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ACGAASEMTDVKRVVIWGTGFVGRMVIPEVVRHPQFELVGVGVSNPDKAGRDVGEICGMGRDIGLIATDD VDALIDLKPDALVHYGPTAAHAEANIELITRFLRAGIDVCSTAMTPWIWPTMHLNPPNWIEPITVACELG ESSCFTTGIDPGFANDLFPMTLMGLCSEVRRVRASELLDYTNYEGDYDREMGIGRPPEYRPMLENPDILV FAWGATVPMIAHAAGIMLDEITTTWDKWVTPTERKTAKGVIAPGHVAAVRFTVNGVYRGETRIQLEHVNR IGSDAAPDWPSGNENDVYRVDIEGTPSIFQETAFRFTDGSGRDAAAAGCLATGLRALNAVPAVNDLSPGW VTALDLPLIPGLGTIR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3771 | - | - | 100% (367) | dihydrodipicolinate reductase |
| M. vanbaalenii PYR-1 | Mvan_4922 | - | 9e-61 | 37.88% (359) | dihydrodipicolinate reductase |
| M. vanbaalenii PYR-1 | Mvan_4970 | - | 6e-54 | 35.31% (354) | dihydrodipicolinate reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0949c | - | 3e-56 | 36.44% (354) | hypothetical protein Mb0949c |
| M. gilvum PYR-GCK | Mflv_2763 | - | 0.0 | 93.30% (358) | dihydrodipicolinate reductase |
| M. tuberculosis H37Rv | Rv0926c | - | 3e-56 | 36.44% (354) | hypothetical protein Rv0926c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0258c | - | 1e-101 | 50.96% (365) | putative dihydropicolinate reductase |
| M. marinum M | MMAR_3359 | - | 0.0 | 86.76% (355) | hypothetical protein MMAR_3359 |
| M. avium 104 | MAV_2176 | dapB | 0.0 | 88.45% (355) | dihydrodipicolinate reductase N-terminus domain-containing |
| M. smegmatis MC2 155 | MSMEG_4350 | dapB | 0.0 | 87.04% (355) | dihydrodipicolinate reductase |
| M. thermoresistible (build 8) | TH_4297 | - | 7e-60 | 36.47% (351) | PUTATIVE putative dihydrodipicolinate reductase, N-terminus |
| M. ulcerans Agy99 | MUL_4353 | - | 9e-31 | 32.59% (359) | hypothetical protein MUL_4353 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0949c|M.bovis_AF2122/97 -----------------------------MAIPVVQLGTGNVGVHSLRAL
Rv0926c|M.tuberculosis_H37Rv -----------------------------MAIPVVQLGTGNVGVHSLRAL
TH_4297|M.thermoresistible__bu ---------------------------------VILWGPGQVGVGALRAV
Mvan_3771|M.vanbaalenii_PYR-1 -------------------MACGAASEMTDVKRVVIWGTGFVGRMVIPEV
Mflv_2763|M.gilvum_PYR-GCK --------------------MVG-----SDVKRVVIWGTGFVGRMVIAEV
