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VDPTDLAFAGAAAQARMLADGALTAPMLLEVYLQRIERLDSHLRAYRVVQFDRARAEAEAAQQRLDAGER LPLLGVPIAIKDDVDIAGEVTTYGSAGHGPAATSDAEVVRRLRAAGAVIIGKTNVPELMIMPFTESLAFG ATRNPWCLNRTPGGSSGGSAAAVAAGLAPVALGSDGGGSIRIPCTWCGLFGLKPQRDRISLEPHDGAWQG LSVNGPIARSVMDAALLLDATTTVPGPEGEFVAAAARQPGRLRIALSTRVPTPLPVRCGKQELAAVHQAG ALLRDLGHDVVVRDPDYPASTYANYLPRFFRGISDDADAQAHPDRLEARTRAIARLGSFFSDRRMAALRA AEVVLSSRIQSIFDDVDVVVTPGAATGPSRIGAYQRRGAVSTLLLVVQRVPYFQVWNLTGQPAAVVPWDF DGDGLPMSVQLVGRPYDEATLLALAAQIESARPWAHRRPSVS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1263 | amiB2 | - | 100% (462) | amidase |
| M. tuberculosis H37Rv | Rv2363 | amiA2 | 3e-94 | 45.15% (454) | amidase |
| M. tuberculosis H37Rv | Rv2888c | amiC | 3e-46 | 33.62% (464) | amidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1294 | amiB2 | 0.0 | 100.00% (462) | amidase |
| M. gilvum PYR-GCK | Mflv_2712 | - | 1e-95 | 44.95% (465) | amidase |
| M. leprae Br4923 | MLBr_01596 | - | 1e-42 | 32.97% (461) | amidase |
| M. abscessus ATCC 19977 | MAB_1674c | - | 1e-94 | 46.32% (462) | amidase |
| M. marinum M | MMAR_4176 | amiB2 | 0.0 | 83.77% (462) | amidase AmiB2 |
| M. avium 104 | MAV_1414 | - | 0.0 | 82.75% (458) | amidase |
| M. smegmatis MC2 155 | MSMEG_4492 | - | 3e-93 | 43.82% (461) | amidase |
| M. thermoresistible (build 8) | TH_2601 | - | 1e-176 | 68.18% (462) | PUTATIVE amidase |
| M. ulcerans Agy99 | MUL_4478 | amiB2 | 0.0 | 82.90% (462) | amidase |
| M. vanbaalenii PYR-1 | Mvan_3824 | - | 4e-94 | 45.18% (456) | amidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2712|M.gilvum_PYR-GCK MPDSS-ARSTSRNRFPDRFPTVANQLFQLASGTATSVDLVRRSLVAIEAS
Mvan_3824|M.vanbaalenii_PYR-1 MADTAYSRITSRR----RFPTLGNQLFQLASGTATSVDLVSRSLQAIEAS
MSMEG_4492|M.smegmatis_MC2_155 MMGKSTACES-------TFPTLTNQLYQLASGAVTSDELVRRSLHAINAS
MAB_1674c|M.abscessus_ATCC_199 MSG---------------FPTLTSQAAALSDGSESSVSLTLTALNAIKSS
Rv1263|M.tuberculosis_H37Rv -----------MDPTDLAFAGAAAQARMLADGALTAPMLLEVYLQRIERL
Mb1294|M.bovis_AF2122/97 -----------MDPTDLAFAGAAAQARMLADGALTAPMLLEVYLQRIERL
MMAR_4176|M.marinum_M -----------MDPSDLAFAGAAAQARMLADGEVTAPMLLEVYLERIERL
MUL_4478|M.ulcerans_Agy99 -----------MDPSDLAFAGAAAQARMLADGEVTAPMLLEVYLERIERL
MAV_1414|M.avium_104 -----------MN--DLAFAGAAAQARMLANGDLSAPELLEVYLERIARL
TH_2601|M.thermoresistible__bu ------MTTSTTDFEDTAFVGAAEQARLLAAGTLTAPALLDGYLERIARL
MLBr_01596|M.leprae_Br4923 -----MQRVHAFGDDALGDLDAVGLADAIRAGWVSRADVIEAAIVRTEAV
: * : : :
Mflv_2712|M.gilvum_PYR-GCK QPTLNAFRVVLAERALADAAEADRLRAAGHDRARRPLLGIPIAVKDDVDV
Mvan_3824|M.vanbaalenii_PYR-1 QPTLNAFRVVLTEQALADAAEADRKRAAGADLSRHPLLGVPIAVKDDVDV
MSMEG_4492|M.smegmatis_MC2_155 QSTLNAFRVVLTEQALADAAKADRDRAAG---KQLPLLGVPIAVKDDVDI
MAB_1674c|M.abscessus_ATCC_199 QSTLNAFRVVCTKTALAEATEADKRLARG---ERLPLLGVPIAIKDDTDL
Rv1263|M.tuberculosis_H37Rv DSHLRAYRVVQFDRARAEAEAAQQRLDAG---ERLPLLGVPIAIKDDVDI
Mb1294|M.bovis_AF2122/97 DSHLRAYRVVQFDRARAEAEAAQQRLDAG---ERLPLLGVPIAIKDDVDI
MMAR_4176|M.marinum_M DSELRAYRVVRYDAAREEAEVAQQRLDAG---ERLPLLGVPIAIKDDVDV
MUL_4478|M.ulcerans_Agy99 DSELRAYRVVRYDAAREEAEVAQQRLDAG---ERLPLLGVPIAIKDDVDV
MAV_1414|M.avium_104 DSQLRCYRVVLADRARREAAAAQSRLDAG---ERLPLLGVPVAIKDDVDV
TH_2601|M.thermoresistible__bu DPQLRSYRVVCAESARREAAAAQQRLDAG---ERAPLLGVPIAIKDDVDV
MLBr_01596|M.leprae_Br4923 NPALGGLAYEAFQWARQTASKAGSGFFSG----------VPTFIKDNIDV
:. * . * * * * :* :**: *:
Mflv_2712|M.gilvum_PYR-GCK AGVPTRFGASGEVPE-AVADAEVVRRLRAAGAVIVGKTNTCELGQWPFTS
Mvan_3824|M.vanbaalenii_PYR-1 AGVPTRFGADGEVPP-AEADAEVVRRLRAAGAVIVGKTNTCELGQWPFTS
MSMEG_4492|M.smegmatis_MC2_155 AGVPTRFGTEGDGRV-AEADSEVARRLRAAGAVIVGKTNTCELGQWHFTS
MAB_1674c|M.abscessus_ATCC_199 AGTPTAFGTAGAVGS-ESEDAELVRRLRAAGAVIVGKTNTCELGQWGFTS
Rv1263|M.tuberculosis_H37Rv AGEVTTYGSAGHGPA-ATSDAEVVRRLRAAGAVIIGKTNVPELMIMPFTE
Mb1294|M.bovis_AF2122/97 AGEVTTYGSAGHGPA-ATSDAEVVRRLRAAGAVIIGKTNVPELMIMPFTE
MMAR_4176|M.marinum_M AGEVTTYGSGGHGAP-AGSDAEMVRRLRAAGAVIIGKTNVPELMMMPYTE
MUL_4478|M.ulcerans_Agy99 AGEVTTYGSGGHGAP-AGSDAEMVRRLRAAGAVIIGKTNVPELMMMPYTE
MAV_1414|M.avium_104 AGEVTTFGSGGHGPA-VSSDAEVVRRLRAAGAVIIGKTNVPELMMMPYTE
TH_2601|M.thermoresistible__bu AGETTTYGTSAHGPA-VEQDAEVVRRLREAGAVILGKTTVPEMMIWPFTE
