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RVAVKDLFDVAGTVTAAGNPTLAAGPAAAHHAAAVAALLSAGATVVAKTATDELAMGMFGVNAHYGTPPN PAAPDRVPGGSSSGSASLVAGGQAELGLGTDTGGSIRVPAAFCGLAGLRTTHGRIDTAGVRAMAPEFDTV GLMAVETSFLAKAFSVLTTPRTPREVTALVLLTDLAALASADVAARTRATAARWAERLGLPLRTASLGGG PDPVRVFWPLMSAQLWDTNGAWVAEARPVLGTGIAERIRAAASVTDAEVEVAEAQRTRFREHLHGLLAGA VAVLPTTMDAAPARTADHAALMAYRDRNLAFVVPASLAGAPQLTMPQGTVTDAGCGTDAPVGASLLGLPG DDELLLSLAEAVQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3155 | - | - | 100% (364) | amidase |
| M. vanbaalenii PYR-1 | Mvan_3153 | - | 2e-25 | 30.85% (389) | amidase |
| M. vanbaalenii PYR-1 | Mvan_4052 | - | 3e-25 | 30.37% (349) | amidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1294 | amiB2 | 4e-23 | 45.24% (126) | amidase |
| M. gilvum PYR-GCK | Mflv_4246 | gatA | 2e-23 | 42.25% (142) | aspartyl/glutamyl-tRNA amidotransferase subunit A |
| M. tuberculosis H37Rv | Rv1263 | amiB2 | 4e-23 | 45.24% (126) | amidase |
| M. leprae Br4923 | MLBr_01702 | gatA | 1e-22 | 40.85% (142) | aspartyl/glutamyl-tRNA amidotransferase subunit A |
| M. abscessus ATCC 19977 | MAB_1558c | - | 3e-29 | 31.38% (376) | allophanate hydrolase |
| M. marinum M | MMAR_3673 | amiA2 | 4e-25 | 29.68% (401) | amidase AmiA2 |
| M. avium 104 | MAV_1414 | - | 7e-24 | 46.83% (126) | amidase |
| M. smegmatis MC2 155 | MSMEG_4062 | - | 3e-39 | 31.89% (370) | glutamyl-tRNA(Gln) amidotransferase subunit A |
| M. thermoresistible (build 8) | TH_0712 | - | 4e-33 | 32.36% (377) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3616 | amiA2 | 9e-26 | 29.72% (397) | amidase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_1558c|M.abscessus_ATCC_199 ----------------------------------------------MGQG
TH_0712|M.thermoresistible__bu -----------------------------------MSAPSAVERVHAAYA
Mvan_3155|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1294|M.bovis_AF2122/97 --MDPTDLAFAGAAAQAR------------MLADGALTAPMLLEVYLQRI
Rv1263|M.tuberculosis_H37Rv --MDPTDLAFAGAAAQAR------------MLADGALTAPMLLEVYLQRI
MAV_1414|M.avium_104 --MN--DLAFAGAAAQAR------------MLANGDLSAPELLEVYLERI
MMAR_3673|M.marinum_M --MVGASGFASGAVSGSGGPRLPTLTDLLYQLASGSVTSVELTRRSLREI
MUL_3616|M.ulcerans_Agy99 --MVGASGFASGAVSGSGGPRLPTLTDLLYQLASGSVTSVELTRRSLREI
Mflv_4246|M.gilvum_PYR-GCK ----MSELIKLDAATLAD------------KISSKEVSSAEVTQAFLDQI
MLBr_01702|M.leprae_Br4923 MIGSLHEIIRLDASTLAA------------KIVAKELSSVEITQACLDQI
MSMEG_4062|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1558c|M.abscessus_ATCC_199 TRTLLDMT-VWIMRRP-----EDDIAAELEASSG---PLAGVRLAVKDNV
TH_0712|M.thermoresistible__bu AIERVDRPEIWITLRPLADALADAVRVDAAARTGAELPLAGLVAAVKNNI
Mvan_3155|M.vanbaalenii_PYR-1 -----------------------------------------MRVAVKDLF
Mb1294|M.bovis_AF2122/97 ERLDSHLRAYRVVQFDRARAEAEAAQQRLDAGERLP--LLGVPIAIKDDV
Rv1263|M.tuberculosis_H37Rv ERLDSHLRAYRVVQFDRARAEAEAAQQRLDAGERLP--LLGVPIAIKDDV
MAV_1414|M.avium_104 ARLDSQLRCYRVVLADRARREAAAAQSRLDAGERLP--LLGVPVAIKDDV
MMAR_3673|M.marinum_M EVSQSTLNAFRVVLTESALADAAAADRRRAAGDAAP--LLGIPIAVKDDV
MUL_3616|M.ulcerans_Agy99 EVSQSTLNAFRVVLTESALADAAAADRRRAAGDAAP--LLGIPIAVKDDV
Mflv_4246|M.gilvum_PYR-GCK AATDGDYHAFLHVGAEQALAAAQTVDRAVAAGEHLPSPLAGVPLALKDVF
MLBr_01702|M.leprae_Br4923 EATDDTYRAFLHVAAEKALSAAAAVDKAVAAGGQLSSTLAGVPLALKDVF
MSMEG_4062|M.smegmatis_MC2_155 --MARASANRFNAWTTIDHEAVARYERARGASAERARILEGIPCGVKDNI
: .:*: .
MAB_1558c|M.abscessus_ATCC_199 DVGGVPTTAACPEYAY-VPD-QDAPAVAALRAAGAVVVGKTNLDQFATGL
TH_0712|M.thermoresistible__bu DVAGIPTTAGCPTFAT-CAATADAPAVARLRTAGAVVIGATNLDQFATGL
Mvan_3155|M.vanbaalenii_PYR-1 DVAGTVTAAGNPTLAAGPAAAHHAAAVAALLSAGATVVAKTATDELAMGM
Mb1294|M.bovis_AF2122/97 DIAGEVTTYGSAGHG--PAATSDAEVVRRLRAAGAVIIGKTNVPELMIMP
Rv1263|M.tuberculosis_H37Rv DIAGEVTTYGSAGHG--PAATSDAEVVRRLRAAGAVIIGKTNVPELMIMP
MAV_1414|M.avium_104 DVAGEVTTFGSGGHG--PAVSSDAEVVRRLRAAGAVIIGKTNVPELMMMP
MMAR_3673|M.marinum_M DVAGVPTAFGTQGYV--RPAAHDSEVVRRLKAAGAVIIGKTNTCELGQWP
MUL_3616|M.ulcerans_Agy99 DVAGVPTAFGTQGYV--QPAAHDSEVVRRLKAAGAVIIGKTNTCELGQWP
Mflv_4246|M.gilvum_PYR-GCK TTTDMPTTCGSKVLEG-WTSPYDATVTAKLRSAGIPILGKTNMDEFAMGS
