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MMATRKRWVAGTAVLLAILLVAGAVFLVRQVFFGPTTITAYFPTATAIYPGDEVRVSGVEVGTIDKIEPE GTQTKMTLKVDRGVQVPANAKAVIVAQNLVAARYVQLTPAYRDGDGATMADGGVIPKERTAIPVEWDEVK TQLMRLSEELGPQAGASGTSISRFVDSAANAMEGNGDKLRETLRQLSGAARIFAEGSGNIVDIIKNLQIF VTALRDSKDQIVLFQNRLATLTSVVNDSRSDLDAALTDLSFAIGEVQRFVVGSRDATVEQIRSLGQVTQV LADNRLALENVLHITPNAIANFENIYYPNGGSVTGAFSLSNFSNPVWFVCGLIGGIANTTAPETAKLCSQ YLGPALRLVNFGNLPFPINPYLRPAISPDRLIYTDPKLAPGGAGPGDPPEIPPTVSAYTGAGDIPPPPGW GAPPGPRGIYQPDPDAPATPSPALYPGAPIPGPPNILSNIPPAPAAGPAPTTVDGLLLPPGAPAAPPVAP NAPLLPAEGTPPS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2511 | - | - | 100% (503) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_4535 | - | e-152 | 58.49% (477) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_4163 | - | e-121 | 55.17% (406) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3526c | mce4D | 2e-76 | 36.31% (471) | MCE-family protein MCE4D |
| M. tuberculosis H37Rv | Rv3496c | mce4D | 2e-76 | 36.31% (471) | MCE-family protein MCE4D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 2e-70 | 32.62% (515) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4150c | - | 3e-78 | 35.90% (468) | MCE-family protein |
| M. marinum M | MMAR_4707 | - | 1e-146 | 56.39% (509) | MCE-family protein |
| M. avium 104 | MAV_0951 | - | 1e-155 | 59.10% (489) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_4787 | - | 1e-167 | 60.99% (505) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_4516 | - | 1e-160 | 58.97% (507) | PUTATIVE virulence factor mce family protein |
| M. ulcerans Agy99 | MUL_4059 | mce4D | 7e-77 | 37.76% (482) | MCE-family protein Mce4D |
| M. vanbaalenii PYR-1 | Mvan_4147 | - | 0.0 | 87.08% (511) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3526c|M.bovis_AF2122/97 ------MMGRVAMLTGSRGLRYATVIALVAALVGGVYVLSSTGNK-RTIV
Rv3496c|M.tuberculosis_H37Rv ------MMGRVAMLTGSRGLRYATVIALVAALVGGVYVLSSTGNK-RTIV
MUL_4059|M.ulcerans_Agy99 ------MMK---QRLSSRGMRTVTIVALVAALVGGLYVLFSGGESGRKVV
MAB_4150c|M.abscessus_ATCC_199 ------------MTTSKTWLKRGAFAMLSVALVGGLLYWVWPSRGTYKIV
Mflv_2511|M.gilvum_PYR-GCK -----------MMATRKRWVAGTAVLLAILLVAGAVFLVRQVFFGPTTIT
Mvan_4147|M.vanbaalenii_PYR-1 -----------MMATRKRWVAGTALLLAILLIAGAALLVRQVFFGPKTIT
MSMEG_4787|M.smegmatis_MC2_155 -------------MNRKRIAKGLAVGLVVLLVAGAAVLVRQVFLAPRTFQ
TH_4516|M.thermoresistible__bu -------------MTRRRLTTWLAVGFVVLLVAGGGLLLRQVVYAPRTFE
MMAR_4707|M.marinum_M -------MMRLEGAARSKVKAVLAVALVGLVVVGTGVALRNTFFRPTTIT
MAV_0951|M.avium_104 --------MSPR-VPRNRLAALAAVVLVGLILAGTAVLVRNTFFGQKTIT
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
:. :.* ..
