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VSGITQNVREATMAIRDFRRACVPALVGGVALTTALGVGAVATAPAPAHVASDVGLKALITHGSATNWNA DGIDKFYGLDWNEKYGPTVVSQFSLFPYNVNPDNLKAALRNNVGDPEPDLVLTSGRGSGAATVTMLLLLN SGRPEDRELVLNTRWILDNSVNRPNGGYGSRYIPFSILGVYPWPTPTDEGVDIVDVGYEYAWNSSAPAYV TNVVALLNSIIAYAYRYKSQAFTGLPVDPALGIDPVTGEPKLEKGYHYIVEVDGTVTKEPLKSLGNTNTA YVTYRADGLPMLQPLRDFGGQFGNAVADLLQPALKVIVDASYPGGDPVANPDRYITASLFTPPDVAIKAI QTLPSAIHQGVEDFKKDLGLTKTKAPAADERQSEPKPVEEQSAPQRDDDTTEAPSAAVAVSSKLATESAA TSVKSVADSGDVKDVKDVKAVEDTKKATDKRVRPRPLRKLVDRVTKALTPKATRPAKTSKPSTGTESGGA STGQSDSGDAKSGDSES
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1176 | - | - | 100% (507) | hypothetical protein MSMEG_1176 |
| M. smegmatis MC2 155 | MSMEG_6144 | - | 2e-12 | 23.64% (516) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_2737 | - | 3e-10 | 23.58% (441) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1828 | PPE28 | 1e-13 | 26.52% (313) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_3250 | - | 2e-09 | 23.75% (421) | hypothetical protein Mflv_3250 |
| M. tuberculosis H37Rv | Rv1800 | PPE28 | 2e-13 | 26.52% (313) | PPE family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4141 | - | 3e-19 | 27.30% (337) | PE/PPE family protein |
| M. marinum M | MMAR_0383 | - | 1e-11 | 25.61% (371) | PE family protein |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_4255 | - | 7e-53 | 34.77% (440) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_2440 | - | 2e-09 | 29.13% (254) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_4081 | - | 3e-43 | 33.50% (400) | hypothetical protein Mvan_4081 |
CLUSTAL 2.0.9 multiple sequence alignment
TH_4255|M.thermoresistible__bu --------------------------------------------------
Mvan_4081|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1828|M.bovis_AF2122/97 MLPNFAVLPPEVNSARVFAGAGSAPMLAAAAAWDDLASELHCAAMSFGSV
Rv1800|M.tuberculosis_H37Rv MLPNFAVLPPEVNSARVFAGAGSAPMLAAAAAWDDLASELHCAAMSFGSV
MUL_2440|M.ulcerans_Agy99 -------------------------MLAAAAAWDGTGQELAAAASAFSSL
MMAR_0383|M.marinum_M --------------------------------------------------
MSMEG_1176|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_3250|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4255|M.thermoresistible__bu --------------------------------------------------
Mvan_4081|M.vanbaalenii_PYR-1 ---------------------------MSKVRHRIGSAACGVAALGMAIT