MLBr_01702|M.leprae_Br4923 TTVDMPTTCGSKILQG-WHSPYDATVTTRLRAAGIPILGKTNMDEFAMGS
MSMEG_4062|M.smegmatis_MC2_155 DVAGLPTADGSAYPAV--VPTRDAQVVLALRAAGAVIVGKNAMHEIAYGA
. *: . .: .. * :** ::. . ::
MAB_1558c|M.abscessus_ATCC_199 VGTRSPYGAVSDSRRPEYISGGSSSGSAVAVATGQADIAIGTDTAGSGRV
TH_0712|M.thermoresistible__bu VGTRSPYGAVRDARRPDRISGGSSSGSAVAVALGLVDVALGTDTAGSGRV
Mvan_3155|M.vanbaalenii_PYR-1 FGVNAHYGTPPNPAAPDRVPGGSSSGSASLVAGGQAELGLGTDTGGSIRV
Mb1294|M.bovis_AF2122/97 FTESLAFGATRNPWCLNRTPGGSSGGSAAAVAAGLAPVALGSDGGGSIRI
Rv1263|M.tuberculosis_H37Rv FTESLAFGATRNPWCLNRTPGGSSGGSAAAVAAGLAPVALGSDGGGSIRI
MAV_1414|M.avium_104 YTESLTFGATRNPWDPRRTPGGSSGGSAAAVAAGLAPLALGSDGGGSIRI
MMAR_3673|M.marinum_M FTSGPGFGHTRNPWARRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRV
MUL_3616|M.ulcerans_Agy99 FTSGPGFGHTRNPWARRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRV
Mflv_4246|M.gilvum_PYR-GCK STENSAYGPTRNPWDTERVPGGSGGGSAAALAAFQAPLAIGTDTGGSIRQ
MLBr_01702|M.leprae_Br4923 STENSAYGPTRNPWNVDRVPGGSGGGSAAALAAFQAPLAIGSDTGGSIRQ
MSMEG_4062|M.smegmatis_MC2_155 TGMVSATAPVVNPRSAEHMPGGSSSGSAAAVAAGDVPFAIGTDTGGSVRV
. :. .***..*** :* . .:*:* .** *
MAB_1558c|M.abscessus_ATCC_199 PAGLQGIVGIKPTVGVISTEGVVPACESYDCVTIFAPSLTTANAAMAAMG
TH_0712|M.thermoresistible__bu PAALQGIVGIKPTIGVVPTDGVVPACRSYDCVTVFARDLDTADAAMGVL-
Mvan_3155|M.vanbaalenii_PYR-1 PAAFCGLAGLRTTHGRIDTAGVRAMAPEFDTVGLMAVETSFLAKAFSVLT
Mb1294|M.bovis_AF2122/97 PCTWCGLFGLKPQRDRISLEPHDGAWQGLSVNGPIARSVMDAALLLDATT
Rv1263|M.tuberculosis_H37Rv PCTWCGLFGLKPQRDRISLEPHDGAWQGLSVNGPIARSVMDAALLLDATT
MAV_1414|M.avium_104 PSTWCGLFGLKPQRDRVSLEPHDDAWYGLSVNGPIARTVIDAAVFLDATS
MMAR_3673|M.marinum_M PAAWTHLVGIKPQRGRISTWPWPETFNGITVNGVLARTVADAALVLDAAS
MUL_3616|M.ulcerans_Agy99 PAAWTHLVGIKPQRGRISTWPWPETFNGITVNGVLARTVADAALVLDAAS
Mflv_4246|M.gilvum_PYR-GCK PAALTATVGVKPTYGTVSRYGLVACASSLDQGGPCARTVLDTALLHQVIA
MLBr_01702|M.leprae_Br4923 PAALTATVGVKPTYGTVSRYGLVACASSLDQGGPCARTVLDTALLHAVIA
MSMEG_4062|M.smegmatis_MC2_155 PAALCGVVGLRPTTGRLQSSGVQPLSPTLDTVGVLAASVGIARAVWHAIS
*. *::. . : * .
