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SGNEVHPDLRRIAVVTPRQLVGPRTLPVMRALIVVAGLRMSRTPPDIEVLTLESGVGVRLYRPAGSNEPA PALLWIHAGGYVMGTAQQDDRLCLRFSSRLGITVASVDYRLAPENPYPAALGDCYSALTWLASLPAVDPA RVAIGGASAGGGLAAALALLARDRGGITPAFQLLVYPMLDDRPSIAPANPHYRLWNGRANRFGWRAYLGD ADARVAVPGRRDDLGGLAPAWIGVGTHDLLHDEDLAYAERLTAAGVPCQVEVVEGAFHGFDRVAPNVGVS QRFFTSQCNSLRAALALSNRT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0217c | lipW | - | 100% (302) | POSSIBLE ESTERASE LIPW |
| M. tuberculosis H37Rv | Rv1400c | lipI | 1e-34 | 38.77% (227) | lipase LipH |
| M. tuberculosis H37Rv | Rv1399c | lipH | 2e-31 | 36.72% (256) | lipase LipH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0223c | lipW | 1e-175 | 99.67% (302) | esterase LipW |
| M. gilvum PYR-GCK | Mflv_0442 | - | 1e-114 | 69.59% (296) | alpha/beta hydrolase domain-containing protein |
| M. leprae Br4923 | MLBr_00314 | - | 9e-17 | 31.40% (242) | putative esterase |
| M. abscessus ATCC 19977 | MAB_0826c | - | 2e-95 | 58.19% (299) | esterase LipW |
| M. marinum M | MMAR_2621 | - | 1e-76 | 51.03% (292) | esterase/lipase |
| M. avium 104 | MAV_4954 | - | 1e-125 | 73.31% (296) | alpha/beta hydrolase fold |
| M. smegmatis MC2 155 | MSMEG_0280 | - | 1e-105 | 65.19% (293) | alpha/beta hydrolase fold |
| M. thermoresistible (build 8) | TH_2573 | - | 1e-106 | 65.31% (294) | PUTATIVE Alpha/beta hydrolase fold-3 domain protein |
| M. ulcerans Agy99 | MUL_3141 | - | 4e-51 | 48.37% (215) | esterase/lipase |
| M. vanbaalenii PYR-1 | Mvan_0225 | - | 1e-105 | 65.88% (296) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0217c|M.tuberculosis_H37Rv ----------------------MSGNEVHPDLRRIAVVTPRQLVGPRTLP
Mb0223c|M.bovis_AF2122/97 ----------------------MSGNEVHPDLRRIAVVTPRQLVGPRTLP
MAV_4954|M.avium_104 --------------MAVGDTDPVPNNDVHPDLQRFARFAPRRLVGPRTLP
Mflv_0442|M.gilvum_PYR-GCK ----------------------MHGVDFHPELRRAARMLPRQVVTPVTLP
Mvan_0225|M.vanbaalenii_PYR-1 ------------MPLPHTHTERVPDIEFHPELRRSARLLPKQVITPLTLP
TH_2573|M.thermoresistible__bu ----------------VARSSKLP-LDFHPDLRRLARFIPRQAVSPVTLP
MSMEG_0280|M.smegmatis_MC2_155 -------------------MTATTPTRFHPDLERVARYIPRHMVNRATLP
MAB_0826c|M.abscessus_ATCC_199 ----------------------MSSPDIHPDLRLAARAFPRQVGLPRTLS
MMAR_2621|M.marinum_M -----------MQARSDGPPAFTKPDAIDPALRAISRILPRGYGLHRGLK
MUL_3141|M.ulcerans_Agy99 MRTPRCAIVWCMQARPDGPPAFTKPDAIDPALRAISRILPRGYGLHRGLK
MLBr_00314|M.leprae_Br4923 --------------MAISAGAPVEIVESGPSIAARLASLTSRLTIRPILA
* : . *
Rv0217c|M.tuberculosis_H37Rv VMRALIVVAGLRMSRTPPDIEVLTLE---------SGVGVRLYRPAGSNE
Mb0223c|M.bovis_AF2122/97 VMRALIVVAGLRMSRTPPDIEVLTLE---------SGVGVRLYRPAGSNE
MAV_4954|M.avium_104 LMRVALAWRG-RLGKPVRDVEVITLG---------SGVGVRLFRPAGAAE
Mflv_0442|M.gilvum_PYR-GCK LLRRASRLMWRRAPAP--DVEVLTLE---------SGVGVRLFRPAGATR
Mvan_0225|M.vanbaalenii_PYR-1 FIRAASRLMWRRNDSPA-DVEVLTLS---------SGVGVRLFRPSGVAP
TH_2573|M.thermoresistible__bu LMRLATRPMTRR--APR-DIEVLTLS---------SGIGIRLFRPPGGGT
MSMEG_0280|M.smegmatis_MC2_155 VFQRLTRLMGRR--VPP-GCEVLTLP---------SGVGIRLFRPPASTT
MAB_0826c|M.abscessus_ATCC_199 ILRASIYLTDLL---PRHGVRRIAVN---------DNVTVRAHVPKNLEE
MMAR_2621|M.marinum_M LPRALMKLAGITG--RLRDVPVVAVN---------DAVSVRLHRPTGLPD
MUL_3141|M.ulcerans_Agy99 LPRALMKLAGITG--RLRDVPVVAVN---------DAVSVRSHRPAGLPD
MLBr_00314|M.leprae_Br4923 VGSYVPQLPWPFGLIDHAARVLLPVTNAARAEVNLSNTSAQLVRAAGVRP
. :.: . : .
Rv0217c|M.tuberculosis_H37Rv ---PAPALLWIHAGGYVMGTAQQDDRLCLRFSSRLGITVASVDYRLAPEN
Mb0223c|M.bovis_AF2122/97 ---PAPALLWIHAGGYVMGTAQQDDRLCLRFSSRLGITVASVDYRLAPEN
MAV_4954|M.avium_104 ---TTPALLWIHGGGYVLGTAQQDDQLCSRFSRRLGITVASVDYRLAPEH
Mflv_0442|M.gilvum_PYR-GCK ---PGPALLWIHGGGYILGDAAQDDVLCRRFAHELGATVASVDYRLAPEF
Mvan_0225|M.vanbaalenii_PYR-1 G--RGPALLWIHGGGYVIGDAAQDDVLCRRFARELGATVASVNYRLAPEY
TH_2573|M.thermoresistible__bu ----GAAMLWIHGGGYVIGCAAQDDALCRRYARELDVTVAAVDYRLAPEN
MSMEG_0280|M.smegmatis_MC2_155 L--PGPALVWIHGGGYVLGSAAQDDAQCLQFARQAGVTVASVEYRLAPQN
MAB_0826c|M.abscessus_ATCC_199 ---PSAALLWIHGGGYVMGTARQDDFFCRKVMHETGIPVVSVDYRLAPEH
MMAR_2621|M.marinum_M ---PGPALLWIHGGGTVMGSAAQEDQYCRKLSHLAGVAVAAVDYRLAPEH
MUL_3141|M.ulcerans_Agy99 ---PGPALLWIHGGGTVMGSAAQEDQYCRKLSHLAGVAVAAVDYRLAPEH
MLBr_00314|M.leprae_Br4923 ADGSGRIVLYLHGGAFLGCGANSHRRLVETLSKLADSPILVVNYRLLPKH
::::*.*. : * .. . .: *:*** *:
Rv0217c|M.tuberculosis_H37Rv PYPAALGDCYSALTWLASLPAVDPARVAIGGASAGGGLAAALALLARDRG
Mb0223c|M.bovis_AF2122/97 PYPAALGDCYSALTWLASLPAVDPARVAIGGASAGGGLAAALALLARDRG
MAV_4954|M.avium_104 RYPVPLEDCYTALTWLAGLPSVDRYRIAIGGASAGGGLAAALALLARDRA
Mflv_0442|M.gilvum_PYR-GCK PYPAPVEDCYSALKWLSALPAVDPSRVAIGGASAGGGIAAALAFLARDRG
Mvan_0225|M.vanbaalenii_PYR-1 PYPVPVEDCYSALHWLTQLPSVDPARVAIGGASAGGGLAAALALLTRDRG
TH_2573|M.thermoresistible__bu PYPIPLEDCYAALLWLTRLPTVDPQRVVIAGGSAGGGLAAALALLARDRG
MSMEG_0280|M.smegmatis_MC2_155 PYPAGLEDCFAALRWLTALPSVDPARVAIGGASAGGGLAASLALLARDRG
MAB_0826c|M.abscessus_ATCC_199 PYPIPLEDCYAALRWLSVQGWIDPTRIAVGGASAGGGLAAALALLARDRG
MMAR_2621|M.marinum_M PYPTPVEDCYAALLWLRQQQWVDPSRIAVAGASAGGLFAATLVQLACDRG
MUL_3141|M.ulcerans_Agy99 PYPTPVEDCYAALLWLRQQQWVDPSRIAVAGASAGDLFAATLVQLACDRG
MLBr_00314|M.leprae_Br4923 SIGMALDDCHDGYQWLRRLG-YDPEQIVLAGDSAGGYLALALAQRLQDVG
: **. . ** * ::.:.* ***. :* :*. * .
Rv0217c|M.tuberculosis_H37Rv GITPAFQLLVYPMLDDRPSIAP--ANPHYRLWNGRANRFGWRAYLG----
Mb0223c|M.bovis_AF2122/97 GITPAFQLLVYPMLDDRTSIAP--ANPHYRLWNGRANRFGWRAYLG----
MAV_4954|M.avium_104 EVSPAFQLLTYPMLDDRSSDTA--PSPNYRLWDNRSNRFGWAAYLG----
Mflv_0442|M.gilvum_PYR-GCK EIPLAAQLLVYPMIDDRTVLRTGLDNPGHRLWNQAANRFGWQAYLG----
Mvan_0225|M.vanbaalenii_PYR-1 EIELAAQLLVYPMIDDRTVHRKGLDHPGHRLWNQSSNRFGWRAYLG----
TH_2573|M.thermoresistible__bu EVAPVAQLLVYPMLDDRTLHRTDLDHPGLRLWNQSSNRFGWSAYLG----
MSMEG_0280|M.smegmatis_MC2_155 -IDVAAQLLVYPMLDDRSSFVPSLDHPGQRLWNQGSNRFGWKAYLG----
MAB_0826c|M.abscessus_ATCC_199 EVAPAAQLLIYPMLDDRSSERTDIDGTNLRLWSGDSNRFGWDSYLG----
MMAR_2621|M.marinum_M DVEPVLQMLVYPMLDDRTGSGP--NGHKRIMWSERDNQQAWQLYLA----
MUL_3141|M.ulcerans_Agy99 DVEPVLQMLVYPMLDDRTGSGP--NGHKRIMWSERDNQQAWQLYLA----
MLBr_00314|M.leprae_Br4923 EEPAALVAISPLLQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAK
. : : : :: .
Rv0217c|M.tuberculosis_H37Rv ---DADARVAVPGRRDDLGGLAPAWIGVGTHDLLHDEDLAYAERLTAAGV
Mb0223c|M.bovis_AF2122/97 ---DADARVAVPGRRDDLGGLAPAWIGVGTHDLLHDEDLAYAERLTAAGV
MAV_4954|M.avium_104 ---DADPHVAVPARRDDLSGLPPAWIGVGTHDLFHDEDLAYAERLRAAGV
Mflv_0442|M.gilvum_PYR-GCK ---DADRDVAVPARRDDLAGLPPAWIGVGTLDLFHDEDLAYAERLRAAGV
Mvan_0225|M.vanbaalenii_PYR-1 ---DADPNEAVPARRDDLAGLPPAWIGVGTLDLFHDEDLAYAERLRVAGV
TH_2573|M.thermoresistible__bu ---DADPEVAVPARQTDLAGLPPAWIGVGTYDLFHDEDLAYAERLRAAGV
MSMEG_0280|M.smegmatis_MC2_155 ---DADPDVAVPARREDLSGLPPAWVGVGTLDLFHDEDLAYAGRLHAAGV
MAB_0826c|M.abscessus_ATCC_199 ---DADRDIAVPGRRTDVAGLAPAWIGIGTADLFHDEDLAYAERLRTAGV
MMAR_2621|M.marinum_M ---GADPSTAAPARRADLSNLPPAWIGVGTLDLFHQECLDYAARLRDAGV
MUL_3141|M.ulcerans_Agy99 ---GADPSTAAPA-------------------------------------
MLBr_00314|M.leprae_Br4923 NKVDDKPEELYEPLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGV
. .
Rv0217c|M.tuberculosis_H37Rv PCQVEVVEGAFHGFDRVAPNVGVSQRFFTSQCNSLRAALALSNRT-----
Mb0223c|M.bovis_AF2122/97 PCQVEVVEGAFHGFDRVAPNVGVSQRFFTSQCNSLRAALALSNRT-----
MAV_4954|M.avium_104 PCQVETIPGAFHGFDLILPKVQVSQRFFDSQCNSLRAALTPAG-------
Mflv_0442|M.gilvum_PYR-GCK PCEVEVVKGAFHGFDGIAPKAEVSQSFFRSQCALLRGAFEPAAA------
Mvan_0225|M.vanbaalenii_PYR-1 QCEVMVVDGAFHGFDGIAPKADVSQSFFNSQCALLRTVFASAAP------
TH_2573|M.thermoresistible__bu PCEVEVVPGAFHGFDAIAPRAGVSRQFFDSQCAMLRGLLRPEAA------
MSMEG_0280|M.smegmatis_MC2_155 PCEIDVVHGAFHGFDGVAPKAAVSRAFRNAQCAFLKRALT----------
MAB_0826c|M.abscessus_ATCC_199 PCELEVVPGAFHGFDKLVPWAGVSRDFVAKACRSLLGALS----------
MMAR_2621|M.marinum_M EVHEQIADGAFHAFDLLAPNAQVSLGFFASQCQFLRTHLHATVSDQPQAP
MUL_3141|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00314|M.leprae_Br4923 PAEIRVWPGQVHVFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL