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MTHDERMTHKKRTFRDRREAGQVLARDLARYRGTRDLMVLGLARGGVPVAWEVAHALHAPLDVCLVRKLG VPQWPELAMGAVATGGGVVLNTGLLHDLGISDDEVGEAITRETAELDRREQAYRGDRGPVSVAGRCVILV DDGIATGASMVAAMRAVRQAGAARVIVGVPVGPASVCRQLRDEADDVVCSTMPEDFRAVGQMFVDFHQVS DDEVRELLAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3513 | - | - | 100% (220) | phosphoribosyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1393 | - | 9e-62 | 57.21% (208) | erythromycin esterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2167 | - | 1e-73 | 67.31% (208) | hypothetical protein Mb2167 |
| M. gilvum PYR-GCK | Mflv_2998 | - | 2e-81 | 67.42% (221) | phosphoribosyltransferase |
| M. tuberculosis H37Rv | Rv2143 | - | 1e-73 | 67.31% (208) | hypothetical protein Rv2143 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4659 | - | 3e-48 | 48.83% (213) | hypothetical protein MAB_4659 |
| M. marinum M | MMAR_3483 | - | 3e-62 | 56.46% (209) | hypothetical protein MMAR_3483 |
| M. avium 104 | MAV_2347 | - | 3e-70 | 63.21% (212) | phosphoribosyltransferase |
| M. smegmatis MC2 155 | MSMEG_4215 | - | 2e-83 | 75.00% (208) | phosphoribosyltransferase |
| M. thermoresistible (build 8) | TH_3117 | - | 2e-49 | 50.72% (207) | PUTATIVE Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) |
| M. ulcerans Agy99 | MUL_3276 | - | 1e-52 | 51.21% (207) | hypothetical protein MUL_3276 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3483|M.marinum_M --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 MEAPPYAGDPTFERLRRSFQPADLLPELQAAGVHYTIAVEAADDPAENES
Rv2143|M.tuberculosis_H37Rv MEAPPYAGDPTFERLRRSFQPADLLPELQAAGVHYTIAVEAADDPAENES
MAV_2347|M.avium_104 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3483|M.marinum_M --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 LLATARHHDWIARVIGWVPLADPDEVTESSTHGRHRPDASWRRDLRCPGL
Rv2143|M.tuberculosis_H37Rv LLATARHHDWIARVIGWVPLADPDEVTESSTHGRHRPDASWRRDLRCPGL
MAV_2347|M.avium_104 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 -------------------------MTHDERMTHKKRTFRDRREAGQVLA
Mflv_2998|M.gilvum_PYR-GCK -------------------------------MKASARTFHDRRDAGRVLA
MMAR_3483|M.marinum_M -----------------------MTSAARADRNAPRRVFRDRHEAGQVLA
MSMEG_4215|M.smegmatis_MC2_155 -------------------------MSAWSVRHDAIRTFQDRREAGRVLA
Mb2167|M.bovis_AF2122/97 LPPGCHQPVLVVGLVGQQPEMRPMNPPSGFLRRTPTRRFRDRRDAGRVLA
Rv2143|M.tuberculosis_H37Rv LPPGCHQPVLVVGLVGQQPEMRPMNPPSGFLRRTPTRRFRDRRDAGRVLA
MAV_2347|M.avium_104 -----------------------------------MRSFRDRREAGRALA
MAB_4659|M.abscessus_ATCC_1997 -------------------------------MSDTHRMFSDRQDAGRVLA
TH_3117|M.thermoresistible__bu -------------------------------MRADTRPFDDRVDAGRRPA
MUL_3276|M.ulcerans_Agy99 -----------------------------------MRQFSDRIDAGRKLG
* * ** :**: .
