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RFELSALIDPQLLSLVEESREFYADRPPGRGPAGVSELLALRETMPEPAECWPPPSVETVSAGGRSVPVR IHAPISRPAAGVLLEIHSGGFYLGSAADSDVRNRRLVNALGVAVVSVDYRLAPEHPWPAAPDDCETAALW LVENAEQRFGTTRLVMTGLSAGSTLVTTTLVRLRDRGIFAFSGAVAECGTYDLSTRTPAGRLIADEYFLR AYAGHAPDRTAPDISPIFASLEKLPPILMVVGAEDILLEDNLAMAARLVAAGVEVDLRVYPASPHAFTGH PTSMARAALEAIDSWIRERLSAEPLTAPSVGIWS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5220 | - | - | 100% (315) | esterase/lipase/thioesterase |
| M. smegmatis MC2 155 | MSMEG_2888 | - | 3e-24 | 32.07% (290) | lipase |
| M. smegmatis MC2 155 | MSMEG_2875 | - | 8e-24 | 31.97% (294) | esterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0223c | lipW | 7e-24 | 34.91% (232) | esterase LipW |
| M. gilvum PYR-GCK | Mflv_0442 | - | 2e-25 | 36.29% (237) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv0217c | lipW | 7e-24 | 34.91% (232) | esterase LipW |
| M. leprae Br4923 | MLBr_00314 | - | 3e-14 | 30.08% (256) | putative esterase |
| M. abscessus ATCC 19977 | MAB_0078 | - | 3e-26 | 32.45% (302) | putative lipase/esterase |
| M. marinum M | MMAR_2621 | - | 4e-25 | 37.83% (230) | esterase/lipase |
| M. avium 104 | MAV_3025 | - | 5e-28 | 30.77% (286) | esterase |
| M. thermoresistible (build 8) | TH_2573 | - | 9e-24 | 34.33% (233) | PUTATIVE Alpha/beta hydrolase fold-3 domain protein |
| M. ulcerans Agy99 | MUL_3141 | - | 2e-19 | 44.54% (119) | esterase/lipase |
| M. vanbaalenii PYR-1 | Mvan_2712 | - | 4e-54 | 57.67% (189) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0223c|M.bovis_AF2122/97 ----------------------MSGNEVHPDLRRIAVVTPRQLVGPRTLP
Rv0217c|M.tuberculosis_H37Rv ----------------------MSGNEVHPDLRRIAVVTPRQLVGPRTLP
Mflv_0442|M.gilvum_PYR-GCK ----------------------MHGVDFHPELRRAARMLPRQVVTPVTLP
TH_2573|M.thermoresistible__bu -----------------VARSSKLPLDFHPDLRRLARFIPRQAVSPVTLP
MMAR_2621|M.marinum_M -----------MQARSDGPPAFTKPDAIDPALRAISRILPRGYGLHRGLK
MUL_3141|M.ulcerans_Agy99 MRTPRCAIVWCMQARPDGPPAFTKPDAIDPALRAISRILPRGYGLHRGLK
MSMEG_5220|M.smegmatis_MC2_155 ----------MRFELSALIDPQLLSLVEESREFYADRPPGRGPAGVSELL
Mvan_2712|M.vanbaalenii_PYR-1 -----------------------MQYADEAHAFRLRRSGARGPRNWDELQ
MAB_0078|M.abscessus_ATCC_1997 ----------------MTLDPQLAALLPALNAGFPRVEKMTG-AQARAAI
MAV_3025|M.avium_104 ----------------MSLEPQIAAIIEQLDSGFPPVQQMSG-AEARALI
MLBr_00314|M.leprae_Br4923 -MAISAGAPVEIVESGPSIAARLASLTSRLTIRPILAVGSYVPQLPWPFG
Mb0223c|M.bovis_AF2122/97 VMRALIVVAGLRMSRTPPDIEVLTLESGVGVRLYRPAGSNEPAPALLWIH
Rv0217c|M.tuberculosis_H37Rv VMRALIVVAGLRMSRTPPDIEVLTLESGVGVRLYRPAGSNEPAPALLWIH
