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GLPTPSPTTTAVVTGASSGIGADLARELAARGHGVTLVARREDRLRALADELSSSNVRVEVVACDVADAD ARAGLFPEIERRGLTVDVLVNNAGIGTIGPVVDSTPEAEIGQVRVNVEAVIDLTTRAVQQMVPRGRGAIL NVGSTAGFQPFPGQSGYAATKAFVRTYTDGLRGELAGTGVTVTALHPGPVRTEFLDTAGMDERTFASAFP KFLWIESREVAEKGIDGLAADRGSVIPGLQNEIPARVFEFLPRRILLPLIRNQHPALRRSRS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0138 | - | - | 100% (273) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2545 | - | 3e-49 | 44.49% (263) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_3538 | - | 4e-46 | 42.91% (254) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2537 | - | 6e-50 | 43.13% (262) | putative short-chain type dehydrogenase/reductase |
| M. tuberculosis H37Rv | Rv2509 | - | 6e-50 | 43.13% (262) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_00429 | - | 4e-49 | 42.96% (270) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1537c | - | 3e-52 | 44.66% (262) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_0254 | - | 2e-65 | 48.89% (270) | ketoacyl reductase |
| M. avium 104 | MAV_1666 | - | 3e-52 | 45.80% (262) | short-chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4722 | - | 1e-50 | 43.89% (262) | short-chain dehydrogenase |
| M. thermoresistible (build 8) | TH_1383 | - | 3e-50 | 43.13% (262) | PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE |
| M. ulcerans Agy99 | MUL_4860 | - | 3e-64 | 48.15% (270) | ketoacyl reductase |
| M. vanbaalenii PYR-1 | Mvan_3113 | - | 4e-53 | 46.97% (264) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4722|M.smegmatis_MC2_155 MPVPAPSPDARAVVTGASQNIGEALATELAARGHHLIITARREEVLTSLA
TH_1383|M.thermoresistible__bu MPVPEPTPDARAVITGASQNIGAALATELAARGHNLIVTARRAEVLTELA
Mb2537|M.bovis_AF2122/97 MPIPAPSPDARAVVTGASQNIGAALATELAARGHHLIVTARREDVLTELA
Rv2509|M.tuberculosis_H37Rv MPIPAPSPDARAVVTGASQNIGAALATELAARGHHLIVTARREDVLTELA
MLBr_00429|M.leprae_Br4923 MPIPAPSPEARAVVTGASQNIGEALATELAAHGHSLIVIARREDVLVDLA
MAV_1666|M.avium_104 MPIPAPSPEARAVVTGASQNIGEALATELAARGHHLIVTARREDLLKDLA
MAB_1537c|M.abscessus_ATCC_199 MPIPAPSPDARAVVTGASQGIGAALAEELAARGHNLIITARRGEILNDLA
MMAR_0254|M.marinum_M MALPPPGKDRAAIVTGASSGIGEEFARILSQRGYQVVLVARSADRLEALA
MUL_4860|M.ulcerans_Agy99 MALPPPGKDRAAIVTGASSGIGEEFARILSQRGYQVVLVARSADRLEALA
Mflv_0138|M.gilvum_PYR-GCK MGLPTPSPTTTAVVTGASSGIGADLARELAARGHGVTLVARREDRLRALA
Mvan_3113|M.vanbaalenii_PYR-1 MSLAKPSAGTTVVITGASSGIGEHIARGLARRGYSLTLIARRRDRLEALS
* :. * .::****..** :* *: :*: : : ** : * *:
MSMEG_4722|M.smegmatis_MC2_155 QRLTERYGVTVEVRAVDLTDPAARATLCDELAE--REISILCANAGTATF
TH_1383|M.thermoresistible__bu DRLTDRHGVTVEVRPLDLADPEQRGTLCAELAE--REISILCANAGVATF
Mb2537|M.bovis_AF2122/97 ARLADKYRVTVDVRPADLADPQERSKLADELAA--RPISILCANAGTATF
Rv2509|M.tuberculosis_H37Rv ARLADKYRVTVDVRPADLADPQERSKLADELAA--RPISILCANAGTATF
MLBr_00429|M.leprae_Br4923 ARLADKYRVAVEVRPADLTDPSERVKLADELTV--RPISILCANAGTATF
MAV_1666|M.avium_104 ARLTEKYRVTVEVRPADLADAGERATLCDELAA--RPISVLCANAGTATF
MAB_1537c|M.abscessus_ATCC_199 NALSEKTGVIVEVRAVDLADPGARDALCTELSE--RNISILCNNAGTATF
MMAR_0254|M.marinum_M GRLGS----DTHPLPADLSVRSDRAGLVDRVAALGLVPDILINNAGLSTL
MUL_4860|M.ulcerans_Agy99 GRLGS----DTHPLPADLSVRSDRAGLVDRVAALGLVPDILINNAGLSTL
Mflv_0138|M.gilvum_PYR-GCK DELSSS-NVRVEVVACDVADADARAGLFPEIERRGLTVDVLVNNAGIGTI
Mvan_3113|M.vanbaalenii_PYR-1 DELCRARSISVDVVALDLNEQSARAEAVERLRS-GAVAG-LVNSAGFGTN
* .. . *: * .: . * .** .*
MSMEG_4722|M.smegmatis_MC2_155 GAVKDLDPAGEKAQVQLNVLGVHDLVLAVLPGMVARRAGGILISGSAAGN
TH_1383|M.thermoresistible__bu GPVHKLDPAEEKAQVQLNVLGVHDLVLAVLPGMVQRRAGGILISGSAAGN
Mb2537|M.bovis_AF2122/97 GPIASLDLAGEKTQVQLNAVAVHDLTLAVLPGMIERKAGGILISGSAAGN
Rv2509|M.tuberculosis_H37Rv GPIASLDLAGEKTQVQLNAVAVHDLTLAVLPGMIERKAGGILISGSAAGN
MLBr_00429|M.leprae_Br4923 GPVSALDPAGEKAQVQLNAVAVHDLTLAVLPGMIERKAGGILISGSAAGN
MAV_1666|M.avium_104 GPVATLDPAGEKAQVQLNVLGVHDLTLAVLPGMVERRAGGILISGSAAGN
MAB_1537c|M.abscessus_ATCC_199 GPIRGLDPAGERKQVQLNAVAVHDLTLAVLPGMLARGAGGILISGSAAGN
MMAR_0254|M.marinum_M GPVAKSVPEQELNLVEVDVAAVVDLCSRFLPAMVERGRGAVLNVASVAGF
MUL_4860|M.ulcerans_Agy99 GPVAKSVPEQEFNLAEVDVAAVVDLCSRFLPAMVERGRGAVFNVASVAGF
Mflv_0138|M.gilvum_PYR-GCK GPVVDSTPEAEIGQVRVNVEAVIDLTTRAVQQMVPRGRGAILNVGSTAGF
Mvan_3113|M.vanbaalenii_PYR-1 GLLQDLPPDRERDQVIVNVLALTELTHAVLPQMVERGAGAVLNIGSIAGF
* : * . ::. .: :* : *: * *.:: .* **
MSMEG_4722|M.smegmatis_MC2_155 SPIPNNATYAASKAFANTFSESLRGELTGVGVHVTLLAPGPVRTELPDPS
TH_1383|M.thermoresistible__bu SPIPNNATYAATKAFANTFSESLRGELKDLGVHVTLLAPGPVRSDLPDPS
Mb2537|M.bovis_AF2122/97 SPIPYNATYAATKAFVNTFSESLRGELRGSGVHVTVLAPGPVRTELPDAS
Rv2509|M.tuberculosis_H37Rv SPIPYNATYAATKAFVNTFSESLRGELRGSGVHVTVLAPGPVRTELPDAS
MLBr_00429|M.leprae_Br4923 SPIPYNATYAATKAFANTFSESLRGELHGSGVHVTLLAPGPVRTELPDHD
MAV_1666|M.avium_104 SPIPYNATYAATKAFVNTFSESLRGELRGSGVHVTLLAPGPVRTDLPDDA
MAB_1537c|M.abscessus_ATCC_199 SPIPNNATYAATKAFANTFSESLRGELKGTGVHVTLLAPGPVRTVEPDPA
MMAR_0254|M.marinum_M APLPGQAAYGAAKAFVLSYTHSLRGELHGSGVSVTALSPGPVDTSFGDVA
MUL_4860|M.ulcerans_Agy99 APLPGQAAYGAAKAFVLSYTHSLRGELHGSGVSVTALSPGPVDTSFGDVA
Mflv_0138|M.gilvum_PYR-GCK QPFPGQSGYAATKAFVRTYTDGLRGELAGTGVTVTALHPGPVRTEFLDTA
Mvan_3113|M.vanbaalenii_PYR-1 QPLPGAAVYSATKAYVQTFSEAVHEGLHGTGVSCTALCPGPVPTEWWEIA
*:* : *.*:**:. :::..:: * . ** * * **** : :
MSMEG_4722|M.smegmatis_MC2_155 E--QSLVERLIPDFLWIDTEYTAKLSLDGLEHNKMRVVPGVTSKAMSVAS
TH_1383|M.thermoresistible__bu E--ASLVDRLVPDFLWISTEHTAKLSLDGLAANKMRVVPGLTSKAMSVAS
Mb2537|M.bovis_AF2122/97 E--ASLVEKLVPDFLWISTEHTARVSLNALERNKMRVVPGLTSKAMSVAS
Rv2509|M.tuberculosis_H37Rv E--ASLVEKLVPDFLWISTEHTARVSLNALERNKMRVVPGLTSKAMSVAS
MLBr_00429|M.leprae_Br4923 E--ASLVEKLVPDFLWISTEHTARLSLDALERNKMRVVPGLTSKAMSVAS
MAV_1666|M.avium_104 E--ASIVERLVPDFLWISTEHTARVSLDALGRNKMRVVPGLTSKAMSVAS
MAB_1537c|M.abscessus_ATCC_199 E--ASIVDKVVPDFLWINGEYTARVSLNALERNKMRVVPGITSKAMSVAA
MMAR_0254|M.marinum_M GFTQQETES-LPKIMWKSVDQVAQAGIDGLAAGKAVVVPGLANRISAELI
MUL_4860|M.ulcerans_Agy99 GFTPQETES-LPKIMWKSVDQVAQAGIDGLAAGKAVVVPGLANRISAELI
Mflv_0138|M.gilvum_PYR-GCK GMDERTFASAFPKFLWIESREVAEKGIDGLAADRGSVIPGLQNEIPARVF
Mvan_3113|M.vanbaalenii_PYR-1 G--EKPPGG----KVAVSVEEVAEAGIAAMREGKRLVVPGLVPKLTGLGG
: . .*. .: .: .: *:**: . .
MSMEG_4722|M.smegmatis_MC2_155 GYAPRAIVTPIVGAVYKKLGGG--
TH_1383|M.thermoresistible__bu GYAPRAIVAPIVGAFYKKLGGG--
Mb2537|M.bovis_AF2122/97 QYAPRAIVAPIVGAFYKRLGGS--
Rv2509|M.tuberculosis_H37Rv QYAPRAIVAPIVGAFYKRLGGS--
MLBr_00429|M.leprae_Br4923 RYAPRAIVASIVGNFYKKLGGG--
MAV_1666|M.avium_104 GYAPRAIVAPIVGSFYKKLGGG--
MAB_1537c|M.abscessus_ATCC_199 GYAPRAVVAPIVGSFYKKLGD---
MMAR_0254|M.marinum_M RVTPPDWMGSIMARIHPAMKRQ--
MUL_4860|M.ulcerans_Agy99 RVTPPDWMGSIMARIHPAMKRQ--
Mflv_0138|M.gilvum_PYR-GCK EFLPRRILLPLIRNQHPALRRSRS
Mvan_3113|M.vanbaalenii_PYR-1 RFTPRALLLPALR--MAAARRR--
* : . :