MAB_1558c|M.abscessus_ATCC_199 AAAGPRLWPANTRLAAPPQPT-IAVPRELPALDEVWCNAFRGAVDD----
TH_0712|M.thermoresistible__bu -AGGGRPFPPDAPLTVPPTTR-VAVPGRLPGLSPAWRQAFESACER----
Mvan_3155|M.vanbaalenii_PYR-1 TPRTPREVTALVLLTDLAALASADVAARTRATAARWAERLGLPLRT----
Mb1294|M.bovis_AF2122/97 -TVPGP---EGEFVAAAARQ-----PGRLRIALSTRVP-TPLPVRCGKQE
Rv1263|M.tuberculosis_H37Rv -TVPGP---EGEFVAAAARQ-----PGRLRIALSTRVP-TPLPVRCGKQE
MAV_1414|M.avium_104 -TVPGP---EGEFVAAATRE-----PGRLRIALSTKVP-TPLPVRVGKPE
MMAR_3673|M.marinum_M GNVEGD---LHKPAPLTASDYVGIAPGPLKIAMSTRFPYTGFRAKLHPEI
MUL_3616|M.ulcerans_Agy99 GNAEGD---LHKPAPLTASDYVGIAPGPLKIAMSTRFPYTGFRAKLHPEI
Mflv_4246|M.gilvum_PYR-GCK GHDPLDSTSVEAPVPDVVAAARTGAGGDLTGVRIGVVKQLRSGEGYQAGV
MLBr_01702|M.leprae_Br4923 GHDARDSTSVEAAVPDIVGAAKAGESGDLHGVRVGVVRQLR-GEGYQSGV
MSMEG_4062|M.smegmatis_MC2_155 GTPYRSPETDDAALTIGVVADDYFVPESTAITEAVSNACASLEQHGAKVR
.
MAB_1558c|M.abscessus_ATCC_199 -LRAAGATIIEIDLTPFLAAAKLLYEGALVSERYA------------AVG
TH_0712|M.thermoresistible__bu -LAGNGIELVEVDLTPFLQAATLLYDGGLVAERHA------------AVG
Mvan_3155|M.vanbaalenii_PYR-1 -ASLGGGPDPVRVFWPLMSAQLWDTNGAWVAEARP------------VLG
Mb1294|M.bovis_AF2122/97 LAAVHQAGALLRDLGHDVVVRDPDYPASTYA-NYLPR---------FFRG
Rv1263|M.tuberculosis_H37Rv LAAVHQAGALLRDLGHDVVVRDPDYPASTYA-NYLPR---------FFRG
MAV_1414|M.avium_104 LAAVQQAGALLRDLGHDVVTADPEYPAAAILGNYLPR---------YLRG
MMAR_3673|M.marinum_M LAATRRVGEQLQLLGHTVERGNPDY-GLRLSWDFLAR---------STAG
MUL_3616|M.ulcerans_Agy99 LASTRRVGEQLQLLGHTVERGNPDY-GLRLSWDFLAR---------STAG
Mflv_4246|M.gilvum_PYR-GCK LASFNAAVDQLTALGAEVTEVDCPHFDYSLPAYYLILPSEVSSNLAKFDG
MLBr_01702|M.leprae_Br4923 LASFQAAVEQLIALGATVSEVDCPHFDYALAAYYLILPSEVSSNLARFDA
MSMEG_4062|M.smegmatis_MC2_155 PVRLGWPEAAVPVYAHIVGCEAALTHRKRLSENPP---------------
:
MAB_1558c|M.abscessus_ATCC_199 EFIDAHPEA---SLDPTVAQIISGA------------------RDIPAHR
TH_0712|M.thermoresistible__bu TFVDEHLAAGDPALDPTVAQIISAA------------------GAVPATT
Mvan_3155|M.vanbaalenii_PYR-1 ---------------TGIAERIRAA------------------ASVTDAE
Mb1294|M.bovis_AF2122/97 ISDDADAQAHPDRLEARTRAIARLG------------------SFFSDRR
Rv1263|M.tuberculosis_H37Rv ISDDADAQAHPDRLEARTRAIARLG------------------SFFSDRR
MAV_1414|M.avium_104 ICDDADSLAHPERLEARTRNMARMG------------------SFFSDRR
MMAR_3673|M.marinum_M LWEWAECLGDGVTLDPRTVTNMRAG------------------HALSQAI
MUL_3616|M.ulcerans_Agy99 LWEWAECLGNGVTLDPRTVTNMRAG------------------HALSQAI
Mflv_4246|M.gilvum_PYR-GCK MRYGLRAGDDGTHSAEEVMALTRAAGFGPEVKRRIMIGAYALSAGYYDAY
MLBr_01702|M.leprae_Br4923 MRYGLRVGDDGSRSAEEVIALTRAAGFGPEVKRRIMIGAYALSAGYYDSY
MSMEG_4062|M.smegmatis_MC2_155 ------------LFQSETRRRLAAG------------------ARTTPHM
.
MAB_1558c|M.abscessus_ATCC_199 LVHDRAEVQRLREQAMTSLAGADALLVPTAPLHPTIEQVNANPIGVNATM
TH_0712|M.thermoresistible__bu LLRDRARLAELTASALARLGDCAALLIPTTTEHPSIAEVAADPVGVNSRL
Mvan_3155|M.vanbaalenii_PYR-1 VEVAEAQRTRFREHLHGLLAGAVAVLPTTMDAAPARTADHAALMAYRDRN
Mb1294|M.bovis_AF2122/97 MAALRAAEVVLSSRIQSIFDDVDVVVTPGAATGPSRIGAYQRRGAVSTLL
Rv1263|M.tuberculosis_H37Rv MAALRAAEVVLSSRIQSIFDDVDVVVTPGAATGPSRIGAYQRRGAVSTLL
MAV_1414|M.avium_104 MAAIRAGEGPLIARIQAIFDDVDVVVTPGTAAGPSRVGAYQRRGAVSTLL
MMAR_3673|M.marinum_M LRNARHHEAAAQRRVGSIFDIVDVVLAPTTAQPPPLARAFDDMGGLATDR
MUL_3616|M.ulcerans_Agy99 LRNARHHEAAAQRRVGSIFDIVDVVLAPTTAQPPPLARAFDDMGGLATDR
Mflv_4246|M.gilvum_PYR-GCK YNQAQKVRTLIARDLDAAYQKVDVLVSPATP-----TTAFRLGEKVDDPL
MLBr_01702|M.leprae_Br4923 YSQAQKVRTLIARDLDKAYRSVDVLVSPATP-----TTAFSLGEKADDPL
MSMEG_4062|M.smegmatis_MC2_155 YVEALRHRARIAYDLLRVFDHCDVLISPTTAILGPRRDRKTADVGGQSVD
.:: .
MAB_1558c|M.abscessus_ATCC_199 -----GTYTNFCNLFDLCAVSVPAGTAGD------AQFGVTVIARAFDDA
TH_0712|M.thermoresistible__bu -----GTYTNFCNLMDLCAVAVPAGTTSDG-----AQFGVTVLGRAGADA
Mvan_3155|M.vanbaalenii_PYR-1 -----LAFVVPASLAGAPQLTMPQGTVTDAGCGTDAPVGASLLGLPGDDE
Mb1294|M.bovis_AF2122/97 LVVQRVPYFQVWNLTGQPAAVVPWDFDGD-----GLPMSVQLVGRPYDEA
Rv1263|M.tuberculosis_H37Rv LVVQRVPYFQVWNLTGQPAAVVPWDFDGD-----GLPMSVQLVGRPYDEA
MAV_1414|M.avium_104 RVGQCVPYQQIWNLTGQPAAVVPWDFDAD-----GLPMSVQLVGRPYDEA
MMAR_3673|M.marinum_M AIIAACPLTWPWNLLGWPSINVPAGFTVD-----GLPIGVQLMGPAESEG
MUL_3616|M.ulcerans_Agy99 AIIAACPLTWPWNLLGWPSINVPAGFTVD-----GLPIGVQLMGPAESEG
Mflv_4246|M.gilvum_PYR-GCK SMYLFDLCTLPLNLAGHCGMSVPSGLSADD----NLPVGLQIMAPALADD
MLBr_01702|M.leprae_Br4923 AMYLFDLCTLPLNLAGHCGMSVPSGLSSDD----DLPVGLQIMAPALADD
MSMEG_4062|M.smegmatis_MC2_155 VGRALVAYTTPWSLTGAPALAVPVGADQHG-----RPLSVQLVGKPGCET
.* . :* . . .. ::. . :
MAB_1558c|M.abscessus_ATCC_199 VAFDIAALATGAPAGQDVWPAAITLSHELAVFGAHLKGGPLEFQLTDLGA
TH_0712|M.thermoresistible__bu LALDLARLVSAPVDG--AAPPGVPAPPTPAVPWPXX--XAADLTDDDHLG
Mvan_3155|M.vanbaalenii_PYR-1 LLLSLAEAVQ----------------------------------------
Mb1294|M.bovis_AF2122/97 TLLALAAQIESARPWAHRRPSVS---------------------------
Rv1263|M.tuberculosis_H37Rv TLLALAAQIESARPWAHRRPSVS---------------------------
MAV_1414|M.avium_104 TLLSLSAQIEAARPWALRRPPVC---------------------------
MMAR_3673|M.marinum_M LLISLAAELEAVSGWATKQPKVWWNTGTSTPPIHSVRPPRR---------
MUL_3616|M.ulcerans_Agy99 LLISLAAELEAVSGWATKQPKVWWNTGTSTPPIHSVRPPRR---------
Mflv_4246|M.gilvum_PYR-GCK RLYRVGAAYEAARGPLPTAL------------------------------
MLBr_01702|M.leprae_Br4923 RLYRVGAAYEAARGPLPSAI------------------------------
MSMEG_4062|M.smegmatis_MC2_155 RVLEAGSIVEAQHRSAAGLR------------------------------
.
MAB_1558c|M.abscessus_ATCC_199 RWVGPIRTATKYRMSALRTTPPKPGLTRSEENGVSIGGEVWRLSP-----
TH_0712|M.thermoresistible__bu RPRGDTETGQRLELLAHLVTGGTR--APATVLAAVVHGELLALAPFGTAD
Mvan_3155|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1294|M.bovis_AF2122/97 --------------------------------------------------
Rv1263|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1414|M.avium_104 --------------------------------------------------
MMAR_3673|M.marinum_M --------------------------------------------------
MUL_3616|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4246|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_01702|M.leprae_Br4923 --------------------------------------------------
MSMEG_4062|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1558c|M.abscessus_ATCC_199 ---AALGTFLAQLPEPMLLGKVECDDGLWRTGFGCDGAAAQAGVDISEHG
TH_0712|M.thermoresistible__bu GVVARAASRLVTMASGLDPHGLGVPEVFWMTQQRDYRAAAQGFASGTRDG
Mvan_3155|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1294|M.bovis_AF2122/97 --------------------------------------------------
Rv1263|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1414|M.avium_104 --------------------------------------------------
MMAR_3673|M.marinum_M --------------------------------------------------
MUL_3616|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4246|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_01702|M.leprae_Br4923 --------------------------------------------------
MSMEG_4062|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1558c|M.abscessus_ATCC_199 S------WPAAIAAGAV-------------
TH_0712|M.thermoresistible__bu LTTWLMLTARALHAGAREAISIAEAQAEAN
Mvan_3155|M.vanbaalenii_PYR-1 ------------------------------
Mb1294|M.bovis_AF2122/97 ------------------------------
Rv1263|M.tuberculosis_H37Rv ------------------------------
MAV_1414|M.avium_104 ------------------------------
MMAR_3673|M.marinum_M ------------------------------
MUL_3616|M.ulcerans_Agy99 ------------------------------
Mflv_4246|M.gilvum_PYR-GCK ------------------------------
MLBr_01702|M.leprae_Br4923 ------------------------------
MSMEG_4062|M.smegmatis_MC2_155 ------------------------------