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SHLVTAPDMLATAAAHVDEIASTLRAANAAAAGPTCNLLAAAGDEVSAATAALFSAYGREYQAVVKQAAA FHSEFTRTLEAAGNAYAHAEAANAARVSHALDTINAPIRTLLGRAPLSPNGSSGAGGLPAIAQLAAESPI TALIMGGTNNPLPDPEYVTDINKAFIQTLFPGAVSQGLFTPEQFWPVTPDLGNLTFNQSVTEGVALLNTA VNNQLALDNKVVAFGYSQSATIINNYINSLMAMGSPNPDDISFVMIGSGNNPVGGLLARFPGFYIPFLDV PFNGATPANSPYPTHIYTAQYDGIAHAPQFPLRILSDINAFMGYFYVHNTYPELMATQVDNAVPLPTSPG YTGNTQYYMFLTQDLPLLQPIRDIPYAGPPIADLFQPQLRVLVDLGYADYGPGGNYADIPTPAGLFSIPN PFAVTYYLIKGSLQAPYGAIVEIGVEAGLIGPEWFPDSYPWVPSINPGLNFYFGQPQVTLLSLMSGGLGN ILHLIPPPVFT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0160c | PE4 | - | 100% (502) | PE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv0159c | PE3 | e-143 | 53.49% (501) | PE family protein |
| M. tuberculosis H37Rv | Rv0151c | PE1 | 9e-91 | 41.44% (473) | PE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0165c | PE4 | 0.0 | 99.60% (502) | PE family protein |
| M. gilvum PYR-GCK | Mflv_1918 | - | 4e-32 | 30.79% (380) | hypothetical protein Mflv_1918 |
| M. leprae Br4923 | MLBr_01183 | - | 1e-10 | 37.93% (87) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4141 | - | 2e-24 | 33.05% (233) | PE/PPE family protein |
| M. marinum M | MMAR_0384 | - | 0.0 | 72.58% (507) | PE family protein, PE4 |
| M. avium 104 | MAV_1346 | - | 6e-17 | 39.39% (132) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_5455 | - | 9e-42 | 35.20% (321) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 8e-46 | 38.91% (311) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_1034 | - | 0.0 | 72.19% (507) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_4726 | - | 3e-36 | 31.44% (369) | hypothetical protein Mvan_4726 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1918|M.gilvum_PYR-GCK MGKGDFGLKASEFTGRSSTRFADSVRRRPGGATYGLYRHDGLGVGTWAWV
MSMEG_5455|M.smegmatis_MC2_155 MGRLLHSLSTAFLVFVAVVVLCVSTS------------------------
Rv0160c|M.tuberculosis_H37Rv ---------MS-HLVTAPDMLATAAA------------------------
Mb0165c|M.bovis_AF2122/97 ---------MS-HLVTAPDMLATAAA------------------------
MMAR_0384|M.marinum_M ---------MS-YVLTAPDLLASAAT------------------------
MUL_1034|M.ulcerans_Agy99 ---------MS-YVLTAPDLLASAAT------------------------
MLBr_01183|M.leprae_Br4923 ---------MPLFLNAEPQALTAAAN------------------------
MAV_1346|M.avium_104 ---------MS-FVTTRPEALLAVAS------------------------
TH_3724|M.thermoresistible__bu ------VVAVGALTWGGXGVASPAGQPE----------------------
Mvan_4726|M.vanbaalenii_PYR-1 MRRRLRSAAWGLLSLVIAVLFAWG--------------------------
MAB_4141|M.abscessus_ATCC_1997 -MAGQYSVPGKRHSLRRYVATITAVA------------------------
