRDVEYYGQTV
MMAR_4753|M.marinum_M LAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGESV
MUL_0324|M.ulcerans_Agy99 LAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGQSV
MAV_2984|M.avium_104 LAEHPDQRRDLVENPALIPQAIEELLRYEPPAPHVSRYVTRDVVVHDQTV
MLBr_02088|M.leprae_Br4923 MLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTL
* * : : * :** **::.. : * .:.*: :
Mb0789c|M.bovis_AF2122/97 PEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCLGA
Rv0766c|M.tuberculosis_H37Rv PEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCLGA
MAB_1216c|M.abscessus_ATCC_199 PAGDILLLLPGSANRDDRVFD-DADQYRIGREIGAKLVSFGSGAHFCLGA
Mvan_4221|M.vanbaalenii_PYR-1 PEGSAMLMLVGSANRDHRRFPPNGDVFDIHREL-RSHMTFGAGTHFCMGN
Mflv_2431|M.gilvum_PYR-GCK PAGSAMLMLVGSANRDHRRFPPDGDVFDIHREL-RSHMTFGAGTHFCMGN
MSMEG_4829|M.smegmatis_MC2_155 PAGSAMLMLVGAANRDHRRFPPNGDVFDIHREQ-FSHMTFGAGTHFCMGN
TH_3021|M.thermoresistible__bu PAGSAMMLLVGAANRDHRRFPPDGDVFDIHREP-RQHLSFGVGAHFCLGN
MMAR_4753|M.marinum_M PEGSIMMMLIGAANRDHRQFPPDGDVFDIRREP-HQHLTFSVGTHYCLGS
MUL_0324|M.ulcerans_Agy99 PEGSIMMMLIGAANRDHRQFRPDGDVFNIRREP-HQHLTFSVGTHYCLGS
MAV_2984|M.avium_104 PEGSVMMMLIGSACRDEAQFGSDAGEFNIHRAV-RPHLTFSMGTHFCLGS
MLBr_02088|M.leprae_Br4923 TEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPS-SRHLAFAVGSHFCLGA
. *. :::* .:* ** : . : * ::*. *:*:*:*
Mb0789c|M.bovis_AF2122/97 HLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR-
Rv0766c|M.tuberculosis_H37Rv HLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR-
MAB_1216c|M.abscessus_ATCC_199 HLARMEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMTVQLRE
Mvan_4221|M.vanbaalenii_PYR-1 ALARLEGKIALEEILKRFPTWEVDWPNAVPSQTTAVRGWESMPTIVS---
Mflv_2431|M.gilvum_PYR-GCK ALARLEGRIALEEILKRFPTWEVDWPNAVPSQTTAVRGWETMPTFV----
MSMEG_4829|M.smegmatis_MC2_155 ALARLELRVALEEILKRFPEWEVDWDNARPSETAAVRGWAAMPTFVR---
TH_3021|M.thermoresistible__bu ALARLEGRVALDEILNRFPEWEVDMSKAELSPTSTVRGWETMPATIP---
MMAR_4753|M.marinum_M ALARLEGRIALEEILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD---
MUL_0324|M.ulcerans_Agy99 ALARLEGRIALEDILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD---
MAV_2984|M.avium_104 ALARLEGRVALEEILKRFPEWEVDLSRATLSPTSTVRGWECMPALVP---
MLBr_02088|M.leprae_Br4923 ALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV----
***:* ::* : *: :: . . :** :* .
Mb0789c|M.bovis_AF2122/97 --
Rv0766c|M.tuberculosis_H37Rv --
MAB_1216c|M.abscessus_ATCC_199 GR
Mvan_4221|M.vanbaalenii_PYR-1 --
Mflv_2431|M.gilvum_PYR-GCK --
MSMEG_4829|M.smegmatis_MC2_155 --
TH_3021|M.thermoresistible__bu --
MMAR_4753|M.marinum_M --
MUL_0324|M.ulcerans_Agy99 --
MAV_2984|M.avium_104 --
MLBr_02088|M.leprae_Br4923 --