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MSPRVPRNRLAALAAVVLVGLILAGTAVLVRNTFFGQKTITAYFTTATAIYPNDEVRVSGVKVGNIKSIE PQGTQAKMTLKVDHDVPIPADAKAVIVASNLVSARYVQLSPAYRDSGPVMPDGAVIPVERTAVPVEWDEV KTQLMRLATDLGPKSGVSGTSVGRFIDSAANALDGNGDKLRQTLAQLSGVGRILANGSGNIVDIIKNLQT FVGALRDSNVQIVQFNDRLATLTSVVNDSKSDLDAALTDLSTAVGEVQRFIAGTRNQTSEQIARLADVTQ ILVDHHMDLENILHVAPNALGNFFNDYNADTGTIVGGFGIMNFANPTFSGLMVPLPVPGCTAVGAIENIT AVESGKLCSLFLGPGLRVLNFNNLPIPINIFLQKSVDPSKILYSEPRLAPGGEGPKPGPPEIPPAVSAYT GLPGDPVGPPGAEPPARIPGAAMPLPPPPSTPMPPPPPPEPGVSGMLLPAQGPQQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0951 | - | - | 100% (475) | virulence factor mce family protein |
| M. avium 104 | MAV_2535 | - | 6e-71 | 35.06% (462) | virulence factor mce family protein |
| M. avium 104 | MAV_0660 | - | 1e-70 | 36.54% (468) | virulence factor mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3526c | mce4D | 7e-73 | 37.61% (452) | MCE-family protein MCE4D |
| M. gilvum PYR-GCK | Mflv_2511 | - | 1e-155 | 59.10% (489) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3496c | mce4D | 8e-73 | 37.61% (452) | MCE-family protein MCE4D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 1e-61 | 31.87% (524) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4150c | - | 1e-73 | 37.33% (442) | MCE-family protein |
| M. marinum M | MMAR_4707 | - | 0.0 | 70.17% (476) | MCE-family protein |
| M. smegmatis MC2 155 | MSMEG_4787 | - | 1e-154 | 59.38% (485) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_4516 | - | 1e-149 | 58.00% (481) | PUTATIVE virulence factor mce family protein |
| M. ulcerans Agy99 | MUL_3921 | mce3D_1 | 6e-76 | 37.94% (456) | MCE-family protein Mce3D_1 |
| M. vanbaalenii PYR-1 | Mvan_4147 | - | 1e-156 | 59.38% (485) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3526c|M.bovis_AF2122/97 -----MMGRVAMLTGSRGLRYATVIALVAALVGG-VYVLSSTGNK-RTIV
Rv3496c|M.tuberculosis_H37Rv -----MMGRVAMLTGSRGLRYATVIALVAALVGG-VYVLSSTGNK-RTIV
MAB_4150c|M.abscessus_ATCC_199 -----------MTTSKTWLKRGAFAMLSVALVGGLLYWVWPSRGT-YKIV
MAV_0951|M.avium_104 -------MSPR-VPRNRLAALAAVVLVGLILAGTAVLVRNTFFGQ-KTIT
MMAR_4707|M.marinum_M ------MMRLEGAARSKVKAVLAVALVGLVVVGTGVALRNTFFRP-TTIT
MSMEG_4787|M.smegmatis_MC2_155 ------------MNRKRIAKGLAVGLVVLLVAGAAVLVRQVFLAP-RTFQ
TH_4516|M.thermoresistible__bu ------------MTRRRLTTWLAVGFVVLLVAGGGLLLRQVVYAP-RTFE
Mflv_2511|M.gilvum_PYR-GCK ----------MMATRKRWVAGTAVLLAILLVAGAVFLVRQVFFGP-TTIT
Mvan_4147|M.vanbaalenii_PYR-1 ----------MMATRKRWVAGTALLLAILLIAGAALLVRQVFFGP-KTIT
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
MUL_3921|M.ulcerans_Agy99 -------------MIRRTKTWLAVLLVGLLAAGVVVLLRTTEVVNRTNVV
. . ..