MLBr_01596|M.leprae_Br4923 AGQPTMRGSDAWVPRNAFDDGEFTRLYLATGPVSLGKTQLSEFGFSASAE
** * *: . *.*..* :*.* :*** *: :.
Mflv_2712|M.gilvum_PYR-GCK GPAFGHTRNPWSREHTPGGSSGGSAAAVAAGLVAAAIGSDGAGSVRIPAA
Mvan_3824|M.vanbaalenii_PYR-1 GPAFGHTRNPWSREHTPGGSSGGSAAAVAAGLVAAAIGSDGAGSVRIPAA
MSMEG_4492|M.smegmatis_MC2_155 GPGFGHTRNPWSRKHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSVRIPAA
MAB_1674c|M.abscessus_ATCC_199 GPGFGHTRNPWSRGHTPGGSSGGSAAAVAAGLVAGAIGSDGAGSVRIPAA
Rv1263|M.tuberculosis_H37Rv SLAFGATRNPWCLNRTPGGSSGGSAAAVAAGLAPVALGSDGGGSIRIPCT
Mb1294|M.bovis_AF2122/97 SLAFGATRNPWCLNRTPGGSSGGSAAAVAAGLAPVALGSDGGGSIRIPCT
MMAR_4176|M.marinum_M SLTFGATRNPWNPARTPGGSSGGSAAAVAAGLAPVAFGSDGGGSIRIPST
MUL_4478|M.ulcerans_Agy99 SLTFGATRNPWNPARTPGRSSGGSAAAVAAGLAPVAFGSDGGGSIRIPST
MAV_1414|M.avium_104 SLTFGATRNPWDPRRTPGGSSGGSAAAVAAGLAPLALGSDGGGSIRIPST
TH_2601|M.thermoresistible__bu TVTFGATRNPWHPDFAPGGSSGGSGAAVAAGLAAMALGSDGMGSIRIPAT
MLBr_01596|M.leprae_Br4923 HMRLGPVRNPWDTDYTAGASSSGSGAFVAAGVVPMAHANDGGGSIRIPAS
:* .**** :.* **.**.* ****:.. * ..** **:***.:
Mflv_2712|M.gilvum_PYR-GCK WTHLVGIKPQRGRISTSPLPE-AFNGITVNGVLARTVSDAAMVLDAAAGN
Mvan_3824|M.vanbaalenii_PYR-1 WTHLVGIKPQRGRISTWPLTE-AFNGITVHGVLARTVSDAALLLDAASGN
MSMEG_4492|M.smegmatis_MC2_155 WTHLVGIKPQRGRISTWPQPE-AFNGVTVHGVLARTVVDAALVLDAASGN
MAB_1674c|M.abscessus_ATCC_199 WTHLIGIKPQRGRISTWPFAE-AFNGITVHGPLARTVADAALLLDAASGN
Rv1263|M.tuberculosis_H37Rv WCGLFGLKPQRDRISLEPHDG-AWQGLSVNGPIARSVMDAALLLDATT-T
Mb1294|M.bovis_AF2122/97 WCGLFGLKPQRDRISLEPHDG-AWQGLSVNGPIARSVMDAALLLDATT-T
MMAR_4176|M.marinum_M WCGVFGLKTQRDRISLEPHDG-AWYGLSVNGPIARSVLDAALLLDATT-T
MUL_4478|M.ulcerans_Agy99 WCGVFGLKTQRDRISLEPHDG-AWYGLSVNGPIARSVLDTALLLDATT-T
MAV_1414|M.avium_104 WCGLFGLKPQRDRVSLEPHDD-AWYGLSVNGPIARTVIDAAVFLDATS-T
TH_2601|M.thermoresistible__bu WNGLFGIKPQRDRVPLAPHDE-AWCGLSVNGPITRTVEDAAVFLDVTT-T
MLBr_01596|M.leprae_Br4923 CNGLVGLKPSRGRLPLDSELRRLPVGIVVNGVLTRSVRDTAAFYREAERI
:.*:*..*.*:. . *: *:* ::*:* *:* . :
Mflv_2712|M.gilvum_PYR-GCK AAGDLHTPAPVTVSDFVSRAPGPLRVAVSTRFPFTGFRATLHPEIRSALD
Mvan_3824|M.vanbaalenii_PYR-1 APGELHTPPPVRVSDYVSRAPGPLRIAMSTKFPFTVFRAGLHPEIRTALQ
MSMEG_4492|M.smegmatis_MC2_155 ADGDLHKPAPIQASDYVGVAPGPLRIAMSTKIPFTGVRAKIHPEILAALQ
MAB_1674c|M.abscessus_ATCC_199 VPGDLHKPPHVRVLDAVHEDPGQLRVALSLKVPFSGFPAQLHPTIEAATR
Rv1263|M.tuberculosis_H37Rv VPG-----PEGEFVAAAARQPGRLRIALSTRVPTP-LPVRCGKQELAAVH
Mb1294|M.bovis_AF2122/97 VPG-----PEGEFVAAAARQPGRLRIALSTRVPTP-LPVRCGKQELAAVH
