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MQYADEAHAFRLRRSGARGPRNWDELQMVRAQHRQETVSVAPATEELAGDVPVRIITPADAPCGVLLDIH SGGFYIGAASDNDVRNRALADRLGVAVVSVDYRLAPEHPWPAAPDDCETVAKWLAESAEARFGTGRLVIG GVSAGATLAMTTLLRLRDRGIDAFAGAVLQYGTFDLSAQTPAGRPASMWNFASIRNLRTASRCTPRRWPT PPSTTSTDGSMTASGREPI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2712 | - | - | 100% (229) | alpha/beta hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2872 | - | 3e-23 | 43.80% (137) | alpha/beta hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2672 | - | 9e-20 | 38.41% (164) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0223c | lipW | 2e-20 | 40.82% (147) | esterase LipW |
| M. gilvum PYR-GCK | Mflv_4552 | - | 9e-22 | 44.00% (125) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv0217c | lipW | 4e-20 | 40.82% (147) | esterase LipW |
| M. leprae Br4923 | MLBr_00314 | - | 4e-08 | 30.48% (105) | putative esterase |
| M. abscessus ATCC 19977 | MAB_2814 | - | 5e-22 | 46.97% (132) | lipase LipH |
| M. marinum M | MMAR_0404 | lipW | 3e-17 | 46.73% (107) | esterase LipW |
| M. avium 104 | MAV_3377 | - | 3e-20 | 42.45% (139) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_5220 | - | 3e-54 | 57.67% (189) | esterase/lipase/thioesterase |
| M. thermoresistible (build 8) | TH_2802 | - | 2e-19 | 35.43% (175) | PUTATIVE esterase |
| M. ulcerans Agy99 | MUL_1054 | lipW | 4e-17 | 46.30% (108) | esterase LipW |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2712|M.vanbaalenii_PYR-1 ------------------------MQYADEAHAFRLRRSGARGPRNWDEL
MSMEG_5220|M.smegmatis_MC2_155 -----------MRFELSALIDPQLLSLVEESREFYADRPPGRGPAGVSEL
Mflv_4552|M.gilvum_PYR-GCK -----------------MRLDPQIAALIDALDGGFPAVHTMTGAQA-RAT
TH_2802|M.thermoresistible__bu ------------MNHPVPPLDPDAAARIASLGP--PAPMRRRGLQAVRDA
MAB_2814|M.abscessus_ATCC_1997 -------------MTATAGIDPIIVKILEAVPI---QLVSPDGPQASRDA
MAV_3377|M.avium_104 ------MPRLDNPADEKPGIDPILQKVLDAVPF---RLSTEDGIDAARQR
Mb0223c|M.bovis_AF2122/97 --------------MSGNEVHPDLRRIAVVTPR---QLVGPRTLPVMRAL
Rv0217c|M.tuberculosis_H37Rv --------------MSGNEVHPDLRRIAVVTPR---QLVGPRTLPVMRAL
MMAR_0404|M.marinum_M MTQPEAVDRLDPLLRAVATARIDFTAESILTIR---ESMNQRRREAAATE
MUL_1054|M.ulcerans_Agy99 --------------------------------------MNQRRREAAATE
MLBr_00314|M.leprae_Br4923 -----MAISAGAPVEIVESGPSIAARLASLTSRLTIRPILAVGSYVPQLP
Mvan_2712|M.vanbaalenii_PYR-1 QMVRAQHRQETVSVAPATEELAG----DVPVRIITP----ADAP-CGVLL
MSMEG_5220|M.smegmatis_MC2_155 LALRETMPEPAECWPPPSVETVSAGGRSVPVRIHAP----ISRPAAGVLL