Mb3526c|M.bovis_AF2122/97 GYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVD
Rv3496c|M.tuberculosis_H37Rv GYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVD
MAB_4150c|M.abscessus_ATCC_199 GHFASAVGLYPGDDVRILGVKAGRISAVEPREGDVKVTMEMPDKFKVPEG
MAV_0951|M.avium_104 AYFTTATAIYPNDEVRVSGVKVGNIKSIEPQGTQAKMTLKVDHDVPIPAD
MMAR_4707|M.marinum_M AYFPTATAIYPGDDVRVSGMKVGTIAAIRPDGTKAKMILHVDHNVPIPAD
MSMEG_4787|M.smegmatis_MC2_155 ALFTSATGIYPGDDVRVSGVKVGTIEAITPEGTQTRLTLKVDRGVPIPAD
TH_4516|M.thermoresistible__bu AIFTSATGIYPGDEVRVSGVAVGSIDSITPEGTHTRMVLKVDRDVPIPAD
Mflv_2511|M.gilvum_PYR-GCK AYFPTATAIYPGDEVRVSGVEVGTIDKIEPEGTQTKMTLKVDRGVQVPAN
Mvan_4147|M.vanbaalenii_PYR-1 AYFPTATAIYPGDEVRVSGVKVGTIDKIEPEGTLTRMTLKVDRDVPVPAD
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
MUL_3921|M.ulcerans_Agy99 AYFENSNGVFTGDEVRILGVPVGKITSIEPQPESVRVSFWYDSKYIVPAD
* : .::..*.*:: *: .* * : * :: : :* .
Mb3526c|M.bovis_AF2122/97 VQAVIMSPNLVAARFIQLTPVYTGG---AVLPDNGRIDLDRTAVPVEWDE
Rv3496c|M.tuberculosis_H37Rv VQAVIMSPNLVAARFIQLTPVYTGG---AVLPDNGRIDLDRTAVPVEWDE
MAB_4150c|M.abscessus_ATCC_199 AQAIIMAPNLVTARFVQLTPAYTDG---KALQDGASLGLDKTAVPIEWDE
MAV_0951|M.avium_104 AKAVIVASNLVSARYVQLSPAYRDS--GPVMPDGAVIPVERTAVPVEWDE
MMAR_4707|M.marinum_M AKAVIVAQNLVAARYVQLTPAYRSS--GPVMADGAVIPIERTAVPVEWDE
MSMEG_4787|M.smegmatis_MC2_155 AKAVIVAQNLVAARYVQLAPAYRSE--GPTLPDDAVIGLDRTAVPVEWDE
TH_4516|M.thermoresistible__bu VKAVIVAPNLVAARYVQLTPAYRSSEGGPTLPDNAVIDLDRTAVPVEWDE
Mflv_2511|M.gilvum_PYR-GCK AKAVIVAQNLVAARYVQLTPAYRDG-DGATMADGGVIPKERTAIPVEWDE
Mvan_4147|M.vanbaalenii_PYR-1 AKAVIVAQNLVAARYVQLTPSYREG-GGPTMGDGGTIPESRTAVPVEWDE
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKGG---PALGDNAVIPLERTQVPVEWDE
MUL_3921|M.ulcerans_Agy99 AKAAILSPTLVTSRAIQLTPAYTGG---PAMSDNAVIPRQRTAVPVEWDD
..* *: .**::* :** * * .: *.. : .:* :*:***:
Mb3526c|M.bovis_AF2122/97 VKEGLTRLAADLSPAAGELQGPLGAAINQAADTLD-GNGDSLHNALRELA
Rv3496c|M.tuberculosis_H37Rv VKEGLTRLAADLSPAAGELQGPLGAAINQAADTLD-GNGDSLHNALRELA
MAB_4150c|M.abscessus_ATCC_199 VKTELAKLSDSLGPQ-GQSKGPVSDFINQAATTFD-GNGDSFRNAVRELS
MAV_0951|M.avium_104 VKTQLMRLATDLGPKSGVSGTSVGRFIDSAANALD-GNGDKLRQTLAQLS
MMAR_4707|M.marinum_M VKDQLMRLATELGPNSKVSSPSISRFIDSAADALGNGNGDKLRQTLAELS
MSMEG_4787|M.smegmatis_MC2_155 VKEQLTRLATELGPRSGVDGTSMARFIETTADAME-GNGEKLRNTISQLS
TH_4516|M.thermoresistible__bu VKEQLMRLATDLGPQRGVDDTSVSRFIETAADAME-GNGAKLRETITQLS
