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MSAWSVRHDAIRTFQDRREAGRVLAQRLSSYRDDPDVLVLGLARGGVPVAWEVAAHLRAPLDVFLVRKLG VPQWQELAMGAVASGGGVVLNEKLMDRLGISDDDMAETLRRETIELERREQAYRGDREPLQVAGRTVILV DDGIATGASMMAAVRAVRGARRVVVAVPVGPPGVCRELAAEADDVVCASMPQDFEAVGQAFADFHQVSDD EVRELLATPTTDPVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4215 | - | - | 100% (225) | phosphoribosyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2167 | - | 2e-76 | 66.97% (218) | hypothetical protein Mb2167 |
| M. gilvum PYR-GCK | Mflv_2998 | - | 7e-74 | 65.28% (216) | phosphoribosyltransferase |
| M. tuberculosis H37Rv | Rv2143 | - | 2e-76 | 66.97% (218) | hypothetical protein Rv2143 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4659 | - | 6e-48 | 49.30% (213) | hypothetical protein MAB_4659 |
| M. marinum M | MMAR_3483 | - | 1e-69 | 62.26% (212) | hypothetical protein MMAR_3483 |
| M. avium 104 | MAV_2347 | - | 2e-75 | 65.74% (216) | phosphoribosyltransferase |
| M. thermoresistible (build 8) | TH_3117 | - | 4e-53 | 53.05% (213) | PUTATIVE Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) |
| M. ulcerans Agy99 | MUL_3276 | - | 7e-49 | 49.04% (208) | hypothetical protein MUL_3276 |
| M. vanbaalenii PYR-1 | Mvan_3513 | - | 2e-83 | 75.00% (208) | phosphoribosyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3483|M.marinum_M --------------------------------------------------
Mb2167|M.bovis_AF2122/97 MEAPPYAGDPTFERLRRSFQPADLLPELQAAGVHYTIAVEAADDPAENES
Rv2143|M.tuberculosis_H37Rv MEAPPYAGDPTFERLRRSFQPADLLPELQAAGVHYTIAVEAADDPAENES
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3483|M.marinum_M --------------------------------------------------
Mb2167|M.bovis_AF2122/97 LLATARHHDWIARVIGWVPLADPDEVTESSTHGRHRPDASWRRDLRCPGL
Rv2143|M.tuberculosis_H37Rv LLATARHHDWIARVIGWVPLADPDEVTESSTHGRHRPDASWRRDLRCPGL
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 -------------------------MSAWSVRHDAIRTFQDRREAGRVLA
MMAR_3483|M.marinum_M -----------------------MTSAARADRNAPRRVFRDRHEAGQVLA
Mb2167|M.bovis_AF2122/97 LPPGCHQPVLVVGLVGQQPEMRPMNPPSGFLRRTPTRRFRDRRDAGRVLA
Rv2143|M.tuberculosis_H37Rv LPPGCHQPVLVVGLVGQQPEMRPMNPPSGFLRRTPTRRFRDRRDAGRVLA
MAV_2347|M.avium_104 -----------------------------------MRSFRDRREAGRALA
Mflv_2998|M.gilvum_PYR-GCK -------------------------------MKASARTFHDRRDAGRVLA
Mvan_3513|M.vanbaalenii_PYR-1 -------------------------MTHDERMTHKKRTFRDRREAGQVLA
MAB_4659|M.abscessus_ATCC_1997 -------------------------------MSDTHRMFSDRQDAGRVLA
TH_3117|M.thermoresistible__bu -------------------------------MRADTRPFDDRVDAGRRPA
MUL_3276|M.ulcerans_Agy99 -----------------------------------MRQFSDRIDAGRKLG
* * ** :**: .
MSMEG_4215|M.smegmatis_MC2_155 QRLSS--YR------DDPDVLVLGLARGGVPVAWEVAAHLRAPLDVFLVR
MMAR_3483|M.marinum_M DLLTA--YR------DRPDVIVLGLARGGIPVAWEVAAALHAPLDAFIVR
Mb2167|M.bovis_AF2122/97 DELAS--YR------GRDRLLVLGLARGGVPVGWEVASALGAELDVFLVR
Rv2143|M.tuberculosis_H37Rv DELAS--YR------GRDRLLVLGLARGGVPVGWEVASALGAELDVFLVR
MAV_2347|M.avium_104 GELMG--YR------NRGDVLVFGLARGGLPVAWEIAAALHAPLDVFLVR
Mflv_2998|M.gilvum_PYR-GCK RDLCDRISRPDAGDGDLGEILVLGLARGGVPVGWEVAQRLKAPLDVCLVR
Mvan_3513|M.vanbaalenii_PYR-1 RDLAR--YR---GTRDL---MVLGLARGGVPVAWEVAHALHAPLDVCLVR
MAB_4659|M.abscessus_ATCC_1997 GMLAPR---------KLRSIVVLALPRGGIPVGREIATALNAPLAVLVVR
TH_3117|M.thermoresistible__bu ERLAS--FR-------GRDVVVLGLPRGGVPVAFAVARALRAPLDVLVVR
MUL_3276|M.ulcerans_Agy99 RRLEF--LR-------GQDIVVLGLPRGGVPVAFEVAKALHAPLDVLLVR
* :*:.*.***:**. :* * * * . :**
MSMEG_4215|M.smegmatis_MC2_155 KLGVPQWQELAMGAVASGGGVVLNEKLMDRLGISDDDMAETLRRETIELE
MMAR_3483|M.marinum_M KLGAPGHEEFAVGALASGGRVVVNDDVVRGLRITPQQLRDTAEREARELV
Mb2167|M.bovis_AF2122/97 KLGVPQWRELAMGALASGGGVVMNDDVVSSLRITDQQVRAAIDSETAELQ
Rv2143|M.tuberculosis_H37Rv KLGVPQWRELAMGALASGGGVVMNDDVVSSLRITDQQVRAAIDSETAELQ
MAV_2347|M.avium_104 KLGVPNWSELAMGALASGGGVVMNDDVVSSLRITDEQVRAVIDSETAELA
Mflv_2998|M.gilvum_PYR-GCK KLGAPQWPELAIGALAGGGGVVLNNELIRSLGVGEDQIRDIVCRETAELH
Mvan_3513|M.vanbaalenii_PYR-1 KLGVPQWPELAMGAVATGGGVVLNTGLLHDLGISDDEVGEAITRETAELD
MAB_4659|M.abscessus_ATCC_1997 KLGVPGHEEYAMGAIASGGEVILDDDIVRSMGVTPIQLDEVTDRERRELA
TH_3117|M.thermoresistible__bu KLGVPFQPELAFGAIGEDGVRVVNDAVVRRTRLTRADMAAVERRERAELQ
MUL_3276|M.ulcerans_Agy99 KLGVPLHSELAFGAIGEGGVQVINSAVVHEAGLGEQEMAAVETAQWAELQ
***.* * *.**:. .* ::: :: : :: : **
MSMEG_4215|M.smegmatis_MC2_155 RREQAYRGDREPLQVAGRTVILVDDGIATGASMMAAVRAVR----GAR--
MMAR_3483|M.marinum_M RREAAYRAGRPPLDVAGKTVVLVDDGLATGASMFAAVQAIR----DAEPA
Mb2167|M.bovis_AF2122/97 RRELAYRGGRPVVDPRARIVILVDDGIATGASMLAAVRTIR----ATGPE
Rv2143|M.tuberculosis_H37Rv RRELAYRGGRPVVDPRARIVILVDDGIATGASMLAAVRTIR----ATGPE
MAV_2347|M.avium_104 RREHAYRGDRPMADLRDKVVILVDDGIATGASMLAAVRALRSGPTGATPR
Mflv_2998|M.gilvum_PYR-GCK RREKAYRGDRGPVTVSGRTVVLVDDGIATGASMIAAVRSVR----EAGAR
Mvan_3513|M.vanbaalenii_PYR-1 RREQAYRGDRGPVSVAGRCVILVDDGIATGASMVAAMRAVR----QAGAA
MAB_4659|M.abscessus_ATCC_1997 RRERIYLAHRS-VEIRDKTVILVDDGIATGATMRVALLTVK----RASPA
TH_3117|M.thermoresistible__bu RRSERYRGGRSRIPLSGRVAVIVDDGVATGATAKAACQVVR----AEGAA
MUL_3276|M.ulcerans_Agy99 RRVQRYRGDRHPIPLRGRIAVIVDDGVATGATAAAACQVAR----AQGAS
** * . * : .::****:****: .* :
MSMEG_4215|M.smegmatis_MC2_155 RVVVAVPVGPPGVCRELAAEADDVVCASMPQDFEAVGQAFADFHQVSDDE
MMAR_3483|M.marinum_M HIVIAVPAAPESSCREFAGLVDDVVCASMPTPFLAVGESFWDFRQVTDEE
Mb2167|M.bovis_AF2122/97 SIVVAVPVGPATACRELAAEADDVVCATMPAAFEAVGQVYNDFHQVTDDE
Rv2143|M.tuberculosis_H37Rv SIVVAVPVGPATACRELAAEADDVVCATMPAAFEAVGQVYNDFHQVTDDE
MAV_2347|M.avium_104 SIVVAVPVGPESACRELGREADEVVCLSTPPGFEAVGQVYGDFHQVSDDE
Mflv_2998|M.gilvum_PYR-GCK RIIVGVPVGPRAACRLLRSEADLVVCSTTPPNFRAVGQVYADFHQVSDEE
Mvan_3513|M.vanbaalenii_PYR-1 RVIVGVPVGPASVCRQLRDEADDVVCSTMPEDFRAVGQMFVDFHQVSDDE
MAB_4659|M.abscessus_ATCC_1997 RVVAAVPVAPRSAVGRFGSLVDDFVVATCPSRFQAVGDAYRDFHQISDRE
TH_3117|M.thermoresistible__bu RVVLAVPVGPPDVAERFAGYADEVVCLQTPPFFSAVGQGYRNFTQTSDDE
MUL_3276|M.ulcerans_Agy99 RVILAVPIGATDTAPRFTEYADEVVCLETPTPYFAVGQGYDNFTQTSDQE
:: .** .. : .* .* * : ***: : :* * :* *
MSMEG_4215|M.smegmatis_MC2_155 VRELLATPTT-------------DPVR-----------------------
MMAR_3483|M.marinum_M VRNLLATPTTGIPALRPAVPTPAEVIRNVAIDAHGGVPPREALEAVIGDA
