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KASARTFHDRRDAGRVLARDLCDRISRPDAGDGDLGEILVLGLARGGVPVGWEVAQRLKAPLDVCLVRKL GAPQWPELAIGALAGGGGVVLNNELIRSLGVGEDQIRDIVCRETAELHRREKAYRGDRGPVTVSGRTVVL VDDGIATGASMIAAVRSVREAGARRIIVGVPVGPRAACRLLRSEADLVVCSTTPPNFRAVGQVYADFHQV SDEEVRELLAAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2998 | - | - | 100% (223) | phosphoribosyltransferase |
| M. gilvum PYR-GCK | Mflv_4988 | - | 2e-53 | 49.77% (215) | erythromycin esterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2167 | - | 1e-68 | 61.36% (220) | hypothetical protein Mb2167 |
| M. tuberculosis H37Rv | Rv2143 | - | 1e-68 | 61.36% (220) | hypothetical protein Rv2143 |
| M. leprae Br4923 | MLBr_00248 | prsA | 3e-05 | 39.39% (66) | ribose-phosphate pyrophosphokinase |
| M. abscessus ATCC 19977 | MAB_4659 | - | 7e-50 | 48.65% (222) | hypothetical protein MAB_4659 |
| M. marinum M | MMAR_3483 | - | 9e-58 | 52.97% (219) | hypothetical protein MMAR_3483 |
| M. avium 104 | MAV_2347 | - | 2e-68 | 60.00% (220) | phosphoribosyltransferase |
| M. smegmatis MC2 155 | MSMEG_4215 | - | 9e-74 | 65.28% (216) | phosphoribosyltransferase |
| M. thermoresistible (build 8) | TH_3117 | - | 1e-46 | 47.27% (220) | PUTATIVE Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) |
| M. ulcerans Agy99 | MUL_3276 | - | 7e-46 | 47.91% (215) | hypothetical protein MUL_3276 |
| M. vanbaalenii PYR-1 | Mvan_3513 | - | 2e-81 | 67.42% (221) | phosphoribosyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 MEAPPYAGDPTFERLRRSFQPADLLPELQAAGVHYTIAVEAADDPAENES
Rv2143|M.tuberculosis_H37Rv MEAPPYAGDPTFERLRRSFQPADLLPELQAAGVHYTIAVEAADDPAENES
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3483|M.marinum_M --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00248|M.leprae_Br4923 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 LLATARHHDWIARVIGWVPLADPDEVTESSTHGRHRPDASWRRDLRCPGL
Rv2143|M.tuberculosis_H37Rv LLATARHHDWIARVIGWVPLADPDEVTESSTHGRHRPDASWRRDLRCPGL
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3483|M.marinum_M --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00248|M.leprae_Br4923 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 -------------------------MSAWSVRHDAIRTFQDRR--EAGRV
Mvan_3513|M.vanbaalenii_PYR-1 -------------------------MTHDERMTHKKRTFRDRR--EAGQV
Mb2167|M.bovis_AF2122/97 LPPGCHQPVLVVGLVGQQPEMRPMNPPSGFLRRTPTRRFRDRR--DAGRV
Rv2143|M.tuberculosis_H37Rv LPPGCHQPVLVVGLVGQQPEMRPMNPPSGFLRRTPTRRFRDRR--DAGRV
MAV_2347|M.avium_104 -----------------------------------MRSFRDRR--EAGRA
Mflv_2998|M.gilvum_PYR-GCK -------------------------------MKASARTFHDRR--DAGRV
MAB_4659|M.abscessus_ATCC_1997 -------------------------------MSDTHRMFSDRQ--DAGRV
MMAR_3483|M.marinum_M -----------------------MTSAARADRNAPRRVFRDRH--EAGQV
TH_3117|M.thermoresistible__bu -------------------------------MRADTRPFDDRV--DAGRR
MUL_3276|M.ulcerans_Agy99 -----------------------------------MRQFSDRI--DAGRK
MLBr_00248|M.leprae_Br4923 -----------------------MLSHDWTDNRKNLMLFSGRAHPELAEQ
* .* : ..