MMAR_3359|M.marinum_M -------------------------MSQSGGKRVVVWGTGFVGRMVIPEI
MAV_2176|M.avium_104 ---------------------MAARMSEHGSKRVVVWGTGFVGKMVIAEI
MSMEG_4350|M.smegmatis_MC2_155 MTGAAPVLGGTLHVPNPIPGVTGITYRGRVKKRVVVWGTGFVGSMVIAEI
MAB_0258c|M.abscessus_ATCC_199 ---------------------------MSDKYPVIVWGTGVVGKLVIREL
MUL_4353|M.ulcerans_Agy99 -------------------------MSGPAKLRVIQWATGGVGKAAIECI
*: ..* ** : :
Mb0949c|M.bovis_AF2122/97 IADPEFELTGVWVSSDAKAGKDAAELAGLADSTGVRASTDLNAVLATGPR
Rv0926c|M.tuberculosis_H37Rv IADPEFELTGVWVSSDAKAGKDAAELAGLADSTGVRASTDLNAVLATGPR
TH_4297|M.thermoresistible__bu IAHPGLELVGLVVHSPAKHGKDAGALCGMP-ETGILATNDIDAALAVDAD
Mvan_3771|M.vanbaalenii_PYR-1 VRHPQFELVGVGVSNPDKAGRDVGEICGMGRDIGLIATDDVDALIDLKPD
Mflv_2763|M.gilvum_PYR-GCK VGHPRFELVGVGVSNPDKVGRDVGDICGLGRDLGLTATDDVDALIDLKPD
MMAR_3359|M.marinum_M VKHPLFELVGVGVSNPDKVGRDVGEICGLSEPVGISATDDVDALIALRPD
MAV_2176|M.avium_104 VKHPLFELVGVGVSNPAKVGRDVADICGLPEPTGVIATDDVDALIALKPD
MSMEG_4350|M.smegmatis_MC2_155 VGHPLFELVGVGVSNPDKVGRDVGEICGLGAPVGVTATDDVDALIALKPD
MAB_0258c|M.abscessus_ATCC_199 LDHPVFELAAVLVHDPAKDGVDVGTLVGS-HPTGLAATTDIDAALGTEG-
MUL_4353|M.ulcerans_Agy99 LNHPQLELAGCWVHSAAKHGLDVGTIIGAA-RFGVTATNDVDELLALDAD
: .* :**.. * . * * *.. : * *: *: *:: :
Mb0949c|M.bovis_AF2122/97 CAVYNAMADNRLPEALEDYRRILAAGINIVGSGPVFLQYPW-QVIPDEII
Rv0926c|M.tuberculosis_H37Rv CAVYNAMADNRLPEALEDYRRILAAGINIVGSGPVFLQYPW-QVIPDEII
TH_4297|M.thermoresistible__bu VVAYFASGDYRYREAAEDIARCLRAGKNVVTTSLVPLCYP--PAADAETV
Mvan_3771|M.vanbaalenii_PYR-1 ALVHYGPTAAHAEANIELITRFLRAGIDVCSTAMTPWIWPTMHLNPPNWI
Mflv_2763|M.gilvum_PYR-GCK ALVHYGPTAARADANIELITRFLRAGIDVCSTAMTPWIWPTMHLNPPNWI
MMAR_3359|M.marinum_M ALVHYGPTAMHAQDNISLITRFLRAGIDVCSTAMTPWIWPTMHLNPPQWI
MAV_2176|M.avium_104 ALVHYGPTAMHAKENIALITRFLRAGIDVCSTAMTPWVWPTMHLNPPNWI
MSMEG_4350|M.smegmatis_MC2_155 ALVHYGPTAAQADANIALITRFLRAGIDVCSTAMTPWVWPKMHLNPPNWI
MAB_0258c|M.abscessus_ATCC_199 TVAYFGPTAQYALENIDNMSRALRSGHNIVSTAMTPWVYP--QVCPPEML
MUL_4353|M.ulcerans_Agy99 CVMYSPQVAD-----EQDVKAILRSGKNVFTP--VGWVYP---DLSKPRV
: * :* :: . . :* :
Mb0949c|M.bovis_AF2122/97 KPLQDAARAGNSSLYVNGIDPGFANDLLPMALAGTCESIEQIRCMEIVDY
Rv0926c|M.tuberculosis_H37Rv KPLQDAARAGNSSLYVNGIDPGFANDLLPMALAGTCESIEQIRCMEIVDY
