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LARASANRFNAWTTIDHEAVARYERARGASAERARILEGIPCGVKDNIDVAGLPTADGSAYPAVVPTRDA QVVLALRAAGAVIVGKNAMHEIAYGATGMVSATAPVVNPRSAEHMPGGSSSGSAAAVAAGDVPFAIGTDT GGSVRVPAALCGVVGLRPTTGRLQSSGVQPLSPTLDTVGVLAASVGIARAVWHAISGTPYRSPETDDAAL TIGVVADDYFVPESTAITEAVSNACASLEQHGAKVRPVRLGWPEAAVPVYAHIVGCEAALTHRKRLSENP PLFQSETRRRLAAGARTTPHMYVEALRHRARIAYDLLRVFDHCDVLISPTTAILGPRRDRKTADVGGQSV DVGRALVAYTTPWSLTGAPALAVPVGADQHGRPLSVQLVGKPGCETRVLEAGSIVEAQHRSAAGLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4062 | - | - | 100% (416) | glutamyl-tRNA(Gln) amidotransferase subunit A |
| M. smegmatis MC2 155 | MSMEG_1088 | gatA | 3e-64 | 41.88% (394) | glutamyl-tRNA(Gln)/aspartyl-tRNA(Asn) amidotransferase, A |
| M. smegmatis MC2 155 | MSMEG_2986 | - | 4e-60 | 38.86% (404) | amidohydrolase, AtzE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3409 | amiD | 3e-42 | 33.17% (398) | amidase AmiD |
| M. gilvum PYR-GCK | Mflv_2712 | - | 7e-40 | 32.78% (418) | amidase |
| M. tuberculosis H37Rv | Rv3375 | amiD | 3e-42 | 33.17% (398) | amidase AmiD |
| M. leprae Br4923 | MLBr_01702 | gatA | 2e-33 | 29.38% (439) | aspartyl/glutamyl-tRNA amidotransferase subunit A |
| M. abscessus ATCC 19977 | MAB_1558c | - | 3e-36 | 34.10% (346) | allophanate hydrolase |
| M. marinum M | MMAR_0984 | amiD | 4e-39 | 31.19% (404) | amidase, AmiD |
| M. avium 104 | MAV_2032 | - | 7e-39 | 32.26% (434) | amidase |
| M. thermoresistible (build 8) | TH_4482 | - | 1e-40 | 32.72% (437) | PUTATIVE Amidase |
| M. ulcerans Agy99 | MUL_3616 | amiA2 | 7e-40 | 32.08% (424) | amidase |
| M. vanbaalenii PYR-1 | Mvan_3824 | - | 2e-39 | 33.57% (423) | amidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2712|M.gilvum_PYR-GCK -MPDSS-ARSTSRNRFPDRFPTVANQLFQLASGTATSVDLVRRSLVAIEA
Mvan_3824|M.vanbaalenii_PYR-1 -MADTAYSRITSRR----RFPTLGNQLFQLASGTATSVDLVSRSLQAIEA
TH_4482|M.thermoresistible__bu -MVDAYKPPAK--------LPTLTDLLYQLASGAVTSQELVRRSLRAIEA
MAV_2032|M.avium_104 ----------------------------------------MGRSLHAIHA
MUL_3616|M.ulcerans_Agy99 MVGASGFASGAVSGSGGPRLPTLTDLLYQLASGSVTSVELTRRSLREIEV
Mb3409|M.bovis_AF2122/97 -MTDADSAVPPRLDEDAISKLELTEVADLIRTRQLTSAEVTESTLRRIER
