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TASTDSDVRFDPYDVGLIADPYPMFARLREEAPLYYNAEYDFYAVSRYADVSKALVDHETYSSARGAILE LIKANLDIPSGMLIFEDPPIHDVHRKLLSRMFTPRRIAALEPMIRDFCAQCLDPLVGTGHFDFVTDLGAQ MPMKVISMLLGIPEDDQEYIRDRGNAQLRTEAGKPMKAAEQGLSVGEQFEAYIDWRAEHPSDDIMTELLN VEFVDETGTTRRLTREEILVYLNVVAGAGNETTTRLIGWTGKVLAEHPDQRRDLVENPALIPQAIEELLR YEPPAPHVSRYVTRDVVVHDQTVPEGSVMMMLIGSACRDEAQFGSDAGEFNIHRAVRPHLTFSMGTHFCL GSALARLEGRVALEEILKRFPEWEVDLSRATLSPTSTVRGWECMPALVP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2984 | - | - | 100% (400) | cytochrome P450 |
| M. avium 104 | MAV_0366 | - | e-130 | 53.62% (401) | cytochrome P450 superfamily protein |
| M. avium 104 | MAV_1389 | - | e-125 | 53.98% (389) | NikQ protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 3e-62 | 37.09% (399) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_2431 | - | 1e-145 | 62.47% (397) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1256c | cyp130 | 2e-65 | 38.74% (382) | cytochrome P450 130 CYP130 |
| M. leprae Br4923 | MLBr_02088 | - | 8e-46 | 32.25% (400) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1406c | - | 5e-66 | 36.78% (397) | cytochrome P450 |
| M. marinum M | MMAR_4753 | cyp189A7 | 1e-175 | 73.62% (398) | cytochrome P450 189A7 Cyp189A7 |
| M. smegmatis MC2 155 | MSMEG_4887 | - | 1e-178 | 75.44% (399) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3021 | - | 1e-165 | 68.75% (400) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0324 | cyp189A7 | 1e-176 | 73.87% (398) | cytochrome P450 189A7 Cyp189A7 |
| M. vanbaalenii PYR-1 | Mvan_4221 | - | 1e-147 | 62.22% (397) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2984|M.avium_104 ------------------MTASTDS----------DVRFDPYDVGLIADP
MSMEG_4887|M.smegmatis_MC2_155 ------------------MTASATQ----------NVYFDPYDVAINADP
MMAR_4753|M.marinum_M ------------------MTVTAAS----------DVYFDPYDVELNADP
MUL_0324|M.ulcerans_Agy99 ------------------MTVTAAS----------DVYFDPYDVELNADP
Mflv_2431|M.gilvum_PYR-GCK ------MSYVRLIQREGAVTISAENSDVHDAET-DELYYDTQSVELNMDP
Mvan_4221|M.vanbaalenii_PYR-1 ------------------MTISADDSDVQNADTAAELYYDPYNVDLNMDP
TH_3021|M.thermoresistible__bu ------------------VTVSAPN----------DVHYDPYDVELNADP
Rv1256c|M.tuberculosis_H37Rv ------------------MTSVMSH------------EFQLATAETWPNP
MAB_1406c|M.abscessus_ATCC_199 --------------MSVDVSHTVAP------------RYVPGTADNWTNP
Mb0789c|M.bovis_AF2122/97 ------------------MTVRVGDP---------ELVLDPYDYDFHEDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
:*
MAV_2984|M.avium_104 YPMFARLREEAPLY-----YNAEYDFYAVSRYADVSKALVDHETYSSARG
MSMEG_4887|M.smegmatis_MC2_155 YPTFARLREEAPLY-----YNEQFDFYALSRFSDVNKALIDHETFSSARG
MMAR_4753|M.marinum_M YPMFRRLREEAPLY-----YNAQHGFYALSRFADVDRAIVDYQTFSSARG
MUL_0324|M.ulcerans_Agy99 YPMFRRLREEAPLY-----YNAQHGFYALSRFADVDRAIVDYQTFSSARG
Mflv_2431|M.gilvum_PYR-GCK YAVFARLREEAPLY-----YNAKHDFYALSRYEDVNKAVIDHETFISGRG
Mvan_4221|M.vanbaalenii_PYR-1 HGVFARLREEAPLY-----YNDKHDFYALSRYEDVNKGVIDHQTFISGRG
TH_3021|M.thermoresistible__bu YPMFKRIREEAPLY-----YNPTHDFYALSRFDDVNSAILDHETFSSARG
Rv1256c|M.tuberculosis_H37Rv WPMYRALRDHDPVHHVVPPQRPEYDYYVLSRHADVWSAARDHQTFSSAQG
MAB_1406c|M.abscessus_ATCC_199 WPMYAALRDHDPVHHVVPEYTPDQDYYVLTRHADVYEAARDWETFSSARG
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYR-----NEERNFWAVSRHHDVLQGFRDSTALSNAYG
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG---MPLTVFSSFSDCDEALRHPLSASDRLKATL
: : : *: : .: :. . ..
