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VRPWIVWATGLLAYIVAVLDRTTLGVSGLAAADRFGAGPSLLSTFVVLQVVVYAGAQVPAGLLLDRYGSR ALIASGAALMASGQLGLAFTESLPAAIAARAVVGLGDAVTFISVLRLVPHWFAPRQIPVVTQLTGICGQL GQVLSAIPFLALLSASGWSVAYASAAALGVLSIVLTLAIVRNTPDGSAATSETMSVRETLTSVKTVWLRP GTRLGFFTHMGTQFSITVFALMWGLPYLTEAQGLSAGVAGALLSLSVVSAIGCGVLIGILTGRYPHRRSR MVLAIITSNAVVWTVVLALPGPAPLWLLIVLIVVISVGGPGSMVGFDFARTFNPRATLGTAQGMVNMGGF IASLLLMQAMGMVMQAMGGISFESFRSAWMVQYVVWALAVVGILITRRKARRLLRDGNDRILLEGVNP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4127 | - | - | 100% (418) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_5021 | - | 2e-12 | 23.54% (463) | EmrB/QacA family drug resistance transporter |
| M. vanbaalenii PYR-1 | Mvan_1951 | - | 5e-11 | 25.14% (362) | major facilitator superfamily transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1282 | - | 7e-09 | 21.31% (183) | drug-transport integral membrane protein |
| M. gilvum PYR-GCK | Mflv_2530 | - | 0.0 | 82.93% (416) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv1250 | - | 7e-09 | 21.31% (183) | drug-transport integral membrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1396 | - | 1e-11 | 26.23% (183) | EmrB/QacA family drug resistance transporter |
| M. marinum M | MMAR_5094 | - | 5e-11 | 24.32% (370) | integral membrane transport protein |
| M. avium 104 | MAV_0729 | - | 2e-08 | 23.28% (189) | EmrB efflux protein |
| M. smegmatis MC2 155 | MSMEG_4767 | - | 0.0 | 75.90% (415) | major facilitator superfamily protein permease |
| M. thermoresistible (build 8) | TH_0390 | - | 0.0 | 77.27% (418) | major facilitator superfamily protein permease |
| M. ulcerans Agy99 | MUL_4170 | - | 2e-11 | 24.32% (370) | integral membrane transport protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4127|M.vanbaalenii_PYR-1 ------------------------------------MRPWIVWATGLLAY
Mflv_2530|M.gilvum_PYR-GCK ------MAHAQGRAPPWVGCFSRTLRQIRPMGRCLRVRPWIVWATGVLAY
MSMEG_4767|M.smegmatis_MC2_155 -----------------------------------MVRPWIVWTTGLLAY
TH_0390|M.thermoresistible__bu -----------------MNPGRRARTAAGDDDERLAVRPWIVWATGLLAY
Mb1282|M.bovis_AF2122/97 ----------------------MTTAIRRAAGSSYFRNPWPALWAMMVGF
Rv1250|M.tuberculosis_H37Rv ----------------------MTTAIRRAAGSSYFRNPWPALWAMMVGF
MAB_1396|M.abscessus_ATCC_1997 ------------------------------MRPEYPR-PWITLWVVLFGL
MMAR_5094|M.marinum_M ------------MRPFRGAVPDEVSGIRVSMNRGNVR-PKLVLGVIVLGS
MUL_4170|M.ulcerans_Agy99 ------------------------------MNRGNVR-PKLVLGVIVLGS
MAV_0729|M.avium_104 MLSGAMEKTRSAAFSVPLATASGPSLRDDEYPDKLDAALFRIAGVCGLAC
. ..
