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SYVRLIQREGAVTISAENSDVHDAETDELYYDTQSVELNMDPYAVFARLREEAPLYYNAKHDFYALSRYE DVNKAVIDHETFISGRGALLEIIKSGMEIPPGTLIFEDPPIHNIHRNLLSRVFTPRKVLALEPQIREFTA RCLDPVVGTGKFDFVKDLGNQMPMRVIGMLLGIPEEDQRRVTDHGEATLQSDSVDLMATGEVFAEFIDYR TEHPSNDIMTDLLNAEFEDETGTRRKLRREELLMYLTVISTAGSETTTRLIGWAGKTLADYPDQRAELAA DHSLIPQAIEEILRWEPPALQIARYVTRDVEYYGQTVPAGSAMLMLVGSANRDHRRFPPDGDVFDIHREL RSHMTFGAGTHFCMGNALARLEGRIALEEILKRFPTWEVDWPNAVPSQTTAVRGWETMPTFV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2431 | - | - | 100% (413) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_1266 | - | e-121 | 55.50% (391) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_4145 | - | e-120 | 55.10% (392) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 5e-62 | 35.75% (400) | cytochrome P450 123 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 5e-62 | 35.75% (400) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 8e-36 | 29.37% (395) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1406c | - | 2e-59 | 36.99% (392) | cytochrome P450 |
| M. marinum M | MMAR_4753 | cyp189A7 | 1e-156 | 66.07% (389) | cytochrome P450 189A7 Cyp189A7 |
| M. avium 104 | MAV_2984 | - | 1e-145 | 62.47% (397) | cytochrome P450 |
| M. smegmatis MC2 155 | MSMEG_4829 | - | 0.0 | 82.95% (387) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3021 | - | 1e-180 | 75.25% (404) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0324 | cyp189A7 | 1e-154 | 65.30% (389) | cytochrome P450 189A7 Cyp189A7 |
| M. vanbaalenii PYR-1 | Mvan_4221 | - | 0.0 | 90.30% (402) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0789c|M.bovis_AF2122/97 ---------------------------MTVRVGDPELVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv ---------------------------MTVRVGDPELVLDPYDYDFHEDP
Mflv_2431|M.gilvum_PYR-GCK ------MSYVRLIQREGAVTISAENSDVHDAET-DELYYDTQSVELNMDP
Mvan_4221|M.vanbaalenii_PYR-1 ------------------MTISADDSDVQNADTAAELYYDPYNVDLNMDP
MSMEG_4829|M.smegmatis_MC2_155 ---------------------MAQPS----TSATPDLYYDPYSVQLNMEP
TH_3021|M.thermoresistible__bu ----------------------------VTVSAPNDVHYDPYDVELNADP
MMAR_4753|M.marinum_M ----------------------------MTVTAASDVYFDPYDVELNADP
MUL_0324|M.ulcerans_Agy99 ----------------------------MTVTAASDVYFDPYDVELNADP
MAV_2984|M.avium_104 ----------------------------MTASTDSDVRFDPYDVGLIADP
MAB_1406c|M.abscessus_ATCC_199 --------------------------MSVDVSHTVAPRYVPGTADNWTNP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
:*
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYR-----NEERNFWAVSRHHDVLQGFRDSTALSNAYG
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYR-----NEERNFWAVSRHHDVLQGFRDSTALSNAYG
Mflv_2431|M.gilvum_PYR-GCK YAVFARLREEAPLY-----YNAKHDFYALSRYEDVNKAVIDHETFISGRG
Mvan_4221|M.vanbaalenii_PYR-1 HGVFARLREEAPLY-----YNDKHDFYALSRYEDVNKGVIDHQTFISGRG
MSMEG_4829|M.smegmatis_MC2_155 HEVFARIREEAPLY-----YNEQHDFYALSRYHDVNKAVIDHETFISGRG
TH_3021|M.thermoresistible__bu YPMFKRIREEAPLY-----YNPTHDFYALSRFDDVNSAILDHETFSSARG
MMAR_4753|M.marinum_M YPMFRRLREEAPLY-----YNAQHGFYALSRFADVDRAIVDYQTFSSARG
MUL_0324|M.ulcerans_Agy99 YPMFRRLREEAPLY-----YNAQHGFYALSRFADVDRAIVDYQTFSSARG
MAV_2984|M.avium_104 YPMFARLREEAPLY-----YNAEYDFYAVSRYADVSKALVDHETYSSARG
MAB_1406c|M.abscessus_ATCC_199 WPMYAALRDHDPVHHVVPEYTPDQDYYVLTRHADVYEAARDWETFSSARG
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQ------LPGMPLTVFSSFSDCDEALRHPLSASDRLK
: : : *: ..: . * . . : .