Mflv_2511|M.gilvum_PYR-GCK VKTQLMRLSEELGPQAGASGTSISRFVDSAANAME-GNGDKLRETLRQLS
Mvan_4147|M.vanbaalenii_PYR-1 VKTQLMRLSEELGPQADVSGTSISRFVDSAANAME-GNGEKLRETLRQLS
MLBr_02592|M.leprae_Br4923 LRDSITKIISKLGPTKEQPKGPFGDVIESFADGLA-GKGKQINATLDSLS
MUL_3921|M.ulcerans_Agy99 VRAQLAKLTKELQPTEPGGVSPLGSVINTAADNLR-GEGANIRDTVIKLS
:: : :: .* * ... :: * : *:* .:. :: .*:
Mb3526c|M.bovis_AF2122/97 QVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVLAD
Rv3496c|M.tuberculosis_H37Rv QVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVLAD
MAB_4150c|M.abscessus_ATCC_199 QAAGRLGDSRTDLFGTIKNLQTLVDALANSNEQIVQFSTHLASVSKVLAA
MAV_0951|M.avium_104 GVGRILANGSGNIVDIIKNLQTFVGALRDSNVQIVQFNDRLATLTSVVND
MMAR_4707|M.marinum_M GVGRILANGSGNIVDIIKNLQTFIGALRDSNVQIVQFNDRLASLTSVLDD
MSMEG_4787|M.smegmatis_MC2_155 GVARILAEGSGNIVDIIKNLQTFVTALRDSNQQVVAFQNRLATLTSVVDG
TH_4516|M.thermoresistible__bu GVARVLAEGSGNVVDIIRNLQTFVTTLRDSNEQVMVFQNRLATLTSVING
Mflv_2511|M.gilvum_PYR-GCK GAARIFAEGSGNIVDIIKNLQIFVTALRDSKDQIVLFQNRLATLTSVVND
Mvan_4147|M.vanbaalenii_PYR-1 GVARIFAEGSGNIVDIIKNLQVFVSALRDSKDQIVLFQNRLATLTSVVND
MLBr_02592|M.leprae_Br4923 RALTALNEGRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLAH
MUL_3921|M.ulcerans_Agy99 QAFSALGDHSTDIFSTVKNLAILVSALQDSTNLMRQLNQNLATVTGLLAN
. : : :.. ::.* :: :* . . : .:* .: :
Mb3526c|M.bovis_AF2122/97 SSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQTLS--DQS
Rv3496c|M.tuberculosis_H37Rv SSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQTLS--DQS
MAB_4150c|M.abscessus_ATCC_199 STENLGATLGALNQALTDVRGFLGDTNSALIDQVNKLSDFVKIFS--DQS
MAV_0951|M.avium_104 SKSDLDAALTDLSTAVGEVQRFIAGTRNQTSEQIARLADVTQILV--DHH
MMAR_4707|M.marinum_M NKSDLDAALTDLSSAVGEVQRFIAGSRDATAEQITRLADLTQILV--DNK
MSMEG_4787|M.smegmatis_MC2_155 SRSDLDAALKNLSVAVGEVQRFVAGSRNQTSEQIQRLADVTSNLV--DQR
TH_4516|M.thermoresistible__bu SRTDLDAALQNLSVAVGEVQRFVAGSRDQTSEQLERLANVTRNLL--DNK
Mflv_2511|M.gilvum_PYR-GCK SRSDLDAALTDLSFAIGEVQRFVVGSRDATVEQIRSLGQVTQVLA--DNR
Mvan_4147|M.vanbaalenii_PYR-1 SRSDLDAALTDLSFAINEVQRFVAGSRDQTAEQIRSLGQVTQVLV--DNR
MLBr_02592|M.leprae_Br4923 SDTDLSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPEPL
MUL_3921|M.ulcerans_Agy99 DPNEVANAVRNLGDTVGEVQRFVADNREALGTTSDKLAGVSQALN--DSL
. :: :: :. : :: *: ... * . . :
Mb3526c|M.bovis_AF2122/97 ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICG----
Rv3496c|M.tuberculosis_H37Rv ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICG----
