For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
KDDFKGAAWRLLVFLSVCALATFALLTVFAQFRFGDGRTYFAEFDNVSGLKSDDLVRIAGVEVGNIEDIS FKADSTVRVEFSADESVVVTDGTRAAIRYDNVIGGRYLALEEGAGGLRALPAGGTIPVTRTQPALDLDSV IGGFRPLFRALDADQVNALSGQLISALQGQGATIGSFLEQAAAVTNTLADRDMLIGQVVDNLNVVLGSLG GQTDRLDLAVTSLSELVHGLAERRVDISNSLAYIDAAAGSVADLLAQSREPFSTVVHETDRSAGIAVADH VYLDNLLNTLPDKYRALGRQGMYGDFFSFYLCELVLKLNGKGGQPVYVKIAGQDSGRCAPK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3981 | - | - | 100% (342) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0364 | - | e-146 | 74.27% (342) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_4603 | - | e-124 | 65.37% (335) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0605 | mce2B | 2e-70 | 43.24% (340) | MCE-family protein MCE2B |
| M. gilvum PYR-GCK | Mflv_2102 | - | 1e-128 | 67.16% (335) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1967 | mce3B | 1e-136 | 70.18% (342) | MCE-family protein MCE3B |
| M. leprae Br4923 | MLBr_02590 | mce1B | 8e-71 | 42.11% (342) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4152c | - | 2e-60 | 35.82% (335) | MCE-family protein |
| M. marinum M | MMAR_2883 | mce3B | 1e-138 | 70.76% (342) | MCE-family protein Mce3B |
| M. avium 104 | MAV_2533 | - | 1e-123 | 63.45% (342) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0347 | - | 1e-118 | 62.95% (332) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3704 | - | 1e-131 | 69.73% (337) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_2869 | mce3B | 1e-137 | 70.18% (342) | MCE-family protein Mce3B |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0605|M.bovis_AF2122/97 ------------------------------------MKTTGTTIKLGIVW
MLBr_02590|M.leprae_Br4923 ------------------------------------MKLTGTVVRLSIFS
MMAR_2883|M.marinum_M ----------------------------------MREDLRGVVIRLGVFL
MUL_2869|M.ulcerans_Agy99 ----------------------------------MREDLRGVVIRLGVFL
Rv1967|M.tuberculosis_H37Rv ----------------------------------MRENLGGVVVRLGVFL
Mvan_3981|M.vanbaalenii_PYR-1 ----------------------------------MKDDFKGAAWRLLVFL
TH_3704|M.thermoresistible__bu VARCAAGGAGTRSGAAGQQRPDTTVKRDDIHRGEFVGSLRAAVWRLAVFL
