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VPGSRVARLCAAGSLLLTLATAPSCGQPGHPTDPPPPSTGTPTATATATATDPVADFAAVSQLMHDAIAA HRLPGAVVQIGHAGKIVFRQAFGSRKLAGEPGLDGSPAPAEPMTEDTIFDLASLSKSLATAPAFLQLYER GLVRIDEPVQTYLPEFNPAGDPRRAQVTLRMLLTHTSGLAGDLSLDGPWGLDKPDKADGIRRALAAWVVF DPGEIFHYSDINFILVGAIIEKLTGEQLDSYVRDRVFAPLGMTDTRYLPAAKTCGPHEIRGTTVALGHYP PWIGQCPAGTWSTALLPRIAPTARDGDTPGLNPDYGHLLRGTVHDPTARRMGGVTGSAGVFSTVGDVGRF AQALLDGLAGRPSAFPLTRSTLEMMTTPQQPGHTPGQLEAANDAIRTATENDPDSTARNYPAVPGQDLRG FGWDIDTAHSRPRGTLFPVGSFGHAGFTGVTLWMDPGSDTYVVVLANVIHQPGGPPIVNLSGEVATATAQ ALGLYR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5895 | - | - | 100% (496) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_3027 | - | 1e-18 | 29.97% (287) | Serine-type D-Ala-D-Ala carboxypeptidase |
| M. vanbaalenii PYR-1 | Mvan_2658 | - | 5e-18 | 25.61% (449) | beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1957 | - | 3e-20 | 33.33% (219) | lipoprotein |
| M. gilvum PYR-GCK | Mflv_0495 | - | 0.0 | 64.65% (495) | beta-lactamase |
| M. tuberculosis H37Rv | Rv1922 | - | 3e-20 | 33.33% (219) | lipoprotein |
| M. leprae Br4923 | MLBr_00119 | lipE | 2e-10 | 25.06% (395) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4800 | - | 0.0 | 67.40% (500) | putative beta-lactamase |
| M. marinum M | MMAR_3399 | - | 1e-158 | 63.05% (452) | hypothetical protein MMAR_3399 |
| M. avium 104 | MAV_3991 | - | 1e-173 | 63.71% (485) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_6805 | - | 0.0 | 64.80% (500) | beta-lactamase |
| M. thermoresistible (build 8) | TH_4016 | - | 0.0 | 72.69% (432) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_1772 | - | 5e-13 | 27.27% (286) | beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1957|M.bovis_AF2122/97 ---------------------------------MDSTVTASIRRMLGLLA
Rv1922|M.tuberculosis_H37Rv ---------------------------------MDSTVTASIRRMLGLLA
Mvan_5895|M.vanbaalenii_PYR-1 ---------------------------------MPGSRVARLCAAGSLLL
TH_4016|M.thermoresistible__bu --------------------------------------------------
Mflv_0495|M.gilvum_PYR-GCK ---------------------------------MTRS-STRLRRLGAAGA
MSMEG_6805|M.smegmatis_MC2_155 MSAGSAPLVTPRRKNALHAATASRTARYRRPVRLSRSRVPRLCAIGAVFA
MAB_4800|M.abscessus_ATCC_1997 -------------------------------MKVPGSHATRVCAVATVLL
MMAR_3399|M.marinum_M --------------------------------------MPAMDAAG----
MAV_3991|M.avium_104 --------------------------------------MLTLVAASSTGR
