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NRKRIAKGLAVGLVVLLVAGAAVLVRQVFLAPRTFQALFTSATGIYPGDDVRVSGVKVGTIEAITPEGTQ TRLTLKVDRGVPIPADAKAVIVAQNLVAARYVQLAPAYRSEGPTLPDDAVIGLDRTAVPVEWDEVKEQLT RLATELGPRSGVDGTSMARFIETTADAMEGNGEKLRNTISQLSGVARILAEGSGNIVDIIKNLQTFVTAL RDSNQQVVAFQNRLATLTSVVDGSRSDLDAALKNLSVAVGEVQRFVAGSRNQTSEQIQRLADVTSNLVDQ RLQVENLLHIAPNAFVNGYNIYNPDSGSPVGQFVFHNMSEPLHFICGAIGAVENVTAPETAKLCAQYLGP ALRLLNFNNVPFPVSPYLMPSANPENLIYSEPNLAPGAGGGSPQPPETPPVLSAYNPGPPPPPPFTGRPP GTPPPGAAQLLPGAPPIVPPNVPSSVRDMLAPAGPPPGPVPETGPAPGPLPAEAPLEPAEGTPPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4787 | - | - | 100% (486) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_2858 | - | e-150 | 59.28% (474) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_5897 | - | 3e-81 | 38.35% (472) | virulence factor mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3526c | mce4D | 1e-76 | 37.90% (438) | MCE-family protein MCE4D |
| M. gilvum PYR-GCK | Mflv_2511 | - | 1e-167 | 60.99% (505) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3496c | mce4D | 2e-76 | 37.90% (438) | MCE-family protein MCE4D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 2e-68 | 33.01% (512) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4150c | - | 9e-78 | 38.01% (463) | MCE-family protein |
| M. marinum M | MMAR_4707 | - | 1e-144 | 56.81% (470) | MCE-family protein |
| M. avium 104 | MAV_0951 | - | 1e-154 | 59.38% (485) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_4516 | - | 0.0 | 75.20% (488) | PUTATIVE virulence factor mce family protein |
| M. ulcerans Agy99 | MUL_4059 | mce4D | 1e-79 | 38.32% (475) | MCE-family protein Mce4D |
| M. vanbaalenii PYR-1 | Mvan_4147 | - | 1e-165 | 61.39% (505) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3526c|M.bovis_AF2122/97 ------MMGRVAMLTGSRGLRYATVIALVAALVGGVYVLSSTGNK-RTIV
Rv3496c|M.tuberculosis_H37Rv ------MMGRVAMLTGSRGLRYATVIALVAALVGGVYVLSSTGNK-RTIV
MUL_4059|M.ulcerans_Agy99 ------MMK---QRLSSRGMRTVTIVALVAALVGGLYVLFSGGESGRKVV
MAB_4150c|M.abscessus_ATCC_199 ------------MTTSKTWLKRGAFAMLSVALVGGLLYWVWPSRGTYKIV
MSMEG_4787|M.smegmatis_MC2_155 -------------MNRKRIAKGLAVGLVVLLVAGAAVLVRQVFLAPRTFQ
TH_4516|M.thermoresistible__bu -------------MTRRRLTTWLAVGFVVLLVAGGGLLLRQVVYAPRTFE
Mflv_2511|M.gilvum_PYR-GCK -----------MMATRKRWVAGTAVLLAILLVAGAVFLVRQVFFGPTTIT
Mvan_4147|M.vanbaalenii_PYR-1 -----------MMATRKRWVAGTALLLAILLIAGAALLVRQVFFGPKTIT
MMAR_4707|M.marinum_M -------MMRLEGAARSKVKAVLAVALVGLVVVGTGVALRNTFFRPTTIT
MAV_0951|M.avium_104 --------MSPR-VPRNRLAALAAVVLVGLILAGTAVLVRNTFFGQKTIT
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
:. :.* ..
