For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
ADDLYYDPYDQGIVADPYPTYARLRDEAPLYYNGRYDFWALSRHADVEKALQDWSTFSNSRSDILELIKS DFDMPKGVMMFEDPPEHTMLRGLMSRVFTPRRMAEIEDQIRRYCVNCLDPLVGSDGFDVIAELAAMMPMR VIGMLLGIPESEQVSVRDANDANLRTRPGAPMKVADPDRIADGRIYSDYVEWRAANPSDDLMTALLNVEF TDEAGVHRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAKVLAEHPQQRREIVEDRSLLGRAVDETLRFEP TGPHVARYLARDFEYDGTTVPAGSAILLLFGAANRDERRYRNPDTFDIHRDNISHLTFGKGLHYCLGANL ARLEGRVALDELLNRWPEWNIDYDTARLAPTSTVRGWEHLRMLVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3187 | - | - | 100% (396) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_4221 | - | e-116 | 50.38% (395) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_0317 | - | 2e-72 | 39.60% (404) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 9e-66 | 37.25% (400) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_1266 | - | 1e-131 | 57.91% (392) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 9e-66 | 37.25% (400) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-42 | 32.80% (378) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 2e-62 | 37.81% (402) | cytochrome P450 |
| M. marinum M | MMAR_0928 | cyp189A6 | 0.0 | 82.40% (392) | cytochrome P450 189A6 Cyp189A6 |
| M. avium 104 | MAV_0366 | - | 0.0 | 83.12% (397) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3693 | - | 0.0 | 86.96% (391) | cytochrome P450 monooxygenase |
| M. thermoresistible (build 8) | TH_4114 | - | 0.0 | 84.01% (394) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0324 | cyp189A7 | 1e-132 | 56.78% (391) | cytochrome P450 189A7 Cyp189A7 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0789c|M.bovis_AF2122/97 --------------------MTVRVGDPE-------LVLDPYDYDFHEDP
Rv0766c|M.tuberculosis_H37Rv --------------------MTVRVGDPE-------LVLDPYDYDFHEDP
MAB_1216c|M.abscessus_ATCC_199 --------------------MTVAETSAVP------LVFDPYDYDFHEDP
Mvan_3187|M.vanbaalenii_PYR-1 ----------------------MADD----------LYYDPYDQGIVADP
MSMEG_3693|M.smegmatis_MC2_155 ---------------------MTVDDSGVVVTGVAGPYYDPYDVGIVADP
MAV_0366|M.avium_104 --------------------MTVANDT--------AVYYDPYDIGIITDP
TH_4114|M.thermoresistible__bu ---------------------MATVET--------DVYYDPYDVDIVADP
MMAR_0928|M.marinum_M --------------MATHIEAAQAHDT--------DVYYDPYDVNITANP
MUL_0324|M.ulcerans_Agy99 --------------------MTVTAAS--------DVYFDPYDVELNADP
Mflv_1266|M.gilvum_PYR-GCK ------------------------MSG---------LYYDPYNVEIDVLP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: *
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
Rv0766c|M.tuberculosis_H37Rv YPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDP
MAB_1216c|M.abscessus_ATCC_199 YPYYRRLRDEAPLYRNDDLKFWALSRHHDVLQGFRNSEALSNANGVSMDK
Mvan_3187|M.vanbaalenii_PYR-1 YPTYARLRDEAPLYYNGRYDFWALSRHADVEKALQDWSTFSNSRSDILEL
MSMEG_3693|M.smegmatis_MC2_155 YPVYARLRDEAPLYHNERYGFWALSRHADVESALANWETFSNSRSDILEL
MAV_0366|M.avium_104 YPTYARLREEAPIYYNERYDFWALSRHSDVERALANWQVFSNRRSDILEL
TH_4114|M.thermoresistible__bu YPVYARLRDEAPIYYNERYDFWALSRYADVEKALLNWETFSNSRSDILEL
MMAR_0928|M.marinum_M YPTYARLREQAPLYYNQRYDFWAISRHADVEKALADWQTFSNSRSDILEL
MUL_0324|M.ulcerans_Agy99 YPMFRRLREEAPLYYNAQHGFYALSRFADVDRAIVDYQTFSSARGAILEF
Mflv_1266|M.gilvum_PYR-GCK YPVYKRLRDEAPLYYNEKFDFWALSRFAEVDSALKDVDNLSNAKGDILEV
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPG-MPLTVFSSFSDCDEALRHPLSASDRLKATLAQ
:* : * : .*: : ..* . : .: . *. :
Mb0789c|M.bovis_AF2122/97 SSRTSEAYR----VMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
Rv0766c|M.tuberculosis_H37Rv SSRTSEAYR----VMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLE
MAB_1216c|M.abscessus_ATCC_199 ASFGPHAKL----VMSFLAMDDPEHLRLRALVSKGFTPRRIRELEGQVVA
Mvan_3187|M.vanbaalenii_PYR-1 IK-SDFDMP----KGVMMFEDPPEHTMLRGLMSRVFTPRRMAEIEDQIRR
MSMEG_3693|M.smegmatis_MC2_155 VK-SDFDMP----PGVMMFTDPPMHTMLRGLMSRVFTPRRMAEIEDQIRR
MAV_0366|M.avium_104 IQ-SKFDMP----GGVMMFQDPPEHTVLRGLMSRVFTPRRMAALEDQIRQ
TH_4114|M.thermoresistible__bu VQ-SDFDMP----PGVMMFQDPPMHTMLRGLMSRVFTPRRMAALEEQIRA
MMAR_0928|M.marinum_M IK-SKYDMP----PGVMMFEDPPVHTMLRGVMSRVFTPRRMAQLEDQIRR
MUL_0324|M.ulcerans_Agy99 IK-ANIDIP----AGVLVFEDPPVHDVHRKLLSRMFTPRKINDLEPKIRE
Mflv_1266|M.gilvum_PYR-GCK VK-AEPVMP----DGVFINEDPPVHTVHRLLVSRAFTPRKMKAIEEQVRA
MLBr_02088|M.leprae_Br4923 QAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAA
:: * * * * ::*: *:*: : :* .:
Mb0789c|M.bovis_AF2122/97 LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRAL
Rv0766c|M.tuberculosis_H37Rv LARIHLDSALQTES---FDFVAEFAGKLPMDVISELIGVPDTDRARIRAL
MAB_1216c|M.abscessus_ATCC_199 LARTHLDRALANASDRSFDFIAEYAGKLPMDVISELMGVPESDRARIREL
Mvan_3187|M.vanbaalenii_PYR-1 YCVNCLDPLVGSDG---FDVIAELAAMMPMRVIGMLLGIPESEQVSVRDA
MSMEG_3693|M.smegmatis_MC2_155 YCVRCLDPLVGSDR---FDIIAELASTMPMRVIGMLLGIPESEQIGVRDA
MAV_0366|M.avium_104 YCIRCLDPLVGSSS---FDIIAELASMMPMRVIGMLLGIPESEQVSVRDA
TH_4114|M.thermoresistible__bu YCVRCLDPLVGAEG---FDIIAELAAMMPMRVIGMLLGIPESDQISVRDA
MMAR_0928|M.marinum_M FCVRCLDPLVGRDS---FDIIAELASMMPMRVIGMLLGIPESDQIGVRDA
MUL_0324|M.ulcerans_Agy99 FCARSLDPLIGSGR---FDFVADLGAQMPMRVIGMLLGVPEEDQEAARDF
Mflv_1266|M.gilvum_PYR-GCK FCQACLDPLQGGDR---FDFTLDLGAEMPMRVIGMLVGMPDSLQRSVRKA