MAB_4150c|M.abscessus_ATCC_199 DDLEQILHVAPNGLANFYNIYNPAAGTLNGMLSIPNLANPVQFICG----
MAV_0951|M.avium_104 MDLENILHVAPNALGNFFNDYNADTGTIVGGFGIMNFANPTFSGLMVPLP
MMAR_4707|M.marinum_M MALKNVLHVTPNALANAYNDYDPDVGNVRGGVGIQNLTNPVFS-------
MSMEG_4787|M.smegmatis_MC2_155 LQVENLLHIAPNAFVNGYNIYNPDSGSPVGQFVFHNMSEPLHF-------
TH_4516|M.thermoresistible__bu LEIENVLHIAPNALANAYNIYNPDTGSPVGQFVLNNFSDPVQF-------
Mflv_2511|M.gilvum_PYR-GCK LALENVLHITPNAIANFENIYYPNGGSVTGAFSLSNFSNPVWF-------
Mvan_4147|M.vanbaalenii_PYR-1 LALENVLHITPNAIANFENIYYPNGGSVTGAFSVSNFSNPVWF-------
MLBr_02592|M.leprae_Br4923 NGVETFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQF-------
MUL_3921|M.ulcerans_Agy99 DDVKQFLHVAPNTLQNYVNIWQPAQGAVSAVPMLNNFANPISF-------
:: .**:: * : : . * . . *:::*
Mb3526c|M.bovis_AF2122/97 -GSFDTAAGPSAPDYYRRAEICRERLGPVLRRLT------VNYPPIMFHP
Rv3496c|M.tuberculosis_H37Rv -GSFDTAAGPSAPDYYRRAEICRERLGPVLRRLT------VNYPPIMFHP
MAB_4150c|M.abscessus_ATCC_199 -GVFETGT---KTEYLKRAEICRERMGPVLRRAT------FNYAPILLHP
MAV_0951|M.avium_104 VPGCTAVGAIENITAVESGKLCSLFLGPGLRVLN------FNNLPIPINI
MMAR_4707|M.marinum_M --ICSQLGAMENVTSVESGKLCGLYLSPALKVFNPLMYFNFNYFPIPINP
MSMEG_4787|M.smegmatis_MC2_155 --ICGAIGAVENVTAPETAKLCAQYLGPALRLLN------FNNVPFPVSP
TH_4516|M.thermoresistible__bu --ICGAIGAIENTTAPETAKLCAQYLGPGLRLLN------FNYLPIGIDP
Mflv_2511|M.gilvum_PYR-GCK --VCGLIGGIANTTAPETAKLCSQYLGPALRLVN------FGNLPFPINP
Mvan_4147|M.vanbaalenii_PYR-1 --VCGLIGGVANTTAPETAKLCAQYLGPALRSIP------IHNLPFPINA
MLBr_02592|M.leprae_Br4923 --ICSAIQAGSRLGYQESAELCAQYLSPVLDAIK------FNYFPFGLNL
MUL_3921|M.ulcerans_Agy99 --LCGAIQAASRLGYEQSAKLCVQYLAPIIKNRQ------YNFLPFGQNL
. .::* :.* : *:
Mb3526c|M.bovis_AF2122/97 LNTITAYKGQIIYDTPATEAKS----------------------ETPVPE
Rv3496c|M.tuberculosis_H37Rv LNTITAYKGQIIYDTPATEAKS----------------------ETPVPE
MAB_4150c|M.abscessus_ATCC_199 INQISAYKGQIIYDTPETEAKS----------------------QAPRED
MAV_0951|M.avium_104 FLQKSVDPSKILYSEPRLAPGG----------------------EGPKPG
MMAR_4707|M.marinum_M ILAPAFDLQNVVYTEQRLAPGG----------------------EGPKPI
MSMEG_4787|M.smegmatis_MC2_155 YLMPSANPENLIYSEPNLAPGA----------------------GGGSPQ
TH_4516|M.thermoresistible__bu FLMPSAKPENIIYSEPRLAPGG----------------------GANLEF
Mflv_2511|M.gilvum_PYR-GCK YLRPAISPDRLIYTDPKLAPG-----------------------GAGPGD
Mvan_4147|M.vanbaalenii_PYR-1 YLRPAVSPERTIYTDPKLAPG-----------------------GAGPGD
