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LMAPTEEHRVEFSNVTALVTGASGGIGEEFAVQLARRGANLILVARRAEKLAALQHTLTSRHPGIVVDVL TVDLALPGSAAELEAAVRELGRTVDVLINNAGVGLHGKFATQEPAPNAAQIQLNCGTLVDLTARFLPPMI ERRHGVVLNLASTAAFQPTPGMAVYGATKAFVLSFTEALWQECRGSGVRVLALCPGATETEFFDRTGEEF LTDGRQTSRQVVDTAFAALDGSSPTVISGFRNKLLASGYRVSPRKVLLAVSEYMLKANR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3324 | - | - | 100% (269) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_3113 | - | 2e-39 | 40.56% (249) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4098 | - | 1e-33 | 37.36% (265) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1571 | - | 3e-40 | 41.94% (248) | ketoacyl reductase |
| M. gilvum PYR-GCK | Mflv_3538 | - | 1e-122 | 83.78% (259) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1544 | - | 3e-40 | 41.94% (248) | ketoacyl reductase |
| M. leprae Br4923 | MLBr_00429 | - | 9e-32 | 34.98% (263) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1537c | - | 7e-34 | 37.15% (253) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_0254 | - | 5e-42 | 43.44% (244) | ketoacyl reductase |
| M. avium 104 | MAV_3226 | - | 2e-39 | 41.22% (245) | ketoacyl reductase |
| M. smegmatis MC2 155 | MSMEG_4722 | - | 1e-32 | 38.89% (252) | short-chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4326 | - | 6e-34 | 35.69% (255) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4860 | - | 4e-41 | 43.03% (244) | ketoacyl reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1571|M.bovis_AF2122/97 MSLP-----KPNNQTTVVITGASSGIGVELARGLAGRGFPLMLVARRRER
Rv1544|M.tuberculosis_H37Rv MSLP-----KPNNQTTVVITGASSGIGVELARGLAGRGFPLMLVARRRER
MAV_3226|M.avium_104 MSLP-----KPDIATTVVITGASSGIGAELARGLARRGFPLLLVARRRER
MLBr_00429|M.leprae_Br4923 MPIP-----APSPEARAVVTGASQNIGEALATELAAHGHSLIVIARREDV
MSMEG_4722|M.smegmatis_MC2_155 MPVP-----APSPDARAVVTGASQNIGEALATELAARGHHLIITARREEV
MAB_1537c|M.abscessus_ATCC_199 MPIP-----APSPDARAVVTGASQGIGAALAEELAARGHNLIITARRGEI
TH_4326|M.thermoresistible__bu --MP-----RP----VALITGPTSGLGEGFARRYAADGHDLVLVARDVQR
Mvan_3324|M.vanbaalenii_PYR-1 MMAPTEEHRVEFSNVTALVTGASGGIGEEFAVQLARRGANLILVARRAEK
Mflv_3538|M.gilvum_PYR-GCK ---------MEFSNVTALVTGASGGIGEEFAVQLARRGANLILVARRAER
MMAR_0254|M.marinum_M MALP-----PPGKDRAAIVTGASSGIGEEFARILSQRGYQVVLVARSADR
MUL_4860|M.ulcerans_Agy99 MALP-----PPGKDRAAIVTGASSGIGEEFARILSQRGYQVVLVARSADR
.::**.: .:* :* : * ::: ** :
Mb1571|M.bovis_AF2122/97 LDELADQLRQE--HCVGVEVLPLDLADTQARAQLADRLRSDA--IAGLCN
Rv1544|M.tuberculosis_H37Rv LDELADQLRQE--HCVGVEVLPLDLADTQARAQLADRLRSDA--IAGLCN