Mb3526c|M.bovis_AF2122/97 GYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVD
Rv3496c|M.tuberculosis_H37Rv GYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVD
MUL_4059|M.ulcerans_Agy99 AYFTSAVGIYPGDEVRILGVPVGRIDSIEPRPADVKITMSVSNDVKIPRD
MAB_4150c|M.abscessus_ATCC_199 GHFASAVGLYPGDDVRILGVKAGRISAVEPREGDVKVTMEMPDKFKVPEG
Mflv_2511|M.gilvum_PYR-GCK AYFPTATAIYPGDEVRVSGVEVGTIDKIEPEGTQTKMTLKVDRGVQVPAN
Mvan_4147|M.vanbaalenii_PYR-1 AYFPTATAIYPGDEVRVSGVKVGTIDKIEPEGTLTRMTLKVDRDVPVPAD
MSMEG_4787|M.smegmatis_MC2_155 ALFTSATGIYPGDDVRVSGVKVGTIEAITPEGTQTRLTLKVDRGVPIPAD
TH_4516|M.thermoresistible__bu AIFTSATGIYPGDEVRVSGVAVGSIDSITPEGTHTRMVLKVDRDVPIPAD
MMAR_4707|M.marinum_M AYFPTATAIYPGDDVRVSGMKVGTIAAIRPDGTKAKMILHVDHNVPIPAD
MAV_0951|M.avium_104 AYFTTATAIYPNDEVRVSGVKVGNIKSIEPQGTQAKMTLKVDHDVPIPAD
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
*.:*..:*..*.*:: *: .* * : * :: : :* .
Mb3526c|M.bovis_AF2122/97 VQAVIMSPNLVAARFIQLTPVYTGG---AVLPDNGRIDLDRTAVPVEWDE
Rv3496c|M.tuberculosis_H37Rv VQAVIMSPNLVAARFIQLTPVYTGG---AVLPDNGRIDLDRTAVPVEWDE
MUL_4059|M.ulcerans_Agy99 AQALIVSPNLVAARFIQLTPVYTGG---AVVPDGASIDLSRTAIPVEWDE
MAB_4150c|M.abscessus_ATCC_199 AQAIIMAPNLVTARFVQLTPAYTDG---KALQDGASLGLDKTAVPIEWDE
Mflv_2511|M.gilvum_PYR-GCK AKAVIVAQNLVAARYVQLTPAYRDG-DGATMADGGVIPKERTAIPVEWDE
Mvan_4147|M.vanbaalenii_PYR-1 AKAVIVAQNLVAARYVQLTPSYREG-GGPTMGDGGTIPESRTAVPVEWDE
MSMEG_4787|M.smegmatis_MC2_155 AKAVIVAQNLVAARYVQLAPAYRSE--GPTLPDDAVIGLDRTAVPVEWDE
TH_4516|M.thermoresistible__bu VKAVIVAPNLVAARYVQLTPAYRSSEGGPTLPDNAVIDLDRTAVPVEWDE
MMAR_4707|M.marinum_M AKAVIVAQNLVAARYVQLTPAYRSS--GPVMADGAVIPIERTAVPVEWDE
MAV_0951|M.avium_104 AKAVIVASNLVSARYVQLSPAYRDS--GPVMPDGAVIPVERTAVPVEWDE
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKGG---PALGDNAVIPLERTQVPVEWDE
..*:*: .**::* :** * * .: *.. : .:* :*:****
Mb3526c|M.bovis_AF2122/97 VKEGLTRLAADLSPAAGELQGPLGAAINQAADTLD-GNGDSLHNALRELA
Rv3496c|M.tuberculosis_H37Rv VKEGLTRLAADLSPAAGELQGPLGAAINQAADTLD-GNGDSLHNALRELA
MUL_4059|M.ulcerans_Agy99 VKESLTQLAVQLSPAAGELQGPLGAAINQAADTLN-GNGDSFHNALRELS
MAB_4150c|M.abscessus_ATCC_199 VKTELAKLSDSLGPQ-GQSKGPVSDFINQAATTFD-GNGDSFRNAVRELS
Mflv_2511|M.gilvum_PYR-GCK VKTQLMRLSEELGPQAGASGTSISRFVDSAANAME-GNGDKLRETLRQLS
Mvan_4147|M.vanbaalenii_PYR-1 VKTQLMRLSEELGPQADVSGTSISRFVDSAANAME-GNGEKLRETLRQLS
MSMEG_4787|M.smegmatis_MC2_155 VKEQLTRLATELGPRSGVDGTSMARFIETTADAME-GNGEKLRNTISQLS
TH_4516|M.thermoresistible__bu VKEQLMRLATDLGPQRGVDDTSVSRFIETAADAME-GNGAKLRETITQLS