MUL_1772|M.ulcerans_Agy99 ----------------------------------MGVARPRWRGPRAAWF
MLBr_00119|M.leprae_Br4923 -----------------------------------MTSDGKIRVPTDLDA
Mb1957|M.bovis_AF2122/97 ATLLLGGCTGQHTTRTAAS---------------------TTYTPHIKAS
Rv1922|M.tuberculosis_H37Rv ATLLLGGCTGQHTTRTAAS---------------------TTYTPHIKAS
Mvan_5895|M.vanbaalenii_PYR-1 TLATAPSCGQPGHPTDPPPPSTGTPTATATATAT-------DPVADFAAV
TH_4016|M.thermoresistible__bu -------------------------------------------------V
Mflv_0495|M.gilvum_PYR-GCK VVLALGACGDRPEPPGTSAVRPPATPTRVLPSPPPPVPE-VTPTGDFSAV
MSMEG_6805|M.smegmatis_MC2_155 VVAATSCSRPAPAPREPAPATGIAAASPAPTAPPTQVTQPVTPTGDFSAV
MAB_4800|M.abscessus_ATCC_1997 ALAGIPSCGRPAQPITAPS---------------------IVPTGPFAPI
MMAR_3399|M.marinum_M -------------------------------------------LAAFAPV
MAV_3991|M.avium_104 VVHTSPSEAPPASMTPHASLVPEST----------------SPAEDFTTI
MUL_1772|M.ulcerans_Agy99 AGARKPSDGRRLTRRPPAAN---------------------LNPVNLDAN
MLBr_00119|M.leprae_Br4923 VTAIGDEDHSDIDS------------------------------AAVERI
Mb1957|M.bovis_AF2122/97 SQDVLDGAINADEPGCSAAVGVEGKVIWSGVRGIADLASG----------
Rv1922|M.tuberculosis_H37Rv SQDVLDGAINADEPGCSAAVGVEGKVIWSGVRGIADLASG----------
Mvan_5895|M.vanbaalenii_PYR-1 SQLMHDAIAAHRLPGAVVQIGHAGKIVFRQAFGSRKLAGEPGLDGSPAPA
TH_4016|M.thermoresistible__bu IGQVDDAVAVRRLPGAVVQIGHAGEVVFRQAFGSRKLAGEPGPTGEPTPA
Mflv_0495|M.gilvum_PYR-GCK ARLVEDAIAARRLPGAVVQVGHAGKVVFRRAFGVRKLESEPGLDGAPAPA
MSMEG_6805|M.smegmatis_MC2_155 TRLVDDAVAARRLPGAVVQIGHAGKIVFRAAFGARKLDGEPGLDGSPSPA
MAB_4800|M.abscessus_ATCC_1997 TTLVNDAVAAPRLPGAVVEIGHAGKIVFRQAFGWRKLPDEPGLNGSPAPA
MMAR_3399|M.marinum_M SRLINDAIAAERLPGAVVVVGHGGKIVFHQAYGSRKLAGEQGLDGVSAPA
MAV_3991|M.avium_104 SKLVNDAIAARGLPGAVVMVGHGGKVVFHQAYGSRKLAGEPGLDGAPAPA
MUL_1772|M.ulcerans_Agy99 QADIREVCDAGLLSGAVTVVWQHGEVLQVNEIGYRDVEAG----------
MLBr_00119|M.leprae_Br4923 WQATRHWYQAGMHPAIQLCIRQHGRVVLNRAIGHG--WGNAPTDPHDAEK
. .. : *.:: *
Mb1957|M.bovis_AF2122/97 AKITTDTVFDIASVSKQFT-ATAILLLVEAGKLTLDDPISQYVPELP---
Rv1922|M.tuberculosis_H37Rv AKITTDTVFDIASVSKQFT-ATAILLLVEAGKLTLDDPISQYVPELP---
Mvan_5895|M.vanbaalenii_PYR-1 EPMTEDTIFDLASLSKSLATAPAFLQLYERGLVRIDEPVQTYLPEFNPA-
TH_4016|M.thermoresistible__bu EPMTEDTMFDLASLTKSLATTVAVLQLAEQGRLRVDDPVQSHLPEFNPQ-
Mflv_0495|M.gilvum_PYR-GCK EPMTEDTVFDIASLTKSLATATAVMQLHEQGRVRIDEPVQTYLPGFNPA-
MSMEG_6805|M.smegmatis_MC2_155 EPMTEDTLFDLASLTKSIATTTAVLQLYEQGKIRLDEPVQTYLPDFNPT-