Mflv_4552|M.gilvum_PYR-GCK IRSRFTPAAEPEPVHSVHDMAVPVDDGEVPVRVYRP--AG--PAPLPALV
TH_2802|M.thermoresistible__bu IESAPLPTDMP-AMASIVDRAVPGPGGDIPVRIHRP--ERGCGDPAPAVL
MAB_2814|M.abscessus_ATCC_1997 YRAIATARPPWIEVANIEDRTIPGPAGEIPVRIYSP----AEGGVRPVFV
MAV_3377|M.avium_104 FRDLP--RRPLHPELRVEDRTIPGPQGAIAVRIYWPP-IHSESRPAPVVL
Mb0223c|M.bovis_AF2122/97 IVVAGLRMSRTPPDIEVLTLESG-----VGVRLYRP---AGSNEPAPALL
Rv0217c|M.tuberculosis_H37Rv IVVAGLRMSRTPPDIEVLTLESG-----VGVRLYRP---AGSNEPAPALL
MMAR_0404|M.marinum_M TAAAGVAVAD-----DVVTGEAGRP---VPVRIYRA---APT--PAPVVV
MUL_1054|M.ulcerans_Agy99 TAAAGVAVAD-----DVATGEAGRP---VPVRIYRA---APT--PAPVVV
MLBr_00314|M.leprae_Br4923 WPFGLIDHAARVLLPVTNAARAEVNLSNTSAQLVRAAGVRPADGSGRIVL
.:: . .:
Mvan_2712|M.vanbaalenii_PYR-1 DIHSGGFYIGAASDNDVRNRALADRLGVAVVSVDYRLAPEHPWPAAPDDC
MSMEG_5220|M.smegmatis_MC2_155 EIHSGGFYLGSAADSDVRNRRLVNALGVAVVSVDYRLAPEHPWPAAPDDC
Mflv_4552|M.gilvum_PYR-GCK FAHGGGFVFCDLDSHDGLCRNLSNRLGAVVISVGYRLAPEHRWPTAAEDM
TH_2802|M.thermoresistible__bu YFHGGGLVMGSNHSFEPLARGLAAASGAVVVAVDYRLAPEHPPPAQFDDA
MAB_2814|M.abscessus_ATCC_1997 LIHGGGWVIGDLDTHDAVARAAAVQADAVVVSVDYRLAPEHPYPAAVEDC
MAV_3377|M.avium_104 YFHGGGFVIGDLDTHDGTARQHAVGAGAIVVSVDYRLAPEHPYPAAVEDA
Mb0223c|M.bovis_AF2122/97 WIHAGGYVMGTAQQDDRLCLRFSSRLGITVASVDYRLAPENPYPAALGDC
Rv0217c|M.tuberculosis_H37Rv WIHAGGYVMGTAQQDDRLCLRFSSRLGITVASVDYRLAPENPYPAALGDC
MMAR_0404|M.marinum_M YCHAGGFALGNLDTDHRQCLELARRARCAVVSVDYRLAPEHPYPAALHDA
MUL_1054|M.ulcerans_Agy99 YCHAGGFALGNLDTDHRQCLERARRARCAVVSVDYRLAPEHPYPAALRDA
MLBr_00314|M.leprae_Br4923 YLHGGAFLGCGANSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDC
*.*. : *.*** *:: *
Mvan_2712|M.vanbaalenii_PYR-1 ETVAKWLAES-AEARFGTGRLVIGGVSAGATLAMTTLLRLRDRGIDAFAG
MSMEG_5220|M.smegmatis_MC2_155 ETAALWLVEN-AEQRFGTTRLVMTGLSAGSTLVTTTLVRLRDRGIFAFSG
Mflv_4552|M.gilvum_PYR-GCK YAVTRWVSGDADALGVDPARIAVGGDSAGGNLAAVTALMARDRGGPALRA
TH_2802|M.thermoresistible__bu WATTRWVAAHADELGLDTSRLAVAGDSAGGALAAAVALAARDRGGPELLA
MAB_2814|M.abscessus_ATCC_1997 WAALQWVHEHAAEIGGDPGRLAVGGDSAGGNLSAVMAQLARD-NGIDLAF
MAV_3377|M.avium_104 WAATLWAAENAAGLHGDPGRIAVAGDSAGGTLAAVTAQRARDRGGPPVRF
Mb0223c|M.bovis_AF2122/97 YSALTWLAS---LPAVDPARVAIGGASAGGGLAAALALLARDRGGITPAF
Rv0217c|M.tuberculosis_H37Rv YSALTWLAS---LPAVDPARVAIGGASAGGGLAAALALLARDRGGITPAF
MMAR_0404|M.marinum_M IEVLTWVVGNATRLGFDARRLAVAGSSAGATLAAGLAHGAADGSLPPVIF
MUL_1054|M.ulcerans_Agy99 IEVLTWVVGNATRLGFDARRLAVAGSSAGATLAAGLAHGAADGSLPPVIF
MLBr_00314|M.leprae_Br4923 HDGYQWLRR----LGYDPEQIVLAGDSAGGYLALALAQRLQDVGEEPAAL
* .. ::.: * ***. * * .
