For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
KGASQTAIVVGGGPNGLAAAITLAKAGLQVTVLEAAEEVGGGARSSEAIVLGLVHDHCSAIHPMAVGSEF LTGLDLDRHGLSWLLPDIDCVHPLDDGSAGVLHRSVGQTADGLGADGRRWRALFDWTSQRFDMLAEDIMG PLLSIPGHPITLARFGVPTVLPASVLARLFRTDQGRALFGGVAAHAFRPLHYPMTSAIGLGIITAGHRHG WPVAAGGSQSITNALVATLDELGGKIETGVRVQTASQLPPADVTMFDLAPDAVAGILGDRMPGRIARAYN KFRRGPGAFKVDFAIEGAVPWTNPQARRAGTVHLGGPYAELAAAEREVHAGRMPQRPFVLVGQQYLADPE RSVGNIHPLWTYAHVPNGYTGDATAAIIAQIERFAPGFREHIVGQTVRSTTEMSRYNPNYVGGDIMTGAK DIRQLTFGPRVTLSPYRTGVPGTYICSAATPPGPGAHGMCGANAAKLALAELK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1580 | - | - | 100% (474) | dehydrogenase |
| M. marinum M | MMAR_2237 | - | e-165 | 58.03% (467) | dehydrogenase |
| M. marinum M | MMAR_1714 | - | 2e-94 | 40.60% (463) | alanine rich dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1467 | - | 1e-169 | 60.47% (468) | dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4235 | - | 1e-90 | 39.74% (463) | hypothetical protein Mflv_4235 |
| M. tuberculosis H37Rv | Rv1432 | - | 1e-169 | 60.47% (468) | dehydrogenase |
| M. leprae Br4923 | MLBr_00062 | gltD | 8e-05 | 54.05% (37) | glutamate synthase subunit beta |
| M. abscessus ATCC 19977 | MAB_4734 | - | 0.0 | 73.08% (468) | dehydrogenase |
| M. avium 104 | MAV_3342 | - | 1e-161 | 57.73% (466) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2377 | - | 4e-92 | 39.74% (463) | P49 protein |
| M. thermoresistible (build 8) | TH_4571 | - | 0.0 | 72.61% (471) | PUTATIVE dehydrogenase |
| M. ulcerans Agy99 | MUL_1826 | - | 1e-164 | 57.82% (467) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2127 | - | 7e-93 | 41.04% (463) | hypothetical protein Mvan_2127 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4235|M.gilvum_PYR-GCK -------------------MGSNGQVELTVVGSGPNGLAAAVICARAGVS
Mvan_2127|M.vanbaalenii_PYR-1 -------------------MGSNVQVELTVVGSGPNGLAAAVICARAGLS
MSMEG_2377|M.smegmatis_MC2_155 -------------------------MDVTVVGSGPNGLTAAVICARAGLA
Mb1467|M.bovis_AF2122/97 ------------------------MTTAVVVGAGPNGLAAAIHLARHGVD
Rv1432|M.tuberculosis_H37Rv ------------------------MTTAVVVGAGPNGLAAAIHLARHGVD
MUL_1826|M.ulcerans_Agy99 ------------------------MTKAVVVGAGPNGLAAAIQLARHGVE
MAV_3342|M.avium_104 ----------------------------MVVGAGPNGLAAAIQLARRGVE
MMAR_1580|M.marinum_M --------------------MKGASQTAIVVGGGPNGLAAAITLAKAGLQ
MAB_4734|M.abscessus_ATCC_1997 ------------------------MSTAVIVGGGPNGLTAAILLAQQGVH
TH_4571|M.thermoresistible__bu VAAERSGADHGHLVPVPRRAGGGGVTTATVVGSGPNGLAAAVTLAKAGVA
MLBr_00062|M.leprae_Br4923 ----------------------------MADPAGFLKYTQRELPRRRPVP
.* : : :
