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VRLDPQIAALIDALDGGFPAVHTMTGAQARATIRSRFTPAAEPEPVHSVHDMAVPVDDGEVPVRVYRPAG PAPLPALVFAHGGGFVFCDLDSHDGLCRNLSNRLGAVVISVGYRLAPEHRWPTAAEDMYAVTRWVSGDAD ALGVDPARIAVGGDSAGGNLAAVTALMARDRGGPALRAQLLLYPVIAADFDTESYRLFGHGFYNPEPALR WYWDQYVPALSDRQHPYASPLHGELTGLPPAVMVMTGHDPLRDEAVAYAQALTDAGVPVVRCEFDGAVHG FMTMPMLDIAHEARRRSCQELTALLHG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4552 | - | - | 100% (307) | alpha/beta hydrolase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_3735 | - | 9e-55 | 42.77% (311) | alpha/beta hydrolase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_4203 | - | 1e-50 | 43.53% (255) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2994c | lipN | 1e-49 | 43.35% (263) | lipase/esterase LipN |
| M. tuberculosis H37Rv | Rv2970c | lipN | 1e-49 | 43.35% (263) | lipase/esterase LipN |
| M. leprae Br4923 | MLBr_00314 | - | 6e-14 | 26.85% (257) | putative esterase |
| M. abscessus ATCC 19977 | MAB_0078 | - | 1e-107 | 60.66% (305) | putative lipase/esterase |
| M. marinum M | MMAR_1746 | lipN | 6e-50 | 41.92% (260) | lipase/esterase LipN |
| M. avium 104 | MAV_3025 | - | 1e-122 | 67.87% (305) | esterase |
| M. smegmatis MC2 155 | MSMEG_2888 | - | 1e-116 | 64.92% (305) | lipase |
| M. thermoresistible (build 8) | TH_2802 | - | 1e-47 | 43.10% (290) | PUTATIVE esterase |
| M. ulcerans Agy99 | MUL_1989 | lipN | 4e-51 | 42.31% (260) | lipase/esterase LipN |
| M. vanbaalenii PYR-1 | Mvan_2888 | - | 1e-115 | 66.45% (307) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2994c|M.bovis_AF2122/97 MTKSLPGVADLRLGANHPRM-WTRRVQGTVVNVGVKVLPWIPTPAKRILS
Rv2970c|M.tuberculosis_H37Rv MTKSLPGVADLRLGANHPRM-WTRRVQGTVVNVGVKVLPWIPTPAKRILS
MMAR_1746|M.marinum_M MTNSLPGETDLHPETVHATMSWLSRVQNTVTVVGAKVIPWVPDVAKRLIT
MUL_1989|M.ulcerans_Agy99 MTNSLPGETDLHPETVHATMSWLSRVQNTVTVVGAKVIPWVPDVAKRLIT
TH_2802|M.thermoresistible__bu --------------------------------MNHPVPPLDPDAAARIAS
MSMEG_2888|M.smegmatis_MC2_155 ------------------------------------MSGLDPQIADIIEA
Mvan_2888|M.vanbaalenii_PYR-1 ------------------------------------MS-LDPQIATIIET