Rv3375|M.tuberculosis_H37Rv -MTDADSAVPPRLDEDAISKLELTEVADLIRTRQLTSAEVTESTLRRIER
MMAR_0984|M.marinum_M -MSDIDPCYAT-----------IAELSHAFATRALSPVEVTRAHLQRIDR
MSMEG_4062|M.smegmatis_MC2_155 -----------------------------------------------MAR
MLBr_01702|M.leprae_Br4923 -MIGSLHEIIR---------LDASTLAAKIVAKELSSVEITQACLDQIEA
MAB_1558c|M.abscessus_ATCC_199 --------------------------------------------MGQGTR
Mflv_2712|M.gilvum_PYR-GCK SQPTLNAFRVVLAERALADAAEADRLRAAGHDRARRPLLGIPIAVKDDVD
Mvan_3824|M.vanbaalenii_PYR-1 SQPTLNAFRVVLTEQALADAAEADRKRAAGADLSRHPLLGVPIAVKDDVD
TH_4482|M.thermoresistible__bu SQSTLNAFRVVLADRALAEAAEADRKRAAG---EHLPLLGVPIAVKDDVD
MAV_2032|M.avium_104 SQPTLNAFRVVLTESALADAAEADRRRAAG---DTAPLLGIPIAVKDDVD
MUL_3616|M.ulcerans_Agy99 SQSTLNAFRVVLTESALADAAAADRRRAAG---DAAPLLGIPIAVKDDVD
Mb3409|M.bovis_AF2122/97 LDPQLKSYAFVMPETALAAARAADADIARG--HYEGVLHGVPIGVKDLCY
Rv3375|M.tuberculosis_H37Rv LDPQLKSYAFVMPETALAAARAADADIARG--HYEGVLHGVPIGVKDLCY
MMAR_0984|M.marinum_M LNPVLHPYMTVLADSALDEARQAEEQIARG--NHRGRLHGVPIAVKDLCF
MSMEG_4062|M.smegmatis_MC2_155 ASANRFNAWTTIDHEAVARYERARGASAER----ARILEGIPCGVKDNID
MLBr_01702|M.leprae_Br4923 TDDTYRAFLHVAAEKALSAAAAVDKAVAAG-GQLSSTLAGVPLALKDVFT
MAB_1558c|M.abscessus_ATCC_199 TLLDMTVWIMRRPEDDIAAELEAS----------SGPLAGVRLAVKDNVD
. : . * *: .:**
Mflv_2712|M.gilvum_PYR-GCK VAGVPTRFGASGEVPE-AVADAEVVRRLRAAGAVIVGKTNTCELGQWPFT
Mvan_3824|M.vanbaalenii_PYR-1 VAGVPTRFGADGEVPP-AEADAEVVRRLRAAGAVIVGKTNTCELGQWPFT
TH_4482|M.thermoresistible__bu IAGVPTRFGAVGDVPP-ATEDAEVVRRLRAAGAVIVGKTHTCELGQWPFT
MAV_2032|M.avium_104 IAGVPTAFGTEGSVPP-ATHDAEVVRRLKAAGAVIVGKTNTCELGQWPFT
MUL_3616|M.ulcerans_Agy99 VAGVPTAFGTQGYVQP-AAHDSEVVRRLKAAGAVIIGKTNTCELGQWPFT
Mb3409|M.bovis_AF2122/97 TVDAPTAAGTTIFRDFRPAYDATVVARLRAAGAVIIGKLAMTEGAYLGYH
Rv3375|M.tuberculosis_H37Rv TVDAPTAAGTTIFRDFRPAYDATVVARLRAAGAVIIGKLAMTEGAYLGYH
MMAR_0984|M.marinum_M TQGIPTTAGMAIHRDFRPSYDATVVSRLRRAGAVLLGKLHMCEAAGAEYH
MSMEG_4062|M.smegmatis_MC2_155 VAGLPTADG-SAYPAVVPTRDAQVVLALRAAGAVIVGKNAMHEIAYGATG
MLBr_01702|M.leprae_Br4923 TVDMPTTCGSKILQGWHSPYDATVTTRLRAAGIPILGKTNMDEFAMGSST
MAB_1558c|M.abscessus_ATCC_199 VGGVPTTAACPEYAYV-PDQDAPAVAALRAAGAVVVGKTNLDQFATGLVG
. ** . . *: .. *: ** ::** : .
Mflv_2712|M.gilvum_PYR-GCK SGPAFGHTRNPWSREHTPGGSSGGSAAAVAAGLVAAAIGSDGAGSVRIPA
Mvan_3824|M.vanbaalenii_PYR-1 SGPAFGHTRNPWSREHTPGGSSGGSAAAVAAGLVAAAIGSDGAGSVRIPA
TH_4482|M.thermoresistible__bu SGPAFGHTRNPWSPRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSVRIPA
MAV_2032|M.avium_104 SGPGFGHTRNPWSRRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRIPA
MUL_3616|M.ulcerans_Agy99 SGPGFGHTRNPWARRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRVPA
Mb3409|M.bovis_AF2122/97 --PSLPTPVNPWDPTAWAGVSSSGCGVATAAGLCFGSIGSDTGGSIRFPT
Rv3375|M.tuberculosis_H37Rv --PSLPTPVNPWDPTAWAGVSSSGCGVATAAGLCFGSIGSDTGGSIRFPT
MMAR_0984|M.marinum_M --PDFPAVVNPWSAERWAGASSSGSAVATVTGLCTASLGSDTGGSIRTPC
MSMEG_4062|M.smegmatis_MC2_155 MVSATAPVVNPRSAEHMPGGSSSGSAAAVAAGDVPFAIGTDTGGSVRVPA
MLBr_01702|M.leprae_Br4923 ENSAYGPTRNPWNVDRVPGGSGGGSAAALAAFQAPLAIGSDTGGSIRQPA
MAB_1558c|M.abscessus_ATCC_199 TRSPYGAVSDSRRPEYISGGSSSGSAVAVATGQADIAIGTDTAGSGRVPA
. :. .* *..*...* .: ::*:* .** * *
Mflv_2712|M.gilvum_PYR-GCK AWTHLVGIKPQRGRISTSPLPEAFNGITVNGVLARTVSDAAMVLDAAAGN
Mvan_3824|M.vanbaalenii_PYR-1 AWTHLVGIKPQRGRISTWPLTEAFNGITVHGVLARTVSDAALLLDAASGN
TH_4482|M.thermoresistible__bu AWTHLVGIKPQRGRISTWPLPEAFNGITVHGVLARTVTDAALVLDAASGN
MAV_2032|M.avium_104 AWTHLVGIKPQRGRISTWPLPEAFNGITVNGVLARTVADAALVLDAASGN
MUL_3616|M.ulcerans_Agy99 AWTHLVGIKPQRGRISTWPWPETFNGITVNGVLARTVADAALVLDAASGN
Mb3409|M.bovis_AF2122/97 SMCGVTGIKPTWGRVSRHGVVELAASYDHVGPITRSAHDAAVLLSVIAG-
Rv3375|M.tuberculosis_H37Rv SMCGVTGIKPTWGRVSRHGVVELAASYDHVGPITRSAHDAAVLLSVIAG-
MMAR_0984|M.marinum_M TMTGATGLKPTWGRVSVHGVFAMAPSLDTIGPMARNAEDTGHVLRAIAG-
MSMEG_4062|M.smegmatis_MC2_155 ALCGVVGLRPTTGRLQSSGVQPLSPTLDTVGVLAASVGIARAVWHAISG-
MLBr_01702|M.leprae_Br4923 ALTATVGVKPTYGTVSRYGLVACASSLDQGGPCARTVLDTALLHAVIAGH
MAB_1558c|M.abscessus_ATCC_199 GLQGIVGIKPTVGVISTEGVVPACESYDCVTIFAPSLTTANAAMAAMGAA
.*::* * :. : . : . ..
