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TAALRPWTGDAADYLAGSAQMLAELEPGVRAFTHVDVDAARTAATRAVGPLAGMPVAVKEIIDVAGMPVT FGSIVFAGRIATEDAEAVARLRRAGAVVVGMTTTTPFACGTTTGTDNPHRPGHTPGGSSAGSAAAVGAGM VPVALASQSQASTLRPASYCGAWGFKPSHLRLPRAGMHLLADVLDDLGLIAASLDNLDAVFGVLAEPSRV PVAPSGPLRVGRLRLDDGGLPRRATVAALDDLLSRLAGPDVTVATDTPVLAETDRLLAGSGRTCFDLFAA QSASRLAHYAAAGETDPRLREMVGHAAALGADGAARALARRDRLRGAWAQLAEHYDVLVALATTNPAPAG HAGTGCRRLPATSSLLGIPALTAPWLTVDGLPQGVQLLGFEGRDEELLAAARVLAETGVNA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3153 | - | - | 100% (412) | amidase |
| M. vanbaalenii PYR-1 | Mvan_3824 | - | 8e-29 | 31.25% (448) | amidase |
| M. vanbaalenii PYR-1 | Mvan_3155 | - | 2e-25 | 30.85% (389) | amidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3200 | - | 9e-30 | 30.77% (442) | amidase |
| M. gilvum PYR-GCK | Mflv_2712 | - | 2e-33 | 33.19% (455) | amidase |
| M. tuberculosis H37Rv | Rv3175 | - | 9e-30 | 30.77% (442) | amidase |
| M. leprae Br4923 | MLBr_01702 | gatA | 5e-22 | 29.80% (349) | aspartyl/glutamyl-tRNA amidotransferase subunit A |
| M. abscessus ATCC 19977 | MAB_1674c | - | 3e-26 | 30.96% (394) | amidase |
| M. marinum M | MMAR_3673 | amiA2 | 5e-29 | 32.08% (399) | amidase AmiA2 |
| M. avium 104 | MAV_1414 | - | 5e-30 | 31.71% (432) | amidase |
| M. smegmatis MC2 155 | MSMEG_2986 | - | 9e-42 | 34.32% (437) | amidohydrolase, AtzE family protein |
| M. thermoresistible (build 8) | TH_0712 | - | 3e-35 | 36.39% (393) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3616 | amiA2 | 1e-28 | 32.50% (400) | amidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3200|M.bovis_AF2122/97 MAMSAKAS---------DDIAWLPATAQLAVLAAKKVSSAELVELYLSRI
Rv3175|M.tuberculosis_H37Rv MAMSAKAS---------DDIAWLPATAQLAVLAAKKVSSAELVELYLSRI
MMAR_3673|M.marinum_M --MVGASGFASGAVSGSGGPRLPTLTDLLYQLASGSVTSVELTRRSLREI
MUL_3616|M.ulcerans_Agy99 --MVGASGFASGAVSGSGGPRLPTLTDLLYQLASGSVTSVELTRRSLREI
Mflv_2712|M.gilvum_PYR-GCK --MPDSS--ARSTSRNRFPDRFPTVANQLFQLASGTATSVDLVRRSLVAI
MAB_1674c|M.abscessus_ATCC_199 --MSG----------------FPTLTSQAAALSDGSESSVSLTLTALNAI
MAV_1414|M.avium_104 --MNDLA--------------FAGAAAQARMLANGDLSAPELLEVYLERI