Mflv_4235|M.gilvum_PYR-GCK VRVVEAQPTAGGGARTLPDPEFSGVSHDICSAVHP-LALASPFFAAFDLR
Mvan_2127|M.vanbaalenii_PYR-1 VRVVEAQPTPGGGARTLPDPEFSGVSHDICSAVHP-LALASPFFAEFDLQ
MSMEG_2377|M.smegmatis_MC2_155 VRVIEAQTTPGGGARTLPDPEFGGVSHDICSAVHP-LALASPFFSAYDLT
Mb1467|M.bovis_AF2122/97 VQVLEARDTIGGGARSG-ELTVPGVIHDHCSAFHP-LGVGSPFWAAIDLQ
Rv1432|M.tuberculosis_H37Rv VQVLEARDTIGGGARSG-ELTVPGVIHDHCSAFHP-LGVGSPFWAAIDLQ
MUL_1826|M.ulcerans_Agy99 VQVLEAHDTIGGGARSG-ELTVPGVIHDHCSAFHP-LGVGSPFWNEIDLQ
MAV_3342|M.avium_104 VQVLEAGETPGGGARSS-ELTVPGVIHDLCSATHP-FGVGSPFWKEIDLP
MMAR_1580|M.marinum_M VTVLEAAEEVGGGARSS-EAIVLGLVHDHCSAIHP-MAVGSEFLTGLDLD
MAB_4734|M.abscessus_ATCC_1997 VTVLEAADSVGGGVRSG-AATGPGLIHDYCSAIHP-MAVGSPVLAGLDLE
TH_4571|M.thermoresistible__bu VTVLEAADEIGGGTRSF-EAIVPGLLHDHCSAIHP-MAVGSPFINEFGLD
MLBr_00062|M.leprae_Br4923 LRLRDWKELYEEFDKETLRNQASRCMDCGIPFCHNGCPLGNLIPEWNDLV
: : : : . . * :.. . .*
Mflv_4235|M.gilvum_PYR-GCK ARGVTLEVPEVSYGNPLPGRRAAIGYLDIDRTCAELE-DGEPWRRLLGPL
Mvan_2127|M.vanbaalenii_PYR-1 ARGVTLAVPEVSYGNPLPGRPAAVGYRDIERTCAELD-DGASWRRLLGPL
MSMEG_2377|M.smegmatis_MC2_155 AHGVRLAVPEIAYANPLVERPAAIGYRDIDRTCAELD-DGRSWRRLLGPL
Mb1467|M.bovis_AF2122/97 RYGLTWKWPDVDCAHPLDDGTAGVLYRSIEATAAGLGPDGKRWQRAVGDL
Rv1432|M.tuberculosis_H37Rv RYGLTWKWPDVDCAHPLDDGTAGVLYRSIEATAAGLGPDGKRWQRAVGDL
MUL_1826|M.ulcerans_Agy99 SYGLTWNWPEVDCAHPLDDGTAGVLHQSIERTAAGMGPDGKRWRCAVGDL
MAV_3342|M.avium_104 SYGLVWKWPQIDCAHPLDDGSAGVLYRSIEQTTAGMGPDATRWRRAVGDL
MMAR_1580|M.marinum_M RHGLSWLLPDIDCVHPLDDGSAGVLHRSVGQTADGLGADGRRWRALFDWT
MAB_4734|M.abscessus_ATCC_1997 KHGLQWLWPEVDCAHPLDDGSCGVLYRDVAATANGLGRDGRRWRALFERP
TH_4571|M.thermoresistible__bu RHGLRWRWPDIDCVHPLDDGTAGVLRRSVDHTAAGLGPDGRVWRALFGRP
MLBr_00062|M.leprae_Br4923 RRGRWHDAVERLHATNNFPDVTGRLCPAPCESACVLGINQDPVTIKQIEL
* : . : : :
Mflv_4235|M.gilvum_PYR-GCK AADCDGVVGLLLGDK--RSIPPSIPAALRVAPRLLAQGTPAWGTLLGEDA
Mvan_2127|M.vanbaalenii_PYR-1 ADDCDGVVGLLLGDK--RSIPPSIPAAVRVAPRLLAQGSPAWGTLAGEDA
MSMEG_2377|M.smegmatis_MC2_155 ADDCDGVVGLMLGDK--RSLPPSIPAALRVAPRMLGQGTALWRLLRGDDA
Mb1467|M.bovis_AF2122/97 AAGFDELAEDLLRPV--LNMPRHPIRLARFGPRAALPATAMARRFHTERA
Rv1432|M.tuberculosis_H37Rv AAGFDELAEDLLRPV--LNMPRHPIRLARFGPRAALPATAMARRFHTERA
MUL_1826|M.ulcerans_Agy99 AAGFDELAGDLLRPV--LGVPRHPLRPAAFGPRAALPATMMARWFRTEQA
MAV_3342|M.avium_104 AAGFDQLASDLMRPV--LRVPHHPVRLARFGPRALLPATVLARWFHTEQA
MMAR_1580|M.marinum_M SQRFDMLAEDIMGPL--LSIPGHPITLARFGVPTVLPASVLARLFRTDQG
MAB_4734|M.abscessus_ATCC_1997 ARNFDLLTADIMGPL--LRIPRHPLALTRFGVPTVLPAAATAQLFRTRQA
TH_4571|M.thermoresistible__bu VDRFDAVNDAVMGPL--LRVPKHPLTLARFGAPTVLPASALARVFRTPAA
MLBr_00062|M.leprae_Br4923 EIIDKAFDEGWVQPLPPQQLTGKTVAVVGSGPAGLAAAQQLTRAGHRVTV
. . : :. . .