MLBr_02088|M.leprae_Br4923 LVDSLLDKGAAAGQ---FDVIADLAFPLAVAVICRLLGVPYEDAPEFGRV
** **. : . :.: ** *:*:*
Mb0789c|M.bovis_AF2122/97 ADAVLHRED-------GVADVPPPAMAASIELMRYYADLIAEFRRRPANN
Rv0766c|M.tuberculosis_H37Rv ADAVLHRED-------GVADVPPPAMAASIELMRYYADLIAEFRRRPANN
MAB_1216c|M.abscessus_ATCC_199 ADGVMHRED-------GLADVPPEAIQASFDLMTYYIEMVRERRRRPTED
Mvan_3187|M.vanbaalenii_PYR-1 NDANLRTRP-------GAP--MKVADPDRIADGRIYSDYVEWRAANPSDD
MSMEG_3693|M.smegmatis_MC2_155 NDANLRTKP-------GAP--MKVAQADKIADGRIYADYVEWRSKNPSDD
MAV_0366|M.avium_104 NDANLRTKP-------GAP--LRVADADSIADGRIYADYVEWRSKNPSDD
TH_4114|M.thermoresistible__bu NDANLRTKP-------GAP--MKVADPGRIADGSIYAEYIDWRARNPSDD
MMAR_0928|M.marinum_M NDANLRTQP-------GTP--MKVARPDKIADGSIYADYIDWRAKNPSDD
MUL_0324|M.ulcerans_Agy99 ATAQLRTEA-------GKP--MKAS-ADGMVSGDFFAHYIDWRAEHPSSD
Mflv_1266|M.gilvum_PYR-GCK AGARLRNKP-------GEP--LPVK-KDNYFNGNMFRDYVAWRKDNPSDD
MLBr_02088|M.leprae_Br4923 SALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGED
:: . . : * .:
Mb0789c|M.bovis_AF2122/97 LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
Rv0766c|M.tuberculosis_H37Rv LTSALLAAELDGD-----RLSDQEIMAFLFLMVIAGNETTTKLLANAVYW
MAB_1216c|M.abscessus_ATCC_199 LTSALLQAEIDGD-----RLTDEEVLAFLFLMVIAGNETTTKLLANAVYW
Mvan_3187|M.vanbaalenii_PYR-1 LMTALLNVEFTDEAGVHRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAKV
MSMEG_3693|M.smegmatis_MC2_155 LMTALLGVEFTDEHGVTRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAKV
MAV_0366|M.avium_104 LMTTLLNVEFDDEDGVRRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAKV
TH_4114|M.thermoresistible__bu LMTALLNVEFTDEHGVVRKLTRREVLHYTQVVAGAGNETTGRLIGWLAKV
MMAR_0928|M.marinum_M LMTALLNVEFDDEHAVRRKLTRTEVLHYTQVVAGAGNETTGRLIGWLAKV
MUL_0324|M.ulcerans_Agy99 IMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAGKV
Mflv_1266|M.gilvum_PYR-GCK LVTELLNVEFEDVDGSRRKLRDEELLVFLGVIANAGSETVGRLFGWLGKV
MLBr_02088|M.leprae_Br4923 LISRLIELDESGD-----QLTEEEIIATCGLLLVAGHETTVNLIANAVLA
: : *: : . :* *:: :: ** **. .*:.
Mb0789c|M.bovis_AF2122/97 AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
Rv0766c|M.tuberculosis_H37Rv AAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTI
MAB_1216c|M.abscessus_ATCC_199 GHRNPDQLATVHADHDRIPLWVEESLRYDTSSQILARTVAEDITVYDTKI
Mvan_3187|M.vanbaalenii_PYR-1 LAEHPQQRREIVEDRSLLGRAVDETLRFEPTGPHVARYLARDFEYDGTTV
MSMEG_3693|M.smegmatis_MC2_155 LAEHPDQRRQIEQDRSLLTRAVDETLRFEPTGPHVARWVARDFEAYGQTV
MAV_0366|M.avium_104 LAEHPDQRREVYRDRSLLTRTVDETLRFEPTGPHVARWMAADFECYGTTV
TH_4114|M.thermoresistible__bu LAEHPDQRRDVYEDRSLLGRVIEETLRFEPTGPHVARWMARDFECYGTTV