MSMEG_4215|M.smegmatis_MC2_155 LAQRLSSYRDDP--------DVLVLGLARGGVPVAWEVAAHLRAPLDVFL
Mvan_3513|M.vanbaalenii_PYR-1 LARDLARYRGTR--------DLMVLGLARGGVPVAWEVAHALHAPLDVCL
Mb2167|M.bovis_AF2122/97 LADELASYRGRD--------RLLVLGLARGGVPVGWEVASALGAELDVFL
Rv2143|M.tuberculosis_H37Rv LADELASYRGRD--------RLLVLGLARGGVPVGWEVASALGAELDVFL
MAV_2347|M.avium_104 LAGELMGYRNRG--------DVLVFGLARGGLPVAWEIAAALHAPLDVFL
Mflv_2998|M.gilvum_PYR-GCK LARDLCDRISRPDAGDGDLGEILVLGLARGGVPVGWEVAQRLKAPLDVCL
MAB_4659|M.abscessus_ATCC_1997 LAGMLAPRKLR---------SIVVLALPRGGIPVGREIATALNAPLAVLV
MMAR_3483|M.marinum_M LADLLTAYRDRP--------DVIVLGLARGGIPVAWEVAAALHAPLDAFI
TH_3117|M.thermoresistible__bu PAERLASFRGRD---------VVVLGLPRGGVPVAFAVARALRAPLDVLV
MUL_3276|M.ulcerans_Agy99 LGRRLEFLRGQD---------IVVLGLPRGGVPVAFEVAKALHAPLDVLL
MLBr_00248|M.leprae_Br4923 VAKELDMHVTTQDAREFAN-GEIFVRFHESVRGCDAFVLQSCPAPVNTWL
. * :.. : .. : * : . :
MSMEG_4215|M.smegmatis_MC2_155 VRKLG----------------VPQWQELAMGAVASGGGVVLNEKLMDRLG
Mvan_3513|M.vanbaalenii_PYR-1 VRKLG----------------VPQWPELAMGAVATGGGVVLNTGLLHDLG
Mb2167|M.bovis_AF2122/97 VRKLG----------------VPQWRELAMGALASGGGVVMNDDVVSSLR
Rv2143|M.tuberculosis_H37Rv VRKLG----------------VPQWRELAMGALASGGGVVMNDDVVSSLR
MAV_2347|M.avium_104 VRKLG----------------VPNWSELAMGALASGGGVVMNDDVVSSLR
Mflv_2998|M.gilvum_PYR-GCK VRKLG----------------APQWPELAIGALAGGGGVVLNNELIRSLG
MAB_4659|M.abscessus_ATCC_1997 VRKLG----------------VPGHEEYAMGAIASGGEVILDDDIVRSMG
MMAR_3483|M.marinum_M VRKLG----------------APGHEEFAVGALASGGRVVVNDDVVRGLR
TH_3117|M.thermoresistible__bu VRKLG----------------VPFQPELAFGAIGEDGVRVVNDAVVRRTR
MUL_3276|M.ulcerans_Agy99 VRKLG----------------VPLHSELAFGAIGEGGVQVINSAVVHEAG
MLBr_00248|M.leprae_Br4923 MEQLIMIDALKRGSAKRITAVIPFYPYARQDKKHRGREPISARLVADLLK
:.:* * . . : :
MSMEG_4215|M.smegmatis_MC2_155 ISDDDMAETLRRETIELE----------RREQAYRGDREPLQVAGRTVIL
Mvan_3513|M.vanbaalenii_PYR-1 ISDDEVGEAITRETAELD----------RREQAYRGDRGPVSVAGRCVIL
Mb2167|M.bovis_AF2122/97 ITDQQVRAAIDSETAELQ----------RRELAYRGGRPVVDPRARIVIL
Rv2143|M.tuberculosis_H37Rv ITDQQVRAAIDSETAELQ----------RRELAYRGGRPVVDPRARIVIL
MAV_2347|M.avium_104 ITDEQVRAVIDSETAELA----------RREHAYRGDRPMADLRDKVVIL
Mflv_2998|M.gilvum_PYR-GCK VGEDQIRDIVCRETAELH----------RREKAYRGDRGPVTVSGRTVVL
MAB_4659|M.abscessus_ATCC_1997 VTPIQLDEVTDRERRELA----------RRERIYLAHR-SVEIRDKTVIL
MMAR_3483|M.marinum_M ITPQQLRDTAEREARELV----------RREAAYRAGRPPLDVAGKTVVL
TH_3117|M.thermoresistible__bu LTRADMAAVERRERAELQ----------RRSERYRGGRSRIPLSGRVAVI
