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SVPGGMTDGPGPGTRPSDRTLVIIPTYNERQNLPLIVGRVHQARPDVDILIVDDDSPDGTGQLADELSVA DPDRIHVMHRTAKEGLGAAYLAGFAWGLGRQYTVLVEMDADGSHPPEQLARLLDAVDAGADVVIGSRYVS GGEVVNWPRRRLVLSRTANGYSRILLGVDIHDITAGYRAYRREVLEKIDLAAVDTKGYGFQVDLTWRSIN AGFTVIEVPITFTEREHGVSKMDGSTIREAIIKVAQWGLRARLDRARGTTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3418 | - | - | 100% (262) | dolichyl-phosphate beta-D-mannosyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2676 | - | 9e-20 | 31.67% (240) | glycosyl transferase family protein |
| M. vanbaalenii PYR-1 | Mvan_0217 | - | 2e-17 | 27.20% (250) | glycosyl transferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2077c | ppm1 | 1e-106 | 73.41% (252) | polyprenol-monophosphomannose synthase Ppm1 |
| M. gilvum PYR-GCK | Mflv_3118 | - | 1e-125 | 83.91% (261) | dolichyl-phosphate beta-D-mannosyltransferase |
| M. tuberculosis H37Rv | Rv2051c | ppm1 | 1e-106 | 73.41% (252) | polyprenol-monophosphomannose synthase Ppm1 |
| M. leprae Br4923 | MLBr_01440 | - | 1e-100 | 69.39% (245) | putative glycosyl transferase |
| M. abscessus ATCC 19977 | MAB_2207 | - | 1e-106 | 74.49% (247) | polyprenol phosphate mannosyl transferase 1 |
| M. marinum M | MMAR_3028 | ppm1B | 1e-106 | 74.90% (247) | polyprenol-monophosphomannose synthase, Ppm1B |
| M. avium 104 | MAV_4605 | - | 6e-17 | 32.26% (217) | glycosyltransferase |
| M. smegmatis MC2 155 | MSMEG_3859 | - | 1e-115 | 77.74% (265) | glycosyl transferase, group 2 family protein |
| M. thermoresistible (build 8) | TH_0733 | - | 2e-98 | 80.00% (215) | Polyprenol-monophosphomannose synthase Ppm1 |
| M. ulcerans Agy99 | MUL_2269 | ppm1B | 1e-106 | 74.49% (247) | C-term polyprenol-monophosphomannose synthase Ppm1B |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3418|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3118|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3859|M.smegmatis_MC2_155 --------------------------------------------------
TH_0733|M.thermoresistible__bu --------------------------------------------------
MAB_2207|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3028|M.marinum_M --------------------------------------------------
MUL_2269|M.ulcerans_Agy99 --------------------------------------------------
Mb2077c|M.bovis_AF2122/97 MKLGAWVAAQLPTTRTAVRTRLTRLVVSIVAGLLLYASFPPRNCWWAAVV
Rv2051c|M.tuberculosis_H37Rv MKLGAWVAAQLPTTRTAVRTRLTRLVVSIVAGLLLYASFPPRNCWWAAVV
MLBr_01440|M.leprae_Br4923 --------------------------------------------------
MAV_4605|M.avium_104 --------------------------------------------------
Mvan_3418|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3118|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3859|M.smegmatis_MC2_155 --------------------------------------------------
TH_0733|M.thermoresistible__bu --------------------------------------------------
MAB_2207|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3028|M.marinum_M --------------------------------------------------
MUL_2269|M.ulcerans_Agy99 --------------------------------------------------
Mb2077c|M.bovis_AF2122/97 ALALLAWVLTHRATTPVGGLGYGLLFGLVFYVSLLPWIGELVGPGPWLAL
Rv2051c|M.tuberculosis_H37Rv ALALLAWVLTHRATTPVGGLGYGLLFGLVFYVSLLPWIGELVGPGPWLAL
MLBr_01440|M.leprae_Br4923 --------------------------------------------------