MAB_4800|M.abscessus_ATCC_1997 EPMTDDTIFDIASLTKPLATSVAVLQLYEGGRVHIDEPVQAYLPDFNPT-
MMAR_3399|M.marinum_M EAMTEDTIFDIASLTKCLATATAIMQLYEQGKVGFDDPVQNHLPGFNPA-
MAV_3991|M.avium_104 EPMTEDTIFDLASLTKCLATAVAVMQLYEQGKVAFDDPVQKYLPAFNTT-
MUL_1772|M.ulcerans_Agy99 LPMQRDTLFRIASMTKPVTVAAAMSMVDE-GKIALRDPITRWAPELRDIR
MLBr_00119|M.leprae_Br4923 IPVTTDTPFCAYSAAKAIT-ATVVHMLVERGHFSLDDRVCEYLPTYTSYG
: ** * * :* .: : .. : * * . . : : *
Mb1957|M.bovis_AF2122/97 -------------DWAQTVTVEQLMHQTSGIPDYVALLAARG--YQVSDR
Rv1922|M.tuberculosis_H37Rv -------------DWAQTVTVEQLMHQTSGIPDYVALLAARG--YQVSDR
Mvan_5895|M.vanbaalenii_PYR-1 -----------GDPRRAQVTLRMLLTHTSGLAGDLSLDGPWG--LDKPDK
TH_4016|M.thermoresistible__bu -----------HDPRRARVTLRMLLTHTSGIAGDLSLDGPWG--LDRPDK
Mflv_0495|M.gilvum_PYR-GCK -----------GDPRRAAVTVRMLLTHTSGIAGDLSLDGPWG--LAGPDK
MSMEG_6805|M.smegmatis_MC2_155 -----------GDPRRARVTLRMLLTHTSGIAGDLSLDGPWG--LTAADK
MAB_4800|M.abscessus_ATCC_1997 -----------NDPRRDQVTLRMLLTHTSGIGGDLSHQGPWG--LKQADK
MMAR_3399|M.marinum_M -----------SDPQRAQVTVRMLLTQTSGEPVDVGLQDVWG--LDGADR
MAV_3991|M.avium_104 -----------NDPQRAKVTIRMLLTNTSGEGIDVSLRDPWG--LAGPDK
MUL_1772|M.ulcerans_Agy99 VLDDPHGPLDRTHPTRRPILIEDLLTHTSGLAYSFSVSGDISRAYMRLPF
MLBr_00119|M.leprae_Br4923 ---------------KHRTTIRHVLTHSAGVPFPTGPRPDVT---RADDH
:. :: :::* .
Mb1957|M.bovis_AF2122/97 TIEAEARQALAAAPELQFKPGTRFDYSNSNYLLLG-EIVHRASGQPLPEF
Rv1922|M.tuberculosis_H37Rv TIEAEARQALAAAPELQFKPGTRFDYSNSNYLLLG-EIVHRASGQPLPEF
Mvan_5895|M.vanbaalenii_PYR-1 ADGIRR----ALAAWVVFDPGEIFHYSDINFILVG-AIIEKLTGEQLDSY
TH_4016|M.thermoresistible__bu AEGVRR----ALGAWVVHEPGRLFHYSDIGFILLG-AIVEKLTGEPLDVY
Mflv_0495|M.gilvum_PYR-GCK ADGVRR----ALGAWVVSDPGEGFHYSDINFIILG-ALVEKITGEPEDSY
MSMEG_6805|M.smegmatis_MC2_155 AEGVKR----ALAAWVVFEPGAMFHYSDIGFIILG-TLVEKITGQSLDGY
MAB_4800|M.abscessus_ATCC_1997 ADGIHR----ALTTPLAFDPGTTFHYSDINFIILG-ALVEKVTGQTLDIY
MMAR_3399|M.marinum_M VEGIHR----ALSTPLQSPPGREFRYSDINYILLG-ALLEKIAGEAEDGY
MAV_3991|M.avium_104 AEGIHR----ALTTPLQSAPAGEFRYSDINYLLLG-ALLEKITGEDEDDY
MUL_1772|M.ulcerans_Agy99 GHGSDAWLAELAALPLVHQPGERVTYS-HAIDLLG-VIMSRIDDKPFYQV
MLBr_00119|M.leprae_Br4923 AYAQQK----LSELRPFYRPGLVHIYHALTWGPLMREIIWTATGKEIRDI
*. * : :: .:
Mb1957|M.bovis_AF2122/97 LSAEIFQPLGLA-----MVVDPVG--KVPNKAVSYEKG------------
Rv1922|M.tuberculosis_H37Rv LSAEIFQPLGLA-----MVVDPVG--KVPNKAVSYEKG------------
Mvan_5895|M.vanbaalenii_PYR-1 VRDRVFAPLGMTDTRYLPAAKTCGPHEIRGTTVALGHY--PPWIGQCPAG
TH_4016|M.thermoresistible__bu VTENVFAPLGMADTRYLPVSKACGPIRMVGNAVVEDES--AEPT-PCGED
Mflv_0495|M.gilvum_PYR-GCK VDRNVFAPLKMSETRYLPVTKVCGPHRVRGTAIAADPH--GQAVDNCPDG
MSMEG_6805|M.smegmatis_MC2_155 VREHVFAPLGMSDTYYLPAANACGPHEIRGNALVSDPD--GPRTTDCPAD
MAB_4800|M.abscessus_ATCC_1997 VQDNIFAPLGMNETRYLPAAKACGPHHIVGTAITLEEG--PRAAPDCATG
MMAR_3399|M.marinum_M VAQHVFAPIGMQDSDFLPAAKACGPHSVRGAAIGWAPAPAGRPRAPCPAG
MAV_3991|M.avium_104 VQHHVFGPLGMHDTRYLPPAKACGPHIIRGAAIAWAPN--GEPMTECPEW
MUL_1772|M.ulcerans_Agy99 LDERILGPAGMTDTGFFVSTQAQR-----RAATMYRLD------------
MLBr_00119|M.leprae_Br4923 LAAEILDPLGFRWTNFGVAEEDVPLVALSHATGRPLPP------------
: .:: * : . :
Mb1957|M.bovis_AF2122/97 ---------------------------TGGNRSEYRVGNPAWEQIG----
Rv1922|M.tuberculosis_H37Rv ---------------------------TGGNRSEYRVGNPAWEQIG----
Mvan_5895|M.vanbaalenii_PYR-1 TWSTALLPRIAPTARDGDT---PGLNPDYGHLLRGTVHDPTARRMGGVTG
TH_4016|M.thermoresistible__bu RWSTSLRARIAPTSCDGDT---PDLNPHRGRLLRGTVHDPTARRMGGVSG
Mflv_0495|M.gilvum_PYR-GCK TWNIDLLERIAPTALDEDT---PGLNPDYGYPLRGTVHDPTARRMGGVAG
MSMEG_6805|M.smegmatis_MC2_155 SWSTGLLTRVAPTALDEDT---PGINPHFGLPLRGTVHDPTARRMGGVAG
MAB_4800|M.abscessus_ATCC_1997 AWSTALLTRIAPTAHDEDT---PGINPHYGRLIRGTVHDPTARRMGGVAG
MMAR_3399|M.marinum_M TWDTALLSHIAPTALDEESGADPSRNPNFNRLLRGTVHDPTARRMGGVAG
MAV_3991|M.avium_104 TWRTTLLPRIAPTARDEESRDDPSKNPDYYALLRGTVHDPTARRMGGVAG
MUL_1772|M.ulcerans_Agy99 ---------------------------ELDQLRHDVMGPPHVRPPSFCNA
MLBr_00119|M.leprae_Br4923 --------IIAAIFRKAIG----------GTVHEVIPYTNTPPFLTTIVP
.
Mb1957|M.bovis_AF2122/97 DGGIQTTPSQLARWADNYRTGSVGGLKLLEAQLAG----AVETEPG----
Rv1922|M.tuberculosis_H37Rv DGGIQTTPSQLARWADNYRTGSVGGLKLLEAQLAG----AVETEPG----
Mvan_5895|M.vanbaalenii_PYR-1 SAGVFSTVGDVGRFAQALLDGLAGRPSAFPLTRSTLEMMTTPQQPGHTPG
TH_4016|M.thermoresistible__bu SAGVFSTAADVGSYAQALLDRLAGRPSRFPLRRSTLQMMTSPQQPGHAPG
Mflv_0495|M.gilvum_PYR-GCK SAGVFTTVHDMGRFAQALLDRVAGRPSPFPLSQAGARMMTTPQQPA----
MSMEG_6805|M.smegmatis_MC2_155 SAGVFTTVHDLGLFAQALLDRRANRPSTFPLQQATVELMTTPQQPG----
MAB_4800|M.abscessus_ATCC_1997 SAGVFSTAGDVGRYCQALLDRLAGRPSTFPLKRATLELMTSPAQPGHNDG
MMAR_3399|M.marinum_M HAGVFSTAHDVSSFAQALLDRLAGRPSTFPLTQATCELMTTPQQPGHDMA
MAV_3991|M.avium_104 NAGVFSTAHDVGVYAQALLDRLAGRPSDFPLQQGTVELMTTPQQPGHDPR
MUL_1772|M.ulcerans_Agy99 GGGLWSTADDYLRFVRLLLGDGTIDGVRVLSPESVRLMRTDRLSDEHKRH
MLBr_00119|M.leprae_Br4923 SSNTVSTANELSRFAEIWLRGGELDGIRVLRSETLLGAVAECRRLR----
.. :* : : . :
Mb1957|M.bovis_AF2122/97 --------------------------------GGDRYGAG-----IVSRA
Rv1922|M.tuberculosis_H37Rv --------------------------------GGDRYGAG-----IVSRA
Mvan_5895|M.vanbaalenii_PYR-1 QLEAANDAIRTATENDPDS----TARNYPAVPGQDLRGFGWDIDTAHSRP
TH_4016|M.thermoresistible__bu QLDVANKAAREAVLSASDDPL--LAPDYPAVPGRDLRGFGWDIDTNQSRP
Mflv_0495|M.gilvum_PYR-GCK -------------------------------PGRDLRGFGWDIDTAHSGP
MSMEG_6805|M.smegmatis_MC2_155 -------------------------------AGPDLRGLGWDIDTPHSRP
MAB_4800|M.abscessus_ATCC_1997 QLKAANDAARLAIEKTSNSTDPLLAPGYPAIAGQNLRGLGWDIDTELSKP
MMAR_3399|M.marinum_M QLDAANAAAREALAHRPNRTDPMLAPRYPAISGQTLFGFGWDIDTPYSAP
MAV_3991|M.avium_104 QLEAANRAARSG------------TPNYPAIKGQNLFGFGWDIDTGYSRP
MUL_1772|M.ulcerans_Agy99 N--------------------------FLGAPFWVGRGFGLNLSVVTDPV
MLBr_00119|M.leprae_Br4923 -------------------------PDFVVGLMPARWGTGFILGTNKFGP
* *
Mb1957|M.bovis_AF2122/97 DGTLDH----AGAWAG----FVTAFHISSDRRTSVAISCNTDKPDPVAMA
Rv1922|M.tuberculosis_H37Rv DGTLDH----AGAWAG----FVTAFHISSDRRTSVAISCNTDKPDPVAMA
Mvan_5895|M.vanbaalenii_PYR-1 RGTLFP----VGSFGHAGFTGVTLWMDPGSDTYVVVLANVIHQPGGPPIV
TH_4016|M.thermoresistible__bu RGSVFP----VGSFGHTGFTGVTLWIDPGSDTYVVVLANVIHQPGGPPVA
Mflv_0495|M.gilvum_PYR-GCK RGSVFP----VGSFGHTGFTGVSVWLDPESDTYVVILGNVIHQRGGPPIT
MSMEG_6805|M.smegmatis_MC2_155 RGTVFP----VGSFGHTGFTGVSMWMDPGSDTYVIVLANVIHQRGGPPIA
MAB_4800|M.abscessus_ATCC_1997 RGMLFP----IGSFGHSGFTGVTLWLDPGSDTYVVVLANVIHQRGGPPIV
MMAR_3399|M.marinum_M RGVVFP----IGSFGGTGFTGTSLWIDPGSDSYVVLLSNAIHLRGSTPIS
MAV_3991|M.avium_104 RGRVFP----IGSFGNTGFTGTTLWMDPGSDTYVILLSNSIHLRGSPPIS
MUL_1772|M.ulcerans_Agy99 QSTPLFGPGGLGTFSWPGAYGTWWQADPGADLILLYLIQHCPDLSVNAAA
MLBr_00119|M.leprae_Br4923 FGRNAP-----AAFGHLGLVNIAIWADPQRSMAAGLIS--SGKPGQDPNA
. .::. . : . .
Mb1957|M.bovis_AF2122/97 DALGRLWM--------------------
Rv1922|M.tuberculosis_H37Rv DALGRLWM--------------------
Mvan_5895|M.vanbaalenii_PYR-1 NLSGEVATATAQALGLYR----------
TH_4016|M.thermoresistible__bu PLSGRVATLAARALHLYGT---------
Mflv_0495|M.gilvum_PYR-GCK PLSGAVATEAARALHLYGS---------
MSMEG_6805|M.smegmatis_MC2_155 TLSGDVATEAARALHLYGT---------
MAB_4800|M.abscessus_ATCC_1997 RLSGHIATVAARMLDLYRN---------
MMAR_3399|M.marinum_M DLRGQVATAAALALGL------------
MAV_3991|M.avium_104 NLRGDVATAAARALHLYGAAPP------
MUL_1772|M.ulcerans_Agy99 AVAGNPGLAKLRTAQPRFVRRTYRALGL
MLBr_00119|M.leprae_Br4923 GRYGALMNTITAEIPVH-----------
*