Mb0789c|M.bovis_AF2122/97 VSLD--PSSRTS--EAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELE
Rv0766c|M.tuberculosis_H37Rv VSLD--PSSRTS--EAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELE
Mflv_2431|M.gilvum_PYR-GCK ALL---EIIKSG--MEIPPGTLIFEDPPIHNIHRNLLSRVFTPRKVLALE
Mvan_4221|M.vanbaalenii_PYR-1 ALL---EIIKSG--MEIPPGTLIFEDPPIHNIHRNLLSRVFTPRKVQALE
MSMEG_4829|M.smegmatis_MC2_155 ALL---ELIKSG--MEIPPGTLIFEDPPIHNIHRNLLSRMFTPRKVLALE
TH_3021|M.thermoresistible__bu AVL---EIIKSG--MEIPPGTLIFEDPPIHNIHRKLLSRMFTPRKIAALE
MMAR_4753|M.marinum_M AIL---EIIKAN--IDIPAGVLVFEDPPVHDVHRKLLSRMFTPRKINDLE
MUL_0324|M.ulcerans_Agy99 AIL---EFIKAN--IDIPAGVLVFEDPPVHDVHRKLLSRMFTPRKINDLE
MAV_2984|M.avium_104 AIL---ELIKAN--LDIPSGMLIFEDPPIHDVHRKLLSRMFTPRRIAALE
MAB_1406c|M.abscessus_ATCC_199 LTVTYGDLEKTG--MGDNP-PMVMQDPPTHTEFRKLVSRGFTPRQVTAVE
MLBr_02088|M.leprae_Br4923 ATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALE
: :: * * * *.*:*: *:*: : :*
Mb0789c|M.bovis_AF2122/97 PQVLELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDRARIR
Rv0766c|M.tuberculosis_H37Rv PQVLELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDRARIR
Mflv_2431|M.gilvum_PYR-GCK PQIREFTARCLDPVVGTGKFDFVKDLGNQMPMRVIGMLLGIPEEDQRRVT
Mvan_4221|M.vanbaalenii_PYR-1 PQIREFTARCLDPLTGTNRFDFVRDLGAQMPMRVIGMLLGIPEEDQRRVT
MSMEG_4829|M.smegmatis_MC2_155 PQIREFTTRCLDAVAGSDTFDFVNDLGEQMPMRVIGMLLGIPEDRQRAIT
TH_3021|M.thermoresistible__bu PRIREFTARCLDPLVGTGRFDFVQDLGEQMPMRVIGMLLGIPEEDQRHVV
MMAR_4753|M.marinum_M PKIREFCARSLDPLIGSGRFDFVADLGAQMPMRVIGMLLGVPEEDQEAAR
MUL_0324|M.ulcerans_Agy99 PKIREFCARSLDPLIGSGRFDFVADLGAQMPMRVIGMLLGVPEEDQEAAR
MAV_2984|M.avium_104 PMIRDFCAQCLDPLVGTGHFDFVTDLGAQMPMKVISMLLGIPEDDQEYIR
MAB_1406c|M.abscessus_ATCC_199 PKVREFVVQRLERLKERGEGDIVVELFKPLPSMVVAHYLGVPEEDRTQFD
MLBr_02088|M.leprae_Br4923 GDIAALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFG
: : *: *.: :: :. *: :*:*
Mb0789c|M.bovis_AF2122/97 ALADAVLHREDG----V---ADVPPPAMAASIELMRYYADLIAEFRRRPA
Rv0766c|M.tuberculosis_H37Rv ALADAVLHREDG----V---ADVPPPAMAASIELMRYYADLIAEFRRRPA
Mflv_2431|M.gilvum_PYR-GCK DHGEATLQSD-----------------SVDLMATGEVFAEFIDYRTEHPS
Mvan_4221|M.vanbaalenii_PYR-1 DHGEATLQSD-----------------SVDLMATGEVFAEFIDHRTEHPS
MSMEG_4829|M.smegmatis_MC2_155 DHGEETLQGT-----------------TVDSLATGEVFAEFIDWRADNPS