MMAR_4707|M.marinum_M VKDQLMRLATELGPNSKVSSPSISRFIDSAADALGNGNGDKLRQTLAELS
MAV_0951|M.avium_104 VKTQLMRLATDLGPKSGVSGTSVGRFIDSAANALD-GNGDKLRQTLAQLS
MLBr_02592|M.leprae_Br4923 LRDSITKIISKLGPTKEQPKGPFGDVIESFADGLA-GKGKQINATLDSLS
:: : :: .*.* ... :: * : *:* .:. :: .*:
Mb3526c|M.bovis_AF2122/97 QVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVLAD
Rv3496c|M.tuberculosis_H37Rv QVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVLAD
MUL_4059|M.ulcerans_Agy99 QVAGRLGDSRNDIFSTVKNLQVLVDALSQSNEQIVQFAGHVASVSQVLAD
MAB_4150c|M.abscessus_ATCC_199 QAAGRLGDSRTDLFGTIKNLQTLVDALANSNEQIVQFSTHLASVSKVLAA
Mflv_2511|M.gilvum_PYR-GCK GAARIFAEGSGNIVDIIKNLQIFVTALRDSKDQIVLFQNRLATLTSVVND
Mvan_4147|M.vanbaalenii_PYR-1 GVARIFAEGSGNIVDIIKNLQVFVSALRDSKDQIVLFQNRLATLTSVVND
MSMEG_4787|M.smegmatis_MC2_155 GVARILAEGSGNIVDIIKNLQTFVTALRDSNQQVVAFQNRLATLTSVVDG
TH_4516|M.thermoresistible__bu GVARVLAEGSGNVVDIIRNLQTFVTTLRDSNEQVMVFQNRLATLTSVING
MMAR_4707|M.marinum_M GVGRILANGSGNIVDIIKNLQTFIGALRDSNVQIVQFNDRLASLTSVLDD
MAV_0951|M.avium_104 GVGRILANGSGNIVDIIKNLQTFVGALRDSNVQIVQFNDRLATLTSVVND
MLBr_02592|M.leprae_Br4923 RALTALNEGRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLAH
. : :. :.. ::.* :: :* .. *.: : .:* .: :
Mb3526c|M.bovis_AF2122/97 SSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQTLSDQS--
Rv3496c|M.tuberculosis_H37Rv SSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQTLSDQS--
MUL_4059|M.ulcerans_Agy99 SSRNLDNTLGTLNQALSDIKGFLRENNSTLIETVNQLGDLTQTLSDQS--
MAB_4150c|M.abscessus_ATCC_199 STENLGATLGALNQALTDVRGFLGDTNSALIDQVNKLSDFVKIFSDQS--
Mflv_2511|M.gilvum_PYR-GCK SRSDLDAALTDLSFAIGEVQRFVVGSRDATVEQIRSLGQVTQVLADNR--
Mvan_4147|M.vanbaalenii_PYR-1 SRSDLDAALTDLSFAINEVQRFVAGSRDQTAEQIRSLGQVTQVLVDNR--
MSMEG_4787|M.smegmatis_MC2_155 SRSDLDAALKNLSVAVGEVQRFVAGSRNQTSEQIQRLADVTSNLVDQR--
TH_4516|M.thermoresistible__bu SRTDLDAALQNLSVAVGEVQRFVAGSRDQTSEQLERLANVTRNLLDNK--
MMAR_4707|M.marinum_M NKSDLDAALTDLSSAVGEVQRFIAGSRDATAEQITRLADLTQILVDNK--
MAV_0951|M.avium_104 SKSDLDAALTDLSTAVGEVQRFIAGTRNQTSEQIARLADVTQILVDHH--
MLBr_02592|M.leprae_Br4923 SDTDLSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPEPL
. :*. :* :. : :: *: ... : * . . :
Mb3526c|M.bovis_AF2122/97 ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICG----
Rv3496c|M.tuberculosis_H37Rv ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICG----
MUL_4059|M.ulcerans_Agy99 DNIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICG----
MAB_4150c|M.abscessus_ATCC_199 DDLEQILHVAPNGLANFYNIYNPAAGTLNGMLSIPNLANPVQFICG----
Mflv_2511|M.gilvum_PYR-GCK LALENVLHITPNAIANFENIYYPNGGSVTGAFSLSNFSNPVWF-------
Mvan_4147|M.vanbaalenii_PYR-1 LALENVLHITPNAIANFENIYYPNGGSVTGAFSVSNFSNPVWF-------
MSMEG_4787|M.smegmatis_MC2_155 LQVENLLHIAPNAFVNGYNIYNPDSGSPVGQFVFHNMSEPLHF-------
TH_4516|M.thermoresistible__bu LEIENVLHIAPNALANAYNIYNPDTGSPVGQFVLNNFSDPVQF-------
MMAR_4707|M.marinum_M MALKNVLHVTPNALANAYNDYDPDVGNVRGGVGIQNLTNPVFS-------
MAV_0951|M.avium_104 MDLENILHVAPNALGNFFNDYNADTGTIVGGFGIMNFANPTFSGLMVPLP
MLBr_02592|M.leprae_Br4923 NGVETFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQF-------
:: .**:: . * : * . *. * . *:::*
Mb3526c|M.bovis_AF2122/97 -GSFDTAAGPSAPDYYRRAEICRERLGPVLRRLT------VNYPPIMFHP
Rv3496c|M.tuberculosis_H37Rv -GSFDTAAGPSAPDYYRRAEICRERLGPVLRRLT------VNYPPIMFHP
MUL_4059|M.ulcerans_Agy99 -GSFDTAAGKSAPDYYRRAELCRERLGPVLRRLT------ANYPPFLFHP
MAB_4150c|M.abscessus_ATCC_199 -GVFETGT---KTEYLKRAEICRERMGPVLRRAT------FNYAPILLHP
Mflv_2511|M.gilvum_PYR-GCK --VCGLIGGIANTTAPETAKLCSQYLGPALRLVN------FGNLPFPINP
Mvan_4147|M.vanbaalenii_PYR-1 --VCGLIGGVANTTAPETAKLCAQYLGPALRSIP------IHNLPFPINA
MSMEG_4787|M.smegmatis_MC2_155 --ICGAIGAVENVTAPETAKLCAQYLGPALRLLN------FNNVPFPVSP
TH_4516|M.thermoresistible__bu --ICGAIGAIENTTAPETAKLCAQYLGPGLRLLN------FNYLPIGIDP
MMAR_4707|M.marinum_M --ICSQLGAMENVTSVESGKLCGLYLSPALKVFNPLMYFNFNYFPIPINP
MAV_0951|M.avium_104 VPGCTAVGAIENITAVESGKLCSLFLGPGLRVLN------FNNLPIPINI
MLBr_02592|M.leprae_Br4923 --ICSAIQAGSRLGYQESAELCAQYLSPVLDAIK------FNYFPFGLNL
. .::* :.* * *: .
Mb3526c|M.bovis_AF2122/97 LNTITAYKGQIIYDTPATEAKSETPVPELTWVPA---------------G
Rv3496c|M.tuberculosis_H37Rv LNTITAYKGQIIYDTPATEAKSETPVPELTWVPA---------------G
MUL_4059|M.ulcerans_Agy99 LNTITAYKGQIIYDTPATQAKAETPVPELTWIPA---------------H
MAB_4150c|M.abscessus_ATCC_199 INQISAYKGQIIYDTPETEAKSQAPREDLVWVRP---------------N
Mflv_2511|M.gilvum_PYR-GCK YLRPAISPDRLIYTDPKLAPG-GAGPGDPPEIPP---------------T
Mvan_4147|M.vanbaalenii_PYR-1 YLRPAVSPERTIYTDPKLAPG-GAGPGDPPEMPP---------------T
MSMEG_4787|M.smegmatis_MC2_155 YLMPSANPENLIYSEPNLAPGAGGGSPQPPETPP---------------V
TH_4516|M.thermoresistible__bu FLMPSAKPENIIYSEPRLAPGGGANLEFEPELPP---------------T
MMAR_4707|M.marinum_M ILAPAFDLQNVVYTEQRLAPGGEGPKPIAPELPP---------------A
MAV_0951|M.avium_104 FLQKSVDPSKILYSEPRLAPGGEGPKPGPPEIPP---------------A
MLBr_02592|M.leprae_Br4923 FSTAEVLPKEVAYSEARLQPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIV
. * .
Mb3526c|M.bovis_AF2122/97 GG--APVGNPADLQSLLV--------------------PPAPG-------
Rv3496c|M.tuberculosis_H37Rv GG--APVGNPADLQSLLV--------------------PPAPG-------
MUL_4059|M.ulcerans_Agy99 PAPQPAPGNTTDLQSLFV--------------------PQAPGPTPGSPP
MAB_4150c|M.abscessus_ATCC_199 GAPPPPKPSPQDLSALMLGPD-------------EVNAPPPPGTEVRPAE
Mflv_2511|M.gilvum_PYR-GCK VSAYTGAGDIPPPPGWGAPPGPRGIYQPDPDAPATPSPALYPGAPIPGPP
Mvan_4147|M.vanbaalenii_PYR-1 VSAYTGAGDIPPPPGWGAPPGPRGIYQPDPDAPATPSPALYPGAPIPGPP
MSMEG_4787|M.smegmatis_MC2_155 LSAYNPG-PPPPPPFTGRPPG----------TPPPGAAQLLPGAPPIVPP
TH_4516|M.thermoresistible__bu VSAYEGV-PPGPPPFTGRPPG----------TPPPGAQQMLPGAPPVVPP
MMAR_4707|M.marinum_M VSAYTGL----PGDTPEAPPP-------------PPPPARIPGAAMPEPP
MAV_0951|M.avium_104 VSAYTGL----PGD-PVGPPG-------------AEPPARIPGAAMPLPP
MLBr_02592|M.leprae_Br4923 APGMQGQQVGPITAALMTPDSLAELMGGPDIEPIQSNLQTPPGPPTAYDE
**
Mb3526c|M.bovis_AF2122/97 --------------------PAPAPPA--------PGAG----------P
Rv3496c|M.tuberculosis_H37Rv --------------------PAPAPPA--------PGAG----------P
MUL_4059|M.ulcerans_Agy99 GYGPAPG-----------PPPAPAPAG--------PDAGLSSPAPGAPLP
MAB_4150c|M.abscessus_ATCC_199 --------------------PGPVPPG--------FPVTADDAPP----P
Mflv_2511|M.gilvum_PYR-GCK NILSNIPPAPAAGPAPTTVDGLLLPP-----GAP---AAPPVAPNAPLLP
Mvan_4147|M.vanbaalenii_PYR-1 NILSNIP----AQPQPQTVDGLLLPPQGNPGGSPPPAPAPAVAPTGPLLP
MSMEG_4787|M.smegmatis_MC2_155 NVPSSVR----DMLAPAGPPPGPVPET-----GPAPGPLPAEAPL---EP
TH_4516|M.thermoresistible__bu NVRSTLQ----GMLNPAGTPHGPAPD------GP---PLPAEAP----AP
MMAR_4707|M.marinum_M ------------------PPSVPAEPS----------PPP-ANLSDMLLP
MAV_0951|M.avium_104 ------------------PPSTPMPPP----------PPPEPGVSGMLLP
MLBr_02592|M.leprae_Br4923 HPVPPPIG-------LQASVPIPSPRPDVVPGPVAPTPSPAANVGDPPLP
*
Mb3526c|M.bovis_AF2122/97 GEHGGGG
Rv3496c|M.tuberculosis_H37Rv GEHGGGG
MUL_4059|M.ulcerans_Agy99 AEQGAGG
MAB_4150c|M.abscessus_ATCC_199 AIPGAPR
Mflv_2511|M.gilvum_PYR-GCK AEGTPPS
Mvan_4147|M.vanbaalenii_PYR-1 AEGMPPA
MSMEG_4787|M.smegmatis_MC2_155 AEGTPPA
TH_4516|M.thermoresistible__bu AEGTPPA
MMAR_4707|M.marinum_M AEGPQP-
MAV_0951|M.avium_104 AQGPQQ-
MLBr_02592|M.leprae_Br4923 AELGAGQ
.