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MSKVRHRIGSAACGVAALGMAITVGGVAATQPASISASPVDLTALIVVGSSTHPDPTGNEDFFGGKFNQA PYNPGGQPGPDLIGLDFRGGAAAIEQALQENSGEDNAVLSSGWGAANASLVLNRLDRAGDPALPKSLFIL DNNVSRPDGGFGTRYPLFALIGVNPFPSPTDTAARAVVDIAYQYNYNSNAPADLLNLVAHVNSLVAYLYG YREQSEIDLPVDVDGRPTVSCGGANTCAVLAGGVDALPCDDARCAIPSGERVLAYVTTRGNTTYVTYTTD ELPLTRLIRAVLGDTVADASAPLLKLIVDSAYYDGNPISSDPSRYRPARLMPSLGELIDTASKVPGAIRE GLETLSDNDSRQSSEPARETVTAQTVEEAGHRDDDPAAPGEDDDDATEVVQDDDEAAEVGQDDGAVDADP AVDESAGAEDSVGNDDAVAAADPEGGLTTDAADGSGEESSE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4081 | - | - | 100% (461) | hypothetical protein Mvan_4081 |
| M. vanbaalenii PYR-1 | Mvan_2068 | - | 3e-16 | 26.26% (377) | hypothetical protein Mvan_2068 |
| M. vanbaalenii PYR-1 | Mvan_4815 | - | 1e-14 | 25.43% (409) | hypothetical protein Mvan_4815 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0165c | PE4 | 9e-10 | 24.75% (303) | PE family protein |
| M. gilvum PYR-GCK | Mflv_3374 | - | 1e-15 | 24.79% (472) | hypothetical protein Mflv_3374 |
| M. tuberculosis H37Rv | Rv0160c | PE4 | 3e-10 | 25.08% (303) | PE family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0384 | - | 3e-11 | 25.21% (361) | PE family protein, PE4 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_1176 | - | 2e-43 | 33.50% (400) | hypothetical protein MSMEG_1176 |
| M. thermoresistible (build 8) | TH_4255 | - | 1e-58 | 41.47% (340) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_1034 | - | 2e-11 | 25.21% (361) | PE family protein |
CLUSTAL 2.0.9 multiple sequence alignment
TH_4255|M.thermoresistible__bu -----------------------------------------VSSRQ--VL
Mvan_4081|M.vanbaalenii_PYR-1 ------------MSKVRHRIGSAACGVAALGMAITVGGVAATQPAS--IS
Mb0165c|M.bovis_AF2122/97 ---------MSHLVTAPDMLATAAAHVDEIASTLRAANAAAAGPTCNLLA
Rv0160c|M.tuberculosis_H37Rv ---------MSHLVTAPDMLATAAAHVDEIASTLRAANAAAAGPTCNLLA
MMAR_0384|M.marinum_M ---------MSYVLTAPDLLASAATDVDGIAATLQVANSAAAAPTSGLLA
MUL_1034|M.ulcerans_Agy99 ---------MSYVLTAPDLLASAATDVDGIAATLQVANSAAAALTSGLLA
