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MSLAKPSAGTTVVITGASSGIGEHIARGLARRGYSLTLIARRRDRLEALSDELCRARSISVDVVALDLNE QSARAEAVERLRSGAVAGLVNSAGFGTNGLLQDLPPDRERDQVIVNVLALTELTHAVLPQMVERGAGAVL NIGSIAGFQPLPGAAVYSATKAYVQTFSEAVHEGLHGTGVSCTALCPGPVPTEWWEIAGEKPPGGKVAVS VEEVAEAGIAAMREGKRLVVPGLVPKLTGLGGRFTPRALLLPALRMAAARRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3113 | - | - | 100% (262) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_0661 | - | 3e-41 | 42.50% (240) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_3324 | - | 2e-39 | 40.56% (249) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1571 | - | 3e-85 | 63.81% (257) | ketoacyl reductase |
| M. gilvum PYR-GCK | Mflv_0138 | - | 3e-53 | 46.97% (264) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1544 | - | 3e-85 | 63.81% (257) | ketoacyl reductase |
| M. leprae Br4923 | MLBr_00429 | - | 2e-42 | 40.16% (254) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1537c | - | 2e-41 | 39.06% (256) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_2367 | - | 4e-83 | 62.65% (257) | ketoacyl reductase |
| M. avium 104 | MAV_3226 | - | 1e-85 | 63.04% (257) | ketoacyl reductase |
| M. smegmatis MC2 155 | MSMEG_0737 | - | 2e-41 | 41.04% (251) | dehydrogenase |
| M. thermoresistible (build 8) | TH_4326 | - | 3e-41 | 41.67% (240) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1543 | - | 7e-83 | 62.26% (257) | ketoacyl reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00429|M.leprae_Br4923 MPIPAPSPEARAVVTGASQNIGEALATELAAHGHSLIVIARREDVLVDLA
MAB_1537c|M.abscessus_ATCC_199 MPIPAPSPDARAVVTGASQGIGAALAEELAARGHNLIITARRGEILNDLA
Mflv_0138|M.gilvum_PYR-GCK MGLPTPSPTTTAVVTGASSGIGADLARELAARGHGVTLVARREDRLRALA
Mb1571|M.bovis_AF2122/97 MSLPKPNNQTTVVITGASSGIGVELARGLAGRGFPLMLVARRRERLDELA
Rv1544|M.tuberculosis_H37Rv MSLPKPNNQTTVVITGASSGIGVELARGLAGRGFPLMLVARRRERLDELA
MMAR_2367|M.marinum_M MSLPKPNKQATVVITGASSGIGVELARGLAGRGFPLMLVARRRERLEELA
MUL_1543|M.ulcerans_Agy99 MTLPKPNKQATVVITGASSGIGVELARGLAGRGFPLMLVARRRERLEELA
MAV_3226|M.avium_104 MSLPKPDIATTVVITGASSGIGAELARGLARRGFPLLLVARRRERLDDLA
Mvan_3113|M.vanbaalenii_PYR-1 MSLAKPSAGTTVVITGASSGIGEHIARGLARRGYSLTLIARRRDRLEALS