Mflv_2712|M.gilvum_PYR-GCK A-------AGDLHTPAPVTVSDFVSRAPGP--LRVAVSTRFPFTGFRATL
Mvan_3824|M.vanbaalenii_PYR-1 A-------PGELHTPPPVRVSDYVSRAPGP--LRIAMSTKFPFTVFRAGL
TH_4482|M.thermoresistible__bu A-------PGDLHQPPPVRVSDYVGQAPGP--LRIAVSTKFPFTLFRAKL
MAV_2032|M.avium_104 V-------DGDRHKPPPITASDYVGKAPGP--LNIALSTRFPYTGFRPKL
MUL_3616|M.ulcerans_Agy99 A-------EGDLHKPAPLTASDYVGIAPGP--LKIAMSTRFPYTGFRAKL
Mb3409|M.bovis_AF2122/97 ---------SDIHDPSCSAEPVPDYAADLA--LTRIPRVGVDWSQTTS-F
Rv3375|M.tuberculosis_H37Rv ---------SDIHDPSCSAEPVPDYAADLA--LTRIPRVGVDWSQTTS-F
MMAR_0984|M.marinum_M ---------ADPQDPTATRVGVPEYVTGSP--EVRTVRIGFDPEYALGGV
MSMEG_4062|M.smegmatis_MC2_155 ----------------------TPYRSPET--DDAALTIGVVADDYFVPE
MLBr_01702|M.leprae_Br4923 D-------ARDSTSVEAAVPDIVGAAKAGESGDLHGVRVGVVRQLRGEGY
MAB_1558c|M.abscessus_ATCC_199 AGPRLWPANTRLAAPPQPTIAVPRELPALDEVWCNAFRGAVDDLRAAGAT
.
Mflv_2712|M.gilvum_PYR-GCK HPEIRSALDGVADQLSQLGHTVLNADP--DYTLGMSWNFLARSTSG----
Mvan_3824|M.vanbaalenii_PYR-1 HPEIRTALQNVADQLTQLGHTIVAADP--DYHLRMSWNFLSRSTSG----
TH_4482|M.thermoresistible__bu HPEIRAAVQTVADQLEQLGHTVFPADP--EYTVGMSWSFLSRSTAG----
MAV_2032|M.avium_104 HPEILAATRAVGKQLELLGHTVVPGNP--DYGMRLSWDFLARSTAG----
MUL_3616|M.ulcerans_Agy99 HPEILASTRRVGEQLQLLGHTVERGNP--DYGLRLSWDFLARSTAG----
Mb3409|M.bovis_AF2122/97 DEDTTAMLADVVKTLDDIGWPVIDVKLPALAPMVAAFGKMRAVETA----
Rv3375|M.tuberculosis_H37Rv DEDTTAMLADVVKTLDDIGWPVIDVKLPALAPMVAAFGKMRAVETA----
MMAR_0984|M.marinum_M EPDVARVVRTALRVLADLGADIREVSLPSTAALAAGWGAYVGAQIA----
MSMEG_4062|M.smegmatis_MC2_155 STAITEAVSNACASLEQHGAKVRPVRLGWPEAAVPVYAHIVGCEAA----
MLBr_01702|M.leprae_Br4923 QSGVLASFQAAVEQLIALGATVSEVDCPHFDYALAAYYLILPSEVSSNLA
MAB_1558c|M.abscessus_ATCC_199 IIEIDLTPFLAAAKLLYEGALVSERYAAVGEFIDAHPEASLDPTVAQ---
. * * : .