Mflv_4235|M.gilvum_PYR-GCK RALFTGVAAHTISRMPSLVASGAGLMLSTLAHAVGWPIPVGGSQAIPDAL
Mvan_2127|M.vanbaalenii_PYR-1 RALFTGVAAHTISRMPSLVSAGAGLMLATLGHTVGWPVPSGGSQAIPDAL
MSMEG_2377|M.smegmatis_MC2_155 RALFSGVAAHTISPMPSLVSAGAGLMLATLAHAVGWPIPIGGSQAIPDAL
Mb1467|M.bovis_AF2122/97 RALFGGAAAHVYTRLDRPLTASLGLMILASGHRHGWPVARGGSGSITKAL
Rv1432|M.tuberculosis_H37Rv RALFGGAAAHVYTRLDRPLTASLGLMILASGHRHGWPVARGGSGSITKAL
MUL_1826|M.ulcerans_Agy99 RALFGGAAAHVYTRLDRPLTASLGLMILASGHRYGWPVAQGGSGSITAAL
MAV_3342|M.avium_104 RALFGGAAAHIYTRLDRPLTASLGLLFLASGHRYGWPVAEGGSGSIIHAL
MMAR_1580|M.marinum_M RALFGGVAAHAFRPLHYPMTSAIGLGIITAGHRHGWPVAAGGSQSITNAL
MAB_4734|M.abscessus_ATCC_1997 RALFGGIAAHAFRPLHYPMTSAIGLGIITAGHRHGWPVAAGGSQSITDAL
TH_4571|M.thermoresistible__bu RALWGGVAAHAFRPLHLPMTSAIGVGIITAGHRHGWAVAEGGSRAITDAM
MLBr_00062|M.leprae_Br4923 FERDDRIGGLLRYGIPEFKMEKRFLERRLDQLRAEGTEFRSGVNVGVDIT
.. : : . .*
Mflv_4235|M.gilvum_PYR-GCK IADLRAHGGELVVGEEVST----PPSGVVLYDTAPTALLDIYGDRLPSRY
Mvan_2127|M.vanbaalenii_PYR-1 LADLQAHGGELVLGEEVTS----PPSGVVLYDTAPTALLRIYGDRLPPGY
MSMEG_2377|M.smegmatis_MC2_155 IADLRAHGGELVLGEEVTE----PPSGVVVYDTAPTALLSIYRDAVPPRY
Mb1467|M.bovis_AF2122/97 AAALDAYGGTVATGVTVTSRRDIPDADIVMLDLSPAAVLGIYGDVMPTRI
Rv1432|M.tuberculosis_H37Rv AAALDAYGGTVATGVTVTSRRDIPDADIVMLDLSPAAVLGIYGDVMPTRI
MUL_1826|M.ulcerans_Agy99 GAALDALGGVVATGITVTSRRDIPDADIVMLDLSPANVLTLYGDEMPARI
MAV_3342|M.avium_104 VAALRAHGGDVATGVTVSDRRDIPDADIVMLDLTPAAALRLYGELMPARI
MMAR_1580|M.marinum_M VATLDELGGKIETGVRVQTASQLPPADVTMFDLAPDAVAGILGDRMPGRI
MAB_4734|M.abscessus_ATCC_1997 SSLLAQFGGRIETGVHVTSFTQLPTADVTLFDLSPTQVADILRDHLPTSV
TH_4571|M.thermoresistible__bu AARLRELGGTIETGVRVRDIADLPPTTITVFDLAPEAVAEILGDRLPPRV
MLBr_00062|M.leprae_Br4923 ADQLCADFDAVVLAGGAATWRELPIPGRELDGVHQAMEFLPWVNRVQEGD
* . : . . * . : . : :
