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MATARRTISDQPRRVFRDRREAGRVLAGLLGGYRGREGLVVLGLARGGIPVAWEVAAALGAPLDAFIVRK LGAPGHEEFAMGALASGGRVVVNDDVVRALRVSPQQLRDVAEREGRELHRREAAYRGGRPPLELAGKTVI LVDDGLATGSSMMAAVQALRELDPAEIVVAVPAAPESTVREFGGLVDDVVCASMPTPFRAVGESFWDFTQ VSDDDVHELLTTPTVGIATARIRLAETPADVITRCAVDAPSGVPPYEALEEVIGDARIVLIGESSHGTHE FYEARAEITKWLIEEKGFCAVAAEADWPDAYRVNRYVRGQDRDASADEALSGFERFPAWMWRNTVVRDFV DWLHARNSRCRADGRREAGFYGLDLYSLHRSMREVIGYLENIDPAAAQRAANRYACFDHTSADDGQAYGF AAAFGAGLSCEQQAVEQLVELHRNAMEYARRDGFVAEDELFYAQQNAQTVRDAEVYYRSMFAGRVSSWNL RDRHMAQTMEALLAHLDRHSGSEPARIVVWAHNSHVGDARATEVGADGQLTLGQLAREKFGEDARLIGFT TYSGTVTAASTWGGVAERKAVRPGLNGSVEELFHEVERPEFLVSPMISKAAAEPLDAVRLARAIGVIYLP ATERQSHYYHVRPGDQYDALIHIDTTTALEPLETTSVWVAGETPETYPTGL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1393 | - | - | 100% (681) | erythromycin esterase |
| M. vanbaalenii PYR-1 | Mvan_3513 | - | 4e-61 | 57.21% (208) | phosphoribosyltransferase |
| M. vanbaalenii PYR-1 | Mvan_5893 | - | 2e-11 | 24.70% (332) | erythromycin esterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2056c | - | 0.0 | 75.09% (586) | hypothetical protein Mb2056c |
| M. gilvum PYR-GCK | Mflv_4988 | - | 0.0 | 85.90% (681) | erythromycin esterase |
| M. tuberculosis H37Rv | Rv2030c | - | 0.0 | 74.74% (681) | hypothetical protein Rv2030c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4659 | - | 2e-59 | 54.72% (212) | hypothetical protein MAB_4659 |
| M. marinum M | MMAR_3483 | - | 0.0 | 76.65% (681) | hypothetical protein MMAR_3483 |
| M. avium 104 | MAV_2347 | - | 1e-68 | 63.26% (215) | phosphoribosyltransferase |
| M. smegmatis MC2 155 | MSMEG_4215 | - | 6e-65 | 60.66% (211) | phosphoribosyltransferase |
| M. thermoresistible (build 8) | TH_3117 | - | 3e-48 | 45.45% (253) | PUTATIVE Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) |
| M. ulcerans Agy99 | MUL_3276 | - | 1e-45 | 41.67% (252) | hypothetical protein MUL_3276 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1393|M.vanbaalenii_PYR-1 --MATARRTISDQPRRVFRDRREAGRVLAGLLGGYRGREGLVVLGLARGG