MAV_2984|M.avium_104 AILELIKANLDIPSG--MLIFEDPPIHDVHRKLLSRMFTPRRIAALEPMI
MSMEG_4887|M.smegmatis_MC2_155 AIVELIKADIEIPSG--ALIFEDPPIHTAHRKLLSRMFTPRKINALEPEI
MMAR_4753|M.marinum_M AILEIIKANIDIPAG--VLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKI
MUL_0324|M.ulcerans_Agy99 AILEFIKANIDIPAG--VLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKI
Mflv_2431|M.gilvum_PYR-GCK ALLEIIKSGMEIPPG--TLIFEDPPIHNIHRNLLSRVFTPRKVLALEPQI
Mvan_4221|M.vanbaalenii_PYR-1 ALLEIIKSGMEIPPG--TLIFEDPPIHNIHRNLLSRVFTPRKVQALEPQI
TH_3021|M.thermoresistible__bu AVLEIIKSGMEIPPG--TLIFEDPPIHNIHRKLLSRMFTPRKIAALEPRI
Rv1256c|M.tuberculosis_H37Rv LTVNYGELEMIGLHDTPPMVMQDPPVHTEFRKLVSRGFTPRQVETVEPTV
MAB_1406c|M.abscessus_ATCC_199 LTVTYGDLEKTGMGDNPPMVMQDPPTHTEFRKLVSRGFTPRQVTAVEPKV
Mb0789c|M.bovis_AF2122/97 VSLDPSSRTSEAYRVMSMLAMDDP-AHLRMRTLVSKGFTPRRIRELEPQV
MLBr_02088|M.leprae_Br4923 AQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDI
: : ** * *.*:*: *:*: : :* :
MAV_2984|M.avium_104 RDFCAQCLDPLVGTGHFDFVTDLGAQMPMKVISMLLGIPEDDQEYIRDRG
MSMEG_4887|M.smegmatis_MC2_155 RRFCAQSLDAVAGVERFDIIKDFGAIMPMRVISALLGIPEEDQEKIRDHG
MMAR_4753|M.marinum_M REFCARSLDPLIGSGRFDFVADLGAQMPMRVIGMLLGVPEEDQEAARDFA
MUL_0324|M.ulcerans_Agy99 REFCARSLDPLIGSGRFDFVADLGAQMPMRVIGMLLGVPEEDQEAARDFA
Mflv_2431|M.gilvum_PYR-GCK REFTARCLDPVVGTGKFDFVKDLGNQMPMRVIGMLLGIPEEDQRRVTDHG
Mvan_4221|M.vanbaalenii_PYR-1 REFTARCLDPLTGTNRFDFVRDLGAQMPMRVIGMLLGIPEEDQRRVTDHG
TH_3021|M.thermoresistible__bu REFTARCLDPLVGTGRFDFVQDLGEQMPMRVIGMLLGIPEEDQRHVVDHG
Rv1256c|M.tuberculosis_H37Rv RKFVVERLEKLRANGGGDIVTELFKPLPSMVVAHYLGVPEEDWTQFDGWT
MAB_1406c|M.abscessus_ATCC_199 REFVVQRLERLKERGEGDIVVELFKPLPSMVVAHYLGVPEEDRTQFDAWT
Mb0789c|M.bovis_AF2122/97 LELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDRARIRALA
MLBr_02088|M.leprae_Br4923 AALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVS
: *: *.: :: :. *: :*:* *
MAV_2984|M.avium_104 NAQLRTEA----------GKPMKAAEQGLSVGEQFEAYIDWRAEHPSDDI
MSMEG_4887|M.smegmatis_MC2_155 NAQMRTEA----------GKPMKAAEEGLVDGSIFEAYIDWRKDNPSDDI
MMAR_4753|M.marinum_M TAQLRTEA----------GKPMKASADGMVSGDFFAHYIDWRAEHPSSDI
MUL_0324|M.ulcerans_Agy99 TAQLRTEA----------GKPMKASADGMVSGDFFAHYIDWRAEHPSSDI
Mflv_2431|M.gilvum_PYR-GCK EATLQSD-----------------SVDLMATGEVFAEFIDYRTEHPSNDI
Mvan_4221|M.vanbaalenii_PYR-1 EATLQSD-----------------SVDLMATGEVFAEFIDHRTEHPSDDI