MMAR_0928|M.marinum_M LAEHPDQRRQVHQDRSLLTRTVDETLRFEPTGPHVARFTLRDYHCYDTTV
MUL_0324|M.ulcerans_Agy99 LAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGQSV
Mflv_1266|M.gilvum_PYR-GCK LADHPDARRELAADPSLIPGAIEEILRMEPPVHNIARYVAKDVTYHGQTV
MLBr_02088|M.leprae_Br4923 MLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTL
:* : : . ::* ** :.. :.* * .:
Mb0789c|M.bovis_AF2122/97 PEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCLGA
Rv0766c|M.tuberculosis_H37Rv PEGEVLLLLPGSANRDDRVFD-DPDDYRIGREIGCKLVSFGSGAHFCLGA
MAB_1216c|M.abscessus_ATCC_199 PAGDILLLLPGSANRDDRVFD-DADQYRIGREIGAKLVSFGSGAHFCLGA
Mvan_3187|M.vanbaalenii_PYR-1 PAGSAILLLFGAANRDERRYR-NPDTFDIHRDNISHLT-FGKGLHYCLGA
MSMEG_3693|M.smegmatis_MC2_155 PAGSAMLLLFGAANRDPRRYT-DPDVFDIHRDNISHLT-FGKGLHYCLGA
MAV_0366|M.avium_104 PAGSAMLLLFGAANRDPRRYT-DPDTFNIHRDNISHIT-FGKGVHYCLGA
TH_4114|M.thermoresistible__bu PAGSAMLLLFGAANRDPRRYD-DPDTFNIHRERGSHLT-FGKGLHFCLGA
MMAR_0928|M.marinum_M PAGSAILMLFGAANRDPRRYH-DPDTFDIRRDNISHLT-FGKGVHYCLGA
MUL_0324|M.ulcerans_Agy99 PEGSIMMMLIGAANRDHRQFRPDGDVFNIRREPHQHLT-FSVGTHYCLGS
Mflv_1266|M.gilvum_PYR-GCK PAGSALLLMAGAANRDERRFD-NPDVFDIRRSP-NHLT-FGRGAHFCLGT
MLBr_02088|M.leprae_Br4923 TEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPSSRHLA-FAVGSHFCLGA
. *. :::: .:**** : * : * ::. *. * *:***:
Mb0789c|M.bovis_AF2122/97 HLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR-
Rv0766c|M.tuberculosis_H37Rv HLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR-
MAB_1216c|M.abscessus_ATCC_199 HLARMEAKVALTELFTRISGYEIDERNSVRVHSSNVRGFAHLPMTVQLRE
Mvan_3187|M.vanbaalenii_PYR-1 NLARLEGRVALDELLNRWPEWNIDYDTARLAPTSTVRGWEHLRMLVG---
MSMEG_3693|M.smegmatis_MC2_155 NLARLEGRVALDELLNRFPEWDIDYSTARLAPTSTVRGWERLDVLVG---
MAV_0366|M.avium_104 NLARLEGRVALDELLNRWPEWDIDYDTAQLASTSTVRGWERLRIVVP---
TH_4114|M.thermoresistible__bu NLARLEGRVALDELLNRWPEWDIDYDTAQLAPTSTVRGWERLRIVFP---
MMAR_0928|M.marinum_M NLARLEGRVALDELLNRWPQWDIDYDSLQLAPTSTVRGWERLRVLVS---
MUL_0324|M.ulcerans_Agy99 ALARLEGRIALEDILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD---
Mflv_1266|M.gilvum_PYR-GCK SLARLEGRIALEEILKRWPDWTFDEDNAHRAPTATVRGWDSMPAIVG---
MLBr_02088|M.leprae_Br4923 ALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV----
***:*. ::* : * . . :** : .
Mb0789c|M.bovis_AF2122/97 --
Rv0766c|M.tuberculosis_H37Rv --
MAB_1216c|M.abscessus_ATCC_199 GR
Mvan_3187|M.vanbaalenii_PYR-1 --
MSMEG_3693|M.smegmatis_MC2_155 --
MAV_0366|M.avium_104 --
TH_4114|M.thermoresistible__bu --
MMAR_0928|M.marinum_M --
MUL_0324|M.ulcerans_Agy99 --
Mflv_1266|M.gilvum_PYR-GCK --
MLBr_02088|M.leprae_Br4923 --