Mvan_3513|M.vanbaalenii_PYR-1 RDLAR--YR---GTRDL---MVLGLARGGVPVAWEVAHALHAPLDVCLVR
Mflv_2998|M.gilvum_PYR-GCK RDLCDRISRPDAGDGDLGEILVLGLARGGVPVGWEVAQRLKAPLDVCLVR
MMAR_3483|M.marinum_M DLLTA--YR------DRPDVIVLGLARGGIPVAWEVAAALHAPLDAFIVR
MSMEG_4215|M.smegmatis_MC2_155 QRLSS--YR------DDPDVLVLGLARGGVPVAWEVAAHLRAPLDVFLVR
Mb2167|M.bovis_AF2122/97 DELAS--YR------GRDRLLVLGLARGGVPVGWEVASALGAELDVFLVR
Rv2143|M.tuberculosis_H37Rv DELAS--YR------GRDRLLVLGLARGGVPVGWEVASALGAELDVFLVR
MAV_2347|M.avium_104 GELMG--YR------NRGDVLVFGLARGGLPVAWEIAAALHAPLDVFLVR
MAB_4659|M.abscessus_ATCC_1997 GMLAPR---------KLRSIVVLALPRGGIPVGREIATALNAPLAVLVVR
TH_3117|M.thermoresistible__bu ERLAS--FR-------GRDVVVLGLPRGGVPVAFAVARALRAPLDVLVVR
MUL_3276|M.ulcerans_Agy99 RRLEF--LR-------GQDIVVLGLPRGGVPVAFEVAKALHAPLDVLLVR
* :*:.*.***:**. :* * * * . :**
Mvan_3513|M.vanbaalenii_PYR-1 KLGVPQWPELAMGAVATGGGVVLNTGLLHDLGISDDEVGEAITRETAELD
Mflv_2998|M.gilvum_PYR-GCK KLGAPQWPELAIGALAGGGGVVLNNELIRSLGVGEDQIRDIVCRETAELH
MMAR_3483|M.marinum_M KLGAPGHEEFAVGALASGGRVVVNDDVVRGLRITPQQLRDTAEREARELV
MSMEG_4215|M.smegmatis_MC2_155 KLGVPQWQELAMGAVASGGGVVLNEKLMDRLGISDDDMAETLRRETIELE
Mb2167|M.bovis_AF2122/97 KLGVPQWRELAMGALASGGGVVMNDDVVSSLRITDQQVRAAIDSETAELQ
Rv2143|M.tuberculosis_H37Rv KLGVPQWRELAMGALASGGGVVMNDDVVSSLRITDQQVRAAIDSETAELQ
MAV_2347|M.avium_104 KLGVPNWSELAMGALASGGGVVMNDDVVSSLRITDEQVRAVIDSETAELA
MAB_4659|M.abscessus_ATCC_1997 KLGVPGHEEYAMGAIASGGEVILDDDIVRSMGVTPIQLDEVTDRERRELA
TH_3117|M.thermoresistible__bu KLGVPFQPELAFGAIGEDGVRVVNDAVVRRTRLTRADMAAVERRERAELQ
MUL_3276|M.ulcerans_Agy99 KLGVPLHSELAFGAIGEGGVQVINSAVVHEAGLGEQEMAAVETAQWAELQ
***.* * *.**:. .* ::: :: : :: : **
Mvan_3513|M.vanbaalenii_PYR-1 RREQAYRGDRGPVSVAGRCVILVDDGIATGASMVAAMRAVR----QAGAA
Mflv_2998|M.gilvum_PYR-GCK RREKAYRGDRGPVTVSGRTVVLVDDGIATGASMIAAVRSVR----EAGAR
MMAR_3483|M.marinum_M RREAAYRAGRPPLDVAGKTVVLVDDGLATGASMFAAVQAIR----DAEPA
MSMEG_4215|M.smegmatis_MC2_155 RREQAYRGDREPLQVAGRTVILVDDGIATGASMMAAVRAVR----GAR--
Mb2167|M.bovis_AF2122/97 RRELAYRGGRPVVDPRARIVILVDDGIATGASMLAAVRTIR----ATGPE
Rv2143|M.tuberculosis_H37Rv RRELAYRGGRPVVDPRARIVILVDDGIATGASMLAAVRTIR----ATGPE
MAV_2347|M.avium_104 RREHAYRGDRPMADLRDKVVILVDDGIATGASMLAAVRALRSGPTGATPR
MAB_4659|M.abscessus_ATCC_1997 RRERIYLAHRS-VEIRDKTVILVDDGIATGATMRVALLTVK----RASPA
TH_3117|M.thermoresistible__bu RRSERYRGGRSRIPLSGRVAVIVDDGVATGATAKAACQVVR----AEGAA
MUL_3276|M.ulcerans_Agy99 RRVQRYRGDRHPIPLRGRIAVIVDDGVATGATAAAACQVAR----AQGAS
** * . * : .::****:****: .* :
Mvan_3513|M.vanbaalenii_PYR-1 RVIVGVPVGPASVCRQLRDEADDVVCSTMPEDFRAVGQMFVDFHQVSDDE
Mflv_2998|M.gilvum_PYR-GCK RIIVGVPVGPRAACRLLRSEADLVVCSTTPPNFRAVGQVYADFHQVSDEE
MMAR_3483|M.marinum_M HIVIAVPAAPESSCREFAGLVDDVVCASMPTPFLAVGESFWDFRQVTDEE
MSMEG_4215|M.smegmatis_MC2_155 RVVVAVPVGPPGVCRELAAEADDVVCASMPQDFEAVGQAFADFHQVSDDE
Mb2167|M.bovis_AF2122/97 SIVVAVPVGPATACRELAAEADDVVCATMPAAFEAVGQVYNDFHQVTDDE
Rv2143|M.tuberculosis_H37Rv SIVVAVPVGPATACRELAAEADDVVCATMPAAFEAVGQVYNDFHQVTDDE
MAV_2347|M.avium_104 SIVVAVPVGPESACRELGREADEVVCLSTPPGFEAVGQVYGDFHQVSDDE
MAB_4659|M.abscessus_ATCC_1997 RVVAAVPVAPRSAVGRFGSLVDDFVVATCPSRFQAVGDAYRDFHQISDRE
TH_3117|M.thermoresistible__bu RVVLAVPVGPPDVAERFAGYADEVVCLQTPPFFSAVGQGYRNFTQTSDDE
MUL_3276|M.ulcerans_Agy99 RVILAVPIGATDTAPRFTEYADEVVCLETPTPYFAVGQGYDNFTQTSDQE
:: .** .. : .* .* * : ***: : :* * :* *
Mvan_3513|M.vanbaalenii_PYR-1 VRELLAG-------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK VRELLAAG------------------------------------------
MMAR_3483|M.marinum_M VRNLLATPTTGIPALRPAVPTPAEVIRNVAIDAHGGVPPREALEAVIGDA
MSMEG_4215|M.smegmatis_MC2_155 VRELLATPTT-------------DPVR-----------------------
Mb2167|M.bovis_AF2122/97 VRELLATPTTGAAT------------------------------------
Rv2143|M.tuberculosis_H37Rv VRELLATPTTGAAT------------------------------------
MAV_2347|M.avium_104 VRELLATPTG----------------------------------------
MAB_4659|M.abscessus_ATCC_1997 VRELLSAPVIR---------------------------------------
TH_3117|M.thermoresistible__bu VIALLRRARADVADTAAADIGDPPPLRDEEVRVDAGGVTVTGHLTVPGQP
MUL_3276|M.ulcerans_Agy99 VVTLLDRARSEFG---AGHQPPVPARRDDGVRVLAGPASVIGRLTIPDRP
* **
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3483|M.marinum_M RIVLIGESSHGTHEFYEARAEITKWLIEQKGFCAVAAEADWPDAYRVNRY
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu IGVVVFAHGSG---RHSPRNRYVADVLRRAGLATLLFDLLTPD-------
MUL_3276|M.ulcerans_Agy99 TGIVVFAHGSGS-SRHSPRNRYVAEVLNQAGLATLLLDLLTPE-------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3483|M.marinum_M VHGLGEDQSAEQALRGFERFPAWMWRNTVVRDFVDWLRERNQRCASNGQR
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu ------------------------------------------------EE
MUL_3276|M.ulcerans_Agy99 ------------------------------------------------EE
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3483|M.marinum_M QAGFYGLDLYSLHRSMQEVVAFLDRVDPAAAARARARYACFDHTAADDGQ
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu LDRANVFDIGLLAERLVGVTQWLAAQPETAALPVGYFGASTGAGAALVAA
MUL_3276|M.ulcerans_Agy99 HNRANVFDIGLLARRLVDVTGWLAAQPDTTALPVGFFGASTGGGAALVAA
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3483|M.marinum_M AYGYAAAFGAGPSCERQAIEQLVDTQRNALDYARRDGLIAEDEAFYAQQN
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu ADPRVQVAAVVSRGGRPDLAGQALGKVRAPTLLIVGGRDRFVLELNHQAR
MUL_3276|M.ulcerans_Agy99 AHPGVKVQAVVSRGGRPDLAGDALREVHAPTLPIVGGRDEAVLELNRQAQ
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3483|M.marinum_M AQTVRNAEVYYRAMFSGRVTSWNLRDQHMAETLAALQAHLDRHREAAPAR
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu AAIPAVCEIAVIPGATHLFEEPGALDQVAELARDWFTDHLSRTGASTRP-
MUL_3276|M.ulcerans_Agy99 AAIPAPCELVVVPGATHLFEEPGALEQVATLARDWFLGHLRHH-------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3483|M.marinum_M IVVWAHNSHVGDARATEVWADGQLTLGQLVRQRYGDDSRLIGLCTYSGTV
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3483|M.marinum_M TAASEWGGIAERKVVRPALHASVEELFHDTGKDAFLVSAATSPEAADPLS
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3483|M.marinum_M GVRLGRAIGVIYLPATERQSHYFHVRPADQFDAMIHIDKTRALEPLETTS
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 ---------------
Mflv_2998|M.gilvum_PYR-GCK ---------------
MMAR_3483|M.marinum_M LWIAGETPETYPSGL
MSMEG_4215|M.smegmatis_MC2_155 ---------------
Mb2167|M.bovis_AF2122/97 ---------------
Rv2143|M.tuberculosis_H37Rv ---------------
MAV_2347|M.avium_104 ---------------
MAB_4659|M.abscessus_ATCC_1997 ---------------
TH_3117|M.thermoresistible__bu ---------------
MUL_3276|M.ulcerans_Agy99 ---------------