MAV_3226|M.avium_104 LDDLANEVGGQ--YSVGVEVLPLDLGDSKARARLAGRLRSES--IAGLCN
MLBr_00429|M.leprae_Br4923 LVDLAARLADK--YRVAVEVRPADLTDPSERVKLADELTVRP--ISILCA
MSMEG_4722|M.smegmatis_MC2_155 LTSLAQRLTER--YGVTVEVRAVDLTDPAARATLCDELAERE--ISILCA
MAB_1537c|M.abscessus_ATCC_199 LNDLANALSEK--TGVIVEVRAVDLADPGARDALCTELSERN--ISILCN
TH_4326|M.thermoresistible__bu LEQLAAELRQS--AGIDVEVLPADLAVAADRAKVADRLADG---VQVLVN
Mvan_3324|M.vanbaalenii_PYR-1 LAALQHTLTSR-HPGIVVDVLTVDLALPGSAAELEAAVRELGRTVDVLIN
Mflv_3538|M.gilvum_PYR-GCK LEALRRTLVAR-HPGIVVDVLTADLSGAGSGAEVEGGVRELGRSVDVLIN
MMAR_0254|M.marinum_M LEALAGRLGSDTHP------LPADLSVRSDRAGLVDRVAALGLVPDILIN
MUL_4860|M.ulcerans_Agy99 LEALAGRLGSDTHP------LPADLSVRSDRAGLVDRVAALGLVPDILIN
* * : . ** : : *
Mb1571|M.bovis_AF2122/97 SAGFGTSGRFWELPFARESEEVVLNALALMELTHAALPGMVKRGAGAVLN
Rv1544|M.tuberculosis_H37Rv SAGFGTSGRFWELPFARESEEVVLNALALMELTHAALPGMVKRGAGAVLN
MAV_3226|M.avium_104 SAGFGTSGVFHELPMERESEEVTLNALALMELTHATLPGMVSRGAGAVLN
MLBr_00429|M.leprae_Br4923 NAGTATFGPVSALDPAGEKAQVQLNAVAVHDLTLAVLPGMIERKAGGILI
MSMEG_4722|M.smegmatis_MC2_155 NAGTATFGAVKDLDPAGEKAQVQLNVLGVHDLVLAVLPGMVARRAGGILI
MAB_1537c|M.abscessus_ATCC_199 NAGTATFGPIRGLDPAGERKQVQLNAVAVHDLTLAVLPGMLARGAGGILI
TH_4326|M.thermoresistible__bu NAGFGTSGEFWTADPTLLQAQLDVNVTAVMHLTHAALPPMLDAHRGTIIN
Mvan_3324|M.vanbaalenii_PYR-1 NAGVGLHGKFATQEPAPNAAQIQLNCGTLVDLTARFLPPMIERRHGVVLN
Mflv_3538|M.gilvum_PYR-GCK NAGIGLHGKFVDQEPEANTAQIQLNCGTLVDLTARFLPGMVERRHGVVLN
MMAR_0254|M.marinum_M NAGLSTLGPVAKSVPEQELNLVEVDVAAVVDLCSRFLPAMVERGRGAVLN
MUL_4860|M.ulcerans_Agy99 NAGLSTLGPVAKSVPEQEFNLAEVDVAAVVDLCSRFLPAMVERGRGAVFN
.** . * . :: : .* ** *: * ::
Mb1571|M.bovis_AF2122/97 IASIAGFQPIPYMAVYSATKAFVLTFSEAVQEELHGTGVSVTALCPGPVP
Rv1544|M.tuberculosis_H37Rv IASIAGFQPIPYMAVYSATKAFVLTFSEAVQEELHGTGVSVTALCPGPVP
MAV_3226|M.avium_104 IASIAGFQPVPYMAVYSATKAFVQTFSEAVHEELHGSGVSVTCLCPGPVP
MLBr_00429|M.leprae_Br4923 SGSAAGNSPIPYNATYAATKAFANTFSESLRGELHGSGVHVTLLAPGPVR
MSMEG_4722|M.smegmatis_MC2_155 SGSAAGNSPIPNNATYAASKAFANTFSESLRGELTGVGVHVTLLAPGPVR
MAB_1537c|M.abscessus_ATCC_199 SGSAAGNSPIPNNATYAATKAFANTFSESLRGELKGTGVHVTLLAPGPVR
TH_4326|M.thermoresistible__bu VASVAGLLPG-RGSTYSASKAWVIAFSEGLANGLTGTGVGIHVVCPGFVR
Mvan_3324|M.vanbaalenii_PYR-1 LASTAAFQPTPGMAVYGATKAFVLSFTEALWQECRGSGVRVLALCPGATE
Mflv_3538|M.gilvum_PYR-GCK VASTAAFQPTPGMAVYGATKAFVLSYTEALWQECRGTGVRILALCPGATE
MMAR_0254|M.marinum_M VASVAGFAPLPGQAAYGAAKAFVLSYTHSLRGELHGSGVSVTALSPGPVD
MUL_4860|M.ulcerans_Agy99 VASVAGFAPLPGQAAYGAAKAFVLSYTHSLRGELHGSGVSVTALSPGPVD
.* *. * :.*.*:**:. :::..: * ** : :.** .
Mb1571|M.bovis_AF2122/97 TEWAEIAS----AERFSIPLAQVSPHDVAEAAIAGMLSGKRTVVPGIVPK
Rv1544|M.tuberculosis_H37Rv TEWAEIAS----AERFSIPLAQVSPHDVAEAAIAGMLSGKRTVVPGIVPK
MAV_3226|M.avium_104 TEWAEIAN----AERFSIPIAQVSPRDVAEAAIGGMLTGRRTVVPGVVPK
MLBr_00429|M.leprae_Br4923 TELPDHDEAS-LVEKLVPDFLWISTEHTARLSLDALERNKMRVVPGLTSK
MSMEG_4722|M.smegmatis_MC2_155 TELPDPSEQS-LVERLIPDFLWIDTEYTAKLSLDGLEHNKMRVVPGVTSK
MAB_1537c|M.abscessus_ATCC_199 TVEPDPAEAS-IVDKVVPDFLWINGEYTARVSLNALERNKMRVVPGITSK
TH_4326|M.thermoresistible__bu TEFHQRAG---IDMSGTPSILYLDVDDVVRTTVARVRKGDVVIVPGLQYK
Mvan_3324|M.vanbaalenii_PYR-1 TEFFDRTG------EEFLTDGRQTSRQVVDTAFAALDGSSPTVISGFRNK
Mflv_3538|M.gilvum_PYR-GCK TEFFDRTG------EKFLTDGRQTAEQVVDTAFAALDKSDPTVVSGLRNA
MMAR_0254|M.marinum_M TSFGDVAGFTQQETESLPKIMWKSVDQVAQAGIDGLAAGKAVVVPGLANR
MUL_4860|M.ulcerans_Agy99 TSFGDVAGFTPQETESLPKIMWKSVDQVAQAGIDGLAAGKAVVVPGLANR
* : .. . : . ::.*.
Mb1571|M.bovis_AF2122/97 FVSTSGRFAPRSLLLPAIRIGNRLRGGPSR
Rv1544|M.tuberculosis_H37Rv FVSTSGRFAPRSLLLPAIRIGNRLRGGPSR
MAV_3226|M.avium_104 VVSTGGRFAPRSLLLPGIRIGNRFRGGPKR
MLBr_00429|M.leprae_Br4923 AMSVASRYAPRAIVASIVGNFYKKLGGG--
MSMEG_4722|M.smegmatis_MC2_155 AMSVASGYAPRAIVTPIVGAVYKKLGGG--
MAB_1537c|M.abscessus_ATCC_199 AMSVAAGYAPRAVVAPIVGSFYKKLGD---
TH_4326|M.thermoresistible__bu VLTTVGRLVPRKLVRALTKVVGKGRGRT--
Mvan_3324|M.vanbaalenii_PYR-1 LLASGYRVSPRKVLLAVSEYMLKANR----
Mflv_3538|M.gilvum_PYR-GCK LLASGYRIAPRKLLLAVSERMLRSS-----
MMAR_0254|M.marinum_M ISAELIRVTPPDWMGSIMARIHPAMKRQ--
MUL_4860|M.ulcerans_Agy99 ISAELIRVTPPDWMGSIMARIHPAMKRQ--
: * : .