Mb1828|M.bovis_AF2122/97 TSGLVVGWWQGSASAAMVDAAASYIGWLSTSAAHAEGAAGLARAAVSVFE
Rv1800|M.tuberculosis_H37Rv TSGLVVGWWQGSASAAMVDAAASYIGWLSTSAAHAEGAAGLARAAVSVFE
MUL_2440|M.ulcerans_Agy99 TSDLAGAAWQGPSAAAMASVATSYVRWLGSAASGAVQTARQVATSAAVFE
MMAR_0383|M.marinum_M -----------------MSYVITAPEMLTTAATDLDGIGSAIKAASAAVA
MSMEG_1176|M.smegmatis_MC2_155 -------------MSGITQNVREATMAIRDFRRACVPALVGGVALTTALG
Mflv_3250|M.gilvum_PYR-GCK -------------------------------------------------M
MAB_4141|M.abscessus_ATCC_1997 -------------------------MAGQYSVPGKRHSLRRYVATITAVA
TH_4255|M.thermoresistible__bu ------VSSRQVLTEAIELSALIAVGSS--TNPAGTGVVNFFQSRFN---
Mvan_4081|M.vanbaalenii_PYR-1 VGGVAATQPASISASPVDLTALIVVGSS--THPDPTGNEDFFGGKFNQAP
Mb1828|M.bovis_AF2122/97 EALAATVHPAMVAANRAQVASLVASNLFGQNAPAIAALESLYEWMWAQDA
Rv1800|M.tuberculosis_H37Rv EALAATVHPAMVAANRAQVASLVASNLFGQNAPAIAALESLYECMWAQDA
MUL_2440|M.ulcerans_Agy99 AARTATVPLELVAANRSALMSMVAANVFGLNAPAIAAIEAQYEQMWAQNV
MMAR_0383|M.marinum_M GPTTG---VAAAAADEVSGAIAKLFGMFGQEYQSVVAQASAFQTEFTR-L
MSMEG_1176|M.smegmatis_MC2_155 VGAVATAPAPAHVASDVGLKALITHGSA--TNWNADGIDKFYGLDWNEKY
Mflv_3250|M.gilvum_PYR-GCK RGILAAAGIAAVAASSVAPTPSVALAAN-----VLTVTGYTFGGTIKWDM
MAB_4141|M.abscessus_ATCC_1997 ATCTVLAPLAMESRTIASTLASYVIGIGGNNDGASANIPRKLGGAYSVDY
TH_4255|M.thermoresistible__bu -----PPGTDVRTVNFLTGPLGIYAALVS-TDESDVVLSSGWG-------
Mvan_4081|M.vanbaalenii_PYR-1 YNPGGQPGPDLIGLDFRGGAAAIEQALQENSGEDNAVLSSGWG-------
Mb1828|M.bovis_AF2122/97 AAMAGYYVGASAVATQLASWLQRLQSIPGAASLDARLPSSAEAPMGVVRA
Rv1800|M.tuberculosis_H37Rv AAMAGYYVGASAVATQLASWLQRLQSIPGAASLDARLPSSAEAPMGVVRA
MUL_2440|M.ulcerans_Agy99 GAMFGYHVGVSEALSGLAPWQEVLSGVSGRVASALEGTSAAAAAALGPTA
MMAR_0383|M.marinum_M LATAGDSYAITEASNALGALNTQAQTLLGGAFGTAAGTSATGP-------
MSMEG_1176|M.smegmatis_MC2_155 GPTVVSQFSLFPYNVNPDNLKAALRNNVGDPEPDLVLTSGRGS-------
Mflv_3250|M.gilvum_PYR-GCK DEMFGGRFCSHNSGNSCTPVRYNSDQSEGGEQDGLRALTAAVT-------
MAB_4141|M.abscessus_ATCC_1997 HP--VSYPGAIWPVSGLTAPTFKTSVAQGRTNLNDEIVTAGNQ-------
:.
TH_4255|M.thermoresistible__bu -----------AANASALLS------------------------------
Mvan_4081|M.vanbaalenii_PYR-1 -----------AANASLVLN------------------------------
Mb1828|M.bovis_AF2122/97 VNSAIAANAAAAQTVGLVMGGSGTPIPSARYVELANALYMSGSVPGVIAQ
Rv1800|M.tuberculosis_H37Rv VNSAIAANAAAAQTVGLVMGGSGTPIPSARYVELANALYMSGSVPGVIAQ
MUL_2440|M.ulcerans_Agy99 LTAAGSALPAAATDVTLVIGGSGFPIPSQSYVDNVVNNFVTPNFPSFTVS
MMAR_0383|M.marinum_M --------LAAGTHVAFVMGGTAIPWPDATYVTAVQDLFIDPHFPGFTTQ