Mflv_1918|M.gilvum_PYR-GCK FARSSRSFPRSRRCWRYPRGVPTPVAVLVANTTALVMGGTFHPLTGPRDS
MSMEG_5455|M.smegmatis_MC2_155 --------------------MPTAAHLLLNHPHALVIGGTGTPVP----P
Rv0160c|M.tuberculosis_H37Rv --------------------HVDEIASTLRAANAAAAGPTCNLLAAAGDE
Mb0165c|M.bovis_AF2122/97 --------------------HVDEIASTLRAANAAAAGPTCNLLAAAGDE
MMAR_0384|M.marinum_M --------------------DVDGIAATLQVANSAAAAPTSGLLAAAQDE
MUL_1034|M.ulcerans_Agy99 --------------------DVDGIAATLQVANSAAAALTSGLLAAAQDE
MLBr_01183|M.leprae_Br4923 --------------------TLEGLSAATVASNAAAAQLTTEIAPPAADD
MAV_1346|M.avium_104 --------------------MLEGLGSSMDAQNAAAAAPTTSIAPAAADE
TH_3724|M.thermoresistible__bu --------------------RAAALRLTATADAIIMPGTKIGYIPSQDEF
Mvan_4726|M.vanbaalenii_PYR-1 ---------------------SVVTSTSAGAGTALVMGGNGHPLSVPQDT
MAB_4141|M.abscessus_ATCC_1997 --------------------ATCTVLAPLAMESRTIASTLASYVIGIGGN
Mflv_1918|M.gilvum_PYR-GCK PEFVTAYLDNAVDNQISAAYGYAVTN---AVAVYTPEEFFPLGG-LTFDD
MSMEG_5455|M.smegmatis_MC2_155 PEYVNGQTDNYIGAEFPGEYRYAVH---------TPQNFWPVYGSMSFDE
Rv0160c|M.tuberculosis_H37Rv VSAATAALFSAYGREYQAVVKQAAA----------------FHSEFTRTL
Mb0165c|M.bovis_AF2122/97 VSAATAALFSAYGREYQAVVKQAAA----------------FHSEFTRTL
MMAR_0384|M.marinum_M VSAAIAKVFSAYGQEYQAAIAQASA----------------FHTEFTRAL
MUL_1034|M.ulcerans_Agy99 VSAAIAKVFSAYGQEYQAAIAQASA----------------FHTEFTRAL
MLBr_01183|M.leprae_Br4923 VSILLAHFFSGHGRQYQAHASQGAT----------------NHQDLIQSL
MAV_1346|M.avium_104 VSALQAAQFSAYGTWYQQVSAQAKA----------------IHQTLVQNL
TH_3724|M.thermoresistible__bu TAYATAVIGATAGAPGAVDYLGVPG----------EFWPATGLDSLTFDA
Mvan_4726|M.vanbaalenii_PYR-1 PDYINKYVTAADDAFIAPSGLCGPQCSLVATYTPAQIRFVNGIFDMTYDE
MAB_4141|M.abscessus_ATCC_1997 NDGASANIPRKLGGAYSVDYHPVSYPG--------AIWPVSGLTAPTFKT
.
Mflv_1918|M.gilvum_PYR-GCK SVAEGLANLGRCLRAEPGCVFNADPAVAARVGTVAPRHDDTFVVFGYSQS
MSMEG_5455|M.smegmatis_MC2_155 STVAGLAALQAEMAKEG-------------------HFGSPLVILGYSSS
Rv0160c|M.tuberculosis_H37Rv EAAGNAYAHAEAANA----ARVSHALDTINAPIRTLLGRAPLSPNGSSGA
Mb0165c|M.bovis_AF2122/97 EAAGNAYAHAEAANA----ARVSHALDTINAPIRTLLGRTPLSPNGSSGA
MMAR_0384|M.marinum_M AAAGAAYAQAEAANASLITAGVSDALTAITTPIQSLLGPAAIGTGGAGSA
MUL_1034|M.ulcerans_Agy99 AAAGAAYAQAEAANASLITAGVSDALTAITTPIQSLLGPAAIGTGGAGSA
MLBr_01183|M.leprae_Br4923 LTSSSAYAGTETAN------------------------------------
MAV_1346|M.avium_104 DTNADSYGATEAANR-------------VNTSAAALQGLAPNVIPNAAPA
TH_3724|M.thermoresistible__bu SVAXGQAMLTPMVDG-------------------AIESDTPIVVFGHSQS
Mvan_4726|M.vanbaalenii_PYR-1 SVAVGQANLNDCIQGSD----CTATLAPYSETGPHTVADSTYVIYAYSQS
MAB_4141|M.abscessus_ATCC_1997 SVAQGRTNLNDEIVT---------------------AGNQPITIVGYSLG
.