Mvan_2712|M.vanbaalenii_PYR-1 AVLQYGTFDLSAQTPAG-----------------------------R---
MSMEG_5220|M.smegmatis_MC2_155 AVAECGTYDLSTRTPAGRLIADEYFLR-----------AYAGHAPDR---
Mflv_4552|M.gilvum_PYR-GCK QLLLYPVIAADFDTESYRLFGHGFYNPEPALRWYWDQYVPALSDRQ----
TH_2802|M.thermoresistible__bu QLLMYPGLDRDLAAPSIVAMPEAPMLSRDDIVYLHELADLGAGTPH----
MAB_2814|M.abscessus_ATCC_1997 QVLWYPATTFDTTLPSMVENAEAPVLDFKTVGALSKWYLGDTNPATA---
MAV_3377|M.avium_104 QLLWYPSTMWDASLPSFAENATAPILDVKAVAEFSRWYAGDVDLSDP---
Mb0223c|M.bovis_AF2122/97 QLLVYPMLDDRTSIAPANPHYR-LWNGRANRFGWRAYLG-DADARV----
Rv0217c|M.tuberculosis_H37Rv QLLVYPMLDDRPSIAPANPHYR-LWNGRANRFGWRAYLG-DADARV----
MMAR_0404|M.marinum_M QLLHQPVLDDRPTASRSEFRATPAFDGEAASLMWRHYLAGQTPSPE----
MUL_1054|M.ulcerans_Agy99 QLLHQPVLDDRPTASRSEFRATPAFDGEAASLMWRHYLAGQTPSPE----
MLBr_00314|M.leprae_Br4923 VAISPLLQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDK
Mvan_2712|M.vanbaalenii_PYR-1 PASMWN--FASIR------------------NLRTASRCTP-------RR
MSMEG_5220|M.smegmatis_MC2_155 TAPDISPIFASLEKLPPILMVVGAEDILLEDNLAMAARLVAAGVEVDLRV
Mflv_4552|M.gilvum_PYR-GCK HPYASPLHG-ELTGLPPAVMVMTGHDPLRDEAVAYAQALTDAGVPVVRCE
TH_2802|M.thermoresistible__bu DPYRVPAYATDLGGLPQTIIVTGACDPIRDWGERYAGRLRDAGVQTTVTR
MAB_2814|M.abscessus_ATCC_1997 GPTLVPARAENFEGLAPAFIGTAQFDPLRDDGAKYAELLRDAGVPVQLHN
MAV_3377|M.avium_104 PADMAPGRATDLSNLPPAYIGVAGYDPLRDDGIRYGERLAAAGVAAQVHN
Mb0223c|M.bovis_AF2122/97 ---AVPGRRDDLGGLAPAWIGVGTHDLLHDEDLAYAERLTAAGVPCQVEV
Rv0217c|M.tuberculosis_H37Rv ---AVPGRRDDLGGLAPAWIGVGTHDLLHDEDLAYAERLTAAGVPCQVEV
MMAR_0404|M.marinum_M ---SVPGRRGQLAGLPATLITCGEIDPFRDEVLDYAQRLLGAGVSTELHI
MUL_1054|M.ulcerans_Agy99 ---SVPGRRGQLAGLPATLITCGEIDPFRDEVLDYAQRLLGAGVSTELHI
MLBr_00314|M.leprae_Br4923 PEELYEPLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIRV
.
Mvan_2712|M.vanbaalenii_PYR-1 WPTPP-STTSTDGSMTASGREPI----------------------
MSMEG_5220|M.smegmatis_MC2_155 YPASPHAFTGHPTSMARAALEAIDSWIRERLSAEPLTAPSVGIWS
Mflv_4552|M.gilvum_PYR-GCK FDGAVHGFMTMP-MLDIAHEARRRSCQELTALLHG----------
TH_2802|M.thermoresistible__bu YPGMYHGFL----MRYESTARGRLALAEIGALLRAKFANPLPF--
MAB_2814|M.abscessus_ATCC_1997 APTLIHGYLGYADIVPSATEERDLSLAALKQALHG----------
MAV_3377|M.avium_104 AETLVHGYLGYAGVVPAATAAMERGLVALRTALQG----------
Mb0223c|M.bovis_AF2122/97 VEGAFHGFDRVAPNVGVSQRFFTSQCNSLRAALALSNRT------
Rv0217c|M.tuberculosis_H37Rv VEGAFHGFDRVAPNVGVSQRFFTSQCNSLRAALALSNRT------
MMAR_0404|M.marinum_M FPRACHGFDSLLPEWTTSQRLFAMQGHALADAFYPD---------
MUL_1054|M.ulcerans_Agy99 FPRACHGFDSLLPEWTTSQRLFAMQGHALADAFYPD---------
MLBr_00314|M.leprae_Br4923 WPGQVHVFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL-
: