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MSVGRLVKALIPLILIAFGVLWPVVFHGGSSASEIDDPVVIADYDVDMVVDDAGDMTAVETLTTEFYTTA RHGIFRYWDVANPNSPYVRQKPEVTSVLLDGRPVPYQMLWEDVGRFRVAKIGDPDRYLSDGTHVFEIRYT IPGVLDPGGTGADRQFAGSTGGPDSSPSVFYWNVIAPAWNNRIDRADITVTLPGDIGTAQCSVGFGVGRE CDELTVDGNRVQLTAESLPPRTPVTLRVGVDVPTPPRAEVLWPHTWDRVLGRSVDGVAWMVGLTVAFGIL ALLWFRSVLERSPGFPLQYAPPPGLGPVQAEYIRTESVSKHGLTATLFYLAERDLVALRQVSDEHWEIKG IAEPGKWADVDPVSIAVASRLKVLNPGSEFDAKKTVKSGEKLNKAKADMAKAVEKWAVESGLLVPRKKEL WLRAANVAAFVLMICGFFRWGFPATMWALPFAAFFLFSAGSWRDGVGTRRTAAGRELWSRAGGFHRMLAT DSAETRFDFSARKDLYTAYIPFAVAAGVAALWAKKYEAYTGAVAPQPDWYGTSTSSSTSRGISGGGGADF DSFESALSSSIGAYTASQSSSSSSSGGGSSSSGGGGGGGGGGGGGSW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2685 | - | - | 100% (607) | hypothetical protein Mvan_2685 |
| M. vanbaalenii PYR-1 | Mvan_2459 | - | 1e-04 | 35.82% (67) | PE_PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-04 | 41.07% (56) | triple helix repeat-containing collagen |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1116 | PE_PGRS21 | 5e-06 | 42.11% (57) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_3732 | - | 0.0 | 78.33% (609) | hypothetical protein Mflv_3732 |
| M. tuberculosis H37Rv | Rv1087 | PE_PGRS21 | 5e-06 | 42.11% (57) | PE-PGRS family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0884 | - | 3e-08 | 40.40% (99) | hypothetical protein MMAR_0884 |
| M. avium 104 | MAV_0118 | - | 5e-05 | 30.30% (99) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_3062 | - | 0.0 | 65.73% (607) | hypothetical protein MSMEG_3062 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1721 | - | 1e-07 | 36.78% (87) | PE_PGRS family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1116|M.bovis_AF2122/97 ---------------MSFVVVAPEVLAAAASDLAGIGSTLAQAN------
Rv1087|M.tuberculosis_H37Rv ---------------MSFVVVAPEVLAAAASDLAGIGSTLAQAN------
MUL_1721|M.ulcerans_Agy99 --------------MSSFVIATPEFLTAAANDLSGIGDAVRAAT------
Mvan_2685|M.vanbaalenii_PYR-1 MSVGRLVKALIPLILIAFGVLWPVVFHGGS-SASEIDDPVVIADYDVDMV
Mflv_3732|M.gilvum_PYR-GCK MTAGRVLKALIPLILIAFGVLWPVVFDGGSGDPTDIDDPVVISHYDVNMA
MSMEG_3062|M.smegmatis_MC2_155 --MRRVVAWTFTLALIVFGLLWPVIFAGGGGDAANVDDPVVITDYRAQFS
MMAR_0884|M.marinum_M --------MDVVLGVAIAGPIARLALVGAAAEGSAVIDQSSVDLAEGPVA
MAV_0118|M.avium_104 ------------MTAPVWMALPPEVHSTLLSSGPGPGPLLAAAATWTGLS
. .
Mb1116|M.bovis_AF2122/97 ---AAALAPTTAVLAAGADEVSAAIASLFGAHGQAYQAVSAQMSAFHAQF
Rv1087|M.tuberculosis_H37Rv ---AAALAPTTAVLAAGADEVSAAIASLFGAHGQAYQAVSAQMSAFHAQF
MUL_1721|M.ulcerans_Agy99 ---GAAAPSTTAIAPLAGDEVSAAVTRMFGAYAQEFQTLSARMEQFYTDC
Mvan_2685|M.vanbaalenii_PYR-1 VDDAGDMTAVETLTTEFYTTARHGIFRYWDVANPNSPYVRQKPEVTSVLL
Mflv_3732|M.gilvum_PYR-GCK IAADGTMTAVETITTEFYSTDRHGIFRYWDVANQNDPHLRQKPEIQSILL
MSMEG_3062|M.smegmatis_MC2_155 IDADGEMKAVETITAEFPS-GRHGIFRYWDVANPNNPHVRQIPEITSIDL
MMAR_0884|M.marinum_M VLTETIVGTNQLLADEGHHLVATRLCWSDQDRAEDLRRALDDSGVLDVAV
MAV_0118|M.avium_104 TQYDSAATELTAVLTGSMPVWDGPTADRYVAAHMPYLAWLQLAGALSAEA
:
Mb1116|M.bovis_AF2122/97 MQALTGAGGAYAAAEA---VNVSAAQSVEQDLLAAINARFERIFGRPLIG
Rv1087|M.tuberculosis_H37Rv MQALTGAGGAYAAAEA---VNVSAAQSVEQDLLAAINARFERIFGRPLIG
MUL_1721|M.ulcerans_Agy99 VRALLTGAGAYSGAEA---ANASPLQTLEQDLLAGINAPSQMLTGRPLIG
Mvan_2685|M.vanbaalenii_PYR-1 DGRPVPYQMLWEDVGR---FRVAKIGDPDRYLSDGTHVFEIRYTIPGVLD
Mflv_3732|M.gilvum_PYR-GCK DGRPVTYQMLWEDAGR---FRVAKIGDADRYLSDGTHVFEIRYTIPGVLD
MSMEG_3062|M.smegmatis_MC2_155 DGRPAPYEMQWADNQR---FRIAKIGDPDSTLSYGTHVFEIAYTVPGVLD
MMAR_0884|M.marinum_M LSESEAVTALLGPAHAGSAVLLVGEETASLSVLGGGDAPPTMLAAAPVEG
MAV_0118|M.avium_104 AAQHQGVATAYTAALA---------AMPTLPELAANHATHAALVATNFFG
. .. . .
Mb1116|M.bovis_AF2122/97 DGANGGPGQDGGPGGLLYGNGGNGGTSTTVGMAGGNGGAAGLIGNGGFGG
Rv1087|M.tuberculosis_H37Rv DGANGGPGQDGGPGGLLYGNGGNGGTSTTVGMAGGNGGAAGLIGNGGFGG
MUL_1721|M.ulcerans_Agy99 NGANG---------------------------------------------
Mvan_2685|M.vanbaalenii_PYR-1 PGGTGADRQFAGSTG-----------GPDSSPSVFYWNVIAPAWNNRIDR
Mflv_3732|M.gilvum_PYR-GCK PGDVGADRQFAETVG-----------GGTPSESVFFWNVIAPAWNNRIER
MSMEG_3062|M.smegmatis_MC2_155 PGSVGADRRFAAESG-----------DPQ-APTTFYWNVIAPAWNNFIRH
MMAR_0884|M.marinum_M DATSTFDTLMAHLDD---------QGGAPGEVLLVGSSEHTTVIADQFRD
MAV_0118|M.avium_104 VNTIPIAVNEADYAR------------MWTQAATTMTTYQATTEAVQMTS
Mb1116|M.bovis_AF2122/97 GGGPGAAGGNGGAGGWLFGNGGAGGAGGLGVAPGVPGGAGGAGGAGGVGG
Rv1087|M.tuberculosis_H37Rv GGGPGAAGGNGGAGGWLFGNGGAGGAGGLGVAPGVPGGAGGAGGAGGVGG
MUL_1721|M.ulcerans_Agy99 VDGTGAAGGD---GGWLVGNGGNGGS-------GAPGQAGGAG------G
Mvan_2685|M.vanbaalenii_PYR-1 ADITVTLPGDIGTAQCSVGFGVGRECDE----LTVDGNRVQLTAESLPPR
Mflv_3732|M.gilvum_PYR-GCK ADVTLTLPGGAGAAQCSVGFGVGRGCDG----LTVDGNRVRFSAQDLPPR
MSMEG_3062|M.smegmatis_MC2_155 ADITVALPADATGAQCSVGYGVGTPCD-----LTVSGNTVRLQADNLEPR
MMAR_0884|M.marinum_M ASTMRVEVPEDPTFALARGAAMAAAGAGSTMAQQVLGGDAGEATTYLPPE
MAV_0118|M.avium_104 VAGSGTGGKAGSGSGSGTGAGTGTGTG-----TGTGTGTGTGTGTGAGSG
. * . .
Mb1116|M.bovis_AF2122/97 PAGLWGHGGAGGAGGAGVAGAGGFEGTIGAGGAGGVGG-----AGGVGGA
Rv1087|M.tuberculosis_H37Rv PAGLWGHGGAGGAGGAGVAGAGGFEGTIGAGGAGGVGG-----AGGVGGA
MUL_1721|M.ulcerans_Agy99 SAGLWGAGGAGGAGGSATTPGG-------AGGAGGTGG-----ANGLIG-
Mvan_2685|M.vanbaalenii_PYR-1 TPVTLRVGVDVPTPPRAEVLWPHTWDRVLGRSVDGVAW-----MVGLTVA
Mflv_3732|M.gilvum_PYR-GCK TPVTVRAGVDVPTPPRATLPWPYTWDRVLGQSVSGAVG-----VGALAVL
MSMEG_3062|M.smegmatis_MC2_155 TPVTLRAGVDVPTPAQAELPWPYTWDPVLGRSVPRVVT-----TGVLTVL
MMAR_0884|M.marinum_M LAATASGQDEDEQLAYSQAGENELLPVTGADEYGDYGPDDDEFADDYEDE
MAV_0118|M.avium_104 TGGGTGAGGGGGTGSFQLPTPEEIWEMLFGPDGEQIPG------------
.
Mb1116|M.bovis_AF2122/97 GGAGGWLYGDAGAGGDGGVGGAGGTGGLGNRGGAGGAGGAGGVGGAGGAA
Rv1087|M.tuberculosis_H37Rv GGAGGWLYGDAGAGGDGGVGGAGGTGGLGNRGGAGGAGGAGGVGGAGGAA
MUL_1721|M.ulcerans_Agy99 -------------GGNGGVGGAG---------GAGAAGGAGAVGSTAQAG
Mvan_2685|M.vanbaalenii_PYR-1 FGILALLWFRSVLERSPGFPLQY----------APPPGLGPVQAEYIRTE
Mflv_3732|M.gilvum_PYR-GCK LGAVALLWFRSVLEKPPGFPLQY----------APPPGLGPVQAEYIRTE
MSMEG_3062|M.smegmatis_MC2_155 AALGALMWLRTTIEPSPGFPVQY----------APPDGLGPVQLEFIRTE
MMAR_0884|M.marinum_M APAGTRLSSRSLLISNAVVAFAVIG------FASLAVAVAVAIRPTASSE
MAV_0118|M.avium_104 -------------QGQPNWSPSE-----------YLQNLGNFFNGNAQAV
. :
Mb1116|M.bovis_AF2122/97 GLWGGGGAGGVGGTGGGAGLGAQSVTFSSSLSG-LSGGDGGAGGAGGAGG
Rv1087|M.tuberculosis_H37Rv GLWGGGGAGGVGGTGGGAGLGAQSVTFSSSLSG-LSGGDGGAGGAGGAGG
MUL_1721|M.ulcerans_Agy99 GTGGDGGAGGAN----------------RQLVS-LFG-AGGAGGADGAGG
Mvan_2685|M.vanbaalenii_PYR-1 SVSKHGLTATLFYLAERDLVALRQVSDEHWEIK-GIAEPGKWADVDPVSI
Mflv_3732|M.gilvum_PYR-GCK SVSKHGLTATLFYLAEQDLIRLRQVNDTHWKIT-STAEPGRWGDVDPVSV
MSMEG_3062|M.smegmatis_MC2_155 AVPSNGLTATLFHLADRGLISLRQESETRWSIR-GMAAPAAWADADEVGI
MMAR_0884|M.marinum_M PVEGHQNAQPGKFMP---LLPTQQQAPVPPPPP-DAPTAGFQGGTIPTVQ
MAV_0118|M.avium_104 AWLQQNLSGLLNPSQFPALINYFIAWQTYRIINWTIRTLRFILQELPLLL
:
Mb1116|M.bovis_AF2122/97 AGGTGGWLYGGGGAAGSGGDGGTGGQGGAGGAGVFSLFGSGGGPGGNGGV
Rv1087|M.tuberculosis_H37Rv AGGTGGWLYGGGGAAGSGGDGGTGGQGGAGGAGVFSLFGSGGGPGGNGGV
MUL_1721|M.ulcerans_Agy99 LGGNG------GDATGFGMTGGDGAMGGAVTVPVNFLAHAGS----DGGI
Mvan_2685|M.vanbaalenii_PYR-1 AVASRLKVLNPGSEFDAKKTVKSGEKLNKAKADMAKAVEKWAVES-----
Mflv_3732|M.gilvum_PYR-GCK AVASRLKIINRGSEFEAKKTAKSGEKLNKAKTDMAKAVESWALDS-----
MSMEG_3062|M.smegmatis_MC2_155 AVGAALKVMSPGATFRADGSVTAGKKLNRAKTDMADAVKKWAFDG-----
MMAR_0884|M.marinum_M GVVPRQATPTVPAPVAPAPAPAPGVVPAPIPLPIPIIIPPWPNWS-----
MAV_0118|M.avium_104 QVGLSLSITSLGGLAGLAGLAGLAGLAAPASAPAPAAMPQPAGMG-----
.
