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MATRKRWVAGTALLLAILLIAGAALLVRQVFFGPKTITAYFPTATAIYPGDEVRVSGVKVGTIDKIEPEG TLTRMTLKVDRDVPVPADAKAVIVAQNLVAARYVQLTPSYREGGGPTMGDGGTIPESRTAVPVEWDEVKT QLMRLSEELGPQADVSGTSISRFVDSAANAMEGNGEKLRETLRQLSGVARIFAEGSGNIVDIIKNLQVFV SALRDSKDQIVLFQNRLATLTSVVNDSRSDLDAALTDLSFAINEVQRFVAGSRDQTAEQIRSLGQVTQVL VDNRLALENVLHITPNAIANFENIYYPNGGSVTGAFSVSNFSNPVWFVCGLIGGVANTTAPETAKLCAQY LGPALRSIPIHNLPFPINAYLRPAVSPERTIYTDPKLAPGGAGPGDPPEMPPTVSAYTGAGDIPPPPGWG APPGPRGIYQPDPDAPATPSPALYPGAPIPGPPNILSNIPAQPQPQTVDGLLLPPQGNPGGSPPPAPAPA VAPTGPLLPAEGMPPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4147 | - | - | 100% (507) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_2854 | - | e-157 | 59.49% (474) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0137 | - | 1e-77 | 35.56% (540) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3526c | mce4D | 6e-74 | 37.16% (436) | MCE-family protein MCE4D |
| M. gilvum PYR-GCK | Mflv_2511 | - | 0.0 | 87.08% (511) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv0592 | mce2D | 5e-76 | 35.59% (503) | MCE-family protein MCE2D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 2e-72 | 34.24% (476) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4150c | - | 7e-73 | 34.05% (467) | MCE-family protein |
| M. marinum M | MMAR_4707 | - | 1e-145 | 56.88% (487) | MCE-family protein |
| M. avium 104 | MAV_0951 | - | 1e-156 | 59.38% (485) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_4787 | - | 1e-165 | 61.39% (505) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_4516 | - | 1e-161 | 59.29% (506) | PUTATIVE virulence factor mce family protein |
| M. ulcerans Agy99 | MUL_4059 | mce4D | 1e-76 | 38.38% (469) | MCE-family protein Mce4D |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3526c|M.bovis_AF2122/97 ------MMGRVAMLTGSRGLRYATVIALVAALVGGVYVLSSTGNK-RTIV
MUL_4059|M.ulcerans_Agy99 ------MMK---QRLSSRGMRTVTIVALVAALVGGLYVLFSGGESGRKVV
MAB_4150c|M.abscessus_ATCC_199 ------------MTTSKTWLKRGAFAMLSVALVGGLLYWVWPSRGTYKIV
Mvan_4147|M.vanbaalenii_PYR-1 -----------MMATRKRWVAGTALLLAILLIAGAALLVRQVFFGPKTIT
Mflv_2511|M.gilvum_PYR-GCK -----------MMATRKRWVAGTAVLLAILLVAGAVFLVRQVFFGPTTIT
MSMEG_4787|M.smegmatis_MC2_155 -------------MNRKRIAKGLAVGLVVLLVAGAAVLVRQVFLAPRTFQ
TH_4516|M.thermoresistible__bu -------------MTRRRLTTWLAVGFVVLLVAGGGLLLRQVVYAPRTFE
MMAR_4707|M.marinum_M -------MMRLEGAARSKVKAVLAVALVGLVVVGTGVALRNTFFRPTTIT
MAV_0951|M.avium_104 --------MSPR-VPRNRLAALAAVVLVGLILAGTAVLVRNTFFGQKTIT
Rv0592|M.tuberculosis_H37Rv MSTIFDIRSLRLPKLSAKVVVVGGLVVVLAVVAAAAGARLYRKLTTTTVV
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
. :.. ..
Mb3526c|M.bovis_AF2122/97 GYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVD
MUL_4059|M.ulcerans_Agy99 AYFTSAVGIYPGDEVRILGVPVGRIDSIEPRPADVKITMSVSNDVKIPRD
MAB_4150c|M.abscessus_ATCC_199 GHFASAVGLYPGDDVRILGVKAGRISAVEPREGDVKVTMEMPDKFKVPEG
Mvan_4147|M.vanbaalenii_PYR-1 AYFPTATAIYPGDEVRVSGVKVGTIDKIEPEGTLTRMTLKVDRDVPVPAD
Mflv_2511|M.gilvum_PYR-GCK AYFPTATAIYPGDEVRVSGVEVGTIDKIEPEGTQTKMTLKVDRGVQVPAN
MSMEG_4787|M.smegmatis_MC2_155 ALFTSATGIYPGDDVRVSGVKVGTIEAITPEGTQTRLTLKVDRGVPIPAD
TH_4516|M.thermoresistible__bu AIFTSATGIYPGDEVRVSGVAVGSIDSITPEGTHTRMVLKVDRDVPIPAD
MMAR_4707|M.marinum_M AYFPTATAIYPGDDVRVSGMKVGTIAAIRPDGTKAKMILHVDHNVPIPAD
MAV_0951|M.avium_104 AYFTTATAIYPNDEVRVSGVKVGNIKSIEPQGTQAKMTLKVDHDVPIPAD
Rv0592|M.tuberculosis_H37Rv AYFSEALALYPGDKVQIMGVRVGSIDKIEPAGDKMRVTLHYSNKYQVPAT
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
*. * .:*..*.*:: *: .* * : * :: : :*
Mb3526c|M.bovis_AF2122/97 VQAVIMSPNLVAARFIQLTPVYTGG---AVLPDNGRIDLDRTAVPVEWDE
MUL_4059|M.ulcerans_Agy99 AQALIVSPNLVAARFIQLTPVYTGG---AVVPDGASIDLSRTAIPVEWDE
MAB_4150c|M.abscessus_ATCC_199 AQAIIMAPNLVTARFVQLTPAYTDG---KALQDGASLGLDKTAVPIEWDE
Mvan_4147|M.vanbaalenii_PYR-1 AKAVIVAQNLVAARYVQLTPSYREG-GGPTMGDGGTIPESRTAVPVEWDE
Mflv_2511|M.gilvum_PYR-GCK AKAVIVAQNLVAARYVQLTPAYRDG-DGATMADGGVIPKERTAIPVEWDE
MSMEG_4787|M.smegmatis_MC2_155 AKAVIVAQNLVAARYVQLAPAYRSE--GPTLPDDAVIGLDRTAVPVEWDE
TH_4516|M.thermoresistible__bu VKAVIVAPNLVAARYVQLTPAYRSSEGGPTLPDNAVIDLDRTAVPVEWDE
MMAR_4707|M.marinum_M AKAVIVAQNLVAARYVQLTPAYRSS--GPVMADGAVIPIERTAVPVEWDE
MAV_0951|M.avium_104 AKAVIVASNLVSARYVQLSPAYRDS--GPVMPDGAVIPVERTAVPVEWDE
Rv0592|M.tuberculosis_H37Rv ATASILNPSLVASRTIQLSPPYTGG---PVLQDGAVIPIERTQVPVEWDQ
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKGG---PALGDNAVIPLERTQVPVEWDE
. * *: .**::* :** * * .: *.. : .:* :*:***:
Mb3526c|M.bovis_AF2122/97 VKEGLTRLAADLSPAAGELQGPLGAAINQAADTLD-GNGDSLHNALRELA
MUL_4059|M.ulcerans_Agy99 VKESLTQLAVQLSPAAGELQGPLGAAINQAADTLN-GNGDSFHNALRELS
MAB_4150c|M.abscessus_ATCC_199 VKTELAKLSDSLGPQ-GQSKGPVSDFINQAATTFD-GNGDSFRNAVRELS
Mvan_4147|M.vanbaalenii_PYR-1 VKTQLMRLSEELGPQADVSGTSISRFVDSAANAME-GNGEKLRETLRQLS
Mflv_2511|M.gilvum_PYR-GCK VKTQLMRLSEELGPQAGASGTSISRFVDSAANAME-GNGDKLRETLRQLS
MSMEG_4787|M.smegmatis_MC2_155 VKEQLTRLATELGPRSGVDGTSMARFIETTADAME-GNGEKLRNTISQLS
TH_4516|M.thermoresistible__bu VKEQLMRLATDLGPQRGVDDTSVSRFIETAADAME-GNGAKLRETITQLS
MMAR_4707|M.marinum_M VKDQLMRLATELGPNSKVSSPSISRFIDSAADALGNGNGDKLRQTLAELS
MAV_0951|M.avium_104 VKTQLMRLATDLGPKSGVSGTSVGRFIDSAANALD-GNGDKLRQTLAQLS
Rv0592|M.tuberculosis_H37Rv LRDSINGILRQLGPTERQPKGPFGDLIESAADNLA-GKGRQLNETLNSLS
MLBr_02592|M.leprae_Br4923 LRDSITKIISKLGPTKEQPKGPFGDVIESFADGLA-GKGKQINATLDSLS
:: : : .*.* ... :: * : *:* .:. :: .*:
Mb3526c|M.bovis_AF2122/97 QVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVLAD
MUL_4059|M.ulcerans_Agy99 QVAGRLGDSRNDIFSTVKNLQVLVDALSQSNEQIVQFAGHVASVSQVLAD
MAB_4150c|M.abscessus_ATCC_199 QAAGRLGDSRTDLFGTIKNLQTLVDALANSNEQIVQFSTHLASVSKVLAA
Mvan_4147|M.vanbaalenii_PYR-1 GVARIFAEGSGNIVDIIKNLQVFVSALRDSKDQIVLFQNRLATLTSVVND
Mflv_2511|M.gilvum_PYR-GCK GAARIFAEGSGNIVDIIKNLQIFVTALRDSKDQIVLFQNRLATLTSVVND
MSMEG_4787|M.smegmatis_MC2_155 GVARILAEGSGNIVDIIKNLQTFVTALRDSNQQVVAFQNRLATLTSVVDG
TH_4516|M.thermoresistible__bu GVARVLAEGSGNVVDIIRNLQTFVTTLRDSNEQVMVFQNRLATLTSVING
MMAR_4707|M.marinum_M GVGRILANGSGNIVDIIKNLQTFIGALRDSNVQIVQFNDRLASLTSVLDD
MAV_0951|M.avium_104 GVGRILANGSGNIVDIIKNLQTFVGALRDSNVQIVQFNDRLATLTSVVND
Rv0592|M.tuberculosis_H37Rv QALTALNEGRGDFVAITRSLALFVSALYQNDQQFVALNENLAEFTDWFTK
MLBr_02592|M.leprae_Br4923 RALTALNEGRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLAH
. : :. :.. :.* :: :* .. *.: : .:* .: .
Mb3526c|M.bovis_AF2122/97 SSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQTLS--DQS
MUL_4059|M.ulcerans_Agy99 SSRNLDNTLGTLNQALSDIKGFLRENNSTLIETVNQLGDLTQTLS--DQS
MAB_4150c|M.abscessus_ATCC_199 STENLGATLGALNQALTDVRGFLGDTNSALIDQVNKLSDFVKIFS--DQS
Mvan_4147|M.vanbaalenii_PYR-1 SRSDLDAALTDLSFAINEVQRFVAGSRDQTAEQIRSLGQVTQVLV--DNR
Mflv_2511|M.gilvum_PYR-GCK SRSDLDAALTDLSFAIGEVQRFVVGSRDATVEQIRSLGQVTQVLA--DNR
MSMEG_4787|M.smegmatis_MC2_155 SRSDLDAALKNLSVAVGEVQRFVAGSRNQTSEQIQRLADVTSNLV--DQR
TH_4516|M.thermoresistible__bu SRTDLDAALQNLSVAVGEVQRFVAGSRDQTSEQLERLANVTRNLL--DNK
MMAR_4707|M.marinum_M NKSDLDAALTDLSSAVGEVQRFIAGSRDATAEQITRLADLTQILV--DNK
MAV_0951|M.avium_104 SKSDLDAALTDLSTAVGEVQRFIAGTRNQTSEQIARLADVTQILV--DHH
Rv0592|M.tuberculosis_H37Rv SDHDLADTVERIDDVLGTVRKFVSDNRSVLAADVNNLADATTTLVQPEPR
MLBr_02592|M.leprae_Br4923 SDTDLSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPEPL
. :* :: :. : :: *: ... : * . :
Mb3526c|M.bovis_AF2122/97 ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICG----
MUL_4059|M.ulcerans_Agy99 DNIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICG----
MAB_4150c|M.abscessus_ATCC_199 DDLEQILHVAPNGLANFYNIYNPAAGTLNGMLSIPNLANPVQFICG----