TH_4297|M.thermoresistible__bu DLIEAACAEGRTTFFNSGVDPGWANDLMALTMTGFSSRVDTITMLEILDY
Mvan_3771|M.vanbaalenii_PYR-1 EPITVACELGESSCFTTGIDPGFANDLFPMTLMGLCSEVRRVRASELLDY
Mflv_2763|M.gilvum_PYR-GCK EPVTVACELGESSCFTTGIDPGFANDLFPMTLMGLCSEVRTVRASELLDY
MMAR_3359|M.marinum_M QPITEACTLGESSCFTTGIDPGFANDLFPMTLMGLCSEVQRVRASELLDY
MAV_2176|M.avium_104 APITEACELGESSCFTTGIDPGFANDLFPMTLMGLCSEVRRVRASELLDY
MSMEG_4350|M.smegmatis_MC2_155 EPITEACEVGQSSCFTTGIDPGFANDLFPMTLMGLCSEVRRVRASELLDY
MAB_0258c|M.abscessus_ATCC_199 ADIQHACEAGQTSCFTTGIDPGFANDLFPMTLLGVGGRVDSVLVQELLDY
MUL_4353|M.ulcerans_Agy99 KAVADAAVAGGVTLHGSGIHPGGITERFPLMVSSLSSAITHVRAEEFSDI
: *. * : . .*:.** .: :.: : . : : *: *
Mb0949c|M.bovis_AF2122/97 ATYDSAVVMFDVMGFGKPMDQIPMLLQPGVLSLAWGSVVRQLAAGLGISL
Rv0926c|M.tuberculosis_H37Rv ATYDSAVVMFDVMGFGKPMDQIPMLLQPGVLSLAWGSVVRQLAAGLGISL
TH_4297|M.thermoresistible__bu APINQPEIMFDFMGFGHPPEHPAPLFDPERLAALWAPTVHLVADGVGLPL
Mvan_3771|M.vanbaalenii_PYR-1 TNYEG--DYDREMGIGRPPEYRPMLENPDILVFAWGATVPMIAHAAGIML
Mflv_2763|M.gilvum_PYR-GCK TNYEG--DYDREMGIGKPPEFTPMLENPDILVFAWGATVPMIAHAAGIML
MMAR_3359|M.marinum_M TNYEG--DYEKEMGIGREPEFSPMLENRDVLIFAWGATVPMIAHAAGIML
MAV_2176|M.avium_104 TNYEG--DYEVEMGIGREPEYSPMLENRDVLIFAWGATVPMIAHAAGIML
MSMEG_4350|M.smegmatis_MC2_155 TNYTG--DYEFEMGIGKPPEHRPLLESPDILIFAWGATVPMIAHAAGVEL
MAB_0258c|M.abscessus_ATCC_199 QYYNG--DFSTPMGLGAPMDQPAVLEIPEVLILAWGHTIPMIADAVGVKL
MUL_4353|M.ulcerans_Agy99 RTYNAPDVVRDIMGFGVPHAQAMQGPMAALLESGFKMSVRMIANHMGFHI
**:* * : : :* *. :
Mb0949c|M.bovis_AF2122/97 DGVEEMYVREPAPEAFNI----ASGHIPKGSAAALRFEVLGLVDGVPAVV
Rv0926c|M.tuberculosis_H37Rv DGVEEMYVREPAPEAFNI----ASGHIPKGSAAALRFEVLGLVDGVPAVV
TH_4297|M.thermoresistible__bu DRVETTIDKWLATERYRV----ASGWIEPGTMGGMRFKLAGIVDGEPRVV
Mvan_3771|M.vanbaalenii_PYR-1 DEITTTWDKWVTPTERKT----AKGVIAPGHVAAVRFTVNGVYRGETRIQ
Mflv_2763|M.gilvum_PYR-GCK DEITTTWDKWVTPDERRT----AKGVIAPGNVAAVRFTINGVYRGETRIQ
MMAR_3359|M.marinum_M DEITTTWEKWVTPTERKS----AKGLIKAGHVAAVRFTINGVYQGETRIQ
MAV_2176|M.avium_104 DEITTTWDKWVTPTERTT----AKGVIKPGHVAAVRFTINGVYRGETRIQ
MSMEG_4350|M.smegmatis_MC2_155 DEITTTWDKWVTPDDRKT----AKGVIGAGNVAAVRFTINGVYRGETRIQ
MAB_0258c|M.abscessus_ATCC_199 DKIDTVYEKWATPTEISYGSAPNTGTIPAGHCAAVRFEIRGWVGGEPKIV
MUL_4353|M.ulcerans_Agy99 DPMIRATHEIAVATSDIAS---DVLPIAADTVAGRKFRWQTLADGKPVIT
* : . .. * . .. :* * . :
Mb0949c|M.bovis_AF2122/97 LEHVTRLR-ADLCPEWPQPAQ-PGGSYRIEISGEPCYAMDI-CLSSRHGD
Rv0926c|M.tuberculosis_H37Rv LEHVTRLR-ADLCPEWPQPAQ-PGGSYRIEISGEPCYAMDI-CLSSRHGD
TH_4297|M.thermoresistible__bu LEHITRMG-EHSAPDWPRHPS-PHGGYRVVVDGLPTYTVDI-EMHGR-GN
Mvan_3771|M.vanbaalenii_PYR-1 LEHVNRIG-SDAAPDWPSGN--ENDVYRVDIEGTPSIFQET-AFRFTDGS
Mflv_2763|M.gilvum_PYR-GCK LEHVNRIG-HDAAPDWPSGT--ESDVYRVDIEGTPSIFQET-AFRFTDGS
MMAR_3359|M.marinum_M LEHVNRIG-HDAAPDWPSGH--DDDVYRVDIEGTPSIFQET-AFRFTDGS
MAV_2176|M.avium_104 LEHVNRIG-LDAAPDWPSGH--DNDVYRVDIEGTPSIFQET-AFRFTDGS
MSMEG_4350|M.smegmatis_MC2_155 LEHVNRIG-ADAAPDWPTGN--DNDVYRVDIEGTPSISQET-AFRFTDGS
MAB_0258c|M.abscessus_ATCC_199 IEHVNRIT-NDTAPQWPRAQSVDNDAYRIEIKGSPNITQET-VFR-DERS
MUL_4353|M.ulcerans_Agy99 AAVNWLMGQADMHPDWSFGER--GERFEIEITGNPSVSLVFKGLQPTSIT
: . *:*. :.: : * * :
Mb0949c|M.bovis_AF2122/97 HNHAGLV---ATAMRIVNAIPAVVAAEPGIRTTLDLPLITG---EGRYAA
Rv0926c|M.tuberculosis_H37Rv HNHAGLV---ATAMRIVNAIPAVVAAEPGIRTTLDLPLITG---EGRYAA
TH_4297|M.thermoresistible__bu NMRGLTY---ATVMRELNAIPAVVAAPPGLLSTLDLPLVTGPVRGGRWTG
Mvan_3771|M.vanbaalenii_PYR-1 GRDAAAAGCLATGLRALNAVPAVNDLSPGWVTALDLPLIPG---LGTIR-
Mflv_2763|M.gilvum_PYR-GCK GRDAAAAGCLATGLRALNAVPAVNDLSPGWVTALDLPLIPG---VGTIR-
MMAR_3359|M.marinum_M GRDPATAGCLATGMRALNAVPAVNDLPPGWVTALDLPLIPG---AGTIR-
MAV_2176|M.avium_104 GRDAAAAGCLATGLRALNAVPAVNELRPGWVTPLDLPLIPG---TGTIR-
MSMEG_4350|M.smegmatis_MC2_155 GRDAAAAGCLATGLRALNAVPAVNQHLPGWVTPLDLPLIPG---LGTIR-
MAB_0258c|M.abscessus_ATCC_199 G-DGAIGGCLATGMRAINAIPAVIDAKPGFLTPLDLPLIAG---RGTIRI
MUL_4353|M.ulcerans_Agy99 EGLQRNPGVVATANHCANAIPVVCAADPGIATYLDLPLFAGRPARASRGL
** : **:*.* ** : *****..* .
Mb0949c|M.bovis_AF2122/97 A-------
Rv0926c|M.tuberculosis_H37Rv A-------
TH_4297|M.thermoresistible__bu TLPPTTRR
Mvan_3771|M.vanbaalenii_PYR-1 --------
Mflv_2763|M.gilvum_PYR-GCK --------
MMAR_3359|M.marinum_M --------
MAV_2176|M.avium_104 --------
MSMEG_4350|M.smegmatis_MC2_155 --------
MAB_0258c|M.abscessus_ATCC_199 --------
MUL_4353|M.ulcerans_Agy99 ER------