Mvan_4127|M.vanbaalenii_PYR-1 IVAVLDRTTLGVSGLAAADRFGAGPSLLSTFVVLQVVVYAGAQVPAGLLL
Mflv_2530|M.gilvum_PYR-GCK MVAVFDRTTLGVSGLAAAERFTAGPTLLSMFVVLQVVVYAAAQVPAGLLL
MSMEG_4767|M.smegmatis_MC2_155 IIAVLDRTTLGVSGLQAADRFSATPTVLSTFVVLQVVVYAGAQVPAGVLL
TH_0390|M.thermoresistible__bu IVAVLDRTTLGVSGLAAADRFNAAPAALSTFVVLQVIVYALAQVPAGLLL
Mb1282|M.bovis_AF2122/97 FMIMLDSTVVAIANPTIMAQLRIGYATVVWVTSAYLLAYAVPMLVAGRLG
Rv1250|M.tuberculosis_H37Rv FMIMLDSTVVAIANPTIMAQLRIGYATVVWVTSAYLLAYAVPMLVAGRLG
MAB_1396|M.abscessus_ATCC_1997 FMILLDSTIVSVANPAIKAGFGADYSSTVWVTSAYLLGYAVPLLITGRLG
MMAR_5094|M.marinum_M FIASIDLTIVNVALPTLSRALQASNAELQWIVDSYAIAAAGLLLAAGNLG
MUL_4170|M.ulcerans_Agy99 FIASIDLTIVNVALPTLSRALQASNAELQWIVDSYAIAAAGLLLAAGNLG
MAV_0729|M.avium_104 IMAVLDSTVVAVAQRTFIAQFGANQAIVSWTIAGYMLAFATVIPITGWAA
:: :* * : :: : : : * :*
Mvan_4127|M.vanbaalenii_PYR-1 DRYGSRALIASGAALMASGQLGLAFTESLPAAIAARAVVGLGDAVTFISV
Mflv_2530|M.gilvum_PYR-GCK DRYGSRALIVSGAALMASGQLVLAFTDSLPVAVAGRAVVGLGDAFTFISV
MSMEG_4767|M.smegmatis_MC2_155 DRFGSRVLIVCGAALMAGGQLVLAFSESLPAAIGARAIVGLGDAVTFISV
TH_0390|M.thermoresistible__bu DRFGSKALIVAGAAVMATGQLILAFTESLTLAILARAIVGLGDAVTFISV
Mb1282|M.bovis_AF2122/97 DRFGPKNLYLIGLGVFTVASLGCGLSSGAGMLIAARVVQGVGAGLLTPQT
Rv1250|M.tuberculosis_H37Rv DRFGPKNLYLIGLGVFTVASLGCGLSSGAGMLIAARVVQGVGAGLLTPQT
MAB_1396|M.abscessus_ATCC_1997 DQFGPRSMYLSGLAVFTAASLWCGLAGSIGWLIAARVVQGIGAAMLTPQT
MMAR_5094|M.marinum_M DRYGRRGWLTIGLVIVGASSAVAASAGSAQAVIGARAVMGVGAAIIFPTS
MUL_4170|M.ulcerans_Agy99 DRYGRRGWLTIGLVIVGASSAVAASAGSAQAVIGARAVMGVGAAIIFPTS
MAV_0729|M.avium_104 DRFGTKRLFMGSVLIFTLGSLLCAVAPNILLLILFRVVQGVGGGMLLPLS
*::* : . :. .. . : . : *.: *:* ..
Mvan_4127|M.vanbaalenii_PYR-1 LRLVPHWFAP-RQIPVVTQLTGICGQLGQVLSAIPFLALLSASGWSVAYA
Mflv_2530|M.gilvum_PYR-GCK LRLVPHWFAP-RQIPVVTQLTGIVGQLGQVLSAVPFLALLSAQGWSVAYA
MSMEG_4767|M.smegmatis_MC2_155 LRLVPHWFKP-SQVPLLTQLTGICGQLGQVLSAVPFLALLTAAGWTPAYL
TH_0390|M.thermoresistible__bu LRLVPHWFRP-RQVPLVTQLTGICGQLGQVLSAVLFLALLTARGWTPAYL
Mb1282|M.bovis_AF2122/97 LSTITRIFPA-HRRGVALGAWGTVASVASLVGPLAGGALVDSMGWEWIFF
Rv1250|M.tuberculosis_H37Rv LSTITRIFPA-HRRGVALGAWGTVASVASLVGPLAGGALVDSMGWEWIFF
MAB_1396|M.abscessus_ATCC_1997 LTVVQRVFPP-ERRGTAMGVWGAVAGIATLVGPVAGGLLVDGWGWQWIFY
MMAR_5094|M.marinum_M LALVTNVFVDSTHRARAIGVWSAVTGIAVVIGPILGGWLIEHFSVGSIFW
MUL_4170|M.ulcerans_Agy99 LALVTNVFVDSTHRARAIGVWSAVTGIAVVIGPILGGWLIEHFSVGSVFW
MAV_0729|M.avium_104 FVILTREAGP-KRVGRLMAVGGIPILLGPIGGPILGGWLIGAYGWKWIFL