MSMEG_1176|M.smegmatis_MC2_155 MSGITQNVREATMAIRDFRRACVPALVGGVALTTALGVGAVATAPAPAHV
Mflv_3374|M.gilvum_PYR-GCK -----------MAKGHNAGKRTRRRRATGIAAAVAIPLLALPVGGASASA
TH_4255|M.thermoresistible__bu TEAIELSALIAVGSSTNPAGTGVVNFFQSRFN--------PPGTDVRTVN
Mvan_4081|M.vanbaalenii_PYR-1 ASPVDLTALIVVGSSTHPDPTGNEDFFGGKFNQAPYNPGGQPGPDLIGLD
Mb0165c|M.bovis_AF2122/97 AAGDEVSAATAALFSAYGREYQAVVKQAAAFHSEFTRTLEAAGNAYAHAE
Rv0160c|M.tuberculosis_H37Rv AAGDEVSAATAALFSAYGREYQAVVKQAAAFHSEFTRTLEAAGNAYAHAE
MMAR_0384|M.marinum_M AAQDEVSAAIAKVFSAYGQEYQAAIAQASAFHTEFTRALAAAGAAYAQAE
MUL_1034|M.ulcerans_Agy99 AAQDEVSAAIAKVFSAYGQEYQAAIAQASAFHTEFTRALAAAGAAYAQAE
MSMEG_1176|M.smegmatis_MC2_155 ASDVGLKALITHGSATNWNADGIDKFYGLDWN-EKYGPTVVSQFSLFPYN
Mflv_3374|M.gilvum_PYR-GCK ATTYEYFPTEPTRVLTLSLLPGGNNDDLNGVMCESPRTCRNVVYSRASTP
: . :
TH_4255|M.thermoresistible__bu FLTG---PLGIYAALVS-TDESD---VVLS---SGWGAANASALLSWFNH
Mvan_4081|M.vanbaalenii_PYR-1 FRGG---AAAIEQALQENSGEDN---AVLS---SGWGAANASLVLNRLDR
Mb0165c|M.bovis_AF2122/97 AANA----ARVSHALDTINAPIR---TLLGRTPLSPNGSSGAGGLPAIAQ
Rv0160c|M.tuberculosis_H37Rv AANA----ARVSHALDTINAPIR---TLLGRAPLSPNGSSGAGGLPAIAQ
MMAR_0384|M.marinum_M AANASLITAGVSDALTAITTPIQ---SLLGPAAIGTGGAGSAGALTAVSS
MUL_1034|M.ulcerans_Agy99 AANASLITAGVSDALTAITTPIQ---SLLGPAAIGTGGAGSAGALTAVSS
MSMEG_1176|M.smegmatis_MC2_155 VNPD-----NLKAALRNNVGDPEPDLVLTSGRGSGAATVTMLLLLNSGRP
Mflv_3374|M.gilvum_PYR-GCK EAVG-----TLDAVLRDGTDGKQ-----IVFAYSQGARVSAAWIREHGGT
: .*
TH_4255|M.thermoresistible__bu TDPAALAGNLWVLDNNVARPNGGWGTRY------PVFALIGVNPIPTP-E
Mvan_4081|M.vanbaalenii_PYR-1 AGDPALPKSLFILDNNVSRPDGGFGTRY------PLFALIGVNPFPSPTD
Mb0165c|M.bovis_AF2122/97 LAAESPITALIMGGTNNPLPDPEYVTDINKAFIQTLFPGAVSQGLFTPEQ
Rv0160c|M.tuberculosis_H37Rv LAAESPITALIMGGTNNPLPDPEYVTDINKAFIQTLFPGAVSQGLFTPEQ
MMAR_0384|M.marinum_M TLMADPVVALIMGGTSVPLPGPGYVSDINNNYIQPLFSGAIPQALFTPEQ
MUL_1034|M.ulcerans_Agy99 TLMADPVVALIMGGTSVPLPGPGYVSDINNNYIQPLFSGAIPQALFTPEQ
MSMEG_1176|M.smegmatis_MC2_155 EDRELVLNTRWILDNSVNRPNGGYGSRY------IPFSILGVYPWPTP-T
Mflv_3374|M.gilvum_PYR-GCK EGVPTAENLTFVLMGNPAR----------------KYSGSDKVRGPDVFP
: . :.
