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VAVVDVGRDPVVFDPFSEEFYRDPQGCYPRLRAEAPVYYNATYDFYALSRHADVAAGLKDFATYSSAYGV DLGMVRRGEKVPAKMIISIDPPEHRAMRSLVNKVFTPRAIEALRTMVTDTVTRFLSAVRGDSFDVVQDFS VYFPVDVITQMLGVPEKYRQQVRLWIDESLHREPGQIDMSEAGMQAMAETWLMYYDLIKQRRADPRDDMI SALIAAEVEREDGTVDRLKDSEIAGFATLLGGAGAETVTKLVGSAVVTFARHPEQWQQLLDDRGKIGVAI EELLRYDAPVQYNVRRSNHPVTLHGVTIPAGAPVFLLGASANRDPDAWTAPDVFDINRDRTEAQNLGFGY GIHSCLGAALARLESSIALDMLLDFMPRYGVEWDGCRRVSMQNVSGWANVPVRIL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2001 | - | - | 100% (405) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_4175 | - | e-134 | 61.32% (393) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_5159 | - | 2e-71 | 38.75% (400) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 3e-74 | 41.19% (403) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_4343 | - | 0.0 | 85.79% (401) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 3e-74 | 41.19% (403) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-37 | 33.44% (308) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 4e-67 | 36.92% (409) | cytochrome P450 |
| M. marinum M | MMAR_4733 | cyp190A3 | 1e-157 | 68.35% (395) | cytochrome P450 190A3 Cyp190A3 |
| M. avium 104 | MAV_0916 | - | 1e-149 | 64.50% (400) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_4818 | - | 1e-144 | 63.54% (395) | putative cytochrome P450 123 |
| M. thermoresistible (build 8) | TH_2856 | - | 1e-155 | 66.58% (395) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0475 | cyp123A3 | 5e-68 | 38.33% (407) | cytochrome P450 123A3 Cyp123A3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0789c|M.bovis_AF2122/97 --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv --------------------------MTVRVGDPE-LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------------MTVAETSAVPLVFDPYDYDFHEDP
MUL_0475|M.ulcerans_Agy99 --------------------------MSVHVGGPE-LVLDPYDYDFHEDP
Mvan_2001|M.vanbaalenii_PYR-1 --------------------------MAVVDVGRDPVVFDPFSEEFYRDP
Mflv_4343|M.gilvum_PYR-GCK --------------------------MDVVGQSVADVHFDPFSADFYDDP
MMAR_4733|M.marinum_M -------------------------------MTTSKVVFDPFSEEFFNGP
TH_2856|M.thermoresistible__bu -------------------------------MTTTKLIFDPFSEDFFNGP
MAV_0916|M.avium_104 -------------------------------MTKPKLVFDPYSEDYFNNP
MSMEG_4818|M.smegmatis_MC2_155 -------------------------------MTTPQMIFDPFSEQYFENP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: : . .*