Mflv_2712|M.gilvum_PYR-GCK -----------------IPEWMDRLGHRVTWDSRTRSNARMGRLLSQH--
Mvan_3824|M.vanbaalenii_PYR-1 -----------------IPEWMDRLGRGVNWDSRTRSNARMGWLLSQN--
TH_4482|M.thermoresistible__bu -----------------LLDWSRRLGDNVLWDKRTVANMRLGRLLSES--
MAV_2032|M.avium_104 -----------------LRDWEERLGDGVVLDPRTVANLRLGHLLGQA--
MUL_3616|M.ulcerans_Agy99 -----------------LWEWAECLGNGVTLDPRTVTNMRAGHALSQA--
Mb3409|M.bovis_AF2122/97 -----------------IAHADTYPARADEYGPIMRAMIDAGHRLAAV--
Rv3375|M.tuberculosis_H37Rv -----------------IAHADTYPARADEYGPIMRAMIDAGHRLAAV--
MMAR_0984|M.marinum_M -----------------VVHERTYPSRSAEYGPFASQLLDAGHAVSGM--
MSMEG_4062|M.smegmatis_MC2_155 -----------------LTHRKRLSENPPLFQSETRRRLAAGARTTPH--
MLBr_01702|M.leprae_Br4923 RFDAMRYGLRVGDDGSRSAEEVIALTRAAGFGPEVKRRIMIGAYALSAGY
MAB_1558c|M.abscessus_ATCC_199 ----------------IISGARDIPAHRLVHDRAEVQRLREQAMTSLAGA
Mflv_2712|M.gilvum_PYR-GCK ---TLRKARAREAAAQQ---------------RIGWIFNLADVVVAPTTA
Mvan_3824|M.vanbaalenii_PYR-1 ---VLRKARAGEAASQQ---------------RIGWIFNLADVVLAPTTA
TH_4482|M.thermoresistible__bu ---ALRKARAREAAAQR---------------RMSWIFNIADVVLAPTTA
MAV_2032|M.avium_104 ---ILRSARRHEAADQR---------------RVGSIFDIVDVVLAPTTA
MUL_3616|M.ulcerans_Agy99 ---ILRNARHHEAAAQR---------------RVGSIFDIVDVVLAPTTA
Mb3409|M.bovis_AF2122/97 ---EYQTLTERRLEFTR---------------SLRRVFHDVDILLMPSAG
Rv3375|M.tuberculosis_H37Rv ---EYQTLTERRLEFTR---------------SLRRVFHDVDILLMPSAG
MMAR_0984|M.marinum_M ---EIARIQRERNLFAG---------------RLAALFEDVDLLVAPVLP
MSMEG_4062|M.smegmatis_MC2_155 ---MYVEALRHRARIAY---------------DLLRVFDHCDVLISPTTA
MLBr_01702|M.leprae_Br4923 YDSYYSQAQKVRTLIAR---------------DLDKAYRSVDVLVSPATP
MAB_1558c|M.abscessus_ATCC_199 DALLVPTAPLHPTIEQVNANPIGVNATMGTYTNFCNLFDLCAVSVPAGTA
. : : : .
Mflv_2712|M.gilvum_PYR-GCK QPPPEAHAFDGLGGLATDRMMIRACPVTWPWNLLGWPSINVP------AG
Mvan_3824|M.vanbaalenii_PYR-1 LPPPEVRAFDDLGGLATDRMMIKACPVTWPWNLLGWPSINVP------AG
TH_4482|M.thermoresistible__bu LPPPEVHAFDQLGGLATDRLMIKACPVTWPWNLLGWPSINVP------AG
MAV_2032|M.avium_104 QPPPLARAFDRLSGFGTDRAMIAACPLTFPWNVLGWPSINVP------AG
MUL_3616|M.ulcerans_Agy99 QPPPLARAFDDMGGLATDRAIIAACPLTWPWNLLGWPSINVP------AG
Mb3409|M.bovis_AF2122/97 IASPTLETMRGLG--QDPELTARLAMPTAPFNVSGNPAICLP------AG
Rv3375|M.tuberculosis_H37Rv IASPTLETMRGLG--QDPELTARLAMPTAPFNVSGNPAICLP------AG
MMAR_0984|M.marinum_M LANLTLDRFRELL--FNPETLPDLLRFTGPFNFSGSPTITLP------GG
MSMEG_4062|M.smegmatis_MC2_155 ILGPRRDRKTADVGGQSVDVGRALVAYTTPWSLTGAPALAVP------VG