MUL_3276|M.ulcerans_Agy99 LGEQEMAAVETAQWAELQ----------RRVQRYRGDRHPIPLRGRIAVI
MLBr_00248|M.leprae_Br4923 TAGADRIVTVDLHTDQIQGFFDGPVDHMRGQNLLTGYIKNNYPDTNMVVV
: . :: * . . .::
MSMEG_4215|M.smegmatis_MC2_155 VDDG--IATGASMMAAVRAVR------GARRVVVAVPVGPPGVCRELAAE
Mvan_3513|M.vanbaalenii_PYR-1 VDDG--IATGASMVAAMRAVRQ----AGAARVIVGVPVGPASVCRQLRDE
Mb2167|M.bovis_AF2122/97 VDDG--IATGASMLAAVRTIR----ATGPESIVVAVPVGPATACRELAAE
Rv2143|M.tuberculosis_H37Rv VDDG--IATGASMLAAVRTIR----ATGPESIVVAVPVGPATACRELAAE
MAV_2347|M.avium_104 VDDG--IATGASMLAAVRALRSGPTGATPRSIVVAVPVGPESACRELGRE
Mflv_2998|M.gilvum_PYR-GCK VDDG--IATGASMIAAVRSVR----EAGARRIIVGVPVGPRAACRLLRSE
MAB_4659|M.abscessus_ATCC_1997 VDDG--IATGATMRVALLTVKR----ASPARVVAAVPVAPRSAVGRFGSL
MMAR_3483|M.marinum_M VDDG--LATGASMFAAVQAIRD----AEPAHIVIAVPAAPESSCREFAGL
TH_3117|M.thermoresistible__bu VDDG--VATGATAKAACQVVR----AEGAARVVLAVPVGPPDVAERFAGY
MUL_3276|M.ulcerans_Agy99 VDDG--VATGATAAAACQVAR----AQGASRVILAVPIGATDTAPRFTEY
MLBr_00248|M.leprae_Br4923 SPDSGRVRIAEKWGDALGGVP-----LAFIHKTRDLRVPNQVVSNRVVGE
*. : . . * : .
MSMEG_4215|M.smegmatis_MC2_155 ADDVVCASMPQDFEAVGQAFADFHQVSDDEVRELLATPTTDPVR------
Mvan_3513|M.vanbaalenii_PYR-1 ADDVVCSTMPEDFRAVGQMFVDFHQVSDDEVRELLAG-------------
Mb2167|M.bovis_AF2122/97 ADDVVCATMPAAFEAVGQVYNDFHQVTDDEVRELLATPTTGAAT------
Rv2143|M.tuberculosis_H37Rv ADDVVCATMPAAFEAVGQVYNDFHQVTDDEVRELLATPTTGAAT------
MAV_2347|M.avium_104 ADEVVCLSTPPGFEAVGQVYGDFHQVSDDEVRELLATPTG----------
Mflv_2998|M.gilvum_PYR-GCK ADLVVCSTTPPNFRAVGQVYADFHQVSDEEVRELLAAG------------
MAB_4659|M.abscessus_ATCC_1997 VDDFVVATCPSRFQAVGDAYRDFHQISDREVRELLSAP------------
MMAR_3483|M.marinum_M VDDVVCASMPTPFLAVGESFWDFRQVTDEEVRNLLATPTTGIPALRPAVP
TH_3117|M.thermoresistible__bu ADEVVCLQTPPFFSAVGQGYRNFTQTSDDEVIALLRRARADVADTAAADI
MUL_3276|M.ulcerans_Agy99 ADEVVCLETPTPYFAVGQGYDNFTQTSDQEVVTLLDRARSEFG---AGHQ
MLBr_00248|M.leprae_Br4923 VEGRTCVLIDDMIDTGGTVAGAVQLLRNDGASDVIIAATHGVLSPPAAER
.: . : * . : . ::
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 ----VIR-------------------------------------------
MMAR_3483|M.marinum_M TPAEVIRNVAIDAHGGVPPREALEAVIGDARIVLIGESSHGTHEFYEARA
TH_3117|M.thermoresistible__bu GDPPPLRDEEVRVDAGGVTVTGHLTVPGQPIGVVVFAHGSG---RHSPRN
MUL_3276|M.ulcerans_Agy99 PPVPARRDDGVRVLAGPASVIGRLTIPDRPTGIVVFAHGSGS-SRHSPRN
MLBr_00248|M.leprae_Br4923 LAQYGTREVIVTNTLPIGEEKRFPQLTVLSIAPLLASTIRAIFENGSVTG
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3483|M.marinum_M EITKWLIEQKGFCAVAAEADWPDAYRVNRYVHGLGEDQSAEQALRGFERF
TH_3117|M.thermoresistible__bu RYVADVLRRAGLATLLFDLLTPDEELDRANVFDIGLLAERLVGVTQWLAA
MUL_3276|M.ulcerans_Agy99 RYVAEVLNQAGLATLLLDLLTPEEEHNRANVFDIGLLARRLVDVTGWLAA
MLBr_00248|M.leprae_Br4923 LFDGEA--------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3483|M.marinum_M PAWMWRNTVVRDFVDWLRERNQRCASNGQRQAGFYGLDLYSLHRSMQEVV
TH_3117|M.thermoresistible__bu QPETAALPVG--------------YFGASTGAGAALVAAADPRVQVAAVV
MUL_3276|M.ulcerans_Agy99 QPDTTALPVG--------------FFGASTGGGAALVAAAHPGVKVQAVV
MLBr_00248|M.leprae_Br4923 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3483|M.marinum_M AFLDRVDPAAAARARARYACFDHTAADDGQAYGYAAAFGAGPSCERQAIE
TH_3117|M.thermoresistible__bu SRGGRPDLAGQALGKVRAPTLLIVGGRDRFVLELNHQARAAIPAVCEIAV
MUL_3276|M.ulcerans_Agy99 SRGGRPDLAGDALREVHAPTLPIVGGRDEAVLELNRQAQAAIPAPCELVV
MLBr_00248|M.leprae_Br4923 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3483|M.marinum_M QLVDTQRNALDYARRDGLIAEDEAFYAQQNAQTVRNAEVYYRAMFSGRVT
TH_3117|M.thermoresistible__bu IPGATHLFEEPGALDQVAELARDWFTDHLSRTGASTRP------------
MUL_3276|M.ulcerans_Agy99 VPGATHLFEEPGALEQVATLARDWFLGHLRHH------------------
MLBr_00248|M.leprae_Br4923 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3483|M.marinum_M SWNLRDQHMAETLAALQAHLDRHREAAPARIVVWAHNSHVGDARATEVWA
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00248|M.leprae_Br4923 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3483|M.marinum_M DGQLTLGQLVRQRYGDDSRLIGLCTYSGTVTAASEWGGIAERKVVRPALH
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00248|M.leprae_Br4923 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3483|M.marinum_M ASVEELFHDTGKDAFLVSAATSPEAADPLSGVRLGRAIGVIYLPATERQS
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00248|M.leprae_Br4923 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 ---------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 ---------------------------------------------
Mb2167|M.bovis_AF2122/97 ---------------------------------------------
Rv2143|M.tuberculosis_H37Rv ---------------------------------------------
MAV_2347|M.avium_104 ---------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK ---------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 ---------------------------------------------
MMAR_3483|M.marinum_M HYFHVRPADQFDAMIHIDKTRALEPLETTSLWIAGETPETYPSGL
TH_3117|M.thermoresistible__bu ---------------------------------------------
MUL_3276|M.ulcerans_Agy99 ---------------------------------------------
MLBr_00248|M.leprae_Br4923 ---------------------------------------------