TH_4255|M.thermoresistible__bu IDGVQVIDIGYQYDANSNAPAYFLNPIADLNSLVAYAQRRLHQSELYLPV
Mvan_4081|M.vanbaalenii_PYR-1 TAARAVVDIAYQYNYNSNAPADLLNLVAHVNSLVAYLYGYREQSEIDLPV
Mb0165c|M.bovis_AF2122/97 FWPVTPDLGNLTFNQSVTEGVALLNTTVNNQLALDNKVVAFGYSQSATII
Rv0160c|M.tuberculosis_H37Rv FWPVTPDLGNLTFNQSVTEGVALLNTAVNNQLALDNKVVAFGYSQSATII
MMAR_0384|M.marinum_M FWPVTPGLGNLTFNQSVAQGVTLLNDAINTQLALGNKVVAFGYSQSATIV
MUL_1034|M.ulcerans_Agy99 FWPVTPGLGNLTFNQSVAQGVTLLNDAINTQLALGNKVVAFGYSQSATIV
MSMEG_1176|M.smegmatis_MC2_155 DEGVDIVDVGYEYAWNSSAPAYVTNVVALLNSIIAYAYRYKSQAFTGLPV
Mflv_3374|M.gilvum_PYR-GCK DLGYRIIDVSQEYDMASDFPDDPSNLLAMLNSTAGFFFTHQTYEPVDIYD
: * :
TH_4255|M.thermoresistible__bu QDDGTIVDATDTVVECPDTCRVVIGWEDD--------GTPQYAEIKKVGD
Mvan_4081|M.vanbaalenii_PYR-1 DVDGRPTVSCGGANTCAVLAGGVDALPCDDARCAIPSGERVLAYVTTRGN
Mb0165c|M.bovis_AF2122/97 NNYINSLMAMGS--PNPDDISFVMIGSGNNPVGGLLARFPGFYIPFLDVP
Rv0160c|M.tuberculosis_H37Rv NNYINSLMAMGS--PNPDDISFVMIGSGNNPVGGLLARFPGFYIPFLDVP
MMAR_0384|M.marinum_M NNEILALMAMGTGAPDPGDLSFIMVGAPNNPDGGLLARFPGFYIPFLDVS
MUL_1034|M.ulcerans_Agy99 NNEILALMAMGTGAPDPGDLSFIMVGAPNNPDGGLLARFPGFYIPFLDVS
MSMEG_1176|M.smegmatis_MC2_155 DPALG-IDPVTGEPKLEKGYHYIVEVDGT--------VTKEPLKSLGNTN
Mflv_3374|M.gilvum_PYR-GCK ----------------------------------------EANYVWTEGH
TH_4255|M.thermoresistible__bu TTYVTYLSNGLPLVQPLRLLG-PVGSTLADVLEPIATVLVNAGYPDNDPI
Mvan_4081|M.vanbaalenii_PYR-1 TTYVTYTTDELPLTRLIRAV---LGDTVADASAPLLKLIVDSAYYDGNPI
Mb0165c|M.bovis_AF2122/97 FNGATPANSPYPTHIYTAQYD-GIAHAPQFPLRILSDINAFMGYFYVHNT
Rv0160c|M.tuberculosis_H37Rv FNGATPANSPYPTHIYTAQYD-GIAHAPQFPLRILSDINAFMGYFYVHNT
MMAR_0384|M.marinum_M FNGATPAANPYPTSIFTAQYD-GIAHAPQYPLNILSDINAIMGYFYVHGN
MUL_1034|M.ulcerans_Agy99 FNGATPAANPYPTSIFTAQYD-GIAHAPQYRLNILSDINAIMGYFYVHGN
MSMEG_1176|M.smegmatis_MC2_155 TAYVTYRADGLPMLQPLRDFGGQFGNAVADLLQPALKVIVDASYPGGDPV
Mflv_3374|M.gilvum_PYR-GCK ITYVFVPTRNLPLLQPLRWFG---LGFVADALNAPLKEIVDRAYDRSYLP
. * . .*
TH_4255|M.thermoresistible__bu AN-PDRYVPGRFLPPPHVVVTALRQLPEAIQDGLTRLHRAGSGSTGPDPA
Mvan_4081|M.vanbaalenii_PYR-1 SSDPSRYRPARLMPSLGELIDTASKVPGAIREGLETLSDNDSRQS-SEPA
Mb0165c|M.bovis_AF2122/97 YPELMATQVDNAVPLPTSPGYTGNTQYYMFLTQDLPLLQPIRDIPYAGPP