Mvan_3153|M.vanbaalenii_PYR-1 ---------------------------MTAALRPWTGDAADYLAGSAQML
MSMEG_2986|M.smegmatis_MC2_155 --MTETADTTG----LTGFFRDHDIHSLAADLRNGHTTSVELVEHSLAAI
TH_0712|M.thermoresistible__bu ---------------------------------MSAPSAVERVHAAYAAI
MLBr_01702|M.leprae_Br4923 ------------MIGSLHEIIRLDASTLAAKIVAKELSSVEITQACLDQI
: . :
Mb3200|M.bovis_AF2122/97 DTYNASLNAIVTVDPDAARRVAKRSDAARARGD--ELGPLHGLPITVKDS
Rv3175|M.tuberculosis_H37Rv DTYNASLNAIVTVDPDAARRVAKRSDAARARGD--ELGPLHGLPITVKDS
MMAR_3673|M.marinum_M EVSQSTLNAFRVVLTESALADAAAADRRRAAG---DAAPLLGIPIAVKDD
MUL_3616|M.ulcerans_Agy99 EVSQSTLNAFRVVLTESALADAAAADRRRAAG---DAAPLLGIPIAVKDD
Mflv_2712|M.gilvum_PYR-GCK EASQPTLNAFRVVLAERALADAAEADRLRAAGHDRARRPLLGIPIAVKDD
MAB_1674c|M.abscessus_ATCC_199 KSSQSTLNAFRVVCTKTALAEATEADKRLARG---ERLPLLGVPIAIKDD
MAV_1414|M.avium_104 ARLDSQLRCYRVVLADRARREAAAAQSRLDAG---ERLPLLGVPVAIKDD
Mvan_3153|M.vanbaalenii_PYR-1 AELEPGVRAFTHVDVDAARTAATRAVGPLAG-----------MPVAVKEI
MSMEG_2986|M.smegmatis_MC2_155 TRLDPTLNAFTAVDAEGALDAARHADAELARGH--DRGVLHGIPVAVKDL
TH_0712|M.thermoresistible__bu ERVDRPEIWITLRPLADALADAVRVDAAARTG---AELPLAGLVAAVKNN
MLBr_01702|M.leprae_Br4923 EATDDTYRAFLHVAAEKALSAAAAVDKAVAAGG-QLSSTLAGVPLALKDV
: * * : ::*:
Mb3200|M.bovis_AF2122/97 YETAGMRTTCGRRDLADYVPTQDAEAVARLRRAGAIIMGKTNMPTGNQDV
Rv3175|M.tuberculosis_H37Rv YETAGMRTTCGRRDLADYVPTQDAEAVARLRRAGAIIMGKTNMPTGNQDV
MMAR_3673|M.marinum_M VDVAGVPTAFGTQGYVRPA-AHDSEVVRRLKAAGAVIIGKTNTCELGQWP
MUL_3616|M.ulcerans_Agy99 VDVAGVPTAFGTQGYVQPA-AHDSEVVRRLKAAGAVIIGKTNTCELGQWP
Mflv_2712|M.gilvum_PYR-GCK VDVAGVPTRFGASGEVPEA-VADAEVVRRLRAAGAVIVGKTNTCELGQWP
MAB_1674c|M.abscessus_ATCC_199 TDLAGTPTAFGTAGAVGSE-SEDAELVRRLRAAGAVIVGKTNTCELGQWG
MAV_1414|M.avium_104 VDVAGEVTTFGSGGHGPAV-SSDAEVVRRLRAAGAVIIGKTNVPELMMMP
Mvan_3153|M.vanbaalenii_PYR-1 IDVAGMPVTFGSIVFAGRIATEDAEAVARLRRAGAVVVGMTTTTPFACGT
MSMEG_2986|M.smegmatis_MC2_155 VDVAGHVTTRGSVVHPG-PATADAECVRRLRTAGAVIVGRNVLHEFAFGA
TH_0712|M.thermoresistible__bu IDVAGIPTTAGCPTFATCAATADAPAVARLRTAGAVVIGATNLDQFATGL
MLBr_01702|M.leprae_Br4923 FTTVDMPTTCGSKILQGWHSPYDATVTTRLRAAGIPILGKTNMDEFAMGS
.. . * *: . **: ** ::* .
Mb3200|M.bovis_AF2122/97 QASNPVFGRTNNPWDAARTSGGSAGGGAAATAAGLTSFDYGSEIGGSTRI
Rv3175|M.tuberculosis_H37Rv QASNPVFGRTNNPWDAARTSGGSAGGGAAATAAGLTSFDYGSEIGGSTRI
MMAR_3673|M.marinum_M FTSGPGFGHTRNPWARRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRV
MUL_3616|M.ulcerans_Agy99 FTSGPGFGHTRNPWARRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRV
Mflv_2712|M.gilvum_PYR-GCK FTSGPAFGHTRNPWSREHTPGGSSGGSAAAVAAGLVAAAIGSDGAGSVRI
MAB_1674c|M.abscessus_ATCC_199 FTSGPGFGHTRNPWSRGHTPGGSSGGSAAAVAAGLVAGAIGSDGAGSVRI
MAV_1414|M.avium_104 YTESLTFGATRNPWDPRRTPGGSSGGSAAAVAAGLAPLALGSDGGGSIRI
Mvan_3153|M.vanbaalenii_PYR-1 TTG------TDNPHRPGHTPGGSSAGSAAAVGAGMVPVALASQSQASTLR
MSMEG_2986|M.smegmatis_MC2_155 TGDRSAHGASRNPWDPSRISGGSSGGSAVATAAGMVPLAVGTDTAGSVRV
TH_0712|M.thermoresistible__bu VGTRSPYGAVRDARRPDRISGGSSSGSAVAVALGLVDVALGTDTAGSGRV
MLBr_01702|M.leprae_Br4923 STENSAYGPTRNPWNVDRVPGGSGGGSAAALAAFQAPLAIGSDTGGSIRQ
:. : .***..*.*.* . . .:: .*
Mb3200|M.bovis_AF2122/97 PAHYCGLYGHKSTWRSVPLVGHIPSAPGNPGRWGQADMACAGVQVRGARD
Rv3175|M.tuberculosis_H37Rv PAHYCGLYGHKSTWRSVPLVGHIPSAPGNPGRWGQADMACAGVQVRGARD
MMAR_3673|M.marinum_M PAAWTHLVGIKPQRGRISTWPWPETFNG---------ITVNGVLARTVAD
MUL_3616|M.ulcerans_Agy99 PAAWTHLVGIKPQRGRISTWPWPETFNG---------ITVNGVLARTVAD
Mflv_2712|M.gilvum_PYR-GCK PAAWTHLVGIKPQRGRISTSPLPEAFNG---------ITVNGVLARTVSD
MAB_1674c|M.abscessus_ATCC_199 PAAWTHLIGIKPQRGRISTWPFAEAFNG---------ITVHGPLARTVAD
MAV_1414|M.avium_104 PSTWCGLFGLKPQRDRVSLEPHDDAWYG---------LSVNGPIARTVID
Mvan_3153|M.vanbaalenii_PYR-1 PASYCGAWGFKPSHLRLPRAGMHLLADV---------LDDLGLIAASLDN
MSMEG_2986|M.smegmatis_MC2_155 PAALCGVVGFKPAYGAIPAQGVWPLAAS---------LDHVGVFARTATG
TH_0712|M.thermoresistible__bu PAALQGIVGIKPTIGVVPTDGVVPACRS---------YDCVTVFARDLDT
MLBr_01702|M.leprae_Br4923 PAALTATVGVKPTYGTVSRYGLVACASS---------LDQGGPCARTVLD
*: * *. :. .
Mb3200|M.bovis_AF2122/97 IIPALEATVGPMRADGG--FSYALAPPRAGALKDFRVAVWAEDPHCPIDA
Rv3175|M.tuberculosis_H37Rv IIPALEATVGPMRADGG--FSYALAPPRAGALKDFRVAVWAEDPHCPIDA
MMAR_3673|M.marinum_M AALVLDAASGNVEGDLHKPAPLTASDYVGIAPGPLKIAMSTRFPYTGFRA
MUL_3616|M.ulcerans_Agy99 AALVLDAASGNAEGDLHKPAPLTASDYVGIAPGPLKIAMSTRFPYTGFRA
Mflv_2712|M.gilvum_PYR-GCK AAMVLDAAAGNAAGDLHTPAPVTVSDFVSRAPGPLRVAVSTRFPFTGFRA
MAB_1674c|M.abscessus_ATCC_199 AALLLDAASGNVPGDLHKPPHVRVLDAVHEDPGQLRVALSLKVPFSGFPA
MAV_1414|M.avium_104 AAVFLDATS-TVPG-----PEGEFVAAATREPGRLRIALSTKVPTP-LPV
Mvan_3153|M.vanbaalenii_PYR-1 LDAVFGVLAEPSRVPVAPSGPLRVGRLRLDDGGLPRRATVAALDDLLSRL
MSMEG_2986|M.smegmatis_MC2_155 AAAAYTAMAGRS------PDPVRAQRVAWLDPACLGPCDPAIIAALSETL
TH_0712|M.thermoresistible__bu ADAAMGVLAGGGRPFPPDAPLTVPPTTRVAVPGRLPGLSPAWRQAFESAC
MLBr_01702|M.leprae_Br4923 TALLHAVIAGHDARDSTSVEAAVPDIVGAAKAGESGDLHGVRVGVVRQLR
.
Mb3200|M.bovis_AF2122/97 DVRRAMDDAVAALRAAGAHVVEQPATIPVDMAVSHNIFQSLVFGAFAVDR
Rv3175|M.tuberculosis_H37Rv DVRRAMDDAVAALRAAGAHVVEQPATIPVDMAVSHNIFQSLVFGAFAVDR
MMAR_3673|M.marinum_M KLH-------PEILAATRRVGEQLQLLGHTVERGNPDY-GLRLSWDFLAR
MUL_3616|M.ulcerans_Agy99 KLH-------PEILASTRRVGEQLQLLGHTVERGNPDY-GLRLSWDFLAR
Mflv_2712|M.gilvum_PYR-GCK TLH-------PEIRSALDGVADQLSQLGHTVLNADPDY-TLGMSWNFLAR
MAB_1674c|M.abscessus_ATCC_199 QLH-------PTIEAATRYVAHQLRSLGHMVSEGDPDY-GVGLGLNFLPR
MAV_1414|M.avium_104 RVG-------KPELAAVQQAGALLRDLGHDVVTADPEYPAAAILGNYLPR
Mvan_3153|M.vanbaalenii_PYR-1 AGP-------------------DVTVATDTPVLAETDRLLAGSGRTCFDL
MSMEG_2986|M.smegmatis_MC2_155 RAA-------------------QITVDGTVGLPFAAGEVFEALS--VLQS
TH_0712|M.thermoresistible__bu ERLAG----------------NGIELVEVDLTPFLQAATLLYDGGLVAER
MLBr_01702|M.leprae_Br4923 GEG-----YQSGVLASFQAAVEQLIALGATVSEVDCPHFDYALAAYYLIL
Mb3200|M.bovis_AF2122/97 STLSPASAAALGLR----------------------AVRHPRGEAANALG
Rv3175|M.tuberculosis_H37Rv STLSPASAAALGLR----------------------AVRHPRGEAANALG
MMAR_3673|M.marinum_M STAGLWEWAECLGD----------------------GVTLDPRTVTNMRA
MUL_3616|M.ulcerans_Agy99 STAGLWEWAECLGN----------------------GVTLDPRTVTNMRA
Mflv_2712|M.gilvum_PYR-GCK STSGIPEWMDRLGH----------------------RVTWDSRTRSNARM
MAB_1674c|M.abscessus_ATCC_199 ATAGLLPWRDRLDA----------------------GAHWDPRTVTNMRT
MAV_1414|M.avium_104 YLRGICDDADSLAH----------------------PERLEARTRNMARM
Mvan_3153|M.vanbaalenii_PYR-1 FAAQSASRLAHYAA----------------------AGETDPRLREMVGH
MSMEG_2986|M.smegmatis_MC2_155 SEAYTEYSAETEQR----------------------ASDIDPEVLGRLLR
TH_0712|M.thermoresistible__bu HAAVGTFVDEHLAAG---------------------DPALDPTVAQIISA
MLBr_01702|M.leprae_Br4923 PSEVSSNLARFDAMRYGLRVGDDGSRSAEEVIALTRAAGFGPEVKRRIMI
Mb3200|M.bovis_AF2122/97 ATLQSHR-----AWLFADAARHEMRDRWAGFFNEFDVLLLPVTPTPAPLH
Rv3175|M.tuberculosis_H37Rv ATLQSHR-----AWLFADAARHEMRDRWAGFFNEFDVLLLPVTPTPAPLH
MMAR_3673|M.marinum_M GHALSQA-----ILRNARHHEAAAQRRVGSIFDIVDVVLAPTTAQPPPLA
MUL_3616|M.ulcerans_Agy99 GHALSQA-----ILRNARHHEAAAQRRVGSIFDIVDVVLAPTTAQPPPLA
Mflv_2712|M.gilvum_PYR-GCK GRLLSQH-----TLRKARAREAAAQQRIGWIFNLADVVVAPTTAQPPPEA
MAB_1674c|M.abscessus_ATCC_199 GRRLAGW-----ALRRARAAEPRLQARVGKIFGSFNVVLAPTTAQPPTGI
MAV_1414|M.avium_104 GSFFSDR-----RMAAIRAGEGPLIARIQAIFDDVDVVVTPGTAAGPSRV
Mvan_3153|M.vanbaalenii_PYR-1 AAALGAD-----GAARALARRDRLRGAWAQLAEHYDVLVALATTNPAPAG
MSMEG_2986|M.smegmatis_MC2_155 GRDTPAW-----QYVRACRQRDRLRAAADTLLTRFDVLAMPAAPTVATEI
TH_0712|M.thermoresistible__bu AGAVPAT-----TLLRDRARLAELTASALARLGDCAALLIPTTTEHPSIA
MLBr_01702|M.leprae_Br4923 GAYALSAGYYDSYYSQAQKVRTLIARDLDKAYRSVDVLVSPATPTTAFSL
. .: :. .
Mb3200|M.bovis_AF2122/97 HNKDHDRLGRTIDVDGVSRSYWDQLKWNALANIAGTPATTMPITTTATG-
Rv3175|M.tuberculosis_H37Rv HNKDHDRLGRTIDVDGVSRSYWDQLKWNALANIAGTPATTMPITTTATG-
MMAR_3673|M.marinum_M R--AFDDMGGLATDRAIIAACPLTWPWNLLG----WPSINVPAGFTVDG-
MUL_3616|M.ulcerans_Agy99 R--AFDDMGGLATDRAIIAACPLTWPWNLLG----WPSINVPAGFTVDG-
Mflv_2712|M.gilvum_PYR-GCK H--AFDGLGGLATDRMMIRACPVTWPWNLLG----WPSINVPAGFTSDG-
MAB_1674c|M.abscessus_ATCC_199 Y--DFDDVGSLATDRGQVGACPMTWPWNVLG----WPSINVPAGFTADG-
MAV_1414|M.avium_104 G--AYQRRGAVSTLLRVGQCVPYQQIWNLTG----QPAAVVPWDFDADG-
Mvan_3153|M.vanbaalenii_PYR-1 --------------HAGTGCRRLPATSSLLG----IPALTAPW-LTVDG-
MSMEG_2986|M.smegmatis_MC2_155 D--QRAHQIDGHAVEVRSALLSLTCPWNLTG----HPALSVPA-GVVSG-
TH_0712|M.thermoresistible__bu E-------VAADPVGVNSRLGTYTNFCNLMD----LCAVAVPAGTTSDG-
MLBr_01702|M.leprae_Br4923 G-------EKADDPLAMYLFDLCTLPLNLAG----HCGMSVPSGLSSDDD
. . * .
Mb3200|M.bovis_AF2122/97 LPIGIQAMGPAGGDRTTVEFAALLTEVLGGFRVPPL--------------
Rv3175|M.tuberculosis_H37Rv LPIGIQAMGPAGGDRTTVEFAALLTEVLGGFRVPPL--------------
MMAR_3673|M.marinum_M LPIGVQLMGPAESEGLLISLAAELEAVSGWATKQPKVWWNTGTSTPPIHS
MUL_3616|M.ulcerans_Agy99 LPIGVQLMGPAESEGLLISLAAELEAVSGWATKQPKVWWNTGTSTPPIHS
Mflv_2712|M.gilvum_PYR-GCK LPIGVQLMGPADSEPLLISLAAALEAINGWATLQPENWWAPQPPTEPDLT
MAB_1674c|M.abscessus_ATCC_199 LPIGVQLMGPANSEPLLISLAAQLESINNWASEIPDPWW-----------
MAV_1414|M.avium_104 LPMSVQLVGRPYDEATLLSLSAQIEAARPWALRRPPVC------------
Mvan_3153|M.vanbaalenii_PYR-1 LPQGVQLLGFEGRDEELLAAARVLAETGVNA-------------------
MSMEG_2986|M.smegmatis_MC2_155 LPVGLQLISAPGNEGMLFDLAARIEHR-----------------------
TH_0712|M.thermoresistible__bu AQFGVTVLGRAGADALALDLARLVSAPVDGAAPPGVPAPPTPAVPWPXXX
MLBr_01702|M.leprae_Br4923 LPVGLQIMAPALADDRLYRVGAAYEAARGPLPSAI---------------
.: :. : .
Mb3200|M.bovis_AF2122/97 --------------------------------------------------
Rv3175|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3673|M.marinum_M VRPPRR--------------------------------------------
MUL_3616|M.ulcerans_Agy99 VRPPRR--------------------------------------------
Mflv_2712|M.gilvum_PYR-GCK APDSVTGQVA----------------------------------------
MAB_1674c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1414|M.avium_104 --------------------------------------------------
Mvan_3153|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2986|M.smegmatis_MC2_155 --------------------------------------------------
TH_0712|M.thermoresistible__bu AADLTDDDHLGRPRGDTETGQRLELLAHLVTGGTRAPATVLAAVVHGELL
MLBr_01702|M.leprae_Br4923 --------------------------------------------------
Mb3200|M.bovis_AF2122/97 --------------------------------------------------
Rv3175|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3673|M.marinum_M --------------------------------------------------
MUL_3616|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2712|M.gilvum_PYR-GCK --------------------------------------------------
MAB_1674c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1414|M.avium_104 --------------------------------------------------
Mvan_3153|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2986|M.smegmatis_MC2_155 --------------------------------------------------
TH_0712|M.thermoresistible__bu ALAPFGTADGVVARAASRLVTMASGLDPHGLGVPEVFWMTQQRDYRAAAQ
MLBr_01702|M.leprae_Br4923 --------------------------------------------------
Mb3200|M.bovis_AF2122/97 ---------------------------------------
Rv3175|M.tuberculosis_H37Rv ---------------------------------------
MMAR_3673|M.marinum_M ---------------------------------------
MUL_3616|M.ulcerans_Agy99 ---------------------------------------
Mflv_2712|M.gilvum_PYR-GCK ---------------------------------------
MAB_1674c|M.abscessus_ATCC_199 ---------------------------------------
MAV_1414|M.avium_104 ---------------------------------------
Mvan_3153|M.vanbaalenii_PYR-1 ---------------------------------------
MSMEG_2986|M.smegmatis_MC2_155 ---------------------------------------
TH_0712|M.thermoresistible__bu GFASGTRDGLTTWLMLTARALHAGAREAISIAEAQAEAN
MLBr_01702|M.leprae_Br4923 ---------------------------------------