Mb3526c|M.bovis_AF2122/97 GYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVD
Rv3496c|M.tuberculosis_H37Rv GYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVD
MUL_4059|M.ulcerans_Agy99 AYFTSAVGIYPGDEVRILGVPVGRIDSIEPRPADVKITMSVSNDVKIPRD
MAB_4150c|M.abscessus_ATCC_199 GHFASAVGLYPGDDVRILGVKAGRISAVEPREGDVKVTMEMPDKFKVPEG
MSMEG_4787|M.smegmatis_MC2_155 ALFTSATGIYPGDDVRVSGVKVGTIEAITPEGTQTRLTLKVDRGVPIPAD
TH_4516|M.thermoresistible__bu AIFTSATGIYPGDEVRVSGVAVGSIDSITPEGTHTRMVLKVDRDVPIPAD
Mflv_2511|M.gilvum_PYR-GCK AYFPTATAIYPGDEVRVSGVEVGTIDKIEPEGTQTKMTLKVDRGVQVPAN
Mvan_4147|M.vanbaalenii_PYR-1 AYFPTATAIYPGDEVRVSGVKVGTIDKIEPEGTLTRMTLKVDRDVPVPAD
MMAR_4707|M.marinum_M AYFPTATAIYPGDDVRVSGMKVGTIAAIRPDGTKAKMILHVDHNVPIPAD
MAV_0951|M.avium_104 AYFTTATAIYPNDEVRVSGVKVGNIKSIEPQGTQAKMTLKVDHDVPIPAD
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
*.:*..:*..*.*:: *: .* * : * :: : :* .
Mb3526c|M.bovis_AF2122/97 VQAVIMSPNLVAARFIQLTPVYTGG---AVLPDNGRIDLDRTAVPVEWDE
Rv3496c|M.tuberculosis_H37Rv VQAVIMSPNLVAARFIQLTPVYTGG---AVLPDNGRIDLDRTAVPVEWDE
MUL_4059|M.ulcerans_Agy99 AQALIVSPNLVAARFIQLTPVYTGG---AVVPDGASIDLSRTAIPVEWDE
MAB_4150c|M.abscessus_ATCC_199 AQAIIMAPNLVTARFVQLTPAYTDG---KALQDGASLGLDKTAVPIEWDE
MSMEG_4787|M.smegmatis_MC2_155 AKAVIVAQNLVAARYVQLAPAYRSE--GPTLPDDAVIGLDRTAVPVEWDE
TH_4516|M.thermoresistible__bu VKAVIVAPNLVAARYVQLTPAYRSSEGGPTLPDNAVIDLDRTAVPVEWDE
Mflv_2511|M.gilvum_PYR-GCK AKAVIVAQNLVAARYVQLTPAYRDG-DGATMADGGVIPKERTAIPVEWDE
Mvan_4147|M.vanbaalenii_PYR-1 AKAVIVAQNLVAARYVQLTPSYREG-GGPTMGDGGTIPESRTAVPVEWDE
MMAR_4707|M.marinum_M AKAVIVAQNLVAARYVQLTPAYRSS--GPVMADGAVIPIERTAVPVEWDE
MAV_0951|M.avium_104 AKAVIVASNLVSARYVQLSPAYRDS--GPVMPDGAVIPVERTAVPVEWDE
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKGG---PALGDNAVIPLERTQVPVEWDE
..*:*: .**::* :** * * .: *.. : .:* :*:****
Mb3526c|M.bovis_AF2122/97 VKEGLTRLAADLSPAAGELQGPLGAAINQAADTLD-GNGDSLHNALRELA
Rv3496c|M.tuberculosis_H37Rv VKEGLTRLAADLSPAAGELQGPLGAAINQAADTLD-GNGDSLHNALRELA
MUL_4059|M.ulcerans_Agy99 VKESLTQLAVQLSPAAGELQGPLGAAINQAADTLN-GNGDSFHNALRELS
MAB_4150c|M.abscessus_ATCC_199 VKTELAKLSDSLGPQ-GQSKGPVSDFINQAATTFD-GNGDSFRNAVRELS