MAV_3025|M.avium_104 ------------------------------------MS-LEPQIAAIIEQ
Mflv_4552|M.gilvum_PYR-GCK ------------------------------------MR-LDPQIAALIDA
MAB_0078|M.abscessus_ATCC_1997 ------------------------------------MT-LDPQLAALLPA
MLBr_00314|M.leprae_Br4923 --------------------------MAISAGAPVEIVESGPSIAARLAS
: * * :
Mb2994c|M.bovis_AF2122/97 AGRSVIIDGNTLDPTLQLMLSTSRIFGVDGLAVDDDIVASRAHMRAICEA
Rv2970c|M.tuberculosis_H37Rv AGRSVIIDGNTLDPTLQLMLSTSRIFGVDGLAVDDDIVASRAHMRAICEA
MMAR_1746|M.marinum_M RGRSVIIDGNTLDPALQLMLSGMRVVGLDGLVIDDDLAASRAHMREAMLG
MUL_1989|M.ulcerans_Agy99 RGRSVIIDGNTLDPALQLMLSGMRVVGLDGLVIDDDLAASRAHMREAMLG
TH_2802|M.thermoresistible__bu LGPPAPMRRRGLQAVRDAIESAPLPTDMPAMAS-----------------
MSMEG_2888|M.smegmatis_MC2_155 LDSGFPPVHTMTGAQARAAIKARFRPAAHPQPMAA---------------
Mvan_2888|M.vanbaalenii_PYR-1 LDSGFPAVHTMTGEQARAAIRSRFVPAAEPEPVAS---------------
MAV_3025|M.avium_104 LDSGFPPVQQMSGAEARALIRSRLVPPAQPEPVAE---------------
Mflv_4552|M.gilvum_PYR-GCK LDGGFPAVHTMTGAQARATIRSRFTPAAEPEPVHS---------------
MAB_0078|M.abscessus_ATCC_1997 LNAGFPRVEKMTGAQARAAIRARYVPPARPLPMRS---------------
MLBr_00314|M.leprae_Br4923 LTSRLTIRPILAVGSYVPQLPWPFGLIDHAARVLLP--------------
Mb2994c|M.bovis_AF2122/97 MPGPQIHVDVTDLSIPGPAGEIPARHYRPS--GGG--ATPLLVFYHGGGW
Rv2970c|M.tuberculosis_H37Rv MPGPQIHVDVTDLSIPGPAGEIPARHYRPS--GGG--ATPLLVFYHGGGW
MMAR_1746|M.marinum_M FPGPQIHVDVEELTLPGPAGDISARHYRPP--GDA--AAPLLVFYHGGGW
MUL_1989|M.ulcerans_Agy99 FPGPQIHVDVEELTLPGPAGDISARHYRPP--GDA--AAPLLVFYHGGGW
TH_2802|M.thermoresistible__bu ---------IVDRAVPGPGGDIPVRIHRPE--RGCGDPAPAVLYFHGGGL
MSMEG_2888|M.smegmatis_MC2_155 ---------VEDATATGSSGDVAVRIYRPA--TPAR-PLPTLVWAHGGGW
Mvan_2888|M.vanbaalenii_PYR-1 ---------VEDRTVPGPDGPVTVRIYRPA--AATDGPVPTMVYAHGGGW
MAV_3025|M.avium_104 ---------VADRLVEGPGGPLRIRVYRPE--AAAP--LPALVYAHGGGF
Mflv_4552|M.gilvum_PYR-GCK ---------VHDMAVPVDDGEVPVRVYRPA--GPAP--LPALVFAHGGGF
MAB_0078|M.abscessus_ATCC_1997 ---------VTDECVYAFGGELPIRVYRPA--VPGP--LPTVVFAHGGGF
MLBr_00314|M.leprae_Br4923 --------VTNAARAEVNLSNTSAQLVRAAGVRPADGSGRIVLYLHGGAF
. : *. ::: ***.
Mb2994c|M.bovis_AF2122/97 TLGDLDTHDALCRLTCRDADIQVLSIDYRLAP-EHPAPAAVEDAYAAFVW
Rv2970c|M.tuberculosis_H37Rv TLGDLDTHDALCRLTCRDADIQVLSIDYRLAP-EHPAPAAVEDAYAAFVW
MMAR_1746|M.marinum_M ALGDLDTHDAVCRLTCRDAGIHVLAIDYRLSP-EDRAPAAIDDAFAAFEW
MUL_1989|M.ulcerans_Agy99 ALGDLDTHDAVCRLTCRDAGIHVLAIDYRLSP-EHRAPAAIDDAFAAFEW
TH_2802|M.thermoresistible__bu VMGSNHSFEPLARGLAAASGAVVVAVDYRLAP-EHPPPAQFDDAWATTRW
MSMEG_2888|M.smegmatis_MC2_155 VFCDLDSHDELCRDIATRVPAVIVSVDYRRAPDEGQWPAAADDMFTATRW
Mvan_2888|M.vanbaalenii_PYR-1 VFCDLDSHDGLCRAFANGMSAVVVSVHYRRASEEGRWPAAAEDVYAVAAW
MAV_3025|M.avium_104 VFCDLDSHDGLCRNLANLVPAVVVSVDYRLAP-ENAWPAAAEDVYAATCW
Mflv_4552|M.gilvum_PYR-GCK VFCDLDSHDGLCRNLSNRLGAVVISVGYRLAP-EHRWPTAAEDMYAVTRW
MAB_0078|M.abscessus_ATCC_1997 VFCDLDSHDGLCRRLAAGIPAVVVSVDYRRAP-EHRWPTAAQDMFLAACW
MLBr_00314|M.leprae_Br4923 LGCGANSHRRLVETLSKLADSPILVVNYRLLP-KHSIGMALDDCHDGYQW
. .:. : . . :: : ** . : :* *
Mb2994c|M.bovis_AF2122/97 AHEHASDEFGALPGRVAVGGDSAGGNLSAVVCQLARDKARYEGGPTPVLQ
Rv2970c|M.tuberculosis_H37Rv AHEHASDEFGALPGRVAVGGDSAGGNLSAVVCQLARDKARYEGGPTPVLQ
MMAR_1746|M.marinum_M AHAHAA-ELGALPGRVAVGGDSAGGNLAAVVSQLARD----SGGPAPIFQ
MUL_1989|M.ulcerans_Agy99 AHAHAA-ELGALPGRVAVGGDSAGGNLAAVVSQLARD----SGGPAPIFQ
TH_2802|M.thermoresistible__bu VAAHAD-ELGLDTSRLAVAGDSAGGALAAAVALAARD----RGGPELLAQ
MSMEG_2888|M.smegmatis_MC2_155 AAAHAA-DLGGAENLLLVGGDSAGGNLAAVTALMARD----RGGPDLAGQ
Mvan_2888|M.vanbaalenii_PYR-1 AAETIG-ELGGDLSALLVGGDSAGGNLAAVTALMARD----RRGPALAGQ
MAV_3025|M.avium_104 ARDHAD-ALGADPARLVVGGDSAGGNLAAVTTVMCRD----RGGPAPAAQ
Mflv_4552|M.gilvum_PYR-GCK VSGDAD-ALGVDPARIAVGGDSAGGNLAAVTALMARD----RGGPALRAQ
MAB_0078|M.abscessus_ATCC_1997 VTRNAP-TLGGDPARVLVCGDSAGGNLAAVTTLMARD----LGGPVLAGQ
MLBr_00314|M.leprae_Br4923 LR-----RLGYDPEQIVLAGDSAGGYLALALAQRLQD-----VGEEPAAL
:* : : ****** *: . :* *
Mb2994c|M.bovis_AF2122/97 WLLYPRTDFTAQ-TRSMGLFGNGFLLTKRDIDWFHTQYLRDSDVDPADPR
Rv2970c|M.tuberculosis_H37Rv WLLYPRTDFTAQ-TRSMGLFGNGFLLTKRDIDWFHTQYLRDSDVDPADPR
MMAR_1746|M.marinum_M WLIYPRTDFAGR-TRSASLFARGFLLTKRDIDWFHSQYLKGSGIEPTDPR
MUL_1989|M.ulcerans_Agy99 WLIYPRTDFAGR-TRSASLFARGFLLTKRDIDWFHSQYLKGSGIEPTDPR
TH_2802|M.thermoresistible__bu LLMYPGLDRDLA-APSIVAMPEAPMLSRDDIVYLHELADLGAG-TPHDPY
MSMEG_2888|M.smegmatis_MC2_155 VLLYPVIAADFD-NESYRRFGAGHYNPRPALQWYWDQYVPAAA-DRVHPY
Mvan_2888|M.vanbaalenii_PYR-1 LLLYPVIAANFD-TESYRRFGEGFYNPLAALQWYWDQYVPNLA-DRVNPY
MAV_3025|M.avium_104 LLIYPVIAADFD-TESYRLFGQGYYNPAPALRWYWDCYVPSTR-DRAHPY
Mflv_4552|M.gilvum_PYR-GCK LLLYPVIAADFD-TESYRLFGHGFYNPEPALRWYWDQYVPALS-DRQHPY
MAB_0078|M.abscessus_ATCC_1997 ILIYPVLDADFD-TPSYRSCGSGYYNTRAAMQWYWDQYLPDPA-LRDHPY
MLBr_00314|M.leprae_Br4923 VAISPLLQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDK
: * : . : .
Mb2994c|M.bovis_AF2122/97 LSPLLAES---LSGLAPALIAVAGFDPLRDEGESYAKALRAAGTAVDLRY
Rv2970c|M.tuberculosis_H37Rv LSPLLAES---LSGLAPALIAVAGFDPLRDEGESYAKALRAAGTAVDLRY
MMAR_1746|M.marinum_M VSPLRAES---LAGLAPALIAVAGFDPLRDEGENYATALRAAGTPVDLRA
MUL_1989|M.ulcerans_Agy99 VSPLRAES---LAGLAPALIAVAGFDPLRDEGENYATALRAAGTPVDLRA
TH_2802|M.thermoresistible__bu RVPAYATD---LGGLPQTIIVTGACDPIRDWGERYAGRLRDAGVQTTVTR
MSMEG_2888|M.smegmatis_MC2_155 ASPLHAD----LSGLPPAITVVAGHDPLRDEGLAYAEALELAGVPTVTRY
Mvan_2888|M.vanbaalenii_PYR-1 ASPLHADD---LSGLPPAITVVAGHDPLRDEGLAYTEALEAAGVETICRY
MAV_3025|M.avium_104 ATPLNAD----LRGLPPAVVVVAGHDPLRDEGLAFGAALEAAGVPTVQLR
Mflv_4552|M.gilvum_PYR-GCK ASPLHGE----LTGLPPAVMVMTGHDPLRDEAVAYAQALTDAGVPVVRCE
MAB_0078|M.abscessus_ATCC_1997 AAPLRAD----LSGLPPAVVVTARYDPPCSEGEAYAAALREAGVPVRYRR
MLBr_00314|M.leprae_Br4923 PEELYEPLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIRV
**. :: : . * .*. .
Mb2994c|M.bovis_AF2122/97 LGSLTHGFLNLFQLGGGSAAGTNELISALRAHLSRV--------
Rv2970c|M.tuberculosis_H37Rv LGSLTHGFLNLFQLGGGSAAGTNELISALRAHLSRV--------
MMAR_1746|M.marinum_M MGSLTHGFLNLFPLGGGCAAATSELISALRAHLTRV--------
MUL_1989|M.ulcerans_Agy99 MGSLTHGFLNLFPLGGGCAAATSELISALRAHLTRV--------
TH_2802|M.thermoresistible__bu YPGMYHGFLMRYESTARGRLALAEIGALLRAKFANPLPF-----
MSMEG_2888|M.smegmatis_MC2_155 FEGGIHGFMTMPSLD-LCRQARAQACSDISALVESIGIAAP---
Mvan_2888|M.vanbaalenii_PYR-1 FDGGVHGFMTMPTFD-ICGRARARVCADIAELVGRPVTN-----
MAV_3025|M.avium_104 YEGGIHGFMTMPMLD-IAHRARNEAAAALADLLRR---------
Mflv_4552|M.gilvum_PYR-GCK FDGAVHGFMTMPMLD-IAHEARRRSCQELTALLHG---------
MAB_0078|M.abscessus_ATCC_1997 YDNAIHGFMTMPGLE-LADAGIQRLCRDVGEMLG----------
MLBr_00314|M.leprae_Br4923 WPGQVHVFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL
. * * . . :