Mb1116|M.bovis_AF2122/97 GGVGGVGGAGGRAGLFGVGGLGGAGGDAGDSGEGGFGGPGLAGGLFGNPG
Rv1087|M.tuberculosis_H37Rv GGVGGVGGAGGRAGLFGVGGLGGAGGDAGDSGEGGFGGPGLAGGLFGNPG
MUL_1721|M.ulcerans_Agy99 G----------------TGGNGGLGGNGGAGGHGGIN-------------
Mvan_2685|M.vanbaalenii_PYR-1 ----------------GLLVPRKKELWLRAANVAAFVLMICGFFRWG-FP
Mflv_3732|M.gilvum_PYR-GCK ----------------GLMVPRRKELWLRAANAVAFILMVCAFFRWG-FP
MSMEG_3062|M.smegmatis_MC2_155 ----------------GLMVRRRKELWLRVANLFAFIAALAGFCLWFGIS
MMAR_0884|M.marinum_M ---------------PGMPTPSTVTVTPTTPTTTAPSTVTPTTPTTTAPS
MAV_0118|M.avium_104 ------------------AQPPVVSAAPAMAPMAPTSPVAPATSAVSTPA
Mb1116|M.bovis_AF2122/97 NGGVGGIGGDAAAGGAG------GAGGNGGWLFGNGGAGGSGGDGGAAGR
Rv1087|M.tuberculosis_H37Rv NGGVGGIGGDAAAGGAGGAGGNGGAGGNGGWLFGNGGAGGSGGDGGAAGR
MUL_1721|M.ulcerans_Agy99 ---TGTRGTASASGGTG----------------GNGGAGGNGGAPGAAN-
Mvan_2685|M.vanbaalenii_PYR-1 ATMWALPFAAFFLFSAG---------------SWRDGVGTRRTAAGRELW
Mflv_3732|M.gilvum_PYR-GCK ATMWAVPFAVFFLLSAG---------------SWRDGVGTRRTAAGRDLW
MSMEG_3062|M.smegmatis_MC2_155 ATMVGLPFAAFFAFSVG---------------CWPAGLGTRRTPAGRQLW
MMAR_0884|M.marinum_M TVTPTTPTTTAPSTLTP--------------TTPTTTVPSTVITPTTTAP
MAV_0118|M.avium_104 PVASAIAPPATPPVPPAP-------------VTGAEGFGYMVGSFGLG--
Mb1116|M.bovis_AF2122/97 GGAGNLGSAGGINAPAGNPGSGSVGIGGAGGAGGTAGLFGDGGAGGAG--
Rv1087|M.tuberculosis_H37Rv GGAGNLGSAGGINAPAGNPGSGSVGIGGAGGAGGTAGLFGDGGAGGAGGA
MUL_1721|M.ulcerans_Agy99 ------------------------AIGGQGGQGGIG---GNGGNGGNG--
Mvan_2685|M.vanbaalenii_PYR-1 S-----------------------RAGGFHRMLATDSAETRFDFSARKDL
Mflv_3732|M.gilvum_PYR-GCK S-----------------------RVGGFHRLLSTDSAESRFDFSARKDL
MSMEG_3062|M.smegmatis_MC2_155 S-----------------------RAGGFHRLLSTDSAETRFDFAARKDL
MMAR_0884|M.marinum_M -------------------------ITPTTVAPTTVNPTTVAPTTVAPTT
MAV_0118|M.avium_104 ------------------------MDSKAQTRARSALAAGRPAASSAGAA
Mb1116|M.bovis_AF2122/97 -AAGGFGGISAATPSAGSEGAMGGAGGVGGNARLLGTGGAGGVGGGGGAG
Rv1087|M.tuberculosis_H37Rv GAAGGFGGISAATPSAGSEGAMGGAGGVGGNARLLGTGGAGGVGGGGGAG
MUL_1721|M.ulcerans_Agy99 -----------GTASSSNTGPTPSAG-----------TGGGGTGGGGGGG
Mvan_2685|M.vanbaalenii_PYR-1 YTAYIPFAVAAGVAALWAKKYEAYTGAVAPQPDWYGTSTSSSTSRGISGG
Mflv_3732|M.gilvum_PYR-GCK YIAYVPFAVAAGVAAVWAQKYQDYTGSVAPQPEWYGSSHSSSSGTAFSGG
MSMEG_3062|M.smegmatis_MC2_155 YVAYIPFAVAAGTAALWAKKYQASVGDIAPQPDWYHS--SSDGGWKFSDG