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVSMDK
MUL_0475|M.ulcerans_Agy99 YPYYRRLRNEAPLYHNQELGFWALSRRRDVHQGFRNSTTLSNRDGVSLDP
Mvan_2001|M.vanbaalenii_PYR-1 QGCYPRLRAEAPVYYNATYDFYALSRHADVAAGLKDFATYSSAYGVDLG-
Mflv_4343|M.gilvum_PYR-GCK HACYPRLRAEAPVYYNQTYEFYALSRHADVAAGLKDFATYSSAYGVDLG-
MMAR_4733|M.marinum_M WETYRRMQAEAPVYYSEQYDFYALTRHADVAAGLKNFERYSSAYGIDLS-
TH_2856|M.thermoresistible__bu YETYRRMREEAPVYYSEEYDFYALSRHADVAAAFKDFETYSSARGVDLA-
MAV_0916|M.avium_104 YEIYRRMREEAPLYYDEKEDFYALTRHVDVAAAFKDYETYSSARGCDLA-
MSMEG_4818|M.smegmatis_MC2_155 FDIYRQMRDDAPLYYDSEQDFYALSRHEDVAAALKDHEAFSSSRGCDLA-
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
* : .*: : ..: * .::. *. :
Mb0789c|M.bovis_AF2122/97 ----SSRTSEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
Rv0766c|M.tuberculosis_H37Rv ----SSRTSEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
MAB_1216c|M.abscessus_ATCC_199 ----ASFGPHAKLVMSFLAMDDPEHLRLRALVSKGFTPRRIRELEGQVVA
MUL_0475|M.ulcerans_Agy99 ----VSRGPHATKTMSFLAIDDPAHLRLRTLVSKGFTPRRIRELEPRVTE
Mvan_2001|M.vanbaalenii_PYR-1 ----MVRRGEKVPAKMIISIDPPEHRAMRSLVNKVFTPRAIEALRTMVTD
Mflv_4343|M.gilvum_PYR-GCK ----MVRRGEKVPAKMIISLDPPEHRAMRSLVNKVFTPRAIEELRAMVSD
MMAR_4733|M.marinum_M ----MVRSGQKPPQ-SIIFMDPPDHRHMRSLLNKVFTPRAIQAQRQTVID
TH_2856|M.thermoresistible__bu ----MVRNPEPPPHRSIIMMDPPEHRHMRSLLNRVFTPRAIQSLRSMVEE
MAV_0916|M.avium_104 ----MVRRGISPEQKSIIFMDPPEHRHMRSLLNKAFTPRAIQSQRETIIE
MSMEG_4818|M.smegmatis_MC2_155 ----MVK-GDEPPQKSIIFMDPPEHRHMRSLLNKAFTPRAVQAQRDTVVE
MLBr_02088|M.leprae_Br4923 QAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAA
:: :* * * :* *:.: *:*: :. . :
Mb0789c|M.bovis_AF2122/97 LARIHLDSALQTES-----FDFVAEFAGKLPMDVISELIGVPDTDRARIR
Rv0766c|M.tuberculosis_H37Rv LARIHLDSALQTES-----FDFVAEFAGKLPMDVISELIGVPDTDRARIR
MAB_1216c|M.abscessus_ATCC_199 LARTHLDRALANASD--RSFDFIAEYAGKLPMDVISELMGVPESDRARIR
MUL_0475|M.ulcerans_Agy99 LAVAHLDTMLDMAGGS-QTVDYVAEFAGKLPMDVISELMGVPVADRDQIR
Mvan_2001|M.vanbaalenii_PYR-1 TVTRFLSAVRGDS------FDVVQDFSVYFPVDVITQMLGVPEKYRQQVR
Mflv_4343|M.gilvum_PYR-GCK TVGRFLAAAVGDAGSEGSEFDVVQDFSAYFPVEVITQMLGVPERFRQQVR
MMAR_4733|M.marinum_M KIDKYLGALDPEG------FDAVQEFSGPFPVEVITTMLGVPERHAQQVR
TH_2856|M.thermoresistible__bu VVDDCLAAVDPAG------FDAVQDFSALFPIEIISRMLGVPTEYRQQMR
MAV_0916|M.avium_104 VVDKYLSAADPDN------FDVVQDFSGPFPVEVITRMAGVPEEYRQQVR
MSMEG_4818|M.smegmatis_MC2_155 QVEHYLGQIDSDE------FDVVQDFSGPFPVEVITRMAGVEPEYRQQVR
MLBr_02088|M.leprae_Br4923 LVDSLLDKGAAAG-----QFDVIADLAFPLAVAVICRLLGVPYEDAPEFG
* .* : : : :.: :* : ** ..
Mb0789c|M.bovis_AF2122/97 -------ALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPA
Rv0766c|M.tuberculosis_H37Rv -------ALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPA
MAB_1216c|M.abscessus_ATCC_199 -------ELADGVMHREDGLADVPPEAIQASFDLMTYYIEMVRERRRRPT
MUL_0475|M.ulcerans_Agy99 -------AMADGVMHREDGVTDVPASAIEASINLIVYYQQMIAERRKKPS
Mvan_2001|M.vanbaalenii_PYR-1 -------LWIDESLHREPGQIDMSEAGMQAMAETWLMYYDLIKQRRADPR
Mflv_4343|M.gilvum_PYR-GCK -------LWIDESLHREPGQIDISESGKQAMAEMWLMYYELIQQRRDDPG
MMAR_4733|M.marinum_M -------HWIDESLTREPGQVEVGEQGMQANINTAMLYYDLVKQRRDDPR
TH_2856|M.thermoresistible__bu -------LWVDDFLHREPGEVEMSRRGVQAATEMAVYLYKLTKQRRHDLG
MAV_0916|M.avium_104 -------HWIDTSLHHEPGQIEVSEAGMQANIDTAMYYFGLVQERRQNPQ
MSMEG_4818|M.smegmatis_MC2_155 -------HWIDTSLSREPGQVAYSEAGMKANIDTAMYYYSLVQKRRENPQ
MLBr_02088|M.leprae_Br4923 RVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPG
* : * : *
Mb0789c|M.bovis_AF2122/97 NNLTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAV
Rv0766c|M.tuberculosis_H37Rv NNLTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAV
MAB_1216c|M.abscessus_ATCC_199 EDLTSALLQAEIDGD-----RLTDEEVLAFLFLMVIAGNETTTKLLANAV
MUL_0475|M.ulcerans_Agy99 DDLTSALLAADVDGD-----RLTDEEVLGFMFLMVIAGNETTTKLLANAA
Mvan_2001|M.vanbaalenii_PYR-1 DDMISALIAAEVEREDGTVDRLKDSEIAGFATLLGGAGAETVTKLVGSAV
Mflv_4343|M.gilvum_PYR-GCK DDMISALIAAEVQREDGAVDRLRDSEIAGFATLLGGAGAETVTKLIGSAA
MMAR_4733|M.marinum_M DDLFTKLINAEIEREDGQVTNLDDLEIAGFATLLGGAGAETVTKLVGNAA
TH_2856|M.thermoresistible__bu DDLLSRLITAEIERENGKRGPLDNVEITQFAMLLGGAGAETVTKLIGNAA
MAV_0916|M.avium_104 DDMISRLIAAEIPGENGQMRKLDDIEITGFATLLGGAGAETVTKLLGNAA
MSMEG_4818|M.smegmatis_MC2_155 DDMISRLIAAEIPGENGEMRRLDDVEITGFATLLGGAGAETVTKLIGTAM
MLBr_02088|M.leprae_Br4923 EDLISRLIELDESGD-----QLTEEEIIATCGLLLVAGHETTVNLIANAV
::: : *: : : * : *: *: ** **..:*:..*
Mb0789c|M.bovis_AF2122/97 YWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDT
Rv0766c|M.tuberculosis_H37Rv YWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDT
MAB_1216c|M.abscessus_ATCC_199 YWGHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAEDITVYDT
MUL_0475|M.ulcerans_Agy99 FWGHKNTDQLTPIYADLSRVPLWVEETLRYDTSSQILARTVVGELTLYDT
Mvan_2001|M.vanbaalenii_PYR-1 VTFARHPEQWQQLLDDRGKIGVAIEELLRYDAPVQYNVRRSNHPVTLHGV
Mflv_4343|M.gilvum_PYR-GCK VTFARHPDQWQQLLADRGKIGVAIEELLRYDAPVQYNVRRSNVDVTVHGV
MMAR_4733|M.marinum_M VVFARNPEQWQKLLDDRSKVPAAVEELLRYEAPSQYQVRRAMEDVELHGV
TH_2856|M.thermoresistible__bu VVFAQHPDQWRLLLEDRSKIPAAVEELLRYEAPAQYNVRCSRREVTLHGV