MAV_4605|M.avium_104 --------------------------------------------------
Mvan_3418|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3118|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3859|M.smegmatis_MC2_155 --------------------------------------------------
TH_0733|M.thermoresistible__bu --------------------------------------------------
MAB_2207|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3028|M.marinum_M --------------------------------------------------
MUL_2269|M.ulcerans_Agy99 --------------------------------------------------
Mb2077c|M.bovis_AF2122/97 ATTCALFPGIFGLFAVVVRLLPGWPIWFAVGWAAQEWLKSILPFGGFPWG
Rv2051c|M.tuberculosis_H37Rv ATTCALFPGIFGLFAVVVRLLPGWPIWFAVGWAAQEWLKSILPFGGFPWG
MLBr_01440|M.leprae_Br4923 --------------------------------------------------
MAV_4605|M.avium_104 --------------------------------------------------
Mvan_3418|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3118|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3859|M.smegmatis_MC2_155 --------------------------------------------------
TH_0733|M.thermoresistible__bu --------------------------------------------------
MAB_2207|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3028|M.marinum_M --------------------------------------------------
MUL_2269|M.ulcerans_Agy99 --------------------------------------------------
Mb2077c|M.bovis_AF2122/97 SVAFGQAEGPLLPLVQLGGVALLSTGVALVGCGLTAIALEIEKWWRTGGQ
Rv2051c|M.tuberculosis_H37Rv SVAFGQAEGPLLPLVQLGGVALLSTGVALVGCGLTAIALEIEKWWRTGGQ
MLBr_01440|M.leprae_Br4923 --------------------------------------------------
MAV_4605|M.avium_104 --------------------------------------------------
Mvan_3418|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3118|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3859|M.smegmatis_MC2_155 --------------------------------------------------
TH_0733|M.thermoresistible__bu --------------------------------------------------
MAB_2207|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3028|M.marinum_M --------------------------------------------------
MUL_2269|M.ulcerans_Agy99 --------------------------------------------------
Mb2077c|M.bovis_AF2122/97 GDAPPAVVLPAACICLVLFAAIVVWPQVRHAGSGSGGEPTVTVAVVQGNV
Rv2051c|M.tuberculosis_H37Rv GDAPPAVVLPAACICLVLFAAIVVWPQVRHAGSGSGGEPTVTVAVVQGNV
MLBr_01440|M.leprae_Br4923 --------------------------------------------------
MAV_4605|M.avium_104 --------------------------------------------------
Mvan_3418|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3118|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3859|M.smegmatis_MC2_155 --------------------------------------------------
TH_0733|M.thermoresistible__bu --------------------------------------------------
MAB_2207|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3028|M.marinum_M --------------------------------------------------
MUL_2269|M.ulcerans_Agy99 --------------------------------------------------
Mb2077c|M.bovis_AF2122/97 PRLGLDFNAQRRAVLDNHVEETLRLAADVHAGLAQQPQFVIWPENSSDID
Rv2051c|M.tuberculosis_H37Rv PRLGLDFNAQRRAVLDNHVEETLRLAADVHAGLAQQPQFVIWPENSSDID
MLBr_01440|M.leprae_Br4923 --------------------------------------------------
MAV_4605|M.avium_104 --------------------------------------------------