MSMEG_0737|M.smegmatis_MC2_155 --MPRP----VALITGPTSGLGAGFARRYALEGYDLVFVARDQQRLEQLA
TH_4326|M.thermoresistible__bu --MPRP----VALITGPTSGLGEGFARRYAADGHDLVLVARDVQRLEQLA
:. * .::**.:..:* :* * *. : . ** : * *:
MLBr_00429|M.leprae_Br4923 ARLADKYRVAVEVRPADLTDPSERVKLADELTVR--PISILCANAGTATF
MAB_1537c|M.abscessus_ATCC_199 NALSEKTGVIVEVRAVDLADPGARDALCTELSER--NISILCNNAGTATF
Mflv_0138|M.gilvum_PYR-GCK DELSSSN-VRVEVVACDVADADARAGLFPEIERRGLTVDVLVNNAGIGTI
Mb1571|M.bovis_AF2122/97 DQLRQEHCVGVEVLPLDLADTQARAQLADRLRSD--AIAGLCNSAGFGTS
Rv1544|M.tuberculosis_H37Rv DQLRQEHCVGVEVLPLDLADTQARAQLADRLRSD--AIAGLCNSAGFGTS
MMAR_2367|M.marinum_M DDLRDKFSIAVEVLPLDLSDAQARTQLADRLRSD--SIAGLCNSAGFGTS
MUL_1543|M.ulcerans_Agy99 DDLRDKFSIAVEVLPLDLSDAQARTQLADRLRSD--SIAGLCNSAGFGTS
MAV_3226|M.avium_104 NEVGGQYSVGVEVLPLDLGDSKARARLAGRLRSE--SIAGLCNSAGFGTS
Mvan_3113|M.vanbaalenii_PYR-1 DELCRARSISVDVVALDLNEQSARAEAVERLRSG--AVAGLVNSAGFGTN
MSMEG_0737|M.smegmatis_MC2_155 DELHHEAGATVETIAADLAVADDRARVAERVRQG---VRVLVNNAGFATS
TH_4326|M.thermoresistible__bu AELRQSAGIDVEVLPADLAVAADRAKVADRLADG---VQVLVNNAGFGTS
: *:. . *: * .: : * .** .*
MLBr_00429|M.leprae_Br4923 GPVSALDPAGEKAQVQLNAVAVHDLTLAVLPGMIERKAGGILISGSAAGN
MAB_1537c|M.abscessus_ATCC_199 GPIRGLDPAGERKQVQLNAVAVHDLTLAVLPGMLARGAGGILISGSAAGN
Mflv_0138|M.gilvum_PYR-GCK GPVVDSTPEAEIGQVRVNVEAVIDLTTRAVQQMVPRGRGAILNVGSTAGF
Mb1571|M.bovis_AF2122/97 GRFWELPFARESEEVVLNALALMELTHAALPGMVKRGAGAVLNIASIAGF
Rv1544|M.tuberculosis_H37Rv GRFWELPFARESEEVVLNALALMELTHAALPGMVKRGAGAVLNIASIAGF
MMAR_2367|M.marinum_M GRFCELPPERESEQVTLNALALMEFTRAALPGMVERGAGAVLNIASIAGF
MUL_1543|M.ulcerans_Agy99 GRFCELPPERESEQVTLNALALMEFTRAALPGMVERGAGAVLNIASIAGF
MAV_3226|M.avium_104 GVFHELPMERESEEVTLNALALMELTHATLPGMVSRGAGAVLNIASIAGF
Mvan_3113|M.vanbaalenii_PYR-1 GLLQDLPPDRERDQVIVNVLALTELTHAVLPQMVERGAGAVLNIGSIAGF
MSMEG_0737|M.smegmatis_MC2_155 GEFWTADFARLRAQLDVNVTAVMELTHAALPAMLDAHEGTIINVASVAGL
TH_4326|M.thermoresistible__bu GEFWTADPTLLQAQLDVNVTAVMHLTHAALPPMLDAHRGTIINVASVAGL
* . :: :*. *: .:* .: *: * :: .* **
MLBr_00429|M.leprae_Br4923 SPIPYNATYAATKAFANTFSESLRGELHGSGVHVTLLAPGPVRTELPDHD
MAB_1537c|M.abscessus_ATCC_199 SPIPNNATYAATKAFANTFSESLRGELKGTGVHVTLLAPGPVRTVEPDPA