MMAR_4176|M.marinum_M VPG-----PDAEFADAAQREPGRLRIALSTKIPTP-LPVRVGQAEVAAVY
MUL_4478|M.ulcerans_Agy99 VPG-----PDAEFADAAQREPGRLRIALSTKIPTP-LPVRVGQAEVAAVY
MAV_1414|M.avium_104 VPG-----PEGEFVAAATREPGRLRIALSTKVPTP-LPVRVGKPELAAVQ
TH_2601|M.thermoresistible__bu APA-----PPGGFVAXXXXXXARLRIAVSTKVPPP-LLARVGPAQRAAVD
MLBr_01596|M.leprae_Br4923 WHN----PKLPPVGDVTQPGRQRLRIAVVTRSVQR----ECSPELRELTL
**:*: :
Mflv_2712|M.gilvum_PYR-GCK GVADQLSQLGHTVLNADPDYT-LGMSWNFLARS--TSGIPEWMDRL----
Mvan_3824|M.vanbaalenii_PYR-1 NVADQLTQLGHTIVAADPDYH-LRMSWNFLSRS--TSGIPEWMDRL----
MSMEG_4492|M.smegmatis_MC2_155 TIADHLGELGHTVKAKDPNYS-LRMSWDFLSRS--TAGLLDWDDRLDT--
MAB_1674c|M.abscessus_ATCC_199 YVAHQLRSLGHMVSEGDPDYG-VGLGLNFLPRA--TAGLLPWRDRL----
Rv1263|M.tuberculosis_H37Rv QAGALLRDLGHDVVVRDPDYP-ASTYANYLPRF--FRGISDDADAQ----
Mb1294|M.bovis_AF2122/97 QAGALLRDLGHDVVVRDPDYP-ASTYANYLPRF--FRGISDDADAQ----
MMAR_4176|M.marinum_M RAGGLLRELGHEVINRDPDYP-AALYADYLPRY--LRGISDDADAL----
MUL_4478|M.ulcerans_Agy99 RAGGLLRELGHEVINRDPDYP-AALYANYLPRY--LRGISDDADAL----
MAV_1414|M.avium_104 QAGALLRDLGHDVVTADPEYPAAAILGNYLPRY--LRGICDDADSL----
TH_2601|M.thermoresistible__bu AAERLLRELGHDVIRRDPDYPPAAVFGNALPRY--FRGVHDDVQML----
MLBr_01596|M.leprae_Br4923 KSARLLEELGHRVERVAEPPVPPNFPDDFLLYWGLLAAMQVRTGRLAFGN
* .*** : : * .:
Mflv_2712|M.gilvum_PYR-GCK -GHRVTWDSRTRSNARMGRLLSQHTLRKARAREAAAQQRIGWIFNLADVV
Mvan_3824|M.vanbaalenii_PYR-1 -GRGVNWDSRTRSNARMGWLLSQNVLRKARAGEAASQQRIGWIFNLADVV
MSMEG_4492|M.smegmatis_MC2_155 AGHGVVYDHRTVANMRIGRLLSQNVLRKARAHEAAVQRRMSWIFNLVDVI
MAB_1674c|M.abscessus_ATCC_199 -DAGAHWDPRTVTNMRTGRRLAGWALRRARAAEPRLQARVGKIFGSFNVV
Rv1263|M.tuberculosis_H37Rv -AHPDRLEARTRAIARLGSFFSDRRMAALRAAEVVLSSRIQSIFDDVDVV
Mb1294|M.bovis_AF2122/97 -AHPDRLEARTRAIARLGSFFSDRRMAALRAAEVVLSSRIQSIFDDVDVV
MMAR_4176|M.marinum_M -AHPHRLEARTRAIARMGSFFSDRRMAALRAAEAALNKRIQSIFDDVDVV
MUL_4478|M.ulcerans_Agy99 -AHPHRLEERTRAIARMGSFFSDRRMAGLRAAEAALNKRIQSIFDDVDVV
MAV_1414|M.avium_104 -AHPERLEARTRNMARMGSFFSDRRMAAIRAGEGPLIARIQAIFDDVDVV
TH_2601|M.thermoresistible__bu -PYPKRLERRTRAFARIGGLVSDRRLAGIRVRQPALVRRVQSIFDDVDVV
MLBr_01596|M.leprae_Br4923 TFDRTKLDSLTLGLDRHASRN-MHRLPKAIMRLRRLRRRTADFFATYDVL
: * * . : * :* :*:
Mflv_2712|M.gilvum_PYR-GCK VAPTTAQPPPEAHAFDGLGGLATDRMMIRACPVTWPWNLLGWPSINVPAG
Mvan_3824|M.vanbaalenii_PYR-1 LAPTTALPPPEVRAFDDLGGLATDRMMIKACPVTWPWNLLGWPSINVPAG
MSMEG_4492|M.smegmatis_MC2_155 IAPTTAQPPPPVHECDRLGWLATERKAIAACPLTWAWNLLGWPSINVPAG
MAB_1674c|M.abscessus_ATCC_199 LAPTTAQPPTGIYDFDDVGSLATDRGQVGACPMTWPWNVLGWPSINVPAG
Rv1263|M.tuberculosis_H37Rv VTPGAATGPSRIGAYQRRGAVSTLLLVVQRVPYFQVWNLTGQPAAVVPWD
Mb1294|M.bovis_AF2122/97 VTPGAATGPSRIGAYQRRGAVSTLLLVVQRVPYFQVWNLTGQPAAVVPWD
MMAR_4176|M.marinum_M ITPGTANGPSRIGAYQRRGAVSTLLLVAQRVPYLQVWNLTGQPAAVVPWD
MUL_4478|M.ulcerans_Agy99 ITPGTANGPSRIGAYQRRGAVSTLLLVAQRVPYLQVWNLTCQAAAVVPWD
MAV_1414|M.avium_104 VTPGTAAGPSRVGAYQRRGAVSTLLRVGQCVPYQQIWNLTGQPAAVVPWD
TH_2601|M.thermoresistible__bu LTPGTATGPSRIGAYQRRGAVSTLAAVAARVPFQAMWNLTGQPAAVVPFG
MLBr_01596|M.leprae_Br4923 LTPTVADETPRIGYLTPTDYQQVMDRLMGWVAFTPLQNVTGEPAISLPLA
::* .* .. . . . *: .: :*
Mflv_2712|M.gilvum_PYR-GCK FTSDGLPIGVQLMGPADSEPLLISLAAALEAINGWATLQPENWWAPQP--
Mvan_3824|M.vanbaalenii_PYR-1 FTSDGLPIGVQLMGPANSEPLLVSLAAALEAINGWAVHQPEDWWTPQP--
MSMEG_4492|M.smegmatis_MC2_155 FTSDGLPIGVQLMGPAESEPLLISLAAELEAITGWAAREPEVWWNTPEGR
MAB_1674c|M.abscessus_ATCC_199 FTADGLPIGVQLMGPANSEPLLISLAAQLESINNWASEIPDPWW------
Rv1263|M.tuberculosis_H37Rv FDGDGLPMSVQLVGRPYDEATLLALAAQIESARPWAHRRPSVS-------
Mb1294|M.bovis_AF2122/97 FDGDGLPMSVQLVGRPYDEATLLALAAQIESARPWAHRRPSVS-------
MMAR_4176|M.marinum_M FDDDGMPISIQLVGKPYDEVTLLSLSAQIEAARPWADRRPPVS-------
MUL_4478|M.ulcerans_Agy99 FDDDGMPISIQLVGKPYDEATLLSLSAQIEAARPWADRRPPVS-------
MAV_1414|M.avium_104 FDADGLPMSVQLVGRPYDEATLLSLSAQIEAARPWALRRPPVC-------
TH_2601|M.thermoresistible__bu RDRHGIPTSVQLVGRPFDEATLLALAAQIEAVRPWAPMRPPIS-------
MLBr_01596|M.leprae_Br4923 QSADGMPVGMMFTADFGQEAQLLELAFELEEARPWARIQIGD--------
.*:* .: : . .* *: *: :* **
Mflv_2712|M.gilvum_PYR-GCK --PTEPDL----TAPDS-----------------VTGQVA------
Mvan_3824|M.vanbaalenii_PYR-1 --PPEPDLGSNVAAPAS-----------------VEGQVA------
MSMEG_4492|M.smegmatis_MC2_155 GLPPVSEITQRVPAPEDEKPAVETTDKPSEPVDDVSQAVAAVNALR
MAB_1674c|M.abscessus_ATCC_199 ----------------------------------------------
Rv1263|M.tuberculosis_H37Rv ----------------------------------------------
Mb1294|M.bovis_AF2122/97 ----------------------------------------------
MMAR_4176|M.marinum_M ----------------------------------------------
MUL_4478|M.ulcerans_Agy99 ----------------------------------------------
MAV_1414|M.avium_104 ----------------------------------------------
TH_2601|M.thermoresistible__bu ----------------------------------------------
MLBr_01596|M.leprae_Br4923 ----------------------------------------------