: : . : . :. : ..: *: . :
Mvan_4127|M.vanbaalenii_PYR-1 SAAALGVLSIVLTLAIVRNTP-----------------------------
Mflv_2530|M.gilvum_PYR-GCK SAAAGGVLLIVVVLLLVRDTP-----------------------------
MSMEG_4767|M.smegmatis_MC2_155 SVGAFGLLVMALVLAVVKNTP-----------------------------
TH_0390|M.thermoresistible__bu SVVALGVLTIALTLALVQNTP-----------------------------
Mb1282|M.bovis_AF2122/97 VNVPVGVIGLILAAYLIPALP-HHPHRFDWFGVGLSGAGMFLIVFGLQQG
Rv1250|M.tuberculosis_H37Rv VNVPVGVIGLILAAYLIPALP-HHPHRFDWFGVGLSGAGMFLIVFGLQQG
MAB_1396|M.abscessus_ATCC_1997 VNVPVGVLGIILGAIYIPRMP-THRHRLDLLGMALSAVGMFAFVFALQEG
MMAR_5094|M.marinum_M VNVPIAVVAIVSVNIFVPTSRNPDRPPLDLPGLLVSTVGVTVLTYTLIEA
MUL_4170|M.ulcerans_Agy99 VNVPIAVVAIVSVNMFVPTSRNPDRPPLDLPGLLVSTVGVTVLTYTLIET
MAV_0729|M.avium_104 INLPIGLTAFALAALLFPKDRSAPSEALDITGALLLSPGVAIFLCGVCSI
. .: : .
Mvan_4127|M.vanbaalenii_PYR-1 ---DGSAATSETM--SVRETLTSVKTVWLRPGTR---LGFFTHMGTQFSI
Mflv_2530|M.gilvum_PYR-GCK ---QGSAASPETM--SVRQTLASVKTVWLRPGTR---LGFFTHMGTQFSI
MSMEG_4767|M.smegmatis_MC2_155 ---HGRVVATETT--SVRDIPGSVKTVWLRPGNR---LGFFTHMGTQFSV
TH_0390|M.thermoresistible__bu ---DGRAAPATMG--TVREIAASLKTVWLRAGTR---LGFFTHMGTQFSV
Mb1282|M.bovis_AF2122/97 QSANWQPWIWAVI--VGGIGFMSLFVYWQARNAREPLIPLEVFNDRNFSL
Rv1250|M.tuberculosis_H37Rv QSANWQPWIWAVI--VGGIGFMSLFVYWQARNAREPLIPLEVFNDRNFSL
MAB_1396|M.abscessus_ATCC_1997 ESFQWAPGVWAMM--AAGLVVLGVFVWWQSANRGEPLIPLRLFADRNFSL
MMAR_5094|M.marinum_M PNIGWASARTAAG--FALAVVLLAVFLWLERRTWHPILDLSIFANRRFSG
MUL_4170|M.ulcerans_Agy99 PNIGWASARTAAG--FALAVVLLAVFLWLERRTWHPILDLSIFANRRFSG
MAV_0729|M.avium_104 PGRHTVADRYVLVPALVGLVLIAAFILHAWYRTEHPLIDLRLFRNPVVTQ
: : . . .:
Mvan_4127|M.vanbaalenii_PYR-1 TVFALMWG-----------LPYLTEAQGLSAGVAGALLSLSVVSAIGCGV
Mflv_2530|M.gilvum_PYR-GCK TVFALMWG-----------LPYLTVAQGLSPGVAGALLSLSVVTGIGSGV
MSMEG_4767|M.smegmatis_MC2_155 TVFALMWG-----------VPYLTVAQGLSTAAAGALLTVSVVTAISAGV
TH_0390|M.thermoresistible__bu TVFALMWG-----------VPYLTVGQGLSTQMAGAMLTLSVAVAIVAGV
Mb1282|M.bovis_AF2122/97 SNLGIAIIAFAGTGMMLPVTFYAQAVCGLSPTHTAVLFAPTAIVGGVLAP
Rv1250|M.tuberculosis_H37Rv SNLRIAIIAFAGTGMMLPVTFYAQAVCGLSPTHTAVLFAPTAIVGGVLAP
MAB_1396|M.abscessus_ATCC_1997 AGVGIASMSFCVISTGLPMMFYTQLALGFSPTKAALTQAPTAIVSGILAP
MMAR_5094|M.marinum_M GTAAVTTAYLVMCGFIFVATQYLQFVAAYRAFDTGVRLVPLAFSYAGLSV
MUL_4170|M.ulcerans_Agy99 GTAAVTTAYLVMCGFIFVATQYLQFVAAYRAFDTGVRLVPLAFSYAGLSV
MAV_0729|M.avium_104 VNVTLLVFAAASVGVGLLVPSYFQIVGHETPMQSGLHMLPIGVGAVLTMP
: * . :.