Mflv_4988|M.gilvum_PYR-GCK --MTTARRAASDQPRRVFRDRREAGQALAGLLGGYRGRENVVVLGLARGG
Mb2056c|M.bovis_AF2122/97 MLMTAAADVTRRSPRRVFRDRREAGRVLAELLAAYRDQPDVIVLGLARGG
Rv2030c|M.tuberculosis_H37Rv MLMTAAADVTRRSPRRVFRDRREAGRVLAELLAAYRDQPDVIVLGLARGG
MMAR_3483|M.marinum_M --MTSAARADRNAPRRVFRDRHEAGQVLADLLTAYRDRPDVIVLGLARGG
MAV_2347|M.avium_104 --------------MRSFRDRREAGRALAGELMGYRNRGDVLVFGLARGG
MSMEG_4215|M.smegmatis_MC2_155 ----MSAWSVRHDAIRTFQDRREAGRVLAQRLSSYRDDPDVLVLGLARGG
MAB_4659|M.abscessus_ATCC_1997 ----------MSDTHRMFSDRQDAGRVLAGMLAPRKLR-SIVVLALPRGG
TH_3117|M.thermoresistible__bu ----------MRADTRPFDDRVDAGRRPAERLASFRGR-DVVVLGLPRGG
MUL_3276|M.ulcerans_Agy99 --------------MRQFSDRIDAGRKLGRRLEFLRGQ-DIVVLGLPRGG
* * ** :**: . * : .::*:.*.***
Mvan_1393|M.vanbaalenii_PYR-1 IPVAWEVAAALGAPLDAFIVRKLGAPGHEEFAMGALASGGRVVVNDDVVR
Mflv_4988|M.gilvum_PYR-GCK IPVAWEVAAALGAPLDAFIVRKLGAPGHDEFAMGALASGGRVVVNDDVVR
Mb2056c|M.bovis_AF2122/97 LPVAWEVAAALHAPLDAFVVRKLGAPGHDEFAVGALASGGRVVVNDDVVR
Rv2030c|M.tuberculosis_H37Rv LPVAWEVAAALHAPLDAFVVRKLGAPGHDEFAVGALASGGRVVVNDDVVR
MMAR_3483|M.marinum_M IPVAWEVAAALHAPLDAFIVRKLGAPGHEEFAVGALASGGRVVVNDDVVR
MAV_2347|M.avium_104 LPVAWEIAAALHAPLDVFLVRKLGVPNWSELAMGALASGGGVVMNDDVVS
MSMEG_4215|M.smegmatis_MC2_155 VPVAWEVAAHLRAPLDVFLVRKLGVPQWQELAMGAVASGGGVVLNEKLMD
MAB_4659|M.abscessus_ATCC_1997 IPVGREIATALNAPLAVLVVRKLGVPGHEEYAMGAIASGGEVILDDDIVR
TH_3117|M.thermoresistible__bu VPVAFAVARALRAPLDVLVVRKLGVPFQPELAFGAIGEDGVRVVNDAVVR
MUL_3276|M.ulcerans_Agy99 VPVAFEVAKALHAPLDVLLVRKLGVPLHSELAFGAIGEGGVQVINSAVVH
:**. :* * *** .::*****.* * *.**:...* :::. ::
Mvan_1393|M.vanbaalenii_PYR-1 ALRVSPQQLRDVAEREGRELHRREAAYRGGRPPLELAGKTVILVDDGLAT
Mflv_4988|M.gilvum_PYR-GCK ALRVSPQQPRDVAEREGRELLRREAAYRAGRPPLELAGKTVIVVDDGLAT
Mb2056c|M.bovis_AF2122/97 GLRITPQQLRDIAEREGRELLRRESAYRGERPPTDITGKTVIVVDDGLAT
Rv2030c|M.tuberculosis_H37Rv GLRITPQQLRDIAEREGRELLRRESAYRGERPPTDITGKTVIVVDDGLAT
MMAR_3483|M.marinum_M GLRITPQQLRDTAEREARELVRREAAYRAGRPPLDVAGKTVVLVDDGLAT
MAV_2347|M.avium_104 SLRITDEQVRAVIDSETAELARREHAYRGDRPMADLRDKVVILVDDGIAT