MMAR_0884|M.marinum_M QQTVVPQPTQETVAPLPTQQTVAPQPTIAPQPTQQAPEPPSGGSSGGSSG
MAV_0118|M.avium_104 AVEQEQGRTRRRPRSVIDPGYRYEFIEGDDEVVAVASAAQDRYRPSDSGG
. . . *
Mb1116|M.bovis_AF2122/97 GDGGRGGVATPGGQGGDAGDGGAGGAGGNGGGGASGAGGWLLGTGGAGGA
Rv1087|M.tuberculosis_H37Rv GDGGRGGVATPGGQGGDAGDGGAGGAGGNGGG-ASGAGGWLLGTGGAGGA
MUL_1721|M.ulcerans_Agy99 GGGGGGGASASG---------AVGGTGGGGGG------------GGAGAA
Mvan_2685|M.vanbaalenii_PYR-1 -GGADFDSFESALSSSIGAYTASQSSSSSSSG------------GGSSSS
Mflv_3732|M.gilvum_PYR-GCK AGGGDFDSFESALSSSIGAYTASQASSSSSGG------------GSSSSS
MSMEG_3062|M.smegmatis_MC2_155 GGGTSFDSFESALSSSISAYTASQSSSSSSSG------------GGGSS-
MMAR_0884|M.marinum_M GGSSSGGGSSSGGGSSSGGGSSSGGGSSSGGG---------SSSGGGSSS
MAV_0118|M.avium_104 SIQGFAGTLPKSGVRASGLNTLAGNESGDGAR---------------IPM
. . .....
Mb1116|M.bovis_AF2122/97 GGNGGNGGKAGFSPGPTNFGLNGAGGGGGVGGNGATGPWLFGDGGAGGGG
Rv1087|M.tuberculosis_H37Rv GGNGGNGGKAGFSPGPTNFGLNGAGGGGGVGGNGATGPWLFGDG------
MUL_1721|M.ulcerans_Agy99 AGTGAVGG-----------------GGGGAAPPAAP--------------
Mvan_2685|M.vanbaalenii_PYR-1 GGGGGGGG----------------GGGGGSW-------------------
Mflv_3732|M.gilvum_PYR-GCK GGGGGGGG----------------GGGGGSW-------------------
MSMEG_3062|M.smegmatis_MC2_155 GGGGGGGG----------------GGGGGSW-------------------
MMAR_0884|M.marinum_M GGGSSSGG-------------GSSSGGGSSSGRGSS--------------
MAV_0118|M.avium_104 LPESWDGP------------------------------------------
. *
Mb1116|M.bovis_AF2122/97 GAGGIGGDGGPTPGSTGAGAAGGHGGDAQLIGNGGHGGAGGTGVPNGSGG
Rv1087|M.tuberculosis_H37Rv ---------GPTPGSTGAGAAGGHGGDAQLIGNGGHGGAGGTGVPNGSGG
MUL_1721|M.ulcerans_Agy99 ----------VAPPEMEAREATP---------------------------
Mvan_2685|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3732|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3062|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0884|M.marinum_M -----------SGGSSSGGHSSGGGS------------------------
MAV_0118|M.avium_104 --------------------------------------------------
Mb1116|M.bovis_AF2122/97 AGGLSGLLFGEPGANG
Rv1087|M.tuberculosis_H37Rv AGGLSGLLFGEPGANG
MUL_1721|M.ulcerans_Agy99 ----------------
Mvan_2685|M.vanbaalenii_PYR-1 ----------------
Mflv_3732|M.gilvum_PYR-GCK ----------------
MSMEG_3062|M.smegmatis_MC2_155 ----------------
MMAR_0884|M.marinum_M ----------------
MAV_0118|M.avium_104 ----------------