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GELPATGHVGSASHQGQTTTSSPHAQFMLARDGVKVTPSVSLVIPVRNEARNVAWVLEQITEDVDEIILV DGASTDATLITALRYRPDIKVVAQDGVGKGSALRTGFFAASGDIIVMMDADGSMAPQEIRHYVHFLRNGY DFVKGSRFIGGGGSLDITAFRKLGNRFLLGVFNSLYDSDLTDLCYGFCAFHRRYLELLELSATGFEIEAE MTVRAMQAGLRIAEVPSLEMPRRSGKSNLRAVRDGTRVLRTVLHGHRSGVSGHLLEVLSQRRGPAAAAAE AC*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_0217 | - | - | 100% (283) | glycosyl transferase family protein |
M. vanbaalenii PYR-1 | Mvan_2676 | - | 1e-50 | 49.56% (228) | glycosyl transferase family protein |
M. vanbaalenii PYR-1 | Mvan_3418 | - | 2e-17 | 27.20% (250) | dolichyl-phosphate beta-D-mannosyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2077c | ppm1 | 1e-12 | 25.20% (254) | polyprenol-monophosphomannose synthase Ppm1 |
M. gilvum PYR-GCK | Mflv_3118 | - | 2e-15 | 26.43% (227) | dolichyl-phosphate beta-D-mannosyltransferase |
M. tuberculosis H37Rv | Rv2051c | ppm1 | 1e-12 | 25.20% (254) | polyprenol-monophosphomannose synthase Ppm1 |
M. leprae Br4923 | MLBr_01440 | - | 6e-13 | 25.79% (252) | putative glycosyl transferase |
M. abscessus ATCC 19977 | MAB_2207 | - | 3e-13 | 28.25% (223) | polyprenol phosphate mannosyl transferase 1 |
M. marinum M | MMAR_2311 | - | 8e-17 | 32.71% (214) | glycosyl transferase |
M. avium 104 | MAV_4605 | - | 4e-10 | 29.35% (201) | glycosyltransferase |
M. smegmatis MC2 155 | MSMEG_3859 | - | 6e-15 | 27.89% (251) | glycosyl transferase, group 2 family protein |
M. thermoresistible (build 8) | TH_0733 | - | 1e-13 | 27.75% (209) | Polyprenol-monophosphomannose synthase Ppm1 |
M. ulcerans Agy99 | MUL_2269 | ppm1B | 6e-13 | 26.14% (264) | C-term polyprenol-monophosphomannose synthase Ppm1B |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_3859|M.smegmatis_MC2_155 -------------------------------------------------- TH_0733|M.thermoresistible__bu -------------------------------------------------- Mflv_3118|M.gilvum_PYR-GCK -------------------------------------------------- MAB_2207|M.abscessus_ATCC_1997 -------------------------------------------------- Mb2077c|M.bovis_AF2122/97 MKLGAWVAAQLPTTRTAVRTRLTRLVVSIVAGLLLYASFPPRNCWWAAVV Rv2051c|M.tuberculosis_H37Rv MKLGAWVAAQLPTTRTAVRTRLTRLVVSIVAGLLLYASFPPRNCWWAAVV MLBr_01440|M.leprae_Br4923 -------------------------------------------------- MUL_2269|M.ulcerans_Agy99 -------------------------------------------------- MAV_4605|M.avium_104 -------------------------------------------------- MMAR_2311|M.marinum_M -------------------------------------------------- Mvan_0217|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_3859|M.smegmatis_MC2_155 -------------------------------------------------- TH_0733|M.thermoresistible__bu -------------------------------------------------- Mflv_3118|M.gilvum_PYR-GCK -------------------------------------------------- MAB_2207|M.abscessus_ATCC_1997 -------------------------------------------------- Mb2077c|M.bovis_AF2122/97 ALALLAWVLTHRATTPVGGLGYGLLFGLVFYVSLLPWIGELVGPGPWLAL Rv2051c|M.tuberculosis_H37Rv ALALLAWVLTHRATTPVGGLGYGLLFGLVFYVSLLPWIGELVGPGPWLAL MLBr_01440|M.leprae_Br4923 -------------------------------------------------- MUL_2269|M.ulcerans_Agy99 -------------------------------------------------- MAV_4605|M.avium_104 -------------------------------------------------- MMAR_2311|M.marinum_M -------------------------------------------------- Mvan_0217|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_3859|M.smegmatis_MC2_155 -------------------------------------------------- TH_0733|M.thermoresistible__bu -------------------------------------------------- Mflv_3118|M.gilvum_PYR-GCK -------------------------------------------------- MAB_2207|M.abscessus_ATCC_1997 -------------------------------------------------- Mb2077c|M.bovis_AF2122/97 ATTCALFPGIFGLFAVVVRLLPGWPIWFAVGWAAQEWLKSILPFGGFPWG Rv2051c|M.tuberculosis_H37Rv ATTCALFPGIFGLFAVVVRLLPGWPIWFAVGWAAQEWLKSILPFGGFPWG MLBr_01440|M.leprae_Br4923 -------------------------------------------------- MUL_2269|M.ulcerans_Agy99 -------------------------------------------------- MAV_4605|M.avium_104 -------------------------------------------------- MMAR_2311|M.marinum_M -------------------------------------------------- Mvan_0217|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_3859|M.smegmatis_MC2_155 -------------------------------------------------- TH_0733|M.thermoresistible__bu -------------------------------------------------- Mflv_3118|M.gilvum_PYR-GCK -------------------------------------------------- MAB_2207|M.abscessus_ATCC_1997 -------------------------------------------------- Mb2077c|M.bovis_AF2122/97 SVAFGQAEGPLLPLVQLGGVALLSTGVALVGCGLTAIALEIEKWWRTGGQ Rv2051c|M.tuberculosis_H37Rv SVAFGQAEGPLLPLVQLGGVALLSTGVALVGCGLTAIALEIEKWWRTGGQ MLBr_01440|M.leprae_Br4923 -------------------------------------------------- MUL_2269|M.ulcerans_Agy99 -------------------------------------------------- MAV_4605|M.avium_104 -------------------------------------------------- MMAR_2311|M.marinum_M -------------------------------------------------- Mvan_0217|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_3859|M.smegmatis_MC2_155 -------------------------------------------------- TH_0733|M.thermoresistible__bu -------------------------------------------------- Mflv_3118|M.gilvum_PYR-GCK -------------------------------------------------- MAB_2207|M.abscessus_ATCC_1997 -------------------------------------------------- Mb2077c|M.bovis_AF2122/97 GDAPPAVVLPAACICLVLFAAIVVWPQVRHAGSGSGGEPTVTVAVVQGNV Rv2051c|M.tuberculosis_H37Rv GDAPPAVVLPAACICLVLFAAIVVWPQVRHAGSGSGGEPTVTVAVVQGNV MLBr_01440|M.leprae_Br4923 -------------------------------------------------- MUL_2269|M.ulcerans_Agy99 -------------------------------------------------- MAV_4605|M.avium_104 -------------------------------------------------- MMAR_2311|M.marinum_M -------------------------------------------------- Mvan_0217|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_3859|M.smegmatis_MC2_155 -------------------------------------------------- TH_0733|M.thermoresistible__bu -------------------------------------------------- Mflv_3118|M.gilvum_PYR-GCK -------------------------------------------------- MAB_2207|M.abscessus_ATCC_1997 -------------------------------------------------- Mb2077c|M.bovis_AF2122/97 PRLGLDFNAQRRAVLDNHVEETLRLAADVHAGLAQQPQFVIWPENSSDID Rv2051c|M.tuberculosis_H37Rv PRLGLDFNAQRRAVLDNHVEETLRLAADVHAGLAQQPQFVIWPENSSDID MLBr_01440|M.leprae_Br4923 -------------------------------------------------- MUL_2269|M.ulcerans_Agy99 -------------------------------------------------- MAV_4605|M.avium_104 -------------------------------------------------- MMAR_2311|M.marinum_M -------------------------------------------------- Mvan_0217|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_3859|M.smegmatis_MC2_155 -------------------------------------------------- TH_0733|M.thermoresistible__bu -------------------------------------------------- Mflv_3118|M.gilvum_PYR-GCK -------------------------------------------------- MAB_2207|M.abscessus_ATCC_1997 -------------------------------------------------- Mb2077c|M.bovis_AF2122/97 PFVNPDAGQRISAAAEAIGAPILIGTLMDVPGRPRENPEWTNTAIVWNPG Rv2051c|M.tuberculosis_H37Rv PFVNPDAGQRISAAAEAIGAPILIGTLMDVPGRPRENPEWTNTAIVWNPG MLBr_01440|M.leprae_Br4923 -------------------------------------------------- MUL_2269|M.ulcerans_Agy99 -------------------------------------------------- MAV_4605|M.avium_104 -------------------------------------------------- MMAR_2311|M.marinum_M -------------------------------------------------- Mvan_0217|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_3859|M.smegmatis_MC2_155 -------------------------------------------------- TH_0733|M.thermoresistible__bu -------------------------------------------------- Mflv_3118|M.gilvum_PYR-GCK -------------------------------------------------- MAB_2207|M.abscessus_ATCC_1997 -------------------------------------------------- Mb2077c|M.bovis_AF2122/97 TGPADRHDKAIVQPFGEYLPMPWLFRHLSGYADRAGHFVPGNGTGVVRIA Rv2051c|M.tuberculosis_H37Rv TGPADRHDKAIVQPFGEYLPMPWLFRHLSGYADRAGHFVPGNGTGVVRIA MLBr_01440|M.leprae_Br4923 -------------------------------------------------- MUL_2269|M.ulcerans_Agy99 -------------------------------------------------- MAV_4605|M.avium_104 -------------------------------------------------- MMAR_2311|M.marinum_M ---------------------------MRIAGEPDLQQLYRNRFGHARES