Rv0160c|M.tuberculosis_H37Rv YPELMATQVDNAVPLPTSPGYTGNTQYYMFLTQDLPLLQPIRDIPYAGPP
MMAR_0384|M.marinum_M YPDLMS---GQAIQLPTSPGYTGNTDYYMYLTQDLPLVQPIRDIPYAGPP
MUL_1034|M.ulcerans_Agy99 YPDLMS---GQAIQLPTSPGYTGNTDYYMYLTQDLPLVQPIRDIPYAGPP
MSMEG_1176|M.smegmatis_MC2_155 AN-PDRYITASLFTPPDVAIKAIQTLPSAIHQGVEDFKKDLGLTKTKAPA
Mflv_3374|M.gilvum_PYR-GCK AQPGFPSTPDPEIEEPQEGSAISAATVQSAAARTTASGAASARAVEQAPV
. *
TH_4255|M.thermoresistible__bu PETGRTESTRFAE--APGAVIRTTGGSVAANGAERLAAAEPTPSVDD---
Mvan_4081|M.vanbaalenii_PYR-1 RET-------------------VTAQTVEEAGHRDDDPAAPGEDDDD---
Mb0165c|M.bovis_AF2122/97 IADLFQPQLRVLV--DLGYADYGPGGNYADIPTPAGLFSIPNPFAVTYYL
Rv0160c|M.tuberculosis_H37Rv IADLFQPQLRVLV--DLGYADYGPGGNYADIPTPAGLFSIPNPFAVTYYL
MMAR_0384|M.marinum_M LADLIQPQLRVLV--DLGYSDYGPGLSYADVPTPAGLLSVPNPFAVSYYL
MUL_1034|M.ulcerans_Agy99 LADLIQPQLRVLV--DLGYSDYGPGLSYADVPTPAGLLSVPNPFAVSYYL
MSMEG_1176|M.smegmatis_MC2_155 ADERQSEPKPVEEQSAPQRDDDTTEAPSAAVAVSSKLATESAATSVKSVA
Mflv_3374|M.gilvum_PYR-GCK DVD-------------------VVDDAGDEIADDDLGADLGADLGDDIGN
TH_4255|M.thermoresistible__bu RRPTRRVSPNFSTRVGSVSGSAEDPAVAEDSTSVPKTGDATPRRVRGVLQ
Mvan_4081|M.vanbaalenii_PYR-1 ATEVVQDDDEAAEVGQDDGAVDADPAVDESAGAEDSVGNDDAVAAADPEG
Mb0165c|M.bovis_AF2122/97 IKGSLQAPYGAIVEIGVEAGLIGPEWFPDSYPWVPSINPGLNFYFGQPQV
Rv0160c|M.tuberculosis_H37Rv IKGSLQAPYGAIVEIGVEAGLIGPEWFPDSYPWVPSINPGLNFYFGQPQV
MMAR_0384|M.marinum_M LKGSLQAPYGAAVEIGVEAGLLGPESFPDTYPWVPSLNPGLNFYLGQPSV
MUL_1034|M.ulcerans_Agy99 LKGSLQAPYGAAVEIGVEAGLLGPESFPDTYPWVPSLNPGLNFYLGQPSV
MSMEG_1176|M.smegmatis_MC2_155 DSGDVKDVKDVKAVEDTKKATDKRVRPRPLRKLVDRVTKALTPKATRPAK
Mflv_3374|M.gilvum_PYR-GCK DGTDVEVDVDVEVDVEKEPASDSDDATDAADAQGDTESPGSGADSGEGDS
. .
TH_4255|M.thermoresistible__bu RPTVGAHERPAGERRETGHTGTPGGADPTE
Mvan_4081|M.vanbaalenii_PYR-1 GLTTDAADGSGEESSE--------------
Mb0165c|M.bovis_AF2122/97 TLLSLMSGGLGNILHLIPPPVFT-------
Rv0160c|M.tuberculosis_H37Rv TLLSLMSGGLGNILHLIPPPVFT-------
MMAR_0384|M.marinum_M TLLSLLSGGLGDIFHLIPPPVFP-------
MUL_1034|M.ulcerans_Agy99 TLLSLLSGGLGDIFHLIPPPVFP-------
MSMEG_1176|M.smegmatis_MC2_155 TSKPSTGTESGGASTGQSDSGDAKSGDSES
Mflv_3374|M.gilvum_PYR-GCK DSGGGQARQSAKPGSSGSDE----------
.