Mvan_4127|M.vanbaalenii_PYR-1 LIGILTGRYPHRRSRMVLAIITSNAVVWTVVLALPGPAPLWLLIVLIVVI
Mflv_2530|M.gilvum_PYR-GCK LIGVVTGRYPHRRSWIVLGIIASNALMWTIVLALSGPAPLWVLVVLVAVI
MSMEG_4767|M.smegmatis_MC2_155 AIGIFTGRHPHRRSRLVLWIIASNASIWTIVLALPGPAPTWLLVVLIVII
TH_0390|M.thermoresistible__bu LIGIFTGRHPHRRSRLVLAIIASNAAAWTAVLALPDRAPLWLLITLIVVI
Mb1282|M.bovis_AF2122/97 FVGMIIDRSHPLCVLGFGFSVLAIAMTWLLCEMAPG-TPIWRLVLPFIAL
Rv1250|M.tuberculosis_H37Rv FVGMIIDRSHPLCVLGFGFSVLAIAMTWLLCEMAPG-TPIWRLVLPFIAL
MAB_1396|M.abscessus_ATCC_1997 LAGWLVDRVRPSILIGGGIALMIASTLWWTLLMRPE-TQMWQLMLPAAGI
MMAR_5094|M.marinum_M IAPRIVERVGTTAVVTSGLVMVAVSVACAG-GFDAG-TPYWLIAAVMAAL
MUL_4170|M.ulcerans_Agy99 IAPRIVERVGTTAVVTSGLVMVAVSVACAG-GFDAG-TPYWLIAAVMAAL
MAV_0729|M.avium_104 LGGAVMDKHGPGKIVLTGLPLMAVGLAVFTYGVARQAAYSPVLVCGLAIM
. : : . : : :
Mvan_4127|M.vanbaalenii_PYR-1 SVGGPGSMVGFDFART--------------FNPRATLGTAQGMVNMGGFI
Mflv_2530|M.gilvum_PYR-GCK SVGGPGSMVGFDFART--------------FNTGATLGTAQGMVNMGGFL
MSMEG_4767|M.smegmatis_MC2_155 SVGGPGSMVGFDFART--------------FNPSATLGTAQGMVNMGGFL
TH_0390|M.thermoresistible__bu SVGGPGSMVGFDFART--------------FNPSATLGTAQGMVNMGGFL
Mb1282|M.bovis_AF2122/97 GVAGAFVWSPLTVTATRNLRPHLAGASSGVFNAVRQLGAVLGSASMAAFM
Rv1250|M.tuberculosis_H37Rv GVAGAFVWSPLTVTATRNLRPHLAGASSGVFNAVRQLGAVLGSASMAAFM
MAB_1396|M.abscessus_ATCC_1997 GAAMACIWGPLATTATRNLPPSVAGAGSGVYNTLRQVGGVVGSSAMGALM
MMAR_5094|M.marinum_M GSGLGLTMAPASEAIMGSLSPTAAGVGSAVTGVARQLGACLGVAIVGSVF
MUL_4170|M.ulcerans_Agy99 GSGLGLTMAPASEAIMGSLSPTAAGVGSAVTGVARQLGACLGVAIVGSVF
MAV_0729|M.avium_104 GLGIGLTTTPLSAALMQALAPHQVARGTTLISVNQQVGGSIGAALMAVIL
. . : . :* * :. .:
Mvan_4127|M.vanbaalenii_PYR-1 ASLLLMQAMG------------MVMQAMGGISFESFRSAWMVQYVVWALA
Mflv_2530|M.gilvum_PYR-GCK ASLLLMQAMG------------MVMDASGGLTFESFRTAWTLQYAVWTLA
MSMEG_4767|M.smegmatis_MC2_155 ASLIVMQAMG------------VVLSHAGSYSFESFRLAWTVQYAIWILA
TH_0390|M.thermoresistible__bu ASLLVMQAMG------------QILDAAGGYSFDSFRLAWTVQYVVWVVA
Mb1282|M.bovis_AF2122/97 TSRIAAEMPGGVDALTGPAGQDATVLQLPEFVREPFAAAMSQSMLLPAFV
Rv1250|M.tuberculosis_H37Rv TSRIAAEMPGGVDALTGPAGQDATVLQLPEFVREPFAAAMSQSMLLPAFV