Mb2167|M.bovis_AF2122/97 VRELLATPTTGAAT------------------------------------
Rv2143|M.tuberculosis_H37Rv VRELLATPTTGAAT------------------------------------
MAV_2347|M.avium_104 VRELLATPTG----------------------------------------
Mflv_2998|M.gilvum_PYR-GCK VRELLAAG------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 VRELLAG-------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 VRELLSAPVIR---------------------------------------
TH_3117|M.thermoresistible__bu VIALLRRARADVADTAAADIGDPPPLRDEEVRVDAGGVTVTGHLTVPGQP
MUL_3276|M.ulcerans_Agy99 VVTLLDRARSEFG---AGHQPPVPARRDDGVRVLAGPASVIGRLTIPDRP
* **
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3483|M.marinum_M RIVLIGESSHGTHEFYEARAEITKWLIEQKGFCAVAAEADWPDAYRVNRY
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu IGVVVFAHGSG---RHSPRNRYVADVLRRAGLATLLFDLLTPD-------
MUL_3276|M.ulcerans_Agy99 TGIVVFAHGSGS-SRHSPRNRYVAEVLNQAGLATLLLDLLTPE-------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3483|M.marinum_M VHGLGEDQSAEQALRGFERFPAWMWRNTVVRDFVDWLRERNQRCASNGQR
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu ------------------------------------------------EE
MUL_3276|M.ulcerans_Agy99 ------------------------------------------------EE
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3483|M.marinum_M QAGFYGLDLYSLHRSMQEVVAFLDRVDPAAAARARARYACFDHTAADDGQ
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu LDRANVFDIGLLAERLVGVTQWLAAQPETAALPVGYFGASTGAGAALVAA
MUL_3276|M.ulcerans_Agy99 HNRANVFDIGLLARRLVDVTGWLAAQPDTTALPVGFFGASTGGGAALVAA
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3483|M.marinum_M AYGYAAAFGAGPSCERQAIEQLVDTQRNALDYARRDGLIAEDEAFYAQQN
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu ADPRVQVAAVVSRGGRPDLAGQALGKVRAPTLLIVGGRDRFVLELNHQAR
MUL_3276|M.ulcerans_Agy99 AHPGVKVQAVVSRGGRPDLAGDALREVHAPTLPIVGGRDEAVLELNRQAQ
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3483|M.marinum_M AQTVRNAEVYYRAMFSGRVTSWNLRDQHMAETLAALQAHLDRHREAAPAR
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu AAIPAVCEIAVIPGATHLFEEPGALDQVAELARDWFTDHLSRTGASTRP-
MUL_3276|M.ulcerans_Agy99 AAIPAPCELVVVPGATHLFEEPGALEQVATLARDWFLGHLRHH-------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3483|M.marinum_M IVVWAHNSHVGDARATEVWADGQLTLGQLVRQRYGDDSRLIGLCTYSGTV
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3483|M.marinum_M TAASEWGGIAERKVVRPALHASVEELFHDTGKDAFLVSAATSPEAADPLS
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3483|M.marinum_M GVRLGRAIGVIYLPATERQSHYFHVRPADQFDAMIHIDKTRALEPLETTS
Mb2167|M.bovis_AF2122/97 --------------------------------------------------
Rv2143|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2347|M.avium_104 --------------------------------------------------
Mflv_2998|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3513|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4659|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3117|M.thermoresistible__bu --------------------------------------------------
MUL_3276|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4215|M.smegmatis_MC2_155 ---------------
MMAR_3483|M.marinum_M LWIAGETPETYPSGL
Mb2167|M.bovis_AF2122/97 ---------------
Rv2143|M.tuberculosis_H37Rv ---------------
MAV_2347|M.avium_104 ---------------
Mflv_2998|M.gilvum_PYR-GCK ---------------
Mvan_3513|M.vanbaalenii_PYR-1 ---------------
MAB_4659|M.abscessus_ATCC_1997 ---------------
TH_3117|M.thermoresistible__bu ---------------
MUL_3276|M.ulcerans_Agy99 ---------------