Mvan_3418|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3118|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3859|M.smegmatis_MC2_155 --------------------------------------------------
TH_0733|M.thermoresistible__bu --------------------------------------------------
MAB_2207|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3028|M.marinum_M --------------------------------------------------
MUL_2269|M.ulcerans_Agy99 --------------------------------------------------
Mb2077c|M.bovis_AF2122/97 PFVNPDAGQRISAAAEAIGAPILIGTLMDVPGRPRENPEWTNTAIVWNPG
Rv2051c|M.tuberculosis_H37Rv PFVNPDAGQRISAAAEAIGAPILIGTLMDVPGRPRENPEWTNTAIVWNPG
MLBr_01440|M.leprae_Br4923 --------------------------------------------------
MAV_4605|M.avium_104 --------------------------------------------------
Mvan_3418|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3118|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3859|M.smegmatis_MC2_155 --------------------------------------------------
TH_0733|M.thermoresistible__bu --------------------------------------------------
MAB_2207|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3028|M.marinum_M --------------------------------------------------
MUL_2269|M.ulcerans_Agy99 --------------------------------------------------
Mb2077c|M.bovis_AF2122/97 TGPADRHDKAIVQPFGEYLPMPWLFRHLSGYADRAGHFVPGNGTGVVRIA
Rv2051c|M.tuberculosis_H37Rv TGPADRHDKAIVQPFGEYLPMPWLFRHLSGYADRAGHFVPGNGTGVVRIA
MLBr_01440|M.leprae_Br4923 --------------------------------------------------
MAV_4605|M.avium_104 --------------------------------------------------
Mvan_3418|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3118|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3859|M.smegmatis_MC2_155 --------------------------------------------------
TH_0733|M.thermoresistible__bu --------------------------------------------------
MAB_2207|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3028|M.marinum_M --------------------------------------------------
MUL_2269|M.ulcerans_Agy99 --------------------------------------------------
Mb2077c|M.bovis_AF2122/97 GVPVGVATCWEVIFDRAPRKSILGGAQLLTVPSNNATFNKTMSEQQLAFA
Rv2051c|M.tuberculosis_H37Rv GVPVGVATCWEVIFDRAPRKSILGGAQLLTVPSNNATFNKTMSEQQLAFA
MLBr_01440|M.leprae_Br4923 --------------------------------------------------
MAV_4605|M.avium_104 --------------------------------------------------
Mvan_3418|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3118|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3859|M.smegmatis_MC2_155 --------------------------------------------------
TH_0733|M.thermoresistible__bu --------------------------------------------------
MAB_2207|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3028|M.marinum_M --------------------------------------------------
MUL_2269|M.ulcerans_Agy99 --------------------------------------------------
Mb2077c|M.bovis_AF2122/97 KVRAVEHDRYVVVAGTTGISAVIAPDGGELIRTDFFQPAYLDSQVRLKTR
Rv2051c|M.tuberculosis_H37Rv KVRAVEHDRYVVVAGTTGISAVIAPDGGELIRTDFFQPAYLDSQVRLKTR
MLBr_01440|M.leprae_Br4923 --------------------------------------------------
MAV_4605|M.avium_104 --------------------------------------------------
Mvan_3418|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3118|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3859|M.smegmatis_MC2_155 --------------------------------------------------
TH_0733|M.thermoresistible__bu --------------------------------------------------
MAB_2207|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3028|M.marinum_M --------------------------------------------------
MUL_2269|M.ulcerans_Agy99 --------------------------------------------------
Mb2077c|M.bovis_AF2122/97 LTPATRWGPILQWILVGAAAAVVLVAMRQNGWFPRPRRSEPKGENDDSDA
Rv2051c|M.tuberculosis_H37Rv LTPATRWGPILQWILVGAAAAVVLVAMRQNGWFPRPRRSEPKGENDDSDA
MLBr_01440|M.leprae_Br4923 --------------------------------------------------
MAV_4605|M.avium_104 --------------------------------------------------
Mvan_3418|M.vanbaalenii_PYR-1 -------------------------------------------MSVPGGM
Mflv_3118|M.gilvum_PYR-GCK -------------------------------------------MSVPGGV
MSMEG_3859|M.smegmatis_MC2_155 -------------------------------------------MSVPGER
TH_0733|M.thermoresistible__bu --------------------------------------------------
MAB_2207|M.abscessus_ATCC_1997 -------------------------------------------MDPVTE-
MMAR_3028|M.marinum_M -------------------------------------------MTTGQPA
MUL_2269|M.ulcerans_Agy99 -------------------------------------------MTTGQPA
Mb2077c|M.bovis_AF2122/97 PPGRSEASGPPALSESDDELIQPEQGGRHSSGFGRHRATSRSYMTTGQPA
Rv2051c|M.tuberculosis_H37Rv PPGRSEASGPPALSESDDELIQPEQGGRHSSGFGRHRATSRSYMTTGQPA
MLBr_01440|M.leprae_Br4923 -------------------------------------------MITGQPA
MAV_4605|M.avium_104 --------------------------------------------------
Mvan_3418|M.vanbaalenii_PYR-1 TDGPGPGT---RPSDRTLVIIPTYNERQNLPLIVGRVHQARPDVDILIVD
Mflv_3118|M.gilvum_PYR-GCK TGREEPAG---RPSARTLVIIPTYNERDNLLSIVSRVNDAAPDVHVLIVD
MSMEG_3859|M.smegmatis_MC2_155 EQGAGEDPATVRPTQRTLVIIPTYNERENLPLIVGRVHHACPQVHILVVD
TH_0733|M.thermoresistible__bu -------------------------------------------VHVLIVD
MAB_2207|M.abscessus_ATCC_1997 -----------RPSARTLVIIPTYNERENLPLILGRLHKAQPDVHVLIVD
MMAR_3028|M.marinum_M PQSPGP-----RPSERTLVIIPTYNERENLPLIHRRVVDACPHVHVLIVD
MUL_2269|M.ulcerans_Agy99 PQSPGP-----RPSERTLVIIPTYNERENLPLIHRRVVDACPHVHVLIVD
Mb2077c|M.bovis_AF2122/97 PPAPGN-----RPSQRVLVIIPTFNERENLPVIHRRLTQACPAVHVLVVD
Rv2051c|M.tuberculosis_H37Rv PPAPGN-----RPSQRVLVIIPTFNERENLPVIHRRLTQACPAVHVLVVD
MLBr_01440|M.leprae_Br4923 RKISGN-----RPSQCVLVIIPTFNELENLPVTHGRLKDAYPEIHVLIVD
MAV_4605|M.avium_104 ---------MPGADGRVTVVLPCLNEEESLPGVLATIP---PGYRALVVD
*:**
Mvan_3418|M.vanbaalenii_PYR-1 DDSPDGTGQLADELSVADPDRIHVMHRTAKEGLGAAYLAGFAWGLGRQYT
Mflv_3118|M.gilvum_PYR-GCK DGSPDGTGELADELALGDPDRIHVMHRTSKDGLGAAYLAGFAWGLNREYT
MSMEG_3859|M.smegmatis_MC2_155 DGSPDGTGALADELALADPDRVHVMHRTSKAGLGAAYLAGFDWGLRRGYS
TH_0733|M.thermoresistible__bu DGSPDGTGELADELALADPDRVHVMHRASKAGLGAAYLAGFRWGLNRQYS
MAB_2207|M.abscessus_ATCC_1997 DGSPDGTGELADEAALADPDRVHVMHRKEKGGLGAAYIAGFGWGLARQYS
MMAR_3028|M.marinum_M DNSPDGTGRLADELVAADPDRIHVLHRTAKNGLGAAYLEGFAWGLSRGYS
MUL_2269|M.ulcerans_Agy99 DNSPDGTGRLADELVAADPDRIHVLHRTAKNGLGAAYLEGFAWGLSRGYS
Mb2077c|M.bovis_AF2122/97 DSSPDGTGQLADELAQADPGRTHVMHRTAKNGLGAAYLAGFAWGLSREYS
Rv2051c|M.tuberculosis_H37Rv DSSPDGTGQLADELAQADPGRTHVMHRTAKNGLGAAYLAGFAWGLSREYS
MLBr_01440|M.leprae_Br4923 DGSPDGTGELADELAQVDPGCTHVMHRTTKDGLGTAYLAGFAWGMSRDYS
MAV_4605|M.avium_104 NNSTDDTAGVARRHGAQ-------VVTETRAGYGAAVHAG---VLAATTP
:.*.*.*. :* . : : * *:* * : .