MLBr_02592|M.leprae_Br4923 FSTAEVLPKEVAYSEARLQPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIV
MUL_3921|M.ulcerans_Agy99 FVGASARPNELTYSEDWLR--------------------------PDYIP
. *
Mb3526c|M.bovis_AF2122/97 LTWVPAGGG--APVGNPADLQSLLVPPA--------------PGPAPAPP
Rv3496c|M.tuberculosis_H37Rv LTWVPAGGG--APVGNPADLQSLLVPPA--------------PGPAPAPP
MAB_4150c|M.abscessus_ATCC_199 LVWVRPNGAPPPPKPSPQDLSALMLGPD--------------EVNAPPPP
MAV_0951|M.avium_104 PPEIPPAVSAYTGL----PGD-PVGPPG-------------AEPPARIPG
MMAR_4707|M.marinum_M APELPPAVSAYTGL----PGDTPEAPPP-------------PPPPARIPG
MSMEG_4787|M.smegmatis_MC2_155 PPETPPVLSAYNPG-PPPPPPFTGRPPG----------TPPPGAAQLLPG
TH_4516|M.thermoresistible__bu EPELPPTVSAYEGV-PPGPPPFTGRPPG----------TPPPGAQQMLPG
Mflv_2511|M.gilvum_PYR-GCK PPEIPPTVSAYTGAGDIPPPPGWGAPPGPRGIYQPDPDAPATPSPALYPG
Mvan_4147|M.vanbaalenii_PYR-1 PPEMPPTVSAYTGAGDIPPPPGWGAPPGPRGIYQPDPDAPATPSPALYPG
MLBr_02592|M.leprae_Br4923 APGMQGQQVGPITAALMTPDSLAELMGGPDIEPIQSNLQTPPGPPTAYDE
MUL_3921|M.ulcerans_Agy99 PQAIPPQQA----------------------------------PPAAAPP
Mb3526c|M.bovis_AF2122/97 APGAGPGEHG----------------------------------------
Rv3496c|M.tuberculosis_H37Rv APGAGPGEHG----------------------------------------
MAB_4150c|M.abscessus_ATCC_199 GTEVRPAEPGP--------------------------------VPPGFPV
MAV_0951|M.avium_104 AAMPLPPPPS-----------------------------TPMPPPPPPEP
MMAR_4707|M.marinum_M AAMPEPPPPS-----------------------------VPAEPSPPP-A
MSMEG_4787|M.smegmatis_MC2_155 APPIVPPNVP-------------SSVRDMLAPAGPPPGPVPETGPAPGPL
TH_4516|M.thermoresistible__bu APPVVPPNVR-------------STLQGMLNPAGTPHGPAPD-GP---PL
Mflv_2511|M.gilvum_PYR-GCK APIPGPPNILSNIPPAPAAGPAPTTVDGLLLPP-----GAP---AAP-PV
Mvan_4147|M.vanbaalenii_PYR-1 APIPGPPNILSNIP----AQPQPQTVDGLLLPPQGNPGGSPPPAPAP-AV
MLBr_02592|M.leprae_Br4923 HPVPPPIGLQ---------------ASVPIPSPRPDVVPGPVAPTPSPAA
MUL_3921|M.ulcerans_Agy99 AQAPPPA------------------VGLPLPAEAP--------ATPDPAA
*
Mb3526c|M.bovis_AF2122/97 ----------GGG--
Rv3496c|M.tuberculosis_H37Rv ----------GGG--
MAB_4150c|M.abscessus_ATCC_199 TADDAPPPAIPGAPR
MAV_0951|M.avium_104 GVSGMLLPAQGPQQ-
MMAR_4707|M.marinum_M NLSDMLLPAEGPQP-
MSMEG_4787|M.smegmatis_MC2_155 PAEAPLEPAEGTPPA
TH_4516|M.thermoresistible__bu PAEAP-APAEGTPPA
Mflv_2511|M.gilvum_PYR-GCK APNAPLLPAEGTPPS
Mvan_4147|M.vanbaalenii_PYR-1 APTGPLLPAEGMPPA
MLBr_02592|M.leprae_Br4923 NVGDPPLPAELGAGQ
MUL_3921|M.ulcerans_Agy99 GLRGIMVPQGVGS--