MSMEG_4787|M.smegmatis_MC2_155 VKEQLTRLATELGPRSGVDGTSMARFIETTADAME-GNGEKLRNTISQLS
TH_4516|M.thermoresistible__bu VKEQLMRLATDLGPQRGVDDTSVSRFIETAADAME-GNGAKLRETITQLS
Mflv_2511|M.gilvum_PYR-GCK VKTQLMRLSEELGPQAGASGTSISRFVDSAANAME-GNGDKLRETLRQLS
Mvan_4147|M.vanbaalenii_PYR-1 VKTQLMRLSEELGPQADVSGTSISRFVDSAANAME-GNGEKLRETLRQLS
MMAR_4707|M.marinum_M VKDQLMRLATELGPNSKVSSPSISRFIDSAADALGNGNGDKLRQTLAELS
MAV_0951|M.avium_104 VKTQLMRLATDLGPKSGVSGTSVGRFIDSAANALD-GNGDKLRQTLAQLS
MLBr_02592|M.leprae_Br4923 LRDSITKIISKLGPTKEQPKGPFGDVIESFADGLA-GKGKQINATLDSLS
:: : :: .*.* ... :: * : *:* .:. :: .*:
Mb3526c|M.bovis_AF2122/97 QVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVLAD
Rv3496c|M.tuberculosis_H37Rv QVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVLAD
MUL_4059|M.ulcerans_Agy99 QVAGRLGDSRNDIFSTVKNLQVLVDALSQSNEQIVQFAGHVASVSQVLAD
MAB_4150c|M.abscessus_ATCC_199 QAAGRLGDSRTDLFGTIKNLQTLVDALANSNEQIVQFSTHLASVSKVLAA
MSMEG_4787|M.smegmatis_MC2_155 GVARILAEGSGNIVDIIKNLQTFVTALRDSNQQVVAFQNRLATLTSVVDG
TH_4516|M.thermoresistible__bu GVARVLAEGSGNVVDIIRNLQTFVTTLRDSNEQVMVFQNRLATLTSVING
Mflv_2511|M.gilvum_PYR-GCK GAARIFAEGSGNIVDIIKNLQIFVTALRDSKDQIVLFQNRLATLTSVVND
Mvan_4147|M.vanbaalenii_PYR-1 GVARIFAEGSGNIVDIIKNLQVFVSALRDSKDQIVLFQNRLATLTSVVND
MMAR_4707|M.marinum_M GVGRILANGSGNIVDIIKNLQTFIGALRDSNVQIVQFNDRLASLTSVLDD
MAV_0951|M.avium_104 GVGRILANGSGNIVDIIKNLQTFVGALRDSNVQIVQFNDRLATLTSVVND
MLBr_02592|M.leprae_Br4923 RALTALNEGRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLAH
. : :. :.. ::.* :: :* .. *.: : .:* .: :
Mb3526c|M.bovis_AF2122/97 SSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQTLSDQS--
Rv3496c|M.tuberculosis_H37Rv SSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQTLSDQS--
MUL_4059|M.ulcerans_Agy99 SSRNLDNTLGTLNQALSDIKGFLRENNSTLIETVNQLGDLTQTLSDQS--
MAB_4150c|M.abscessus_ATCC_199 STENLGATLGALNQALTDVRGFLGDTNSALIDQVNKLSDFVKIFSDQS--
MSMEG_4787|M.smegmatis_MC2_155 SRSDLDAALKNLSVAVGEVQRFVAGSRNQTSEQIQRLADVTSNLVDQR--
TH_4516|M.thermoresistible__bu SRTDLDAALQNLSVAVGEVQRFVAGSRDQTSEQLERLANVTRNLLDNK--
Mflv_2511|M.gilvum_PYR-GCK SRSDLDAALTDLSFAIGEVQRFVVGSRDATVEQIRSLGQVTQVLADNR--
Mvan_4147|M.vanbaalenii_PYR-1 SRSDLDAALTDLSFAINEVQRFVAGSRDQTAEQIRSLGQVTQVLVDNR--
MMAR_4707|M.marinum_M NKSDLDAALTDLSSAVGEVQRFIAGSRDATAEQITRLADLTQILVDNK--
MAV_0951|M.avium_104 SKSDLDAALTDLSTAVGEVQRFIAGTRNQTSEQIARLADVTQILVDHH--
MLBr_02592|M.leprae_Br4923 SDTDLSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPEPL
. :*. :* :. : :: *: ... : * . . :
Mb3526c|M.bovis_AF2122/97 ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICG----
Rv3496c|M.tuberculosis_H37Rv ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICG----
MUL_4059|M.ulcerans_Agy99 DNIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICG----
MAB_4150c|M.abscessus_ATCC_199 DDLEQILHVAPNGLANFYNIYNPAAGTLNGMLSIPNLANPVQFICG----
MSMEG_4787|M.smegmatis_MC2_155 LQVENLLHIAPNAFVNGYNIYNPDSGSPVGQFVFHNMSEPLHF-------
TH_4516|M.thermoresistible__bu LEIENVLHIAPNALANAYNIYNPDTGSPVGQFVLNNFSDPVQF-------
Mflv_2511|M.gilvum_PYR-GCK LALENVLHITPNAIANFENIYYPNGGSVTGAFSLSNFSNPVWF-------
Mvan_4147|M.vanbaalenii_PYR-1 LALENVLHITPNAIANFENIYYPNGGSVTGAFSVSNFSNPVWF-------
MMAR_4707|M.marinum_M MALKNVLHVTPNALANAYNDYDPDVGNVRGGVGIQNLTNPVFS-------
MAV_0951|M.avium_104 MDLENILHVAPNALGNFFNDYNADTGTIVGGFGIMNFANPTFSGLMVPLP
MLBr_02592|M.leprae_Br4923 NGVETFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQF-------
:: .**:: . * : * . *. * . *:::*
Mb3526c|M.bovis_AF2122/97 -GSFDTAAGPSAPDYYRRAEICRERLGPVLRRLT------VNYPPIMFHP
Rv3496c|M.tuberculosis_H37Rv -GSFDTAAGPSAPDYYRRAEICRERLGPVLRRLT------VNYPPIMFHP
MUL_4059|M.ulcerans_Agy99 -GSFDTAAGKSAPDYYRRAELCRERLGPVLRRLT------ANYPPFLFHP
MAB_4150c|M.abscessus_ATCC_199 -GVFETGT---KTEYLKRAEICRERMGPVLRRAT------FNYAPILLHP
MSMEG_4787|M.smegmatis_MC2_155 --ICGAIGAVENVTAPETAKLCAQYLGPALRLLN------FNNVPFPVSP
TH_4516|M.thermoresistible__bu --ICGAIGAIENTTAPETAKLCAQYLGPGLRLLN------FNYLPIGIDP
Mflv_2511|M.gilvum_PYR-GCK --VCGLIGGIANTTAPETAKLCSQYLGPALRLVN------FGNLPFPINP
Mvan_4147|M.vanbaalenii_PYR-1 --VCGLIGGVANTTAPETAKLCAQYLGPALRSIP------IHNLPFPINA
MMAR_4707|M.marinum_M --ICSQLGAMENVTSVESGKLCGLYLSPALKVFNPLMYFNFNYFPIPINP
MAV_0951|M.avium_104 VPGCTAVGAIENITAVESGKLCSLFLGPGLRVLN------FNNLPIPINI
MLBr_02592|M.leprae_Br4923 --ICSAIQAGSRLGYQESAELCAQYLSPVLDAIK------FNYFPFGLNL
. .::* :.* * *: .
Mb3526c|M.bovis_AF2122/97 LNTITAYKGQIIYDTPATEAKSETPVPELTWVPAGGG--APVGNPADLQS
Rv3496c|M.tuberculosis_H37Rv LNTITAYKGQIIYDTPATEAKSETPVPELTWVPAGGG--APVGNPADLQS
MUL_4059|M.ulcerans_Agy99 LNTITAYKGQIIYDTPATQAKAETPVPELTWIPAHPAPQPAPGNTTDLQS
MAB_4150c|M.abscessus_ATCC_199 INQISAYKGQIIYDTPETEAKSQAPREDLVWVRPNGAPPPPKPSPQDLSA
MSMEG_4787|M.smegmatis_MC2_155 YLMPSANPENLIYSEPNLAPGAGGGSPQPPETPPVLSAYNPG-PPPPPPF
TH_4516|M.thermoresistible__bu FLMPSAKPENIIYSEPRLAPGGGANLEFEPELPPTVSAYEGV-PPGPPPF
Mflv_2511|M.gilvum_PYR-GCK YLRPAISPDRLIYTDPKLAPG-GAGPGDPPEIPPTVSAYTGAGDIPPPPG
Mvan_4147|M.vanbaalenii_PYR-1 YLRPAVSPERTIYTDPKLAPG-GAGPGDPPEMPPTVSAYTGAGDIPPPPG
MMAR_4707|M.marinum_M ILAPAFDLQNVVYTEQRLAPGGEGPKPIAPELPPAVSAYTGL----PGDT
MAV_0951|M.avium_104 FLQKSVDPSKILYSEPRLAPGGEGPKPGPPEIPPAVSAYTGL----PGD-
MLBr_02592|M.leprae_Br4923 FSTAEVLPKEVAYSEARLQPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIV
. * .
Mb3526c|M.bovis_AF2122/97 LLV----------------PPAPG--------------------------
Rv3496c|M.tuberculosis_H37Rv LLV----------------PPAPG--------------------------
MUL_4059|M.ulcerans_Agy99 LFV----------------PQAPGPTPGSPPGYGP-----APG-------
MAB_4150c|M.abscessus_ATCC_199 LMLGPD---------EVNAPPPPGTEVRPAE-------------------
MSMEG_4787|M.smegmatis_MC2_155 TGRPPG----------TPPPGAAQLLPGAPPIV-------PPNVP-----
TH_4516|M.thermoresistible__bu TGRPPG----------TPPPGAQQMLPGAPPVV-------PPNVR-----
Mflv_2511|M.gilvum_PYR-GCK WGAPPGPRGIYQPDPDAPATPSPALYPGAPIPG-------PPNILSNIPP
Mvan_4147|M.vanbaalenii_PYR-1 WGAPPGPRGIYQPDPDAPATPSPALYPGAPIPG-------PPNILSNIP-
MMAR_4707|M.marinum_M PEAPPP-------------PPPPARIPGAAMPE-------PPPPS-----
MAV_0951|M.avium_104 PVGPPG-------------AEPPARIPGAAMPL-------PPPPS-----
MLBr_02592|M.leprae_Br4923 APGMQGQQVGPITAALMTPDSLAELMGGPDIEPIQSNLQTPPGPPTAYDE
Mb3526c|M.bovis_AF2122/97 ---------------------PAPAPPAPGAG----------PGEHGGGG
Rv3496c|M.tuberculosis_H37Rv ---------------------PAPAPPAPGAG----------PGEHGGGG
MUL_4059|M.ulcerans_Agy99 -------------------PPPAPAPAGPDAGLSSPAPGAPLPAEQGAGG
MAB_4150c|M.abscessus_ATCC_199 ---------------------PGPVPPGFPVTADDAPP----PAIPGAPR
MSMEG_4787|M.smegmatis_MC2_155 --------SSVRDMLAPAGPPPGPVPETGPAPGPLPAEAPLEPAEGTPPA
TH_4516|M.thermoresistible__bu --------STLQGMLNPAGTPHGPAPD-GP---PLPAEAP-APAEGTPPA
Mflv_2511|M.gilvum_PYR-GCK APAAGPAPTTVDGLLLPP-----GAP---AAP-PVAPNAPLLPAEGTPPS
Mvan_4147|M.vanbaalenii_PYR-1 ---AQPQPQTVDGLLLPPQGNPGGSPPPAPAP-AVAPTGPLLPAEGMPPA
MMAR_4707|M.marinum_M ------------------------VPAEPSPPP-ANLSDMLLPAEGPQP-
MAV_0951|M.avium_104 ------------------------TPMPPPPPPEPGVSGMLLPAQGPQQ-
MLBr_02592|M.leprae_Br4923 HPVPPPIGLQASVPIPSPRPDVVPGPVAPTPSPAANVGDPPLPAELGAGQ
* *.