Mflv_4235|M.gilvum_PYR-GCK ARTLRRYRYGPGVAKVDFVLSGEIPWRDKRLASAPTLH-MGGDRATMALA
Mvan_2127|M.vanbaalenii_PYR-1 AKTLRRYRYGPGVAKVDFVLSGEIPWRDPRLANAPTLH-LGGDRATMARA
MSMEG_2377|M.smegmatis_MC2_155 AKALRNYTYGSGVAKVDFVLSGEIPWRDPRLAQSPTLH-LGGSREQMALA
Mb1467|M.bovis_AF2122/97 NRSYRRYRAGSSAFKVDFAIEGDVGWTNPDCRRAGTVH-LGGTFAEIADT
Rv1432|M.tuberculosis_H37Rv NRSYRRYRAGSSAFKVDFAIEGDVGWTNPDCRRAGTVH-LGGTFAEIADT
MUL_1826|M.ulcerans_Agy99 KRSYRRYREGSSAFKVDFAIEGDIPWTNPDCRRAGTVH-LGGTFAEIADT
MAV_3342|M.avium_104 ARSYRRYRQGSSAFKVDFAVEGDIPWTNPHCARAGSVH-LGGSFAEIADT
MMAR_1580|M.marinum_M ARAYNKFRRGPGAFKVDFAIEGAVPWTNPQARRAGTVH-LGGPYAELAAA
MAB_4734|M.abscessus_ATCC_1997 ARGLSRFRYGPGAFKVDFAIEDGVPWTNPDAGRAGTVH-LGGTFAEVAST
TH_4571|M.thermoresistible__bu ARAYRAFRRGPGAFKVDFAVEGGVPWCNPDAHRAGTVH-VGGTFEEIAAT
MLBr_00062|M.leprae_Br4923 DVLGDDGQPPITAKDKKVVIIGGG---DTGADCLGAVHRQGAIHVHQLEI
. . ...: . : ::* *.
Mflv_4235|M.gilvum_PYR-GCK EKDIAEGRHAQWPMVLASLPHLADPGRIDAAGRRPLWTYAHVPAGSTVDM
Mvan_2127|M.vanbaalenii_PYR-1 EKDVAAGRHAEWPMVLASLPHLADPGRVDPQGRRPLWTYAHVPAGSTVDM
MSMEG_2377|M.smegmatis_MC2_155 ESEVARGRHAEWPMVLAASPHIADPGRIDARGRRPLWTYAHVPSGSPVDM
Mb1467|M.bovis_AF2122/97 ERQRAQGTMVQRPFVLVGQQYLADPSRS-VGNINPIWAYAHVPFGYTGDA
Rv1432|M.tuberculosis_H37Rv ERQRAQGTMVQRPFVLVGQQYLADPSRS-VGNINPIWAYAHVPFGYTGDA
MUL_1826|M.ulcerans_Agy99 ERQRAQGRMVQRPFVLIGQQYLADPSRS-AGNINPIWAYAHVPFGYAGDA
MAV_3342|M.avium_104 ERQRAQGKLAPRPFVLVGQQYLADPSRS-AGGINPIWAYAHVPFGYTGDA
MMAR_1580|M.marinum_M EREVHAGRMPQRPFVLVGQQYLADPERS-VGNIHPLWTYAHVPNGYTGDA
MAB_4734|M.abscessus_ATCC_1997 ERAVHAGRMPERPFVLVGQQYLADPGRS-NGNIHPLWTYAHVPHGFTGDA
TH_4571|M.thermoresistible__bu ERDVNAGRMPERPFVLVAQQYVADPGRS-VGDIHPVWSYAHVPHGYPGDA
MLBr_00062|M.leprae_Br4923 MPRPPDARAASTPWPTYPLMYRVSPAHE--EGGERVFSVNTEEFVGKNGR
. * : ..* : . . ::: .