Mvan_4147|M.vanbaalenii_PYR-1 LALENVLHITPNAIANFENIYYPNGGSVTGAFSVSNFSNPVWF-------
Mflv_2511|M.gilvum_PYR-GCK LALENVLHITPNAIANFENIYYPNGGSVTGAFSLSNFSNPVWF-------
MSMEG_4787|M.smegmatis_MC2_155 LQVENLLHIAPNAFVNGYNIYNPDSGSPVGQFVFHNMSEPLHF-------
TH_4516|M.thermoresistible__bu LEIENVLHIAPNALANAYNIYNPDTGSPVGQFVLNNFSDPVQF-------
MMAR_4707|M.marinum_M MALKNVLHVTPNALANAYNDYDPDVGNVRGGVGIQNLTNPVFS-------
MAV_0951|M.avium_104 MDLENILHVAPNALGNFFNDYNADTGTIVGGFGIMNFANPTFSGLMVPLP
Rv0592|M.tuberculosis_H37Rv DGLETALHVLPTYASNFNNLYYPLHSSLVGQFVFPNFANPIQL-------
MLBr_02592|M.leprae_Br4923 NGVETFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQF-------
:: **: * : * . .. * . *:::*
Mb3526c|M.bovis_AF2122/97 -GSFDTAAGPSAPDYYRRAEICRERLGPVLRRLT------VNYPPIMFHP
MUL_4059|M.ulcerans_Agy99 -GSFDTAAGKSAPDYYRRAELCRERLGPVLRRLT------ANYPPFLFHP
MAB_4150c|M.abscessus_ATCC_199 -GVFETGT---KTEYLKRAEICRERMGPVLRRAT------FNYAPILLHP
Mvan_4147|M.vanbaalenii_PYR-1 --VCGLIGGVANTTAPETAKLCAQYLGPALRSIP------IHNLPFPINA
Mflv_2511|M.gilvum_PYR-GCK --VCGLIGGIANTTAPETAKLCSQYLGPALRLVN------FGNLPFPINP
MSMEG_4787|M.smegmatis_MC2_155 --ICGAIGAVENVTAPETAKLCAQYLGPALRLLN------FNNVPFPVSP
TH_4516|M.thermoresistible__bu --ICGAIGAIENTTAPETAKLCAQYLGPGLRLLN------FNYLPIGIDP
MMAR_4707|M.marinum_M --ICSQLGAMENVTSVESGKLCGLYLSPALKVFNPLMYFNFNYFPIPINP
MAV_0951|M.avium_104 VPGCTAVGAIENITAVESGKLCSLFLGPGLRVLN------FNNLPIPINI
Rv0592|M.tuberculosis_H37Rv --ICSAIQAGSRLGYQESAELCAQYLAPVLDALK------FNYLPFGSNP
MLBr_02592|M.leprae_Br4923 --ICSAIQAGSRLGYQESAELCAQYLSPVLDAIK------FNYFPFGLNL
. .::* :.* * *:
Mb3526c|M.bovis_AF2122/97 LNTITAYKGQIIYDTPATEAKSETPVPELTWVPAGGG--APVGNPADLQS
MUL_4059|M.ulcerans_Agy99 LNTITAYKGQIIYDTPATQAKAETPVPELTWIPAHPAPQPAPGNTTDLQS
MAB_4150c|M.abscessus_ATCC_199 INQISAYKGQIIYDTPETEAKSQAPREDLVWVRPNGAPPPPKPSPQDLSA
Mvan_4147|M.vanbaalenii_PYR-1 YLRPAVSPERTIYTDPKLAPG-GAGPGDPPEMPPTVSAYTGAGDIPPPPG
Mflv_2511|M.gilvum_PYR-GCK YLRPAISPDRLIYTDPKLAPG-GAGPGDPPEIPPTVSAYTGAGDIPPPPG
MSMEG_4787|M.smegmatis_MC2_155 YLMPSANPENLIYSEPNLAPGAGGGSPQPPETPPVLSAYNPG-PPPPPPF
TH_4516|M.thermoresistible__bu FLMPSAKPENIIYSEPRLAPGGGANLEFEPELPPTVSAYEGV-PPGPPPF
MMAR_4707|M.marinum_M ILAPAFDLQNVVYTEQRLAPGGEGPKPIAPELPPAVSAYTGL----PGDT
MAV_0951|M.avium_104 FLQKSVDPSKILYSEPRLAPGGEGPKPGPPEIPPAVSAYTGL----PGD-
Rv0592|M.tuberculosis_H37Rv FSSAATLPKEVAYSEERLRPPPGYKDTTVPGIFSRDTPFSHGNHEPGWVV
MLBr_02592|M.leprae_Br4923 FSTAEVLPKEVAYSEARLQPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIV
. * .