Mflv_1918|M.gilvum_PYR-GCK AAVASLLKRQLIDAP--GPEPAATTFMLAANPMRPNGGVLGRFPALTIPI
MSMEG_5455|M.smegmatis_MC2_155 TRILTADKNRRIAD---GDYAVDINYVLVSDVAKGNGGVMARFPGWHIPI
Rv0160c|M.tuberculosis_H37Rv GGLPAIAQLAAESPI--TALIMGGTNNPLPDPEYVTDINKAFIQTLFPGA
Mb0165c|M.bovis_AF2122/97 GGLPAIAQLAAESPI--TALIMGGTNNPLPDPEYVTDINKAFIQTLFPGA
MMAR_0384|M.marinum_M GALTAVSSTLMADPV--VALIMGGTSVPLPGPGYVSDINNNYIQPLFSGA
MUL_1034|M.ulcerans_Agy99 GALTAVSSTLMADPV--VALIMGGTSVPLPGPGYVSDINNNYIQPLFSGA
MLBr_01183|M.leprae_Br4923 -------HDSL---------------------------------------
MAV_1346|M.avium_104 ADPPPAGTTSLGT-------------------------SIGWAQNVGAAA
TH_3724|M.thermoresistible__bu AVIATKEKQRLLAEYPDPDTAPDVTFVMVANPNRPNGGLLARFPGLYIPI
Mvan_4726|M.vanbaalenii_PYR-1 ATVAANQKLQLIAHP----VASTVSFLLVANPNRPDGGILERFVGAYIPL
MAB_4141|M.abscessus_ATCC_1997 AVVVSKSHSDLLQRYP--GGNPNIQFVLMGSANTPNGGIFARFPWLKIPL
Mflv_1918|M.gilvum_PYR-GCK LGITFHGATPTAGVDG-AYRTVDVVRQYDGLGGDFPVRPLNLLATVNALL
MSMEG_5455|M.smegmatis_MC2_155 LGVTFDGATRTDSDGY-AFDTKSISFVHDGWS-DFPVYPLNVLALANAVA
Rv0160c|M.tuberculosis_H37Rv VSQGLFTPEQFWPVTP-DLGNLTFNQSVTEGVALLNTAVNNQLALDNKVV
Mb0165c|M.bovis_AF2122/97 VSQGLFTPEQFWPVTP-DLGNLTFNQSVTEGVALLNTTVNNQLALDNKVV
MMAR_0384|M.marinum_M IPQALFTPEQFWPVTP-GLGNLTFNQSVAQGVTLLNDAINTQLALGNKVV
MUL_1034|M.ulcerans_Agy99 IPQALFTPEQFWPVTP-GLGNLTFNQSVAQGVTLLNDAINTQLALGNKVV
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 SDFITLGEGQFAPVPG-AAGIPNFNPGLTAATTAGPPAPAAPAAAAGAPV
TH_3724|M.thermoresistible__bu LGVTFNGATP-APADG-PFDSYDVAREFDGWA-DFPRYPLNLVATANAIL
Mvan_4726|M.vanbaalenii_PYR-1 LGITFNGSTPTFSPQPRPLTTVDVARQYDGWA-DFPTNPLNLLADLNAIM
MAB_4141|M.abscessus_ATCC_1997 ADIESNGAWE-----PDQFKTKVINTEYDTYG-DFPAY-FNPLALANSIA
Mflv_1918|M.gilvum_PYR-GCK GYGIMH-GETVDVPF--------AQARFQGREGDTDYYLIGTDLLPLLQP
MSMEG_5455|M.smegmatis_MC2_155 GIAVLH-PTYPELDR--------PDLVPVGSTGDTEYFVIGTDIMPLLMP
Rv0160c|M.tuberculosis_H37Rv AFGYSQ-SATIINNY--------INSLMAMGS--PNPDDISFVMIGSGNN
Mb0165c|M.bovis_AF2122/97 AFGYSQ-SATIINNY--------INSLMAMGS--PNPDDISFVMIGSGNN
MMAR_0384|M.marinum_M AFGYSQ-SATIVNNE--------ILALMAMGTGAPDPGDLSFIMVGAPNN
MUL_1034|M.ulcerans_Agy99 AFGYSQ-SATIVNNE--------ILALMAMGTGAPDPGDLSFIMVGAPNN
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 LASMGR-GPSIGGLS--------VPPSWAPGGVAPAANATPAQLVG----