Mflv_4235|M.gilvum_PYR-GCK AETITGVFERFAPGFRDLVVGVRSVPAARLADHNANLVGGDIGVGGNNMF
Mvan_2127|M.vanbaalenii_PYR-1 AEAVTEVIERFAPGFRDVVVGVRSVPAARLSAHNANLVGGDIGVGGNNMV
MSMEG_2377|M.smegmatis_MC2_155 ADTVTSILERFAPGFRDLVVAVRSVPASQMSHHNANLIGGDIGVGGNNMI
Mb1467|M.bovis_AF2122/97 TAAVIDQIERFAPGFRDRIVATVSTSTTELQTYNRNFIGGDIIGGANDRL
Rv1432|M.tuberculosis_H37Rv TAAVIDQIERFAPGFRDRIVATVSTSTTELQTYNRNFIGGDIIGGANDRL
MUL_1826|M.ulcerans_Agy99 TAAVIDQIERFAPGFRDRITATVSKSTAELQAYNRNFIGGDIIGGANDGL
MAV_3342|M.avium_104 TALVVDQIERFAPGFRDRVVATVSRGTADLAAYNANYIGGDILGGANDGL
MMAR_1580|M.marinum_M TAAIIAQIERFAPGFREHIVGQTVRSTTEMSRYNPNYVGGDIMTGAKDIR
MAB_4734|M.abscessus_ATCC_1997 TQALIDQIERFAPGFRDRIVATAVRSTTDMTVYNPNYVGGDIVTGAKDIR
TH_4571|M.thermoresistible__bu TEAVVAQIERFAPGFRDRIVGYRTESAEGMARFNANFTGGDILTGAKDIR
MLBr_00062|M.leprae_Br4923 VHALKAHEVTMQDGRFVKVENSVFELEADLVLLAMGFVGPEKPGLLTDLG
. : : * : : . * : .:
Mflv_4235|M.gilvum_PYR-GCK SALTG--PALRWNPWATPIPRTYLCSSATP-PGGGVHGMAGYYAARTVLR
Mvan_2127|M.vanbaalenii_PYR-1 SALTG--PALRWNPWSTPIPKAYLCSSATP-PGGGVHGMAGFYAARTVLR
MSMEG_2377|M.smegmatis_MC2_155 SALTG--PTPRVNPWTTPIPKAYLCSSATP-PGSGVHGMSGFYAARTVLR
Mb1467|M.bovis_AF2122/97 QVIFR--PRVAVDPYAIGVPGVYLCSQSAP-PGAGIHGLCGYHAAESALR
Rv1432|M.tuberculosis_H37Rv QVIFR--PRVAVDPYAIGVPGVYLCSQSAP-PGAGIHGLCGYHAAESALR
MUL_1826|M.ulcerans_Agy99 QVIFR--PRIALDPYAIGVPGVYLCSQSAP-PGAGIHGLCGYHAAESALQ
MAV_3342|M.avium_104 QVILR--PRVSVSPYATGVPGVYLCSQSTP-PGPGIHGLCGYHAAEAALG
MMAR_1580|M.marinum_M QLTFG--PRVTLSPYRTGVPGTYICSAATP-PGPGAHGMCGANAAKLALA
MAB_4734|M.abscessus_ATCC_1997 QLVFG--PRTTAHPYRLGIPGMYICSAATP-PGPGAHGMCGAHAAAEALR
TH_4571|M.thermoresistible__bu QLTFG--PRITLSPYATGAPGYYICSAATP-PGPGAHGMCGYHAAQTALR
MLBr_00062|M.leprae_Br4923 VKFTDRGNVARGADFDTSVPGVFVAGDMGRGQSLIVWAIAEGRAAAAAVD
: * ::.. . .:. ** .:
Mflv_4235|M.gilvum_PYR-GCK REFGIREMPPLAP--------
Mvan_2127|M.vanbaalenii_PYR-1 REFGIRELPPLAP--------
MSMEG_2377|M.smegmatis_MC2_155 REFGLG-LPALR---------
Mb1467|M.bovis_AF2122/97 WLRKRR---------------
Rv1432|M.tuberculosis_H37Rv WLRKRR---------------
MUL_1826|M.ulcerans_Agy99 GLRKRR---------------
MAV_3342|M.avium_104 WLRRRGG--------------
MMAR_1580|M.marinum_M ELK------------------
MAB_4734|M.abscessus_ATCC_1997 HLRASI---------------
TH_4571|M.thermoresistible__bu ELAR-----------------
MLBr_00062|M.leprae_Br4923 RFLMGATALPAPVKPSSLPLQ