Mflv_2102|M.gilvum_PYR-GCK ----------------------------------MSVSIRRDATRLGAFL
MAV_2533|M.avium_104 ----------------------------------MKENLTGTLWRLAIYV
MSMEG_0347|M.smegmatis_MC2_155 ----------------------------------MNKEVLSTLIRVSAFL
MAB_4152c|M.abscessus_ATCC_199 -------------------------------------MKRATQIKVIVFT
::
Mb0605|M.bovis_AF2122/97 LVLSVFTVMIIVVFGQVRFHHT-TGYSAVFTHVSGLRAGQFVRAAGVEVG
MLBr_02590|M.leprae_Br4923 LVLLLFTVMIIVVFGQMRFGRT-NGYTAEFTNISGLRTGQFVRASGVEVG
MMAR_2883|M.marinum_M TVCALTAFLLVAVFGQVRFGDG-NTYYAEFSNVSNLREGKLVRIAGVEVG
MUL_2869|M.ulcerans_Agy99 TVCALTAFLLVAVFGQVRFGDG-NTYYAEFSNVSNLREGKLVRIAGVEVG
Rv1967|M.tuberculosis_H37Rv AVCLLTAFLLIAVFGEVRFGDG-KTYYAEFANVSNLRTGKLVRIAGVEVG
Mvan_3981|M.vanbaalenii_PYR-1 SVCALATFALLTVFAQFRFGDG-RTYFAEFDNVSGLKSDDLVRIAGVEVG
TH_3704|M.thermoresistible__bu VVCLFGAFTLLAVFAELRFDRG-VNYFAEFANVSGLKEGDMVRIAGVEVG
Mflv_2102|M.gilvum_PYR-GCK AVCLLGVFGLFAVFGQMRFGEKTQQYRAEFVNVTGLETNDFVRIAGVEVG
MAV_2533|M.avium_104 VVSVLGMFTLVAVFGQLRFQSE-KTYKAQFANVSGLEGGNFVRIAGVEVG
MSMEG_0347|M.smegmatis_MC2_155 TVCAVGVFALFSIFADLRFGER-KQYTAQFSDISGLKEGDFVRIAGVEVG
MAB_4152c|M.abscessus_ATCC_199 VVMLLVAAGLIITFGEFRFGSG-KRYHAMFSTASDLRSGQKVRIAGVPVG
* . :. *.:.** * * * :.*. .. ** :** **
Mb0605|M.bovis_AF2122/97 KVAKVTLIDGDKQVLVDFTVDRSLSLDQATTASIRYLNLIGDRYLELGRG
MLBr_02590|M.leprae_Br4923 KVNSVALINGGTRVRVKFNVDRSVPLYQSTTAQIRYLDLIGNRYLELKHG
MMAR_2883|M.marinum_M KVEKIS-INPDSTVKVGFTADNSVTLTQGTQAVIRYDNLFGDRYLALEEG
MUL_2869|M.ulcerans_Agy99 KVEKIS-INPDATVKVEFTADNSVTLTQGTQAVIRYDNLFGDRYLALEEG
Rv1967|M.tuberculosis_H37Rv KVTRIS-INPDATVRVQFTADNSVTLTRGTRAVIRYDNLFGDRYLALEEG
Mvan_3981|M.vanbaalenii_PYR-1 NIEDIS-FKADSTVRVEFSADESVVVTDGTRAAIRYDNVIGGRYLALEEG
TH_3704|M.thermoresistible__bu KVQNIA-VNRDGTVRVGFSAEESVVLTEGSRAQIRYDDPIGNRFLALLEG
Mflv_2102|M.gilvum_PYR-GCK KVENVE-IQPDTTAVVEFTADDSVVLTQGSRAVIRYDDLIGGRYLALEEG
MAV_2533|M.avium_104 KVKNIT-VEPDSTVLVEFTAAEKVVLTEGTRAAIRFADLTGGRYVALEEG
MSMEG_0347|M.smegmatis_MC2_155 QVQKVS-MDENALVLVEFAMEDSVELTSTSTAVIRYDNLIGGRYLELKQG
MAB_4152c|M.abscessus_ATCC_199 RVKNVS-LNRDNSVEVTFDVDSKYQLYSSSRAIIRYENLVGDRYLEITAG
.: : .. . . * * . : : * **: : *.*:: : *