TH_3021|M.thermoresistible__bu EATIRTER----------GG----KMSGLATGEVFAEYIDYRAKHPSDDI
Rv1256c|M.tuberculosis_H37Rv QAIVAAN--------AVDGATTGALDAVGSMMAYFTGLIERRRTEPADDA
MAB_1406c|M.abscessus_ATCC_199 DGIVAAASGGA---IDIEAMQGEVAQTIGELMMYFTGLIERRRAEPEDDT
Mb0789c|M.bovis_AF2122/97 DAVLHRED-------GVADVPPPAMAASIELMRYYADLIAEFRRRPANNL
MLBr_02088|M.leprae_Br4923 ALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGEDL
: : * .:
MAV_2984|M.avium_104 MTELLNVEFVDETGTTRRLTREEILVYLNVVAGAGNETTTRLIGWTGKVL
MSMEG_4887|M.smegmatis_MC2_155 MTELLNVEFTDEHGVTRNLTREELLIYINVVAGAGNETTTRLIGWAAKTL
MMAR_4753|M.marinum_M MTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGKVL
MUL_0324|M.ulcerans_Agy99 MTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGKVL
Mflv_2431|M.gilvum_PYR-GCK MTDLLNAEFEDETGTRRKLRREELLMYLTVISTAGSETTTRLIGWAGKTL
Mvan_4221|M.vanbaalenii_PYR-1 MTDLLNAEFEDETGTRRRLRRDELLMYLTVIATAGSETTTRLIGWAGKTL
TH_3021|M.thermoresistible__bu MTELMNAEFEDETGTVRKLGREELLLYLTVIATAGSETTTRLIGWTGKLL
Rv1256c|M.tuberculosis_H37Rv ISHLVAAGVGADGDTAGTLS---ILAFTFTMVTGGNDTVTGMLGGSMPLL
MAB_1406c|M.abscessus_ATCC_199 VSHLVAAGVGADGDISGTLQ---ILGFAFTMVTGGNDTTTGMLGGAIQLL
Mb0789c|M.bovis_AF2122/97 TSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYWA
MLBr_02088|M.leprae_Br4923 ISRLIELDESGD-----QLTEEEIIATCGLLLVAGHETTVNLIANAVLAM
: *: : * :: : .* :*.. ::. :
MAV_2984|M.avium_104 AEHPDQRRDLVENPALIPQAIEELLRYEPPAPHVSRYVTRDVVVHDQTVP
MSMEG_4887|M.smegmatis_MC2_155 AEHPDQRRQLVENPALIPQAIEEILRFEPPAPHVARYVTRDVEYHGRTVP
MMAR_4753|M.marinum_M AEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGESVP
MUL_0324|M.ulcerans_Agy99 AEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGQSVP
Mflv_2431|M.gilvum_PYR-GCK ADYPDQRAELAADHSLIPQAIEEILRWEPPALQIARYVTRDVEYYGQTVP
Mvan_4221|M.vanbaalenii_PYR-1 ADYPEQRAQLVADPALIPQAIEEILRWEPPALQIARYVTRDVEYYGQVVP
TH_3021|M.thermoresistible__bu SEHPDQRAELVADRSLLPQAIEEILRFEPPAPHMCRYVTRDVEYYGQTVP
Rv1256c|M.tuberculosis_H37Rv HRRPDQRRLLLDDPEGIPDAVEELLRLTSPVQGLARTTTRDVTIGDTTIP
MAB_1406c|M.abscessus_ATCC_199 HQNPAQRQKLIDDPSLIPGAVEEFLRLTSPVQGLARTATRDVIIGDTTIP
Mb0789c|M.bovis_AF2122/97 AHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTIP
MLBr_02088|M.leprae_Br4923 LRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLT
* * : : * :** ** .. : * .::*: :.