MSMEG_1176|M.smegmatis_MC2_155 ----------GAATVTMLLLLN----------------------------
Mflv_3250|M.gilvum_PYR-GCK ----------AASGPTTVLG------------------------------
MAB_4141|M.abscessus_ATCC_1997 ----------PITIVGYSLG------------------------------
:
TH_4255|M.thermoresistible__bu -----------------WFNHTDPAALAGNLWVLDNNVARPNGGWGT---
Mvan_4081|M.vanbaalenii_PYR-1 -----------------RLDRAGDPALPKSLFILDNNVSRPDGGFGT---
Mb1828|M.bovis_AF2122/97 ---ALVTPQGLYPVVV-IKNLTFDSSVAQGAVILESAIRQQIAAGNN-VT
Rv1800|M.tuberculosis_H37Rv ---ALFTPQGLYPVVV-IKNLTFDSSVAQGAVILESAIRQQIAAGNN-VT
MUL_2440|M.ulcerans_Agy99 NAISLFTPAESYWITG-IKTMTEDASWAEGLTILDTAIKAQLAAGNN-VV
MMAR_0383|M.marinum_M ---VLFTPEQLWPFTSNLGSLTFGQSVAQGVAILRDALSAQLSDPANTAV
MSMEG_1176|M.smegmatis_MC2_155 -----------------SGRPEDRELVLNTRWILDNSVNRPNGGYGS---
Mflv_3250|M.gilvum_PYR-GCK ---------------------FSQGATISGLWIRENAGEADAPSPRQ---
MAB_4141|M.abscessus_ATCC_1997 ---------------------------AVVVSKSHSDLLQRYPGGNP---
TH_4255|M.thermoresistible__bu --------RYPVFALIGVNPIPTP-EIDGVQVIDIGYQYDANSNAPAYFL
Mvan_4081|M.vanbaalenii_PYR-1 --------RYPLFALIGVNPFPSPTDTAARAVVDIAYQYNYNSNAPADLL
Mb1828|M.bovis_AF2122/97 VFGYSQSATISSLVMANLAASADPPSPDELSFTLIGNPNNPNGGVATRFP
Rv1800|M.tuberculosis_H37Rv VFGYSQSATISSLVMANLAASADPPSPDELSFTLIGNPNNPNGGVATRFP
MUL_2440|M.ulcerans_Agy99 VQGYSQGAGIASLEMSNLKAAGVPTG--SVSFSLIGNAMNPNGGLYERFA
MMAR_0383|M.marinum_M VFGYSQSATIATNQIRAFMSQLNPPSPSQLSFVLTGNPNNPDGGVLERFN
MSMEG_1176|M.smegmatis_MC2_155 --------RYIPFSILGVYPWPTPTD-EGVDIVDVGYEYAWNSSAPAYVT
Mflv_3250|M.gilvum_PYR-GCK -----------------------------LSFVMVANPHRQYGGIRPHYD
MAB_4141|M.abscessus_ATCC_1997 ----------------------------NIQFVLMGSANTPNGGIFARFP
. . ..
TH_4255|M.thermoresistible__bu NPIADLNSLVAYAQRR--LHQSELYLPVQDDGTIVDATDTVVECPDTCRV
Mvan_4081|M.vanbaalenii_PYR-1 NLVAHVNSLVAYLYGY--REQSEIDLPVDVDGRPTVSCGGANTCAVLAGG
Mb1828|M.bovis_AF2122/97 GISFPSLGVTATGATP-HNLYPTKIYTIEYDGVADFPRYPLNFVSTLNAI
Rv1800|M.tuberculosis_H37Rv GISFPSLGVTATGATP-HNLYPTKIYTIEYDGVADFPRYPLNFVSTLNAI
MUL_2440|M.ulcerans_Agy99 GLVSPSLGKTFWGATP-DNYYTTDVYTLEYDGFADFPRYPPNFVSDLNAI
MMAR_0383|M.marinum_M GLYLPIVDVLFNGATPPDSPYPTAIYTAQYDGIANFPRYPLNVVSDVNAI
MSMEG_1176|M.smegmatis_MC2_155 NVVALLNSIIAYAYRY---------KSQAFTGLPVDPALGIDPVTGEPKL
Mflv_3250|M.gilvum_PYR-GCK --IGDSTPTSDYKVLD---------IAVEYDGAADFPANPLNLLAFANAL
MAB_4141|M.abscessus_ATCC_1997 WLKIPLADIESNGAWE-PDQFKTKVINTEYDTYGDFPAY-FNPLALANSI
. .
TH_4255|M.thermoresistible__bu VIGWEDD---------------------GTPQYAEIKKVGDTTYVTYLSN
Mvan_4081|M.vanbaalenii_PYR-1 VDALPCDDARCAIPS-------------GERVLAYVTTRGNTTYVTYTTD
Mb1828|M.bovis_AF2122/97 AGTYYVHSNYFILTP--------EQIDAAVPLTNTVGPT-MTQYYIIRTE
Rv1800|M.tuberculosis_H37Rv AGTYYVHSNYFILTP--------EQIDAAVPLTNTVGPT-MTQYYIIRTE
MUL_2440|M.ulcerans_Agy99 MGIYYVHTQYPTLTA--------AQVATAFTLP-TEGAT-MTTYHMIPTE
MMAR_0383|M.marinum_M MGFLYDEHYYAGLTSDPNAIGSGPTVANAVQLPTSPGYTGNTEYYMVLGQ
MSMEG_1176|M.smegmatis_MC2_155 EKGYHYIVEVDGTVT---------------KEPLKSLGNTNTAYVTYRAD
Mflv_3250|M.gilvum_PYR-GCK AGFQYVHVPGYNEID-------------LDTAEKLVWVEGNTTYVLIRRE
MAB_4141|M.abscessus_ATCC_1997 AAIQYAHPDAYYDRIDP------AALDDPDNPNVVKTVQGNTTYYLVRAE
* * :
TH_4255|M.thermoresistible__bu GLPLVQPLRLLG--PVGSTLADVLEPIATVLVNAGYPD--NDPIAN-PDR
Mvan_4081|M.vanbaalenii_PYR-1 ELPLTRLIRAV----LGDTVADASAPLLKLIVDSAYYD--GNPISSDPSR
Mb1828|M.bovis_AF2122/97 NLPLLEPLRSVP--IVGNPLANLVQPNLKVIVNLGYGDPAYGYSTSPPNV
Rv1800|M.tuberculosis_H37Rv NLPLLEPLRSVP--IVGNPLANLVQPNLKVIVNLGYGDPAYGYSTSPPNV
MUL_2440|M.ulcerans_Agy99 NLPLLEPLRGVP--FIGNTLADLVQPDLKVLVNLGYGDPNYGYSTGPANV
MMAR_0383|M.marinum_M HLPLTDPLRQIP--YVGTPIADLIQPSLRVIVDLGYSD--YGPGQNYADI
MSMEG_1176|M.smegmatis_MC2_155 GLPMLQPLRDFGG-QFGNAVADLLQPALKVIVDASYPG---GDPVANPDR
Mflv_3250|M.gilvum_PYR-GCK NLPLLEPLRNLG----LGALADQLNAPLKEIIDSAYDR-------DYPDL
MAB_4141|M.abscessus_ATCC_1997 HLPLLQPLRDLTNPIGASFVLDAIEPTLRVFIDMAYDR------DTGPGT
**: :* . : : . ::: .* ..
TH_4255|M.thermoresistible__bu YVPGRFLPPPHVVVTALRQLPEAIQDGLTRLHRAGSGSTGPDPAPETGRT
Mvan_4081|M.vanbaalenii_PYR-1 YRPARLMPSLGELIDTASKVPGAIREGLETLSDNDSRQS-SEPARET---
Mb1828|M.bovis_AF2122/97 ATPFGLFPEVSPVVIADALAAGTQQGIGDFAYDVSHLELP-LPADGSTMP
Rv1800|M.tuberculosis_H37Rv ATPFGLFPEVSPVVIADALVAGTQQGIGDFAYDVSHLELP-LPADGSTMP
MUL_2440|M.ulcerans_Agy99 PTPFGLFPDVAPATVFDALVAGTQQGISDAAADIGAWQLPSLPDISLSGI
MMAR_0383|M.marinum_M PTPASLFSLPNPLAVSYYLGKGAVQGVQAFMVDEGWLPQSYLPDTYPYVA
MSMEG_1176|M.smegmatis_MC2_155 YITASLFTPPDVAIKAIQTLPSAIHQGVEDFKKDLGLTKTKAPAADERQS
Mflv_3250|M.gilvum_PYR-GCK VDEEDHAEVLQQALATRGRSTATLSTRISTAVENDIDPEIDNTAEVETQT
MAB_4141|M.abscessus_ATCC_1997 TTQFSFFTPSKNIVDAFNKLPTAIAEGAHNVENGLAGATPKQSASPEKPA
: .