Mvan_0217|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_3859|M.smegmatis_MC2_155 -------------------------------------------------- TH_0733|M.thermoresistible__bu -------------------------------------------------- Mflv_3118|M.gilvum_PYR-GCK -------------------------------------------------- MAB_2207|M.abscessus_ATCC_1997 -------------------------------------------------- Mb2077c|M.bovis_AF2122/97 GVPVGVATCWEVIFDRAPRKSILGGAQLLTVPSNNATFNKTMSEQQLAFA Rv2051c|M.tuberculosis_H37Rv GVPVGVATCWEVIFDRAPRKSILGGAQLLTVPSNNATFNKTMSEQQLAFA MLBr_01440|M.leprae_Br4923 -------------------------------------------------- MUL_2269|M.ulcerans_Agy99 -------------------------------------------------- MAV_4605|M.avium_104 -------------------------------------------------- MMAR_2311|M.marinum_M RAAIWAVLVRDFFQAWVRRSDTVLDLGCGYGEFLNHVCAARRIGVDLNPD Mvan_0217|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_3859|M.smegmatis_MC2_155 -------------------------------------------------- TH_0733|M.thermoresistible__bu -------------------------------------------------- Mflv_3118|M.gilvum_PYR-GCK -------------------------------------------------- MAB_2207|M.abscessus_ATCC_1997 -------------------------------------------------- Mb2077c|M.bovis_AF2122/97 KVRAVEHDRYVVVAGTTGISAVIAPDGGELIRTDFFQPAYLDSQVRLKTR Rv2051c|M.tuberculosis_H37Rv KVRAVEHDRYVVVAGTTGISAVIAPDGGELIRTDFFQPAYLDSQVRLKTR MLBr_01440|M.leprae_Br4923 -------------------------------------------------- MUL_2269|M.ulcerans_Agy99 -------------------------------------------------- MAV_4605|M.avium_104 -------------------------------------------------- MMAR_2311|M.marinum_M SADMLEPGIEFHGGRADDLSFLADESVDVVFTSNLLEHLQSKAEVERTIA Mvan_0217|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_3859|M.smegmatis_MC2_155 -------------------------------------------------- TH_0733|M.thermoresistible__bu -------------------------------------------------- Mflv_3118|M.gilvum_PYR-GCK -------------------------------------------------- MAB_2207|M.abscessus_ATCC_1997 -------------------------------------------------- Mb2077c|M.bovis_AF2122/97 LTPATRWGPILQWILVGAAAAVVLVAMRQNGWFPRPRRSEPKGENDDSDA Rv2051c|M.tuberculosis_H37Rv LTPATRWGPILQWILVGAAAAVVLVAMRQNGWFPRPRRSEPKGENDDSDA MLBr_01440|M.leprae_Br4923 -------------------------------------------------- MUL_2269|M.ulcerans_Agy99 -------------------------------------------------- MAV_4605|M.avium_104 -------------------------------------------------- MMAR_2311|M.marinum_M EAHRVLK---PGGHLIAMGPNIRFLSGDYWDFWDHTVPISDRSLIEVLES Mvan_0217|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_3859|M.smegmatis_MC2_155 --------------------------------------MSVPGEREQGAG TH_0733|M.thermoresistible__bu -------------------------------------------------- Mflv_3118|M.gilvum_PYR-GCK --------------------------------------MSVPG---GVTG MAB_2207|M.abscessus_ATCC_1997 -------------------------------------------------- Mb2077c|M.bovis_AF2122/97 PPGRSEASGPPALSESDDELIQPEQGGRHSSGFGRHRATSRSYMTTGQPA Rv2051c|M.tuberculosis_H37Rv PPGRSEASGPPALSESDDELIQPEQGGRHSSGFGRHRATSRSYMTTGQPA MLBr_01440|M.leprae_Br4923 -------------------------------------------MITGQPA MUL_2269|M.ulcerans_Agy99 -------------------------------------------MTTGQPA MAV_4605|M.avium_104 -------------------------------------------------- MMAR_2311|M.marinum_M QHLRIVDDYDRFLPYTTRSPWPQAPILVRQYLRSRAAWPIFGKQFVIRAR Mvan_0217|M.vanbaalenii_PYR-1 ---------------------MGELPATGHVGSASHQGQTTTSSPHAQFM MSMEG_3859|M.smegmatis_MC2_155 EDPATVRPTQRTLVIIPTYNERENLPLIVGRVHHACPQVHILVVDDGSPD TH_0733|M.thermoresistible__bu --------------------------------------VHVLIVDDGSPD Mflv_3118|M.gilvum_PYR-GCK REEPAGRPSARTLVIIPTYNERDNLLSIVSRVNDAAPDVHVLIVDDGSPD MAB_2207|M.abscessus_ATCC_1997 MDPVTERPSARTLVIIPTYNERENLPLILGRLHKAQPDVHVLIVDDGSPD Mb2077c|M.bovis_AF2122/97 PPAPGNRPSQRVLVIIPTFNERENLPVIHRRLTQACPAVHVLVVDDSSPD Rv2051c|M.tuberculosis_H37Rv PPAPGNRPSQRVLVIIPTFNERENLPVIHRRLTQACPAVHVLVVDDSSPD MLBr_01440|M.leprae_Br4923 RKISGNRPSQCVLVIIPTFNELENLPVTHGRLKDAYPEIHVLIVDDGSPD MUL_2269|M.ulcerans_Agy99 PQSPGPRPSERTLVIIPTYNERENLPLIHRRVVDACPHVHVLIVDDNSPD MAV_4605|M.avium_104 ----MPGADGRVTVVLPCLNEEESLPGVLATIP---PGYRALVVDNNSTD MMAR_2311|M.marinum_M KERTDLDDERLISVVIPVYNEGENIQVCVRRLTEALSDVPHELLVCYDFD Mvan_0217|M.vanbaalenii_PYR-1 LARDGVKVTPSVSLVIPVRNEARNVAWVLEQIT---EDVDEIILVDGAST :: MSMEG_3859|M.smegmatis_MC2_155 GTGALADELALAD-PDRVHVMHRTSKAGLGAAYLAGFDWGLRRGYSVLVE TH_0733|M.thermoresistible__bu GTGELADELALAD-PDRVHVMHRASKAGLGAAYLAGFRWGLNRQYSVLVE Mflv_3118|M.gilvum_PYR-GCK GTGELADELALGD-PDRIHVMHRTSKDGLGAAYLAGFAWGLNREYTVLVE MAB_2207|M.abscessus_ATCC_1997 GTGELADEAALAD-PDRVHVMHRKEKGGLGAAYIAGFGWGLARQYSVLVE Mb2077c|M.bovis_AF2122/97 GTGQLADELAQAD-PGRTHVMHRTAKNGLGAAYLAGFAWGLSREYSVLVE Rv2051c|M.tuberculosis_H37Rv GTGQLADELAQAD-PGRTHVMHRTAKNGLGAAYLAGFAWGLSREYSVLVE MLBr_01440|M.leprae_Br4923 GTGELADELAQVD-PGCTHVMHRTTKDGLGTAYLAGFAWGMSRDYSVLVE MUL_2269|M.ulcerans_Agy99 GTGRLADELVAAD-PDRIHVLHRTAKNGLGAAYLEGFAWGLSRGYSVLVE MAV_4605|M.avium_104 DTAGVARRHGAQ--------VVTETRAGYGAAVHAG---VLAATTPIVAV MMAR_2311|M.marinum_M EDTTLPALAAMPDKPGTLRLVRNSIGKGVANALIAGFA---AARGDVVVT Mvan_0217|M.vanbaalenii_PYR-1 DATLITALRYRPD-----IKVVAQDGVGKGSALRTGF---FAASGDIIVM :. : * . * * ::. MSMEG_3859|M.smegmatis_MC2_155 MDADGSHAPEELSRLLDAV-DAGADLAIGSRYVPGGTVRNWPWRRLVLSK TH_0733|M.thermoresistible__bu MDADGSHAPEELHRLLDAV-DAGADLAIGSRYVDGGQVRNWPRRRLLLSR Mflv_3118|M.gilvum_PYR-GCK MDADGSHAPEDLHRLLAEI-DAGADVVIGSRYVEGGDVRNWPRRRMVLSR MAB_2207|M.abscessus_ATCC_1997 MDADGSHAPEQLSRLLDAV-DAGADLAIGSRYVPGGTVVNWPWRRLVLSR Mb2077c|M.bovis_AF2122/97 MDADGSHAPEQLQRLLDAV-DAGADLAIGSRYVAGGTVRNWPWRRLVLSK Rv2051c|M.tuberculosis_H37Rv MDADGSHAPEQLQRLLDAV-DAGADLAIGSRYVAGGTVRNWPWRRLVLSK MLBr_01440|M.leprae_Br4923 MDADGSHAPEQLHRLLGAV-DAGADLAIGSRYVNGGTVRNWPWQRLALSK MUL_2269|M.ulcerans_Agy99 MDADGSHAPEQLHRLLDAV-DAGADLSIGSRYVPGGTVRNWPWQRLALSK MAV_4605|M.avium_104 LDADGSMDGADLPRLVAAL-EAGADLVTGRRRPVRG--LRWPWVARVGTV MMAR_2311|M.marinum_M SMADLSDPPSVIPLMAAKIRDEGADIVSGSRYMPGGSQTGGPRLKTLMSR Mvan_0217|M.vanbaalenii_PYR-1 MDADGSMAPQEIRHYVHFL-RNGYDFVKGSRFIGGGGSLDITAFRKLGNR ** * : : * *. * * * . . MSMEG_3859|M.smegmatis_MC2_155 TANTYSRFLLGVGIHDITAGYRAYRREVLEKIDLSAVDSKGYCFQIDLTW TH_0733|M.thermoresistible__bu TANTYSRLLLGVDIRDITAGYRAYRREVLEKIDLDAVDSKGYCFQIDLTW Mflv_3118|M.gilvum_PYR-GCK TANAYSRILLGVDIHDITAGYRAYRREVLEKIDLAAVDSKGYGFQVDLTW MAB_2207|M.abscessus_ATCC_1997 SANVYARLVLGVKPHDITAGYRAYRREVLEKLDLGAVESHGYCFQIDLTL Mb2077c|M.bovis_AF2122/97 TANTYSRLALGIGIHDITAGYRAYRREALEAIDLDGVDSKGYCFQIDLTW Rv2051c|M.tuberculosis_H37Rv TANTYSRLALGIGIHDITAGYRAYRREALEAIDLDGVDSKGYCFQIDLTW MLBr_01440|M.leprae_Br4923 TANKYSRLALGIDVHDITAGYRAYRREVLEAIDLDSVASKGYCFQIDLTW MUL_2269|M.ulcerans_Agy99 TANTYSRLALGIGVHDITAGYRAYRREVLEKIDLASVDSKGYCFQIEMTW MAV_4605|M.avium_104 VMSWRLRTRHGLPVHDIAP-MRVARRDALLGLGVADRRS---GYPLELLV MMAR_2311|M.marinum_M TAGLSLHYVGRVPTHDATTNFRGYSRRFLDEVPVESIKG--FEVGLELTT Mvan_0217|M.vanbaalenii_PYR-1 FLLGVFNSLYDSDLTDLCYGFCAFHRRYLELLELS---ATGFEIEAEMTV . * * * : : . :: MSMEG_3859|M.smegmatis_MC2_155 RAINNGFSVVEVPITFTERELGVSKMSGSNIREAMFKVAEWGIRGRLDRA TH_0733|M.thermoresistible__bu RAINHGFKVVEVPITFTERELGQSKMSGSNIREAIFKVAEWGIRGRLDRA Mflv_3118|M.gilvum_PYR-GCK RSINAGFTVVEVPITFTEREHGVSKMDGSTIREAIIKVAQWGMRARIDRA MAB_2207|M.abscessus_ATCC_1997 RTIAHGFEVAEVPITFTERAIGESKMSGSIINEALVKVTKWGVQSRLDRA Mb2077c|M.bovis_AF2122/97 RTVSNGFVVTEVPITFTERELGVSKMSGSNIREALVKVARWGIEGRLSRS Rv2051c|M.tuberculosis_H37Rv RTVSNGFVVTEVPITFTERELGVSKMSGSNIREALVKVARWGIEGRLSRS MLBr_01440|M.leprae_Br4923 RTVNNGFVIIEVPITFTEREFGLSKMSGSNIREALVKVTRWGIDGRIQRA MUL_2269|M.ulcerans_Agy99 RSVNSGFVVVEVPITFTEREIGVSKMSGSNIREALFKVTRWGVKGRFAGS MAV_4605|M.avium_104 RAAAAGWRVVELDVRYGPRTGGKSKVSGSLRGSITAILDFWKVIS----- MMAR_2311|M.marinum_M KAHLMGFRVDEVPSSWEDRTAGTSKFDLVGWLPSYLHWYGLAMRGPVLRG Mvan_0217|M.vanbaalenii_PYR-1 RAMQAGLRIAEVPSLEMPRRSGKSNLRAVRDGTRVLRTVLHGHRSGVSGH :: * : *: * * *:. . MSMEG_3859|M.smegmatis_MC2_155 RGVVR--------------------------- TH_0733|M.thermoresistible__bu RGIVR--------------------------- Mflv_3118|M.gilvum_PYR-GCK RGNTP--------------------------- MAB_2207|M.abscessus_ATCC_1997 RGVNR--------------------------- Mb2077c|M.bovis_AF2122/97 DHARARPDIARPGAGGSRVSRADVTE------ Rv2051c|M.tuberculosis_H37Rv DHARARPDIARPGAGGSRVSRADVTE------ MLBr_01440|M.leprae_Br4923 RTGRAYNSVSRGGGTGSSPSAP---------- MUL_2269|M.ulcerans_Agy99 EGGGDRAHTHDHS------------------- MAV_4605|M.avium_104 -------------------------------- MMAR_2311|M.marinum_M TTGSLAALGAMWLARRRRCVDAQQSRKTLPSK Mvan_0217|M.vanbaalenii_PYR-1 LLEVLSQRRGPAAAAAEAC-------------