MAV_2984|M.avium_104 EGSVMMMLIGSACRDEAQFGSDAGEFNIHRAV-RPHLTFSMGTHFCLGSA
MSMEG_4887|M.smegmatis_MC2_155 EGSVMMLLIGAAVRDSRQFPPDGEVFDINRAP-RQHLAFSVGTHFCLGSA
MMAR_4753|M.marinum_M EGSIMMMLIGAANRDHRQFPPDGDVFDIRREP-HQHLTFSVGTHYCLGSA
MUL_0324|M.ulcerans_Agy99 EGSIMMMLIGAANRDHRQFRPDGDVFNIRREP-HQHLTFSVGTHYCLGSA
Mflv_2431|M.gilvum_PYR-GCK AGSAMLMLVGSANRDHRRFPPDGDVFDIHREL-RSHMTFGAGTHFCMGNA
Mvan_4221|M.vanbaalenii_PYR-1 EGSAMLMLVGSANRDHRRFPPNGDVFDIHREL-RSHMTFGAGTHFCMGNA
TH_3021|M.thermoresistible__bu AGSAMMLLVGAANRDHRRFPPDGDVFDIHREP-RQHLSFGVGAHFCLGNA
Rv1256c|M.tuberculosis_H37Rv AGRRVLLLYGSANRDERQYGPDAAELDVTRCP-RNILTFSHGAHHCLGAA
MAB_1406c|M.abscessus_ATCC_199 AGRRALLLYGSANRDEREYGNDAAELDVLRKP-RNILTFSHGNHHCLGAA
Mb0789c|M.bovis_AF2122/97 EGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCLGAH
MLBr_02088|M.leprae_Br4923 EGDTMVLLLAAANRDPAVYS-RPDEFDPDRPS-SRHLAFAVGSHFCLGAA
* ::* .:* ** : * ::*. * *.*:*
MAV_2984|M.avium_104 LARLEGRVALEEILKRFPEWEVDLSRATLSPTSTVRGWECMPALVP--
MSMEG_4887|M.smegmatis_MC2_155 LARLEGRVALEEILKRFPEWDVDLASAELSPTSTVRGWDSLPVIVR--
MMAR_4753|M.marinum_M LARLEGRIALEEILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD--
MUL_0324|M.ulcerans_Agy99 LARLEGRIALEDILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD--
Mflv_2431|M.gilvum_PYR-GCK LARLEGRIALEEILKRFPTWEVDWPNAVPSQTTAVRGWETMPTFV---
Mvan_4221|M.vanbaalenii_PYR-1 LARLEGKIALEEILKRFPTWEVDWPNAVPSQTTAVRGWESMPTIVS--
TH_3021|M.thermoresistible__bu LARLEGRVALDEILNRFPEWEVDMSKAELSPTSTVRGWETMPATIP--
Rv1256c|M.tuberculosis_H37Rv AARMQCRVALTELLARCPDFEVAESRIVWSGGSYVRRPLSVPFRVTS-
MAB_1406c|M.abscessus_ATCC_199 AARMQSRIALEELLTRIPDFEVDLDGVTWADGSYVRRPLTVPIRVR--
Mb0789c|M.bovis_AF2122/97 LARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR
MLBr_02088|M.leprae_Br4923 LARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV---
**:: ::* : * :: :* :* .