TH_4255|M.thermoresistible__bu ESTRFAE-----------------------APGAVIRTTGGSVAANGAER
Mvan_4081|M.vanbaalenii_PYR-1 -------------------------------------VTAQTVEEAGHRD
Mb1828|M.bovis_AF2122/97 STAPGS-------GTPVPPLS---IDSLIDDLQVANRNLANTISKVAATS
Rv1800|M.tuberculosis_H37Rv STAPGS-------GTPVPPLS---IDSLIDDLQVANRNLANTISKVAATS
MUL_2440|M.ulcerans_Agy99 SNALGSDPWSALSNATLPTLSVSTIENAIKGVQTATTDIANTISFDATTA
MMAR_0383|M.marinum_M SLSPGLN---------------------------------VYLGQPSVTG
MSMEG_1176|M.smegmatis_MC2_155 EPKPVEE---------------------QSAPQRDDDTTEAPSAAVAVSS
Mflv_3250|M.gilvum_PYR-GCK EVEIQAD-------------------------------IEADIEAGDDSA
MAB_4141|M.abscessus_ATCC_1997 SPPVPQP-------------GPTNPGSATTQIPAPEAPTPSVVSLSTAEP
TH_4255|M.thermoresistible__bu LAAAEPTPSVDDRRPTRRVSPNFSTRVG-SVSGSAEDPAVAEDSTSVPKT
Mvan_4081|M.vanbaalenii_PYR-1 DDPAAPGEDDDDATEVVQDDDEAAEVGQ-DDGAVDADPAVDESAGAEDSV
Mb1828|M.bovis_AF2122/97 YATVLPTADIANAALTIVPSYNIHLFLEGIQQALKGDPMGLVNAVGYPLA
Rv1800|M.tuberculosis_H37Rv YATVLPTADIANAALTIVPSYNIHLFLEGIQQALKGDPMGLVNAVGYPLA
MUL_2440|M.ulcerans_Agy99 YATLLPTADVVNAMVTTLPAYNLKLFLDGILQVLDGDPAGLIYALGAPIA
MMAR_0383|M.marinum_M LSLLTGALGTAARDLGWIPSWD----------------------------
MSMEG_1176|M.smegmatis_MC2_155 KLATESAATSVKSVADSGDVKDVKDVKAVEDTKKATDKRVRPRPLRKLVD
Mflv_3250|M.gilvum_PYR-GCK AIELDDDASADSDPTGTGDAPTGTADSSEDAGESSTDAADSDASSDSAKP
MAB_4141|M.abscessus_ATCC_1997 PAPPASAKAADPTAISVSTAGASTARDQDFQPDTKPDPKSTPPPTKDSVG
TH_4255|M.thermoresistible__bu GDATPRRVRGVLQRPTVGAHERPAGERRETGHTGTPGGADPTE-------
Mvan_4081|M.vanbaalenii_PYR-1 GNDDAVAAADPEGGLTTDAADGSGEESSE---------------------
Mb1828|M.bovis_AF2122/97 ADVALFTAAGGLQLLIIISAGRTIANDISAIVP-----------------
Rv1800|M.tuberculosis_H37Rv ADVALFTAAGGLQLLIIISAGRTIANDISAIVP-----------------
MUL_2440|M.ulcerans_Agy99 ADTALVTLLAGFNLYAYLYAFNKILPGVL---------------------
MMAR_0383|M.marinum_M --------------------------------------------------
MSMEG_1176|M.smegmatis_MC2_155 RVTKALTPKATRPAKTSKPSTGTESGGASTGQSDSGDAKSGDSES-----
Mflv_3250|M.gilvum_PYR-GCK DASEDRGDPGE---------------------------------------
MAB_4141|M.abscessus_ATCC_1997 EADKSKNTLKPTLRLPKLPVAQPGTAPKSPKFPSLKNHLKSVPGLSEKKN
TH_4255|M.thermoresistible__bu -----------------------------------
Mvan_4081|M.vanbaalenii_PYR-1 -----------------------------------
Mb1828|M.bovis_AF2122/97 -----------------------------------
Rv1800|M.tuberculosis_H37Rv -----------------------------------
MUL_2440|M.ulcerans_Agy99 -----------------------------------
MMAR_0383|M.marinum_M -----------------------------------
MSMEG_1176|M.smegmatis_MC2_155 -----------------------------------
Mflv_3250|M.gilvum_PYR-GCK -----------------------------------
MAB_4141|M.abscessus_ATCC_1997 PAADASSKHSQPANAPAHTSDKTSDHASETGRGAA