Mflv_0442|M.gilvum_PYR-GCK LLRRASRLMWRRAPAP--DVEVLTLESGVGVRLFRPAGATRPGPALLWIH
TH_2573|M.thermoresistible__bu LMRLATRPMTRRAPR---DIEVLTLSSGIGIRLFRPPGGG-TGAAMLWIH
MMAR_2621|M.marinum_M LPRALMKLAGITGRLR--DVPVVAVNDAVSVRLHRPTGLPDPGPALLWIH
MUL_3141|M.ulcerans_Agy99 LPRALMKLAGITGRLR--DVPVVAVNDAVSVRSHRPAGLPDPGPALLWIH
MSMEG_5220|M.smegmatis_MC2_155 ALRETMPEPAECWPPPS-VETVSAGGRSVPVRIHAP-ISRPAAGVLLEIH
Mvan_2712|M.vanbaalenii_PYR-1 MVRAQHRQETVSVAPAT-EELAG----DVPVRIITP-ADAP-CGVLLDIH
MAB_0078|M.abscessus_ATCC_1997 RARYVPPARPLPMRSVT-DECVYAFGGELPIRVYRP-AVPGPLPTVVFAH
MAV_3025|M.avium_104 RSRLVPPAQPEPVAEVA-DRLVEGPGGPLRIRVYRP-EAAAPLPALVYAH
MLBr_00314|M.leprae_Br4923 LIDHAARVLLPVTNAAR-AEVNLSNTSAQLVRAAGVRPADGSGRIVLYLH
:* :: *
Mb0223c|M.bovis_AF2122/97 AGGYVMGTAQQDDRLCLRFSSRLGITVASVDYRLAPENPYPAALGDCYSA
Rv0217c|M.tuberculosis_H37Rv AGGYVMGTAQQDDRLCLRFSSRLGITVASVDYRLAPENPYPAALGDCYSA
Mflv_0442|M.gilvum_PYR-GCK GGGYILGDAAQDDVLCRRFAHELGATVASVDYRLAPEFPYPAPVEDCYSA
TH_2573|M.thermoresistible__bu GGGYVIGCAAQDDALCRRYARELDVTVAAVDYRLAPENPYPIPLEDCYAA
MMAR_2621|M.marinum_M GGGTVMGSAAQEDQYCRKLSHLAGVAVAAVDYRLAPEHPYPTPVEDCYAA
MUL_3141|M.ulcerans_Agy99 GGGTVMGSAAQEDQYCRKLSHLAGVAVAAVDYRLAPEHPYPTPVEDCYAA
MSMEG_5220|M.smegmatis_MC2_155 SGGFYLGSAADSDVRNRRLVNALGVAVVSVDYRLAPEHPWPAAPDDCETA
Mvan_2712|M.vanbaalenii_PYR-1 SGGFYIGAASDNDVRNRALADRLGVAVVSVDYRLAPEHPWPAAPDDCETV
MAB_0078|M.abscessus_ATCC_1997 GGGFVFCDLDSHDGLCRRLAAGIPAVVVSVDYRRAPEHRWPTAAQDMFLA
MAV_3025|M.avium_104 GGGFVFCDLDSHDGLCRNLANLVPAVVVSVDYRLAPENAWPAAAEDVYAA
MLBr_00314|M.leprae_Br4923 GGAFLGCGANSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDG
.*. . : *:** *: . *
Mb0223c|M.bovis_AF2122/97 LTWLAS---LPAVDPARVAIGGASAGGGLAAALALLARDRGGITPAFQLL
Rv0217c|M.tuberculosis_H37Rv LTWLAS---LPAVDPARVAIGGASAGGGLAAALALLARDRGGITPAFQLL
Mflv_0442|M.gilvum_PYR-GCK LKWLSA---LPAVDPSRVAIGGASAGGGIAAALAFLARDRGEIPLAAQLL
TH_2573|M.thermoresistible__bu LLWLTR---LPTVDPQRVVIAGGSAGGGLAAALALLARDRGEVAPVAQLL
MMAR_2621|M.marinum_M LLWLRQ---QQWVDPSRIAVAGASAGGLFAATLVQLACDRGDVEPVLQML
MUL_3141|M.ulcerans_Agy99 LLWLRQ---QQWVDPSRIAVAGASAGDLFAATLVQLACDRGDVEPVLQML
MSMEG_5220|M.smegmatis_MC2_155 ALWLVENAEQRFG-TTRLVMTGLSAGSTLVTTTLVRLRDRGIFAFSGAVA
Mvan_2712|M.vanbaalenii_PYR-1 AKWLAESAEARFG-TGRLVIGGVSAGATLAMTTLLRLRDRGIDAFAGAVL
MAB_0078|M.abscessus_ATCC_1997 ACWVTRNAPTLGGDPARVLVCGDSAGGNLAAVTTLMARDLGGPVLAGQIL
MAV_3025|M.avium_104 TCWARDHADALGADPARLVVGGDSAGGNLAAVTTVMCRDRGGPAPAAQLL
MLBr_00314|M.leprae_Br4923 YQWLRR----LGYDPEQIVLAGDSAGGYLALALAQRLQDVGE-EPAALVA
* . :: : * *** :. . * * :
Mb0223c|M.bovis_AF2122/97 VYPMLDDRTSIAP--ANPHYRLWNGRANRFGWRAYLGDADARVAVPGR--
Rv0217c|M.tuberculosis_H37Rv VYPMLDDRPSIAP--ANPHYRLWNGRANRFGWRAYLGDADARVAVPGR--
Mflv_0442|M.gilvum_PYR-GCK VYPMIDDRTVLRTGLDNPGHRLWNQAANRFGWQAYLGDADRDVAVPAR--
TH_2573|M.thermoresistible__bu VYPMLDDRTLHRTDLDHPGLRLWNQSSNRFGWSAYLGDADPEVAVPAR--
MMAR_2621|M.marinum_M VYPMLDDRTGSGP--NGHKRIMWSERDNQQAWQLYLAGADPSTAAPAR--
MUL_3141|M.ulcerans_Agy99 VYPMLDDRTGSGP--NGHKRIMWSERDNQQAWQLYLAGADPSTAAPA---
MSMEG_5220|M.smegmatis_MC2_155 ECGTYDLSTRTPAGRLIADEYF---------LRAYAGHAPDRTAPDISP-
Mvan_2712|M.vanbaalenii_PYR-1 QYGTFDLSAQTPAG---------------------------RPASMWN--
MAB_0078|M.abscessus_ATCC_1997 IYPVLDADFDTPSYRSCGSGYYNTRAAMQWYWDQYLPDPALRDHPYAAP-
MAV_3025|M.avium_104 IYPVIAADFDTESYRLFGQGYYNPAPALRWYWDCYVPSTRDRAHPYATP-
MLBr_00314|M.leprae_Br4923 ISPLLQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDKPE
Mb0223c|M.bovis_AF2122/97 ------RDDLGGLAPAWIGVGTHDLLHDEDLAYAERLTAAGVPCQVEVVE
Rv0217c|M.tuberculosis_H37Rv ------RDDLGGLAPAWIGVGTHDLLHDEDLAYAERLTAAGVPCQVEVVE
Mflv_0442|M.gilvum_PYR-GCK ------RDDLAGLPPAWIGVGTLDLFHDEDLAYAERLRAAGVPCEVEVVK
TH_2573|M.thermoresistible__bu ------QTDLAGLPPAWIGVGTYDLFHDEDLAYAERLRAAGVPCEVEVVP
MMAR_2621|M.marinum_M ------RADLSNLPPAWIGVGTLDLFHQECLDYAARLRDAGVEVHEQIAD
MUL_3141|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_5220|M.smegmatis_MC2_155 -----IFASLEKLPPILMVVGAEDILLEDNLAMAARLVAAGVEVDLRVYP
Mvan_2712|M.vanbaalenii_PYR-1 ------FASIR------------------NLRTASRCTP-------RRWP
MAB_0078|M.abscessus_ATCC_1997 -----LRADLSGLPPAVVVTARYDPPCSEGEAYAAALREAGVPVRYRRYD
MAV_3025|M.avium_104 -----LNADLRGLPPAVVVVAGHDPLRDEGLAFGAALEAAGVPTVQLRYE
MLBr_00314|M.leprae_Br4923 ELYEPLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWP
Mb0223c|M.bovis_AF2122/97 GAFHGFDRVAPNVGVSQRFFTSQCNSLRAALALSNRT-------
Rv0217c|M.tuberculosis_H37Rv GAFHGFDRVAPNVGVSQRFFTSQCNSLRAALALSNRT-------
Mflv_0442|M.gilvum_PYR-GCK GAFHGFDGIAPKAEVSQSFFRSQCALLRGAFEPAAA--------
TH_2573|M.thermoresistible__bu GAFHGFDAIAPRAGVSRQFFDSQCAMLRGLLRPEAA--------
MMAR_2621|M.marinum_M GAFHAFDLLAPNAQVSLGFFASQCQFLRTHLHATVSDQPQAP--
MUL_3141|M.ulcerans_Agy99 --------------------------------------------
MSMEG_5220|M.smegmatis_MC2_155 ASPHAFTGHPT-SMARAALEAIDSWIRERLSAEPLTAPSVGIWS
Mvan_2712|M.vanbaalenii_PYR-1 TPP-STTSTDG-SMTASGREPI----------------------
MAB_0078|M.abscessus_ATCC_1997 NAIHGFMTMPGLELADAGIQRLCRDVGEMLG-------------
MAV_3025|M.avium_104 GGIHGFMTMPMLDIAHRARNEAAAALADLLRR------------
MLBr_00314|M.leprae_Br4923 GQVHVFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL--