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RSFRDRREAGRALAGELMGYRNRGDVLVFGLARGGLPVAWEIAAALHAPLDVFLVRKLGVPNWSELAMGA LASGGGVVMNDDVVSSLRITDEQVRAVIDSETAELARREHAYRGDRPMADLRDKVVILVDDGIATGASML AAVRALRSGPTGATPRSIVVAVPVGPESACRELGREADEVVCLSTPPGFEAVGQVYGDFHQVSDDEVREL LATPTG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2347 | - | - | 100% (217) | phosphoribosyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2167 | - | 3e-87 | 76.74% (215) | hypothetical protein Mb2167 |
| M. gilvum PYR-GCK | Mflv_4988 | - | 2e-68 | 61.86% (215) | erythromycin esterase |
| M. tuberculosis H37Rv | Rv2143 | - | 3e-87 | 76.74% (215) | hypothetical protein Rv2143 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4659 | - | 4e-52 | 51.40% (214) | hypothetical protein MAB_4659 |
| M. marinum M | MMAR_3483 | - | 2e-69 | 61.86% (215) | hypothetical protein MMAR_3483 |
| M. smegmatis MC2 155 | MSMEG_4215 | - | 2e-75 | 65.74% (216) | phosphoribosyltransferase |
| M. thermoresistible (build 8) | TH_3117 | - | 9e-48 | 51.66% (211) | PUTATIVE Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) |
| M. ulcerans Agy99 | MUL_3276 | - | 4e-47 | 49.06% (212) | hypothetical protein MUL_3276 |
| M. vanbaalenii PYR-1 | Mvan_3513 | - | 3e-70 | 63.21% (212) | phosphoribosyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4988|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3483|M.marinum_M --------------------------------------------------
Mb2167|M.bovis_AF2122/97 MEAPPYAGDPTFERLRRSFQPADLLPELQAAGVHYTIAVEAADDPAENES
Rv2143|M.tuberculosis_H37Rv MEAPPYAGDPTFERLRRSFQPADLLPELQAAGVHYTIAVEAADDPAENES
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4988|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3483|M.marinum_M --------------------------------------------------
Mb2167|M.bovis_AF2122/97 LLATARHHDWIARVIGWVPLADPDEVTESSTHGRHRPDASWRRDLRCPGL
Rv2143|M.tuberculosis_H37Rv LLATARHHDWIARVIGWVPLADPDEVTESSTHGRHRPDASWRRDLRCPGL
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4988|M.gilvum_PYR-GCK -----------------------MTTARRAASDQPRRVFRDRREAGQALA
MMAR_3483|M.marinum_M -----------------------MTSAARADRNAPRRVFRDRHEAGQVLA
Mb2167|M.bovis_AF2122/97 LPPGCHQPVLVVGLVGQQPEMRPMNPPSGFLRRTPTRRFRDRRDAGRVLA
Rv2143|M.tuberculosis_H37Rv LPPGCHQPVLVVGLVGQQPEMRPMNPPSGFLRRTPTRRFRDRRDAGRVLA
MAV_2347|M.avium_104 -----------------------------------MRSFRDRREAGRALA
MSMEG_4215|M.smegmatis_MC2_155 -------------------------MSAWSVRHDAIRTFQDRREAGRVLA
Mvan_3513|M.vanbaalenii_PYR-1 -------------------------MTHDERMTHKKRTFRDRREAGQVLA
MAB_4659|M.abscessus_ATCC_1997 -------------------------------MSDTHRMFSDRQDAGRVLA
TH_3117|M.thermoresistible__bu -------------------------------MRADTRPFDDRVDAGRRPA
MUL_3276|M.ulcerans_Agy99 -----------------------------------MRQFSDRIDAGRKLG
* * ** :**: .
Mflv_4988|M.gilvum_PYR-GCK GLLGGYRGRENVVVLGLARGGIPVAWEVAAALGAPLDAFIVRKLGAPGHD
MMAR_3483|M.marinum_M DLLTAYRDRPDVIVLGLARGGIPVAWEVAAALHAPLDAFIVRKLGAPGHE
Mb2167|M.bovis_AF2122/97 DELASYRGRDRLLVLGLARGGVPVGWEVASALGAELDVFLVRKLGVPQWR
Rv2143|M.tuberculosis_H37Rv DELASYRGRDRLLVLGLARGGVPVGWEVASALGAELDVFLVRKLGVPQWR
MAV_2347|M.avium_104 GELMGYRNRGDVLVFGLARGGLPVAWEIAAALHAPLDVFLVRKLGVPNWS
MSMEG_4215|M.smegmatis_MC2_155 QRLSSYRDDPDVLVLGLARGGVPVAWEVAAHLRAPLDVFLVRKLGVPQWQ
Mvan_3513|M.vanbaalenii_PYR-1 RDLARYRGTRDLMVLGLARGGVPVAWEVAHALHAPLDVCLVRKLGVPQWP
MAB_4659|M.abscessus_ATCC_1997 GMLAPRKLR-SIVVLALPRGGIPVGREIATALNAPLAVLVVRKLGVPGHE
TH_3117|M.thermoresistible__bu ERLASFRGR-DVVVLGLPRGGVPVAFAVARALRAPLDVLVVRKLGVPFQP
MUL_3276|M.ulcerans_Agy99 RRLEFLRGQ-DIVVLGLPRGGVPVAFEVAKALHAPLDVLLVRKLGVPLHS
* : ::*:.*.***:**. :* * * * . :*****.*
Mflv_4988|M.gilvum_PYR-GCK EFAMGALASGGRVVVNDDVVRALRVSPQQPRDVAEREGRELLRREAAYRA
MMAR_3483|M.marinum_M EFAVGALASGGRVVVNDDVVRGLRITPQQLRDTAEREARELVRREAAYRA
Mb2167|M.bovis_AF2122/97 ELAMGALASGGGVVMNDDVVSSLRITDQQVRAAIDSETAELQRRELAYRG
Rv2143|M.tuberculosis_H37Rv ELAMGALASGGGVVMNDDVVSSLRITDQQVRAAIDSETAELQRRELAYRG
MAV_2347|M.avium_104 ELAMGALASGGGVVMNDDVVSSLRITDEQVRAVIDSETAELARREHAYRG
MSMEG_4215|M.smegmatis_MC2_155 ELAMGAVASGGGVVLNEKLMDRLGISDDDMAETLRRETIELERREQAYRG
Mvan_3513|M.vanbaalenii_PYR-1 ELAMGAVATGGGVVLNTGLLHDLGISDDEVGEAITRETAELDRREQAYRG
MAB_4659|M.abscessus_ATCC_1997 EYAMGAIASGGEVILDDDIVRSMGVTPIQLDEVTDRERRELARRERIYLA
TH_3117|M.thermoresistible__bu ELAFGAIGEDGVRVVNDAVVRRTRLTRADMAAVERRERAELQRRSERYRG
MUL_3276|M.ulcerans_Agy99 ELAFGAIGEGGVQVINSAVVHEAGLGEQEMAAVETAQWAELQRRVQRYRG
* *.**:. .* ::: :: : : . : ** ** * .
Mflv_4988|M.gilvum_PYR-GCK GRPPLELAGKTVIVVDDGLATGSSMFAAVQALQ----EMDPAEVVIAVPA
MMAR_3483|M.marinum_M GRPPLDVAGKTVVLVDDGLATGASMFAAVQAIR----DAEPAHIVIAVPA
Mb2167|M.bovis_AF2122/97 GRPVVDPRARIVILVDDGIATGASMLAAVRTIR----ATGPESIVVAVPV
Rv2143|M.tuberculosis_H37Rv GRPVVDPRARIVILVDDGIATGASMLAAVRTIR----ATGPESIVVAVPV
MAV_2347|M.avium_104 DRPMADLRDKVVILVDDGIATGASMLAAVRALRSGPTGATPRSIVVAVPV
MSMEG_4215|M.smegmatis_MC2_155 DREPLQVAGRTVILVDDGIATGASMMAAVRAVR------GARRVVVAVPV
Mvan_3513|M.vanbaalenii_PYR-1 DRGPVSVAGRCVILVDDGIATGASMVAAMRAVRQ----AGAARVIVGVPV
MAB_4659|M.abscessus_ATCC_1997 HRS-VEIRDKTVILVDDGIATGATMRVALLTVKR----ASPARVVAAVPV
TH_3117|M.thermoresistible__bu GRSRIPLSGRVAVIVDDGVATGATAKAACQVVR----AEGAARVVLAVPV
MUL_3276|M.ulcerans_Agy99 DRHPIPLRGRIAVIVDDGVATGATAAAACQVAR----AQGASRVILAVPI
* : .::****:***:: .* . : . :: .**
Mflv_4988|M.gilvum_PYR-GCK APESTCREFAAIVDDVVCASMPTPFLAVGESFWDFRQVTDDEVRELLETP
MMAR_3483|M.marinum_M APESSCREFAGLVDDVVCASMPTPFLAVGESFWDFRQVTDEEVRNLLATP
Mb2167|M.bovis_AF2122/97 GPATACRELAAEADDVVCATMPAAFEAVGQVYNDFHQVTDDEVRELLATP
Rv2143|M.tuberculosis_H37Rv GPATACRELAAEADDVVCATMPAAFEAVGQVYNDFHQVTDDEVRELLATP
MAV_2347|M.avium_104 GPESACRELGREADEVVCLSTPPGFEAVGQVYGDFHQVSDDEVRELLATP
MSMEG_4215|M.smegmatis_MC2_155 GPPGVCRELAAEADDVVCASMPQDFEAVGQAFADFHQVSDDEVRELLATP
Mvan_3513|M.vanbaalenii_PYR-1 GPASVCRQLRDEADDVVCSTMPEDFRAVGQMFVDFHQVSDDEVRELLAG-
MAB_4659|M.abscessus_ATCC_1997 APRSAVGRFGSLVDDFVVATCPSRFQAVGDAYRDFHQISDREVRELLSAP
TH_3117|M.thermoresistible__bu GPPDVAERFAGYADEVVCLQTPPFFSAVGQGYRNFTQTSDDEVIALLRRA
MUL_3276|M.ulcerans_Agy99 GATDTAPRFTEYADEVVCLETPTPYFAVGQGYDNFTQTSDQEVVTLLDRA
.. .: .*:.* * : ***: : :* * :* ** **
Mflv_4988|M.gilvum_PYR-GCK TVGFATARIRLAETPAEVIDRCAVDAPAGVPPLEALDELIGDARIVLIGE
MMAR_3483|M.marinum_M TTGIPALRP-AVPTPAEVIRNVAIDAHGGVPPREALEAVIGDARIVLIGE
Mb2167|M.bovis_AF2122/97 TTGAAT--------------------------------------------
Rv2143|M.tuberculosis_H37Rv TTGAAT--------------------------------------------
MAV_2347|M.avium_104 TG------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 TTDPVR--------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 VIR-----------------------------------------------
TH_3117|M.thermoresistible__bu RADVADTAAADIGDPPPLRDEEVRVDAGGVTVTGHLTVPGQPIGVVVFAH
MUL_3276|M.ulcerans_Agy99 RSEFG---AGHQPPVPARRDDGVRVLAGPASVIGRLTIPDRPTGIVVFAH
Mflv_4988|M.gilvum_PYR-GCK SSHGTEEFYAARAEITKWLIEEKGFCGVAAEADWPDAYRVNRYVRGQAGD
MMAR_3483|M.marinum_M SSHGTHEFYEARAEITKWLIEQKGFCAVAAEADWPDAYRVNRYVHGLGED
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu GSG----RHSPRNRYVADVLRRAGLATLLFDLLTPDE-------------
MUL_3276|M.ulcerans_Agy99 GSGS--SRHSPRNRYVAEVLNQAGLATLLLDLLTPEE-------------
Mflv_4988|M.gilvum_PYR-GCK GSAEEALRGFERFPAWMWRNTVVRDFVAWLRACNADRRAQGRREAGFYGL
MMAR_3483|M.marinum_M QSAEQALRGFERFPAWMWRNTVVRDFVDWLRERNQRCASNGQRQAGFYGL
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4988|M.gilvum_PYR-GCK DLYSLHRSMQEVIDFLDRVDPDAAQRARERYSCFDHSSGDDGQAYGFAAA
MMAR_3483|M.marinum_M DLYSLHRSMQEVVAFLDRVDPAAAARARARYACFDHTAADDGQAYGYAAA
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu ---ELDRANVFDIGLLAERLVGVTQWLAAQPETAALPVGYFGASTGAGAA
MUL_3276|M.ulcerans_Agy99 ---EHNRANVFDIGLLARRLVDVTGWLAAQPDTTALPVGFFGASTGGGAA
Mflv_4988|M.gilvum_PYR-GCK FGAGLSCEHQAVEQLVEMHRSAVEYARRDGLLAEDELFYAQQNAQTVRDA
MMAR_3483|M.marinum_M FGAGPSCERQAIEQLVDTQRNALDYARRDGLIAEDEAFYAQQNAQTVRNA
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu LVAAADPRVQVAAVVSRGGR-------------------PDLAGQALGKV
MUL_3276|M.ulcerans_Agy99 LVAAAHPGVKVQAVVSRGGR-------------------PDLAGDALREV
Mflv_4988|M.gilvum_PYR-GCK EVYYRSMFGGRVTSWNLRDRHMAETLEALLRHLDRQGGSEPARIVVWAHN
MMAR_3483|M.marinum_M EVYYRAMFSGRVTSWNLRDQHMAETLAALQAHLDRHREAAPARIVVWAHN
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu RAPTLLIVGGR------------DRFVLELNHQARAAIPAVCEIAVIPGA
MUL_3276|M.ulcerans_Agy99 HAPTLPIVGGR------------DEAVLELNRQAQAAIPAPCELVVVPGA
Mflv_4988|M.gilvum_PYR-GCK SHVGDARATEVGADGQLTLGQLAREKFGDHVRLIGYTTYTGTVTAASEWG
MMAR_3483|M.marinum_M SHVGDARATEVWADGQLTLGQLVRQRYGDDSRLIGLCTYSGTVTAASEWG
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu THLFEE------PGALDQVAELARDWFTDHLSRTGASTRP----------
MUL_3276|M.ulcerans_Agy99 THLFEE------PGALEQVATLARDWFLGHLRHH----------------
Mflv_4988|M.gilvum_PYR-GCK GLAERKAVRPALNGSVEELFHEVDRPAFLVSPLISHAAAEPLDAVRLGRA
MMAR_3483|M.marinum_M GIAERKVVRPALHASVEELFHDTGKDAFLVSAATSPEAADPLSGVRLGRA
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4988|M.gilvum_PYR-GCK IGVIYLPATERQSHYYHVRPSEQFDGIIHIDRTTALEPLEVTSTWAAGET
MMAR_3483|M.marinum_M IGVIYLPATERQSHYFHVRPADQFDAMIHIDKTRALEPLETTSLWIAGET
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4988|M.gilvum_PYR-GCK PETYPTGL
MMAR_3483|M.marinum_M PETYPSGL
Mb2167|M.bovis_AF2122/97 --------
Rv2143|M.tuberculosis_H37Rv --------
MAV_2347|M.avium_104 --------
MSMEG_4215|M.smegmatis_MC2_155 --------
Mvan_3513|M.vanbaalenii_PYR-1 --------
MAB_4659|M.abscessus_ATCC_1997 --------
TH_3117|M.thermoresistible__bu --------
MUL_3276|M.ulcerans_Agy99 --------