TH_3724|M.thermoresistible__bu GIYYLH-GGYYELLTENPDILDDPERTIVQQYGDTTYYLIRTEQLPLLRP
Mvan_4726|M.vanbaalenii_PYR-1 GTILLH-PNYSDAGT----------PQLQGQYQDSTYYLIPAPITPVLVP
MAB_4141|M.abscessus_ATCC_1997 AIQYAHPDAYYDRIDPAALDDPDNPNVVKTVQGNTTYYLVRAEHLPLLQP
Mflv_1918|M.gilvum_PYR-GCK LLLF-VP---RPILSALDAPLRVLVEDAYDRDAGPGDPTTARWWPVKDFA
MSMEG_5455|M.smegmatis_MC2_155 LETIGVP---RPILLAVDEPLRVLVEAGYRRDIAPGAPTPARLIPIVNPI
Rv0160c|M.tuberculosis_H37Rv PVGGLLA---RFPGFYIPFLDVPFNGATPANSPYPTHIYTAQYDGIAHAP
Mb0165c|M.bovis_AF2122/97 PVGGLLA---RFPGFYIPFLDVPFNGATPANSPYPTHIYTAQYDGIAHAP
MMAR_0384|M.marinum_M PDGGLLA---RFPGFYIPFLDVSFNGATPAANPYPTSIFTAQYDGIAHAP
MUL_1034|M.ulcerans_Agy99 PDGGLLA---RFPGFYIPFLDVSFNGATPAANPYPTSIFTAQYDGIAHAP
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 ------------AGFTSAAPDTAPVTAVPGGVPSMATAGRGGYG--LGAP
TH_3724|M.thermoresistible__bu LRDLGVP---EEFVDALEPYVRRIVDLGYDRNTPYGEPAPVRVLPPLTPA
Mvan_4726|M.vanbaalenii_PYR-1 LTWVPIVG--KPLAIALDPAVRVLVEMGYDRTVNPGQPTPARYLYVPNLI
MAB_4141|M.abscessus_ATCC_1997 LRDLTNPIGASFVLDAIEPTLRVFIDMAYDRDTGPGTTTQFSFFTPSKNI
Mflv_1918|M.gilvum_PYR-GCK GTAAKLIASVPV----AVDNLTEGFGLGRVLGTPVPGVFGVGG-------
MSMEG_5455|M.smegmatis_MC2_155 TLTRNFIAAIPV----GVDDAMEELGHGRPLGTQPSGVFGVGGEDTELKG
Rv0160c|M.tuberculosis_H37Rv QFPLRILSDINA----FMGYFYVHNTYPELMATQVDNAVPLPTSPGYTGN
Mb0165c|M.bovis_AF2122/97 QFPLRILSDINA----FMGYFYVHNTYPELMATQVDNAVPLPTSPGYTGN
MMAR_0384|M.marinum_M QYPLNILSDINA----IMGYFYVHGNYPDLMS---GQAIQLPTSPGYTGN
MUL_1034|M.ulcerans_Agy99 QYRLNILSDINA----IMGYFYVHGNYPDLMS---GQAIQLPTSPGYTGN
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 RYGVKPTVMPKP----AI--------------------------------
TH_3724|M.thermoresistible__bu PGPATQHNAG----------------------------------------
Mvan_4726|M.vanbaalenii_PYR-1 KAALNFAMAIPTGWDDAISYLTGDPDCRPFHTTVPASPFGVGGPPVYTGA
MAB_4141|M.abscessus_ATCC_1997 VDAFNKLPTAIAEGAHNVENGLAGATPKQSASPEKPASPPVPQPGPTNPG
Mflv_1918|M.gilvum_PYR-GCK ----------PDLPDVDEGGAVTSDIDEDAVAQRDSASSTERSAPAEESR
MSMEG_5455|M.smegmatis_MC2_155 LPAGVISLAKPTLPVSSHTTVVEKTERKDLAKPAAEPEPVVEDEPAVEDE
Rv0160c|M.tuberculosis_H37Rv TQYYMFLTQDLPLLQPIRDIPYAGPPIADLFQPQLRVLVDLGYADYGPGG
Mb0165c|M.bovis_AF2122/97 TQYYMFLTQDLPLLQPIRDIPYAGPPIADLFQPQLRVLVDLGYADYGPGG
MMAR_0384|M.marinum_M TDYYMYLTQDLPLVQPIRDIPYAGPPLADLIQPQLRVLVDLGYSDYGPGL
MUL_1034|M.ulcerans_Agy99 TDYYMYLTQDLPLVQPIRDIPYAGPPLADLIQPQLRVLVDLGYSDYGPGL