TH_3021|M.thermoresistible__bu DHGEATIRTER--------------GGKMSGLATGEVFAEYIDYRAKHPS
MMAR_4753|M.marinum_M DFATAQLRTEAG----------KPMKASADGMVSGDFFAHYIDWRAEHPS
MUL_0324|M.ulcerans_Agy99 DFATAQLRTEAG----------KPMKASADGMVSGDFFAHYIDWRAEHPS
MAV_2984|M.avium_104 DRGNAQLRTEAG----------KPMKAAEQGLSVGEQFEAYIDWRAEHPS
MAB_1406c|M.abscessus_ATCC_199 AWTDGIVAAASGGAIDI---EAMQGEVAQTIGELMMYFTGLIERRRAEPE
MLBr_02088|M.leprae_Br4923 RVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPG
: : *
Mb0789c|M.bovis_AF2122/97 NNLTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAV
Rv0766c|M.tuberculosis_H37Rv NNLTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAV
Mflv_2431|M.gilvum_PYR-GCK NDIMTDLLNAEFEDETGTRRKLRREELLMYLTVISTAGSETTTRLIGWAG
Mvan_4221|M.vanbaalenii_PYR-1 DDIMTDLLNAEFEDETGTRRRLRRDELLMYLTVIATAGSETTTRLIGWAG
MSMEG_4829|M.smegmatis_MC2_155 DDIMTDLLNAEFEDETGTVRKLRRDELLLYLTVIATAGSETTTRALGWAG
TH_3021|M.thermoresistible__bu DDIMTELMNAEFEDETGTVRKLGREELLLYLTVIATAGSETTTRLIGWTG
MMAR_4753|M.marinum_M SDIMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAG
MUL_0324|M.ulcerans_Agy99 SDIMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAG
MAV_2984|M.avium_104 DDIMTELLNVEFVDETGTTRRLTREEILVYLNVVAGAGNETTTRLIGWTG
MAB_1406c|M.abscessus_ATCC_199 DDTVSHLVAAGVGADGDISGTLQ---ILGFAFTMVTGGNDTTTGMLGGAI
MLBr_02088|M.leprae_Br4923 EDLISRLIELDESGD-----QLTEEEIIATCGLLLVAGHETTVNLIANAV
.: : *: : * :: : .* :**. :. :
Mb0789c|M.bovis_AF2122/97 YWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDT
Rv0766c|M.tuberculosis_H37Rv YWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDT
Mflv_2431|M.gilvum_PYR-GCK KTLADYPDQRAELAADHSLIPQAIEEILRWEPPALQIARYVTRDVEYYGQ
Mvan_4221|M.vanbaalenii_PYR-1 KTLADYPEQRAQLVADPALIPQAIEEILRWEPPALQIARYVTRDVEYYGQ
MSMEG_4829|M.smegmatis_MC2_155 KTLADHPDQRRDLVENPALIPQAIEELLRWEPPALQIARYVTRDVEYYGK
TH_3021|M.thermoresistible__bu KLLSEHPDQRAELVADRSLLPQAIEEILRFEPPAPHMCRYVTRDVEYYGQ
MMAR_4753|M.marinum_M KVLAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGE
MUL_0324|M.ulcerans_Agy99 KVLAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGQ
MAV_2984|M.avium_104 KVLAEHPDQRRDLVENPALIPQAIEELLRYEPPAPHVSRYVTRDVVVHDQ
MAB_1406c|M.abscessus_ATCC_199 QLLHQNPAQRQKLIDDPSLIPGAVEEFLRLTSPVQGLARTATRDVIIGDT
MLBr_02088|M.leprae_Br4923 LAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQT
* * : : * :** ** .. : * .::*:
Mb0789c|M.bovis_AF2122/97 TIPEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCL
Rv0766c|M.tuberculosis_H37Rv TIPEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCL
Mflv_2431|M.gilvum_PYR-GCK TVPAGSAMLMLVGSANRDHRRFPPDGDVFDIHREL-RSHMTFGAGTHFCM
Mvan_4221|M.vanbaalenii_PYR-1 VVPEGSAMLMLVGSANRDHRRFPPNGDVFDIHREL-RSHMTFGAGTHFCM
MSMEG_4829|M.smegmatis_MC2_155 TVPAGSAMLMLVGAANRDHRRFPPNGDVFDIHREQ-FSHMTFGAGTHFCM
TH_3021|M.thermoresistible__bu TVPAGSAMMLLVGAANRDHRRFPPDGDVFDIHREP-RQHLSFGVGAHFCL
MMAR_4753|M.marinum_M SVPEGSIMMMLIGAANRDHRQFPPDGDVFDIRREP-HQHLTFSVGTHYCL
MUL_0324|M.ulcerans_Agy99 SVPEGSIMMMLIGAANRDHRQFRPDGDVFNIRREP-HQHLTFSVGTHYCL
MAV_2984|M.avium_104 TVPEGSVMMMLIGSACRDEAQFGSDAGEFNIHRAV-RPHLTFSMGTHFCL
MAB_1406c|M.abscessus_ATCC_199 TIPAGRRALLLYGSANRDEREYGNDAAELDVLRKP-RNILTFSHGNHHCL
MLBr_02088|M.leprae_Br4923 TLTEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPS-SRHLAFAVGSHFCL
:. * ::* .:* ** : * ::*. * *.*:
Mb0789c|M.bovis_AF2122/97 GAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQA
Rv0766c|M.tuberculosis_H37Rv GAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQA
Mflv_2431|M.gilvum_PYR-GCK GNALARLEGRIALEEILKRFPTWEVDWPNAVPSQTTAVRGWETMPTFV--
Mvan_4221|M.vanbaalenii_PYR-1 GNALARLEGKIALEEILKRFPTWEVDWPNAVPSQTTAVRGWESMPTIVS-
MSMEG_4829|M.smegmatis_MC2_155 GNALARLELRVALEEILKRFPEWEVDWDNARPSETAAVRGWAAMPTFVR-
TH_3021|M.thermoresistible__bu GNALARLEGRVALDEILNRFPEWEVDMSKAELSPTSTVRGWETMPATIP-
MMAR_4753|M.marinum_M GSALARLEGRIALEEILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD-
MUL_0324|M.ulcerans_Agy99 GSALARLEGRIALEDILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD-
MAV_2984|M.avium_104 GSALARLEGRVALEEILKRFPEWEVDLSRATLSPTSTVRGWECMPALVP-
MAB_1406c|M.abscessus_ATCC_199 GAAAARMQSRIALEELLTRIPDFEVDLDGVTWADGSYVRRPLTVPIRVR-
MLBr_02088|M.leprae_Br4923 GAALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV--
* **:: ::* : *: :: :* :* .
Mb0789c|M.bovis_AF2122/97 R
Rv0766c|M.tuberculosis_H37Rv R
Mflv_2431|M.gilvum_PYR-GCK -
Mvan_4221|M.vanbaalenii_PYR-1 -
MSMEG_4829|M.smegmatis_MC2_155 -
TH_3021|M.thermoresistible__bu -
MMAR_4753|M.marinum_M -
MUL_0324|M.ulcerans_Agy99 -
MAV_2984|M.avium_104 -
MAB_1406c|M.abscessus_ATCC_199 -
MLBr_02088|M.leprae_Br4923 -