MSMEG_4215|M.smegmatis_MC2_155 RLGISDDDMAETLRRETIELERREQAYRGDREPLQVAGRTVILVDDGIAT
MAB_4659|M.abscessus_ATCC_1997 SMGVTPIQLDEVTDRERRELARRERIYLAHR-SVEIRDKTVILVDDGIAT
TH_3117|M.thermoresistible__bu RTRLTRADMAAVERRERAELQRRSERYRGGRSRIPLSGRVAVIVDDGVAT
MUL_3276|M.ulcerans_Agy99 EAGLGEQEMAAVETAQWAELQRRVQRYRGDRHPIPLRGRIAVIVDDGVAT
: : : ** ** * . * : .: .::****:**
Mvan_1393|M.vanbaalenii_PYR-1 GSSMMAAVQALR----ELDPAEIVVAVPAAPESTVREFGGLVDDVVCASM
Mflv_4988|M.gilvum_PYR-GCK GSSMFAAVQALQ----EMDPAEVVIAVPAAPESTCREFAAIVDDVVCASM
Mb2056c|M.bovis_AF2122/97 GASMFAAVQALR----DAQPAQIVIAVPAAPESTCREFAGLVDDVVCATM
Rv2030c|M.tuberculosis_H37Rv GASMFAAVQALR----DAQPAQIVIAVPAAPESTCREFAGLVDDVVCATM
MMAR_3483|M.marinum_M GASMFAAVQAIR----DAEPAHIVIAVPAAPESSCREFAGLVDDVVCASM
MAV_2347|M.avium_104 GASMLAAVRALRSGPTGATPRSIVVAVPVGPESACRELGREADEVVCLST
MSMEG_4215|M.smegmatis_MC2_155 GASMMAAVRAVR------GARRVVVAVPVGPPGVCRELAAEADDVVCASM
MAB_4659|M.abscessus_ATCC_1997 GATMRVALLTVK----RASPARVVAAVPVAPRSAVGRFGSLVDDFVVATC
TH_3117|M.thermoresistible__bu GATAKAACQVVR----AEGAARVVLAVPVGPPDVAERFAGYADEVVCLQT
MUL_3276|M.ulcerans_Agy99 GATAAAACQVAR----AQGASRVILAVPIGATDTAPRFTEYADEVVCLET
*:: .* . : . :: *** .. . .: .*:.*
Mvan_1393|M.vanbaalenii_PYR-1 PTPFRAVGESFWDFTQVSDDDVHELLTTPTVGIATARIRLAETPADVITR
Mflv_4988|M.gilvum_PYR-GCK PTPFLAVGESFWDFRQVTDDEVRELLETPTVGFATARIRLAETPAEVIDR
Mb2056c|M.bovis_AF2122/97 PTPFLAVGESFWDFRQVTDEEVRRLLATPTAGPSLRRP-AASTAADVLRR
Rv2030c|M.tuberculosis_H37Rv PTPFLAVGESFWDFRQVTDEEVRRLLATPTAGPSLRRP-AASTAADVLRR
MMAR_3483|M.marinum_M PTPFLAVGESFWDFRQVTDEEVRNLLATPTTGIPALRP-AVPTPAEVIRN
MAV_2347|M.avium_104 PPGFEAVGQVYGDFHQVSDDEVRELLATPTG-------------------
MSMEG_4215|M.smegmatis_MC2_155 PQDFEAVGQAFADFHQVSDDEVRELLATPTTDPVR---------------
MAB_4659|M.abscessus_ATCC_1997 PSRFQAVGDAYRDFHQISDREVRELLSAPVIR------------------
TH_3117|M.thermoresistible__bu PPFFSAVGQGYRNFTQTSDDEVIALLRRARADVADTAAADIGDPPPLRDE
MUL_3276|M.ulcerans_Agy99 PTPYFAVGQGYDNFTQTSDQEVVTLLDRARSEFG---AGHQPPVPARRDD
* : ***: : :* * :* :* ** .
Mvan_1393|M.vanbaalenii_PYR-1 CAVDAPSGVPPYEALEEVIGDARIVLIGESSHGTHEFYEARAEITKWLIE
Mflv_4988|M.gilvum_PYR-GCK CAVDAPAGVPPLEALDELIGDARIVLIGESSHGTEEFYAARAEITKWLIE
Mb2056c|M.bovis_AF2122/97 VAIDAPGGVPTHEVLAELVGDARIVLIGESSHGTHEFYQARAAMTQWLIE
Rv2030c|M.tuberculosis_H37Rv VAIDAPGGVPTHEVLAELVGDARIVLIGESSHGTHEFYQARAAMTQWLIE
MMAR_3483|M.marinum_M VAIDAHGGVPPREALEAVIGDARIVLIGESSHGTHEFYEARAEITKWLIE
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu EVRVDAGGVTVTGHLTVPGQPIGVVVFAHGSG------------------
MUL_3276|M.ulcerans_Agy99 GVRVLAGPASVIGRLTIPDRPTGIVVFAHGSGS-----------------
Mvan_1393|M.vanbaalenii_PYR-1 EKGFCAVAAEADWPDAYRVNRYVRGQDRDASADEALSGFERFPAWMWRNT
Mflv_4988|M.gilvum_PYR-GCK EKGFCGVAAEADWPDAYRVNRYVRGQAGDGSAEEALRGFERFPAWMWRNT
Mb2056c|M.bovis_AF2122/97 EKGFGAVAAEADWPDAYRVNRYVRGLGEDTNADEALSGFERFPAWMWRNT
Rv2030c|M.tuberculosis_H37Rv EKGFGAVAAEADWPDAYRVNRYVRGLGEDTNADEALSGFERFPAWMWRNT
MMAR_3483|M.marinum_M QKGFCAVAAEADWPDAYRVNRYVHGLGEDQSAEQALRGFERFPAWMWRNT
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1393|M.vanbaalenii_PYR-1 VVRDFVDWLHARNSRCRADGRREAGFYGLDLYSLHRSMREVIGYLENIDP
Mflv_4988|M.gilvum_PYR-GCK VVRDFVAWLRACNADRRAQGRREAGFYGLDLYSLHRSMQEVIDFLDRVDP
Mb2056c|M.bovis_AF2122/97 VVRDFVEWLRTRNQRYESGALRQAGFYGLDLYSLHRSIQEVISYLDKVDP
Rv2030c|M.tuberculosis_H37Rv VVRDFVEWLRTRNQRYESGALRQAGFYGLDLYSLHRSIQEVISYLDKVDP
MMAR_3483|M.marinum_M VVRDFVDWLRERNQRCASNGQRQAGFYGLDLYSLHRSMQEVVAFLDRVDP
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------RHSPRNRYVADVLRRAGLATLLFDLLTPDEELDRANVFDIGL
MUL_3276|M.ulcerans_Agy99 -------SRHSPRNRYVAEVLNQAGLATLLLDLLTPEEEHNRANVFDIGL
Mvan_1393|M.vanbaalenii_PYR-1 AAAQRAANRYACFDHTSADDGQAYGFAAAFGAGLSCEQQAVEQLVELHRN
Mflv_4988|M.gilvum_PYR-GCK DAAQRARERYSCFDHSSGDDGQAYGFAAAFGAGLSCEHQAVEQLVEMHRS
Mb2056c|M.bovis_AF2122/97 RAAARARARYACFDHACADDGQAYGFAAAFGAGPSCEREAVEQLVDVQRN
Rv2030c|M.tuberculosis_H37Rv RAAARARARYACFDHACADDGQAYGFAAAFGAGPSCEREAVEQLVDVQRN
MMAR_3483|M.marinum_M AAAARARARYACFDHTAADDGQAYGYAAAFGAGPSCERQAIEQLVDTQRN
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu LAERLVGVTQWLAAQPETAALPVGYFGASTGAG-----------------
MUL_3276|M.ulcerans_Agy99 LARRLVDVTGWLAAQPDTTALPVGFFGASTGGG-----------------
Mvan_1393|M.vanbaalenii_PYR-1 AMEYARRDGFVAEDELFYAQQNAQTVRDAEVYYRSMFAGRVSSWNLRDRH
Mflv_4988|M.gilvum_PYR-GCK AVEYARRDGLLAEDELFYAQQNAQTVRDAEVYYRSMFGGRVTSWNLRDRH
Mb2056c|M.bovis_AF2122/97 ALAYARQDGLLAEDELFYAQQNAQTVRDAEVYYRAMFSGRVTSWNLRDQH
Rv2030c|M.tuberculosis_H37Rv ALAYARQDGLLAEDELFYAQQNAQTVRDAEVYYRAMFSGRVTSWNLRDQH
MMAR_3483|M.marinum_M ALDYARRDGLIAEDEAFYAQQNAQTVRNAEVYYRAMFSGRVTSWNLRDQH
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------AALVAAADPRVQVAAVVSRGGRPDLAGQALGKVRAPTLLIVG
MUL_3276|M.ulcerans_Agy99 --------AALVAAAHPGVKVQAVVSRGGRPDLAGDALREVHAPTLPIVG
Mvan_1393|M.vanbaalenii_PYR-1 MAQTMEALLAHLDRHSGSEPARIVVWAHNSHVGDARATEVGADGQLTLGQ
Mflv_4988|M.gilvum_PYR-GCK MAETLEALLRHLDRQGGSEPARIVVWAHNSHVGDARATEVGADGQLTLGQ
Mb2056c|M.bovis_AF2122/97 MAQTLGSLLTHLDRHLDAPPARIVVWAHNSHVGDARATEVWADGQLTLGQ
Rv2030c|M.tuberculosis_H37Rv MAQTLGSLLTHLDRHLDAPPARIVVWAHNSHVGDARATEVWADGQLTLGQ
MMAR_3483|M.marinum_M MAETLAALQAHLDRHREAAPARIVVWAHNSHVGDARATEVWADGQLTLGQ
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu GRDRFVLELNHQARAAIPAVCEIAVIPGATHLFEE------PGALDQVAE
MUL_3276|M.ulcerans_Agy99 GRDEAVLELNRQAQAAIPAPCELVVVPGATHLFEE------PGALEQVAT
Mvan_1393|M.vanbaalenii_PYR-1 LAREKFGEDARLIGFTTYSGTVTAASTWGGVAERKAVRPGLNGSVEELFH
Mflv_4988|M.gilvum_PYR-GCK LAREKFGDHVRLIGYTTYTGTVTAASEWGGLAERKAVRPALNGSVEELFH
Mb2056c|M.bovis_AF2122/97 IVRERYGDESRSIGFSTYTGTVTAASEWGGIAQRKAVRPALH--------
Rv2030c|M.tuberculosis_H37Rv IVRERYGDESRSIGFSTYTGTVTAASEWGGIAQRKAVRPALHGSVEELFH
MMAR_3483|M.marinum_M LVRQRYGDDSRLIGLCTYSGTVTAASEWGGIAERKVVRPALHASVEELFH
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu LARDWFTDHLSRTGASTRP-------------------------------
MUL_3276|M.ulcerans_Agy99 LARDWFLGHLRHH-------------------------------------
Mvan_1393|M.vanbaalenii_PYR-1 EVERPEFLVSPMISKAAAEPLDAVRLARAIGVIYLPATERQSHYYHVRPG
Mflv_4988|M.gilvum_PYR-GCK EVDRPAFLVSPLISHAAAEPLDAVRLGRAIGVIYLPATERQSHYYHVRPS
Mb2056c|M.bovis_AF2122/97 -----------AVSRSSSTRLQTVSWCQRG--------------------
Rv2030c|M.tuberculosis_H37Rv QT-ADSFLVSARLSRDAEAPLDVVRLGRAIGVVYLPATERQSHYLHVRPA
MMAR_3483|M.marinum_M DTGKDAFLVSAATSPEAADPLSGVRLGRAIGVIYLPATERQSHYFHVRPA
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1393|M.vanbaalenii_PYR-1 DQYDALIHIDTTTALEPLETTSVWVAGETPETYPTGL
Mflv_4988|M.gilvum_PYR-GCK EQFDGIIHIDRTTALEPLEVTSTWAAGETPETYPTGL
Mb2056c|M.bovis_AF2122/97 -------------------------------------
Rv2030c|M.tuberculosis_H37Rv DQFDAMIHIDQTRALEPLEVTSRWIAGENPETYPTGL
MMAR_3483|M.marinum_M DQFDAMIHIDKTRALEPLETTSLWIAGETPETYPSGL
MAV_2347|M.avium_104 -------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 -------------------------------------
MAB_4659|M.abscessus_ATCC_1997 -------------------------------------
TH_3117|M.thermoresistible__bu -------------------------------------
MUL_3276|M.ulcerans_Agy99 -------------------------------------