Mb0605|M.bovis_AF2122/97 ---HSGQRLAPGATIPLEHTHPALDLDALLGGFRPLFQTLDPDKVNSIAS
MLBr_02590|M.leprae_Br4923 EGQGSEKIMPAGGLIPLSRTSPALDLDALIGGFKPLFRALDPDKINTIAS
MMAR_2883|M.marinum_M A--GGLTILKPGQTIPLANTKPALDLDALIGGFRPLFRALDPHQVNALSD
MUL_2869|M.ulcerans_Agy99 A--GGLTILKPGQTIPLANTKPALDFDDLIDGFRPLFRALDPHQVNALSD
Rv1967|M.tuberculosis_H37Rv A--GGLAVLRPGHTIPLARTQPALDLDALIGGFKPLFRALNPEQVNALSE
Mvan_3981|M.vanbaalenii_PYR-1 A--GGLRALPAGGTIPVTRTQPALDLDSVIGGFRPLFRALDADQVNALSG
TH_3704|M.thermoresistible__bu A--GGVARLAPGDTIPVDRTDPALDLDAVIGGFRPLFRALDADQVNALTG
Mflv_2102|M.gilvum_PYR-GCK A--GGTQKLNPGGTIPLARTSPALDLDALIGGFRPLFRALDPDQINALSG
MAV_2533|M.avium_104 A--GNIRRLSPGATIPLARTEPALDLDALIGGFRPLFRALDPDQVNKLTG
MSMEG_0347|M.smegmatis_MC2_155 E--EPGAVLQAGATIPLARTRPALDLDELIGGFRPLFKALDPDQVNALST
MAB_4152c|M.abscessus_ATCC_199 P--GELHKLPDGGTLDKEHTQPALDLDALLGGLRPVLKGFDAAKVNEISN
: * : .* ****:* ::.*::*::: ::. ::* ::
Mb0605|M.bovis_AF2122/97 SIITVFQGQGATINDILDQTASLTATLADRDHAIGEVVNNLNTVLATTVK
MLBr_02590|M.leprae_Br4923 AIVAAFQGQGGTINDILDQTAQLTTAIGERDQAIGEVVKNLNVVLDTTVR
MMAR_2883|M.marinum_M QLLQAFQGQGPTIGTFLDQAAAVTNTLADRDQLIGQVVTNLNVVLGSLGG
MUL_2869|M.ulcerans_Agy99 QLLQAFQGQGPTIGTFLDQAAAVTNTLADRDQLIGQVVTNLNVVLGSLGG
Rv1967|M.tuberculosis_H37Rv QLLHAFAGQGPTIGSLLAQSAAVTNTLADRDRLIGQVITNLNVVLGSLGA
Mvan_3981|M.vanbaalenii_PYR-1 QLISALQGQGATIGSFLEQAAAVTNTLADRDMLIGQVVDNLNVVLGSLGG
TH_3704|M.thermoresistible__bu QLIKAFSGQGPTIASFLDQAAAVTNTLADRDVLIGEVIDNLATVLGTLGG
Mflv_2102|M.gilvum_PYR-GCK QLISALQGQGGTINSFLAQTAALTSTLADRDQLIGEVIINLNTVLGSLGD
MAV_2533|M.avium_104 QLIAAFQGQGGTIGSFLTQAAALTNTLADRDHLIGQVIVNLNTVLGSLGG
MSMEG_0347|M.smegmatis_MC2_155 QLVQVFQGQGATISSFLDQTAAMTSTLADRDQLIGEVIGNLDVLLGSLGE
MAB_4152c|M.abscessus_ATCC_199 AFIQILQGQGGTLSQLLGDTSSFTSGLAERDQLIGDVINHLNEVLATVDS
:: : *** *: :* ::: .* :.:** **:*: :* :* :
Mb0605|M.bovis_AF2122/97 HQTEFDRTVDKLEVLITGLKNRADPLAAAAAHISSAAGTLADLLGADRPL
MLBr_02590|M.leprae_Br4923 HRKEFDQTVNNLEILITGLKDHGDQLAGSFAHISNAAGTVANLLAEDHAL
MMAR_2883|M.marinum_M QSDRLDKAVASLSQLIAGLSERRTDISNAVAYTNAAAGSVADLLSQARAP
MUL_2869|M.ulcerans_Agy99 QSDRLDKAVASLSQLIAGLSERRTDISNAVAYTNAAAGSVADLLSKARAP
Rv1967|M.tuberculosis_H37Rv HTDRLDQAVTSLSALIHRLAQRKTDISNAVAYTNAAAGSVADLLSQARAP
Mvan_3981|M.vanbaalenii_PYR-1 QTDRLDLAVTSLSELVHGLAERRVDISNSLAYIDAAAGSVADLLAQSREP
TH_3704|M.thermoresistible__bu HSERFDQAVDSLSELVSGLSVRRSELSQAIAGIDSGAGSFADLLADAREP
Mflv_2102|M.gilvum_PYR-GCK QSDQFAKAVDSLSQLVEGLSDRRQEISDGLAYTNAAAGSIADFLTEARPP
MAV_2533|M.avium_104 QSGQFARAVDSLSELVAGLEARKQDISNGMAYANAAAGSITDLLAQARPP
MSMEG_0347|M.smegmatis_MC2_155 QSHQFDKAVNSLSELVAGLSARRTDITNAIANSDNAATEIADLLAQARPP
MAB_4152c|M.abscessus_ATCC_199 KSTQFSSSVDQLQQLISGLAQQRDVVAGALPPLASTASSLESVLKDTRPY
: .: :* .*. *: * : :: . . * . ..* :
Mb0605|M.bovis_AF2122/97 LHSSFGHLEGIQQPLIDELAELDHVLGKLPDAYRIIGRAGGIYGDFFNFY
MLBr_02590|M.leprae_Br4923 LHKSINYLDGIQQPLIDQRLQLEDYLHKLPTVLNQIGRTIGSYGDFVNFY
MMAR_2883|M.marinum_M LSKALHETDRVATIALADHDYLDNLLNTLPDRYQALVRQ-GMYGDFFAFY
MUL_2869|M.ulcerans_Agy99 FSKALHETDRVATIALADHDYLDNLLNTLPDRYQALVRQ-GMYGDFFAFY
Rv1967|M.tuberculosis_H37Rv LAKVVRETDRVAGIAAADHDYLDNLLNTLPDKYQALVRQ-GMYGDFFAFY
Mvan_3981|M.vanbaalenii_PYR-1 FSTVVHETDRSAGIAVADHVYLDNLLNTLPDKYRALGRQ-GMYGDFFSFY
TH_3704|M.thermoresistible__bu FRRVVHELDRVAAIAVADHEYLDELLNRLPDKYRALNRQ-ALHGDFFNFY
Mflv_2102|M.gilvum_PYR-GCK LKKTIDETDRAAGIVVADHEYFDNLINTLPDAYQVLARQ-GIYGDFFSFY
MAV_2533|M.avium_104 VKKVVHEADRTAGTMLADREWLEKYLDHWPDAFKILNRQ-GLYGDFFSFY
MSMEG_0347|M.smegmatis_MC2_155 LQNVVTQADRAAAIAVADHEYLDNILNTLPDKYRVLGRQ-AMYGDYFSFY
MAB_4152c|M.abscessus_ATCC_199 IKGTIEQARQLATRVDERKADVNVVVENLAENYLRLNAL-GAYGSFFNIY
. . .: : . : . :*.:. :*
Mb0605|M.bovis_AF2122/97 LCDISLKVNGLQPGGPVRTVKLFGQP---TGRCTPQ--
MLBr_02590|M.leprae_Br4923 SCDITLKINGLQPGGPVRTVRLFQQP---TGRCTPQ--
MMAR_2883|M.marinum_M LCDVVLKVNGK--GGQPVYIKVAGQA---TGRCTPK--
MUL_2869|M.ulcerans_Agy99 LCDVVLKVNGK--GGQPVYIKVAGQA---TGRCTPK--
Rv1967|M.tuberculosis_H37Rv LCDVVLKVNGK--GGQPVYIKLAGQD---SGRCAPK--
Mvan_3981|M.vanbaalenii_PYR-1 LCELVLKLNGK--GGQPVYVKIAGQD---SGRCAPK--
TH_3704|M.thermoresistible__bu LCEAVLKLNGK--GGQPVFVKIAGQP---TGRCTPK--
Mflv_2102|M.gilvum_PYR-GCK LCDIVLKLNGK--GGQPVYVKVAGQS---SGRCAPR--
MAV_2533|M.avium_104 LCDIVLKLNGK--GGQPVYVKVAGQA---SGRCTPR--
MSMEG_0347|M.smegmatis_MC2_155 LCDLILKLNGK--GGQPVYVKLAEQV---TGRCAPK--
MAB_4152c|M.abscessus_ATCC_199 YCSIRIKVNGP--VGTDWLIPFGGPPDPSKGRCAFKNE
*. :*:** * : . .***: :