MAV_0916|M.avium_104 VIFARHPDQWQKLQDDRDKIPGAVEELLRYEGPVQYNVRYTLKEAHVSGG
MSMEG_4818|M.smegmatis_MC2_155 VTFAKFPDQWQKLLDDRSKVPAAVEELLRYEGPVQYNVRYTLKEARVPSG
MLBr_02088|M.leprae_Br4923 LAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQT
: . * : : : :** ***: . : * :
Mb0789c|M.bovis_AF2122/97 TIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIG-CKLVSFGSGAHFCL
Rv0766c|M.tuberculosis_H37Rv TIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIG-CKLVSFGSGAHFCL
MAB_1216c|M.abscessus_ATCC_199 KIPAGDILLLLPGSANRDDRVFDDADQYRIGREIG-AKLVSFGSGAHFCL
MUL_0475|M.ulcerans_Agy99 TIPEGDVVLLLPGSAHRDERAFRDPDEYLIGREIG-SKLLSFGSGAHFCL
Mvan_2001|M.vanbaalenii_PYR-1 TIPAGAPVFLLGASANRDPDAWTAPDVFDINRDRTEAQNLGFGYGIHSCL
Mflv_4343|M.gilvum_PYR-GCK TIPAGAPVFLLGASANRDPEAWTAPDTFDINRDRSEAQNLAFGYGIHSCL
MMAR_4733|M.marinum_M TIPAGKPVFLINGAANRDPHAWTDPDKFDIDRDPHEATNLGFGYGIHSCL
TH_2856|M.thermoresistible__bu TIPAGKPVFLIGGSANRDPRAWTDPDTFDIERDRTEAQNLGFGYGIHSCL
MAV_0916|M.avium_104 VIPAGKPVFLCGAAANRDPEAFTDADTFDIERDQTEAQHLGLGYGIHSCL
MSMEG_4818|M.smegmatis_MC2_155 TIPAGKPVFLLKASANRDERAWTDPDVFDIDRDRTEAQNLGLGYGIHSCL
MLBr_02088|M.leprae_Br4923 TLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS--RHLAFAVGSHFCL
:. * :.* .:*:** .: .* : * :.:. * * **
Mb0789c|M.bovis_AF2122/97 GAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQA
Rv0766c|M.tuberculosis_H37Rv GAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQA
MAB_1216c|M.abscessus_ATCC_199 GAHLARMEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMTVQL
MUL_0475|M.ulcerans_Agy99 GAHLARMEARVALTELFKRIRGYQVDEGNAVRVHSSNVRGFAHLPITVEV
Mvan_2001|M.vanbaalenii_PYR-1 GAALARLESSIALDMLLDFMPRYGVEWDGCRRVSMQNVSGWANVPVRIL-
Mflv_4343|M.gilvum_PYR-GCK GAALARLESAIALDKLLDLMPRYEVRWDRCRRVSMQNVSGWSHVPVRILP
MMAR_4733|M.marinum_M GAALARMESAIALEKLLDFMPAFEVDWAGCKRVHMQNVAGWQSVPVRVLR
TH_2856|M.thermoresistible__bu GAALARMESAIALERMLDFMPRYEVDWDNCRRVNMQNVAGWQNVPVRMLG
MAV_0916|M.avium_104 GAALARLESRIALERLLDFMPRYEVDWAGCRRVTMQNVAGWKNVPVKVLR
MSMEG_4818|M.smegmatis_MC2_155 GAALARLESTIALERLLDFMPRYEVKWDGLQRVHMQNVAGYSHVPVKVLR
MLBr_02088|M.leprae_Br4923 GAALARLEATVTLSAISARFPQVQLAGELVYKPNVA-MRGMSALPVQV--
** ***:*: ::* : : : : : * :*: :
Mb0789c|M.bovis_AF2122/97 R---
Rv0766c|M.tuberculosis_H37Rv R---
MAB_1216c|M.abscessus_ATCC_199 REGR
MUL_0475|M.ulcerans_Agy99 A---
Mvan_2001|M.vanbaalenii_PYR-1 ----
Mflv_4343|M.gilvum_PYR-GCK ----
MMAR_4733|M.marinum_M ----
TH_2856|M.thermoresistible__bu R---
MAV_0916|M.avium_104 ----
MSMEG_4818|M.smegmatis_MC2_155 ----
MLBr_02088|M.leprae_Br4923 ----