MAB_1396|M.abscessus_ATCC_1997 TARLTATMP----AMP-PGSGSTPEAALPPGLRAPFSAAMAQSMLLGIAA
MMAR_5094|M.marinum_M ASVYLRSMS-----SNAALHGLDPAARAAMRQSMAAAKQVLDQLPVGEAP
MUL_4170|M.ulcerans_Agy99 ASVYLRSMS-----SNAALHGLDPAARAAMRQSMAAAKQVLDQLPVGEAP
MAV_0729|M.avium_104 TNQFNRNPALMAANEAAGMHPVTGKRGLPVDPSTVPRPAMTPELAGHVSH
: .
Mvan_4127|M.vanbaalenii_PYR-1 VVGILITRRKARRLLRDGNDRILLEGVNP---------------------
Mflv_2530|M.gilvum_PYR-GCK VLGVLITRRKARRQLAE-DDRFLLEDIQT---------------------
MSMEG_4767|M.smegmatis_MC2_155 TIGILITRHKTRRLMAAEQERMLLEGFEAHPPR-----------------
TH_0390|M.thermoresistible__bu AVGILITRKKARRQMALEQERMLLESFEPGPRRHTGPDRTNRPHG-----
Mb1282|M.bovis_AF2122/97 ALFGIVAALFLVDFTGAAVAKEPLPESDGDADDDDYVEYILRREPEEDCD
Rv1250|M.tuberculosis_H37Rv ALFGIVAALFLVDFTGAAVAKEPLPESDGDADDDDYVEYILRREPEEDCD
MAB_1396|M.abscessus_ATCC_1997 LALGLVAALFMRP-GGSQVGAVPLDDVVSVED------------------
MMAR_5094|M.marinum_M AIRHAVESAFLESFGVGCLACAVFAAVGAVVV------------------
MUL_4170|M.ulcerans_Agy99 AIRHAVESAFLESFGVGCLACAVFAAVGAVVV------------------
MAV_0729|M.avium_104 HLSHAYTAVFVLAVVLVACTIIPASFLPRKPPSPPAGD------------
Mvan_4127|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2530|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4767|M.smegmatis_MC2_155 --------------------------------------------------
TH_0390|M.thermoresistible__bu --------------------------------------------------
Mb1282|M.bovis_AF2122/97 TQPLRASRPAAAAASRSGAGGPLAVSWSTSAQGMPPGPPGRRAWQADTES
Rv1250|M.tuberculosis_H37Rv TQPLRASRPAAAAASRSGAGGPLAVSWSTSAQGMPPGPPGRRAWQADTES
MAB_1396|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_5094|M.marinum_M ---------AFLLPARGEVRDDVAVSVAASAIGPAEGGK-----------
MUL_4170|M.ulcerans_Agy99 ---------AFLLPARGEVRDDVAVSVAASAIGPAEGGK-----------
MAV_0729|M.avium_104 --------------------------------------------------
Mvan_4127|M.vanbaalenii_PYR-1 ------
Mflv_2530|M.gilvum_PYR-GCK ------
MSMEG_4767|M.smegmatis_MC2_155 ------
TH_0390|M.thermoresistible__bu ------
Mb1282|M.bovis_AF2122/97 TAPSAL
Rv1250|M.tuberculosis_H37Rv TAPSAL
MAB_1396|M.abscessus_ATCC_1997 ------
MMAR_5094|M.marinum_M ------
MUL_4170|M.ulcerans_Agy99 ------
MAV_0729|M.avium_104 ------