Mflv_0138|M.gilvum_PYR-GCK QPFPGQSGYAATKAFVRTYTDGLRGELAGTGVTVTALHPGPVRTEFLDTA
Mb1571|M.bovis_AF2122/97 QPIPYMAVYSATKAFVLTFSEAVQEELHGTGVSVTALCPGPVPTEWAEIA
Rv1544|M.tuberculosis_H37Rv QPIPYMAVYSATKAFVLTFSEAVQEELHGTGVSVTALCPGPVPTEWAEIA
MMAR_2367|M.marinum_M QPIPFMAVYSASKAFVLTFSEAVQEELHGTGVSVTALCPGPVPTEWAEIA
MUL_1543|M.ulcerans_Agy99 QPIPFMAVYSASKAFVLTFSEAVQEELHGTGVSVTALCPGPVPTEWAEIA
MAV_3226|M.avium_104 QPVPYMAVYSATKAFVQTFSEAVHEELHGSGVSVTCLCPGPVPTEWAEIA
Mvan_3113|M.vanbaalenii_PYR-1 QPLPGAAVYSATKAYVQTFSEAVHEGLHGTGVSCTALCPGPVPTEWWEIA
MSMEG_0737|M.smegmatis_MC2_155 VPGRG-STYSASKAWVVSFTEGLANGLIGTGVGVHALCPGFVRTEFHARA
TH_4326|M.thermoresistible__bu LPGRG-STYSASKAWVIAFSEGLANGLTGTGVGIHVVCPGFVRTEFHQRA
* : *:*:**:. ::::.: * *:** : ** * *
MLBr_00429|M.leprae_Br4923 --EASLVEKLVPDFLWISTEHTARLSLDALERNKMRVVPGLTSKAMSVAS
MAB_1537c|M.abscessus_ATCC_199 --EASIVDKVVPDFLWINGEYTARVSLNALERNKMRVVPGITSKAMSVAA
Mflv_0138|M.gilvum_PYR-GCK GMDERTFASAFPKFLWIESREVAEKGIDGLAADRGSVIPGLQNEIPARVF
Mb1571|M.bovis_AF2122/97 SAERFSIP-----LAQVSPHDVAEAAIAGMLSGKRTVVPGIVPKFVSTSG
Rv1544|M.tuberculosis_H37Rv SAERFSIP-----LAQVSPHDVAEAAIAGMLSGKRTVVPGIVPKFVSTSG
MMAR_2367|M.marinum_M SAERFSIP-----LAQVSPHDVAEAAIEGMLTGKRTVVPGVVPKFVSTSG
MUL_1543|M.ulcerans_Agy99 SAERFSIP-----LARVSPHDVAEAAIEGMLTGKRTVVPGVVPKFVSTSG
MAV_3226|M.avium_104 NAERFSIP-----IAQVSPRDVAEAAIGGMLTGRRTVVPGVVPKVVSTGG
Mvan_3113|M.vanbaalenii_PYR-1 -GEKPPGG-----KVAVSVEEVAEAGIAAMREGKRLVVPGLVPKLTGLGG
MSMEG_0737|M.smegmatis_MC2_155 GIDMAGTPS----FMWLEVDDVVRDCLADVAKDKVVIVPGLQYKALTTGG
TH_4326|M.thermoresistible__bu GIDMSGTPS----ILYLDVDDVVRTTVARVRKGDVVIVPGLQYKVLTTVG
: :. ... : : . ::**: :
MLBr_00429|M.leprae_Br4923 RYAPRAIVASIVGNFYKKLGGG--
MAB_1537c|M.abscessus_ATCC_199 GYAPRAVVAPIVGSFYKKLGD---
Mflv_0138|M.gilvum_PYR-GCK EFLPRRILLPLIRNQHPALRRSRS
Mb1571|M.bovis_AF2122/97 RFAPRSLLLPAIRIGNRLRGGPSR
Rv1544|M.tuberculosis_H37Rv RFAPRSLLLPAIRIGNRLRGGPSR
MMAR_2367|M.marinum_M RYLPRSVLLPAIRIGNKLRGGPSH
MUL_1543|M.ulcerans_Agy99 RYLPRSVLLPAIRIGNKLRGGPSH
MAV_3226|M.avium_104 RFAPRSLLLPGIRIGNRFRGGPKR
Mvan_3113|M.vanbaalenii_PYR-1 RFTPRALLLPALRMAAARRR----
MSMEG_0737|M.smegmatis_MC2_155 RMAPRNLVRAVTKVVGKGRART--
TH_4326|M.thermoresistible__bu RLVPRKLVRALTKVVGKGRGRT--
** :: .