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
TH_3724|M.thermoresistible__bu -----------------QGITVASATSTPDKRTPVVEAPVEEPPVQTGRS
Mvan_4726|M.vanbaalenii_PYR-1 IDPYGEPTPYLAPPVETHGEAAPGSGSPAAHPAGTEPPETVTFSPTTEST
MAB_4141|M.abscessus_ATCC_1997 SATTQIPAPEAPTPSVVSLSTAEPPAPPASAKAADPTAISVSTAGASTAR
Mflv_1918|M.gilvum_PYR-GCK SAVGGADSDGRDDVVDPEPAAPEAETSE-----------AETVTETEADD
MSMEG_5455|M.smegmatis_MC2_155 TPVADTKKASPKPLRPKVRGPISFDAPK-----------LPTIRKATGDR
Rv0160c|M.tuberculosis_H37Rv NYADIPTPAGLFSIPNPFAVTYYLIKGS-----------LQAPYGAIVEI
Mb0165c|M.bovis_AF2122/97 NYADIPTPAGLFSIPNPFAVTYYLIKGS-----------LQAPYGAIVEI
MMAR_0384|M.marinum_M SYADVPTPAGLLSVPNPFAVSYYLLKGS-----------LQAPYGAAVEI
MUL_1034|M.ulcerans_Agy99 SYADVPTPAGLLSVPNPFAVSYYLLKGS-----------LQAPYGAAVEI
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
TH_3724|M.thermoresistible__bu TLKREKPVSARHLVRNSLRAVPGLRRGE-----------PAATP------
Mvan_4726|M.vanbaalenii_PYR-1 PSTLLPETPAESEDMPPDFVENDTPDSD-----------EVSPTEDDALK
MAB_4141|M.abscessus_ATCC_1997 DQDFQPDTKPDPKSTPPPTKDSVGEADKSKNTLKPTLRLPKLPVAQPGTA
Mflv_1918|M.gilvum_PYR-GCK ---------ADDADDGADADDEDIDADGADADGEDTAGNTAEAA------
MSMEG_5455|M.smegmatis_MC2_155 PLKRLLSALTPKRPKPASSHDAGPAAGNKDTDNADKPAARADDAA-----
Rv0160c|M.tuberculosis_H37Rv GVEAGLIGPEWFPDSYPWVPSINPGLNFYFGQPQVTLLSLMSGGLGNILH
Mb0165c|M.bovis_AF2122/97 GVEAGLIGPEWFPDSYPWVPSINPGLNFYFGQPQVTLLSLMSGGLGNILH
MMAR_0384|M.marinum_M GVEAGLLGPESFPDTYPWVPSLNPGLNFYLGQPSVTLLSLLSGGLGDIFH
MUL_1034|M.ulcerans_Agy99 GVEAGLLGPESFPDTYPWVPSLNPGLNFYLGQPSVTLLSLLSGGLGDIFH
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
TH_3724|M.thermoresistible__bu -------TPDVTPDVTPDAPAGQPEPAEPNESAAPPAAAEADDASE----
Mvan_4726|M.vanbaalenii_PYR-1 DTETINESQDGPTESASGVSGEDAADADSRSADADSLSADAGDSAPADAA
MAB_4141|M.abscessus_ATCC_1997 PKSPKFPSLKNHLKSVPGLSEKKNPAADASSKHSQPANAPAHTSDKTSDH
Mflv_1918|M.gilvum_PYR-GCK ---------
MSMEG_5455|M.smegmatis_MC2_155 ---------
Rv0160c|M.tuberculosis_H37Rv LIPPPVFT-
Mb0165c|M.bovis_AF2122/97 LIPPPVFT-
MMAR_0384|M.marinum_M LIPPPVFP-
MUL_1034|M.ulcerans_Agy99 LIPPPVFP-
MLBr_01183|M.leprae_Br4923 ---------
MAV_1346|M.avium_104 ---------
TH_3724|M.thermoresistible__bu ---------
Mvan_4726|M.vanbaalenii_PYR-1 AADTAA---
MAB_4141|M.abscessus_ATCC_1997 ASETGRGAA