Mvan_3418|M.vanbaalenii_PYR-1 VLVEMDADGSHPPEQLARLLDAVDAGADVVIGSRYVSGGEVVNWPRRRLV
Mflv_3118|M.gilvum_PYR-GCK VLVEMDADGSHAPEDLHRLLAEIDAGADVVIGSRYVEGGDVRNWPRRRMV
MSMEG_3859|M.smegmatis_MC2_155 VLVEMDADGSHAPEELSRLLDAVDAGADLAIGSRYVPGGTVRNWPWRRLV
TH_0733|M.thermoresistible__bu VLVEMDADGSHAPEELHRLLDAVDAGADLAIGSRYVDGGQVRNWPRRRLL
MAB_2207|M.abscessus_ATCC_1997 VLVEMDADGSHAPEQLSRLLDAVDAGADLAIGSRYVPGGTVVNWPWRRLV
MMAR_3028|M.marinum_M VLVEMDADGSHAPEQLHRLLDAVDAGADLSIGSRYVPGGTVRNWPWRRLA
MUL_2269|M.ulcerans_Agy99 VLVEMDADGSHAPEQLHRLLDAVDAGADLSIGSRYVPGGTVRNWPWQRLA
Mb2077c|M.bovis_AF2122/97 VLVEMDADGSHAPEQLQRLLDAVDAGADLAIGSRYVAGGTVRNWPWRRLV
Rv2051c|M.tuberculosis_H37Rv VLVEMDADGSHAPEQLQRLLDAVDAGADLAIGSRYVAGGTVRNWPWRRLV
MLBr_01440|M.leprae_Br4923 VLVEMDADGSHAPEQLHRLLGAVDAGADLAIGSRYVNGGTVRNWPWQRLA
MAV_4605|M.avium_104 IVAVLDADGSMDGADLPRLVAALEAGADLVTGRRRPVRG--LRWPWVARV
::. :***** :* **: ::****: * * * .**
Mvan_3418|M.vanbaalenii_PYR-1 LSRTANGYSRILLGVDIHDITAGYRAYRREVLEKIDLAAVDTKGYGFQVD
Mflv_3118|M.gilvum_PYR-GCK LSRTANAYSRILLGVDIHDITAGYRAYRREVLEKIDLAAVDSKGYGFQVD
MSMEG_3859|M.smegmatis_MC2_155 LSKTANTYSRFLLGVGIHDITAGYRAYRREVLEKIDLSAVDSKGYCFQID
TH_0733|M.thermoresistible__bu LSRTANTYSRLLLGVDIRDITAGYRAYRREVLEKIDLDAVDSKGYCFQID
MAB_2207|M.abscessus_ATCC_1997 LSRSANVYARLVLGVKPHDITAGYRAYRREVLEKLDLGAVESHGYCFQID
MMAR_3028|M.marinum_M LSKTANTYSRLALGIGVHDITAGYRAYRREVLEKIDLASVDSKGYCFQIE
MUL_2269|M.ulcerans_Agy99 LSKTANTYSRLALGIGVHDITAGYRAYRREVLEKIDLASVDSKGYCFQIE
Mb2077c|M.bovis_AF2122/97 LSKTANTYSRLALGIGIHDITAGYRAYRREALEAIDLDGVDSKGYCFQID
Rv2051c|M.tuberculosis_H37Rv LSKTANTYSRLALGIGIHDITAGYRAYRREALEAIDLDGVDSKGYCFQID
MLBr_01440|M.leprae_Br4923 LSKTANKYSRLALGIDVHDITAGYRAYRREVLEAIDLDSVASKGYCFQID
MAV_4605|M.avium_104 GTVVMSWRLRTRHGLPVHDIAP-MRVARRDALLGLGVADRRS---GYPLE
: . * *: :**:. *. **:.* :.: : : ::
Mvan_3418|M.vanbaalenii_PYR-1 LTWRSINAGFTVIEVPITFTEREHGVSKMDGSTIREAIIKVAQWGLRARL
Mflv_3118|M.gilvum_PYR-GCK LTWRSINAGFTVVEVPITFTEREHGVSKMDGSTIREAIIKVAQWGMRARI
MSMEG_3859|M.smegmatis_MC2_155 LTWRAINNGFSVVEVPITFTERELGVSKMSGSNIREAMFKVAEWGIRGRL
TH_0733|M.thermoresistible__bu LTWRAINHGFKVVEVPITFTERELGQSKMSGSNIREAIFKVAEWGIRGRL
MAB_2207|M.abscessus_ATCC_1997 LTLRTIAHGFEVAEVPITFTERAIGESKMSGSIINEALVKVTKWGVQSRL
MMAR_3028|M.marinum_M MTWRSVNSGFVVVEVPITFTEREIGVSKMSGSNIREALFKVTRWGVKGRF
MUL_2269|M.ulcerans_Agy99 MTWRSVNSGFVVVEVPITFTEREIGVSKMSGSNIREALFKVTRWGVKGRF
Mb2077c|M.bovis_AF2122/97 LTWRTVSNGFVVTEVPITFTERELGVSKMSGSNIREALVKVARWGIEGRL
Rv2051c|M.tuberculosis_H37Rv LTWRTVSNGFVVTEVPITFTERELGVSKMSGSNIREALVKVARWGIEGRL
MLBr_01440|M.leprae_Br4923 LTWRTVNNGFVIIEVPITFTEREFGLSKMSGSNIREALVKVTRWGIDGRI
MAV_4605|M.avium_104 LLVRAAAAGWRVVELDVRYGPRTGGKSKVSGSLRGSITAILDFWKVIS--
: *: *: : *: : : * * **:.** . : * : .
Mvan_3418|M.vanbaalenii_PYR-1 DRARGTTR---------------------
Mflv_3118|M.gilvum_PYR-GCK DRARGNTP---------------------
MSMEG_3859|M.smegmatis_MC2_155 DRARGVVR---------------------
TH_0733|M.thermoresistible__bu DRARGIVR---------------------
MAB_2207|M.abscessus_ATCC_1997 DRARGVNR---------------------
MMAR_3028|M.marinum_M AGSEGGGDRAHTHDHS-------------
MUL_2269|M.ulcerans_Agy99 AGSEGGGDRAHTHDHS-------------
Mb2077c|M.bovis_AF2122/97 SRSDHARARPDIARPGAGGSRVSRADVTE
Rv2051c|M.tuberculosis_H37Rv SRSDHARARPDIARPGAGGSRVSRADVTE
MLBr_01440|M.leprae_Br4923 QRARTGRAYNSVSRGGGTGSSPSAP----
MAV_4605|M.avium_104 -----------------------------