Mb3526c|M.bovis_AF2122/97 LLVPPAPG----------------PAPAPPAP-GAG--------------
MUL_4059|M.ulcerans_Agy99 LFVPQAPGPTPGSPPGYGPAPGPPPAPAPAGP-DAGL-------------
MAB_4150c|M.abscessus_ATCC_199 LMLGPDEVNAP-------PPPGTEVRPAEPGPVPPGF-------------
Mvan_4147|M.vanbaalenii_PYR-1 WGAPPGPRGIYQPDPDAPATPSPALYPGAPIPGPPNILSNIP----AQPQ
Mflv_2511|M.gilvum_PYR-GCK WGAPPGPRGIYQPDPDAPATPSPALYPGAPIPGPPNILSNIPPAPAAGPA
MSMEG_4787|M.smegmatis_MC2_155 TGRPPG----------TPPPGAAQLLPGAPPIVPPNVPSSVR----DMLA
TH_4516|M.thermoresistible__bu TGRPPG----------TPPPGAQQMLPGAPPVVPPNVRSTLQ----GMLN
MMAR_4707|M.marinum_M PEAPPP-------------PPPPARIPGAAMPEPP---------------
MAV_0951|M.avium_104 PVGPPG-------------AEPPARIPGAAMPLPP---------------
Rv0592|M.tuberculosis_H37Rv APGMQGMQVQPFTANMLTPESLAELLGGPDIAPPPPGTNLP-GPPNAYDE
MLBr_02592|M.leprae_Br4923 APGMQGQQVGPITAALMTPDSLAELMGGPDIEPIQSNLQTPPGPPTAYDE
.
Mb3526c|M.bovis_AF2122/97 ---------------------------------PGEHGGGG---------
MUL_4059|M.ulcerans_Agy99 ------------------------SSPAPGAPLPAEQGAGG---------
MAB_4150c|M.abscessus_ATCC_199 ------------------------PVTADDAPPPAIPGAPR---------
Mvan_4147|M.vanbaalenii_PYR-1 PQTVDGLLLPPQGNPGGSPPPAPAPAVAPTGPLLPAEGMPPA--------
Mflv_2511|M.gilvum_PYR-GCK PTTVDGLLLPP-----GAP---AAPPVAPNAPLLPAEGTPPS--------
MSMEG_4787|M.smegmatis_MC2_155 PAGPPPGPVPET-----GPAPGPLPAEAPL---EPAEGTPPA--------
TH_4516|M.thermoresistible__bu PAGTPHGPAPD------GP---PLPAEAP----APAEGTPPA--------
MMAR_4707|M.marinum_M ---PPSVPAEPS----------PPP-ANLSDMLLPAEGPQP---------
MAV_0951|M.avium_104 ---PPSTPMPPP----------PPPEPGVSGMLLPAQGPQQ---------
Rv0592|M.tuberculosis_H37Rv SNPLPPPW---------YPQPASLP--------AAGATGQP------GPG
MLBr_02592|M.leprae_Br4923 H-PVPPPIGLQASVPIPSPRPDVVPGPVAPTPSPAANVGDPPLPAELGAG
Mb3526c|M.bovis_AF2122/97 -
MUL_4059|M.ulcerans_Agy99 -
MAB_4150c|M.abscessus_ATCC_199 -
Mvan_4147|M.vanbaalenii_PYR-1 -
Mflv_2511|M.gilvum_PYR-GCK -
MSMEG_4787|M.smegmatis_MC2_155 -
TH_4516|M.thermoresistible__bu -
MMAR_4707|M.marinum_M -
MAV_0951|M.avium_104 -
Rv0592|M.tuberculosis_H37Rv Q
MLBr_02592|M.leprae_Br4923 Q