MLBr_01702|M.leprae_Br4923 TTAFSLG-----EKADDPLAMYLFDLCTLPLNLAGHCGMSVP------SG
MAB_1558c|M.abscessus_ATCC_199 GDAQFGVTVIARAFDDAVAFDIAALATGAPAGQDVWPAAITLSHELAVFG
* . *
Mflv_2712|M.gilvum_PYR-GCK FTSDG-LPIGVQLMGPADSEPLLISLAAALEAINGWATLQPENWWAPQPP
Mvan_3824|M.vanbaalenii_PYR-1 FTSDG-LPIGVQLMGPANSEPLLVSLAAALEAINGWAVHQPEDWWTPQPP
TH_4482|M.thermoresistible__bu FTSDG-LPIGVQLMGPANSEPLLVSLAAALEGINGWAARQPRPWWLT-PP
MAV_2032|M.avium_104 FTSDG-LPIGVQLMGPANSEGMLISLAAELEAVSGWASKQPQPWWDQSAD
MUL_3616|M.ulcerans_Agy99 FTVDG-LPIGVQLMGPAESEGLLISLAAELEAVSGWATKQPKVWWNTGTS
Mb3409|M.bovis_AF2122/97 TTARG-TPLGVQFIGREFDEHLLVRAGHAFQQVTGYHRRRPPV-------
Rv3375|M.tuberculosis_H37Rv TTARG-TPLGVQFIGREFDEHLLVRAGHAFQQVTGYHRRRPPV-------
MMAR_0984|M.marinum_M FDSHG-GPIGFQFVARHFDEPLLIRAGRAFQSATDWHLRRPPVQ------
MSMEG_4062|M.smegmatis_MC2_155 ADQHG-RPLSVQLVGKPGCETRVLEAGSIVEAQHRSAAGLR---------
MLBr_01702|M.leprae_Br4923 LSSDDDLPVGLQIMAPALADDRLYRVGAAYEAARGPLPSAI---------
MAB_1558c|M.abscessus_ATCC_199 AHLKG-GPLEFQLTDLGARWVGPIRTATKYRMSALRTTPPKPGLTRSEEN
. *: .*: . .
Mflv_2712|M.gilvum_PYR-GCK TEPDL----TAPDSVTGQVA------------------------------
Mvan_3824|M.vanbaalenii_PYR-1 PEPDLGSNVAAPASVEGQVA------------------------------
TH_4482|M.thermoresistible__bu AAPXX----XASAAAS----------------------------------
MAV_2032|M.avium_104 TPPAP----GQPAPTG----------------------------------
MUL_3616|M.ulcerans_Agy99 TPPIH----SVRPPRR----------------------------------
Mb3409|M.bovis_AF2122/97 --------------------------------------------------
Rv3375|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0984|M.marinum_M --------------------------------------------------
MSMEG_4062|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01702|M.leprae_Br4923 --------------------------------------------------
MAB_1558c|M.abscessus_ATCC_199 GVSIGGEVWRLSPAALGTFLAQLPEPMLLGKVECDDGLWRTGFGCDGAAA
Mflv_2712|M.gilvum_PYR-GCK ---------------------
Mvan_3824|M.vanbaalenii_PYR-1 ---------------------
TH_4482|M.thermoresistible__bu ---------------------
MAV_2032|M.avium_104 ---------------------
MUL_3616|M.ulcerans_Agy99 ---------------------
Mb3409|M.bovis_AF2122/97 ---------------------
Rv3375|M.tuberculosis_H37Rv ---------------------
MMAR_0984|M.marinum_M ---------------------
MSMEG_4062|M.smegmatis_MC2_155 ---------------------
MLBr_01702|M.leprae_Br4923 ---------------------
MAB_1558c|M.abscessus_ATCC_199 QAGVDISEHGSWPAAIAAGAV