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VRRVVAWTFTLALIVFGLLWPVIFAGGGGDAANVDDPVVITDYRAQFSIDADGEMKAVETITAEFPSGRH GIFRYWDVANPNNPHVRQIPEITSIDLDGRPAPYEMQWADNQRFRIAKIGDPDSTLSYGTHVFEIAYTVP GVLDPGSVGADRRFAAESGDPQAPTTFYWNVIAPAWNNFIRHADITVALPADATGAQCSVGYGVGTPCDL TVSGNTVRLQADNLEPRTPVTLRAGVDVPTPAQAELPWPYTWDPVLGRSVPRVVTTGVLTVLAALGALMW LRTTIEPSPGFPVQYAPPDGLGPVQLEFIRTEAVPSNGLTATLFHLADRGLISLRQESETRWSIRGMAAP AAWADADEVGIAVGAALKVMSPGATFRADGSVTAGKKLNRAKTDMADAVKKWAFDGGLMVRRRKELWLRV ANLFAFIAALAGFCLWFGISATMVGLPFAAFFAFSVGCWPAGLGTRRTPAGRQLWSRAGGFHRLLSTDSA ETRFDFAARKDLYVAYIPFAVAAGTAALWAKKYQASVGDIAPQPDWYHSSSDGGWKFSDGGGGTSFDSFE SALSSSISAYTASQSSSSSSSGGGGSSGGGGGGGGGGGGGSW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3062 | - | - | 100% (602) | hypothetical protein MSMEG_3062 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3420 | PE_PGRS52 | 2e-06 | 37.50% (80) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_3732 | - | 0.0 | 63.86% (606) | hypothetical protein Mflv_3732 |
| M. tuberculosis H37Rv | Rv0746 | PE_PGRS9 | 1e-07 | 40.62% (64) | PE-PGRS family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0884 | - | 5e-07 | 36.08% (97) | hypothetical protein MMAR_0884 |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1721 | - | 1e-06 | 62.86% (35) | PE_PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_2685 | - | 0.0 | 65.73% (607) | hypothetical protein Mvan_2685 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3420|M.bovis_AF2122/97 ---MSFVIANPEMLAAAATDLAGIRSAISAATAAAAAPTIQVAAAGADEV
MUL_1721|M.ulcerans_Agy99 --MSSFVIATPEFLTAAANDLSGIGDAVRAATGAAAPSTTAIAPLAGDEV
Rv0746|M.tuberculosis_H37Rv ---MSFVLAMPEVLGSAATDLAALGSVLGAADAAAAATTTGIVAAAQDEV
Mflv_3732|M.gilvum_PYR-GCK ---MTAGRVLKALIPLILIAFGVLWPVVFDGGSGDPTDIDDPVVISHYDV
Mvan_2685|M.vanbaalenii_PYR-1 ---MSVGRLVKALIPLILIAFGVLWPVVFHGGS-SASEIDDPVVIADYDV
MSMEG_3062|M.smegmatis_MC2_155 -----MRRVVAWTFTLALIVFGLLWPVIFAGGGGDAANVDDPVVITDYRA
MMAR_0884|M.marinum_M MDVVLGVAIAGPIARLALVGAAAEGSAVIDQSSVDLAEGPVAVLTETIVG
. .: . . .
Mb3420|M.bovis_AF2122/97 SLAISALFGQHAQAYQALSAQATIFHDQFVQALTSGGNLYAAAES-----
MUL_1721|M.ulcerans_Agy99 SAAVTRMFGAYAQEFQTLSARMEQFYTDCVRALLTGAGAYSGAEAA----
Rv0746|M.tuberculosis_H37Rv SAAIAALFSAHGRAYQVASAQAAAVHAQFVEALSAGAGAYASAEAAGAAV
Mflv_3732|M.gilvum_PYR-GCK NMAIAADGTMTAVETITTEFYSTDRHGIFRYWDVANQNDPHLRQKP----
Mvan_2685|M.vanbaalenii_PYR-1 DMVVDDAGDMTAVETLTTEFYTTARHGIFRYWDVANPNSPYVRQKP----
MSMEG_3062|M.smegmatis_MC2_155 QFSIDADGEMKAVETITAEFPS-GRHGIFRYWDVANPNNPHVRQIP----
MMAR_0884|M.marinum_M TNQLLADEGHHLVATRLCWSDQDRAEDLRRALDDSGVLDVAVLSES----
: :. .
Mb3420|M.bovis_AF2122/97 -----HTVEQMVLNAINAPTQTLFGR------PLIGDGANGTAENPDGQN
MUL_1721|M.ulcerans_Agy99 NASPLQTLEQDLLAGINAPSQMLTGR------PLIGNGAN----------
Rv0746|M.tuberculosis_H37Rv LANPAQSVQQDLLAAVNAQSVALTGR------PLIGNGANG---------
Mflv_3732|M.gilvum_PYR-GCK ------EIQSILLDGRPVTYQMLWEDAGRFRVAKIG--------------
Mvan_2685|M.vanbaalenii_PYR-1 ------EVTSVLLDGRPVPYQMLWEDVGRFRVAKIG--------------
MSMEG_3062|M.smegmatis_MC2_155 ------EITSIDLDGRPAPYEMQWADNQRFRIAKIG--------------
MMAR_0884|M.marinum_M ------EAVTALLGPAHAGSAVLLVGEETASLSVLGGGDAP---------
* . . :*
Mb3420|M.bovis_AF2122/97 GGLLFGNGGNGFTQTTAGVAGGNGGSAGLIGNGGAGGIGGAGTGTGGHGG
MUL_1721|M.ulcerans_Agy99 --------------------------------------------------
Rv0746|M.tuberculosis_H37Rv ---------------APGTGANGAPGGWLLGNGGAGGSAAAGSGLPG---
Mflv_3732|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2685|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3062|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0884|M.marinum_M --------------------------------------------------
Mb3420|M.bovis_AF2122/97 AGGAGGRAWLWGTGGAGGAGAAAIGNAVTPGGAGGAGGAGGDGGWLFGDG
MUL_1721|M.ulcerans_Agy99 -------------------------------GVDGTGAAGGDGGWLVGNG
Rv0746|M.tuberculosis_H37Rv --GAGGAAGLFGTGGAGGAGGS------STVGDGEAGGAGGSGGWLLGTG
Mflv_3732|M.gilvum_PYR-GCK -----------DADRYLSDGTHVFEIRYTIPGVLDPGDVGADRQFAETVG
Mvan_2685|M.vanbaalenii_PYR-1 -----------DPDRYLSDGTHVFEIRYTIPGVLDPGGTGADRQFAGSTG
MSMEG_3062|M.smegmatis_MC2_155 -----------DPDSTLSYGTHVFEIAYTVPGVLDPGSVGADRRFAAESG
MMAR_0884|M.marinum_M ---------PTMLAAAPVEGDATSTFDTLMAHLDDQGGAPGEVLLVGSSE
* . ..
Mb3420|M.bovis_AF2122/97 GAGGTGGNGGS-----GFNSLTSSVGGAGGAGGHAGLFGAGGTGGTGGIG
MUL_1721|M.ulcerans_Agy99 GNGGSGAPG-----------------QAGGAGGSAGLWGAGGAGGAG---
Rv0746|M.tuberculosis_H37Rv GVGGVGGLG-------------AGAGGAGGVGGAGGLLGAGGHGGAGGLG
Mflv_3732|M.gilvum_PYR-GCK GGTPSESVFFWNVIAPAWNNRIERADVTLTLPGGAGAAQCSVGFGVGRGC
Mvan_2685|M.vanbaalenii_PYR-1 GPDSSPSVFYWNVIAPAWNNRIDRADITVTLPGDIGTAQCSVGFGVGREC
MSMEG_3062|M.smegmatis_MC2_155 DPQ-APTTFYWNVIAPAWNNFIRHADITVALPADATGAQCSVGYGVGTPC
MMAR_0884|M.marinum_M HTTVIADQFR-----DASTMRVEVPEDPTFALARGAAMAAAGAGSTMAQQ
. . .. ..
Mb3420|M.bovis_AF2122/97 GQNTETGPAASNGGAGGAGGGGGYLVGDGGAGGTGGAGGKNSSGGATLTG
MUL_1721|M.ulcerans_Agy99 ------GSATTPGGAG-------------GAGGTGGANG-------LIGG
Rv0746|M.tuberculosis_H37Rv ---AVTGGVGGTGGAGGLLAG--LLAGPGGAGGTGGRGFLNNGGVGGAGG
Mflv_3732|M.gilvum_PYR-GCK DGLTVDGNRVRFSAQDLPPRTPVTVRAGVDVPTPPRATLPWPYTWDRVLG
Mvan_2685|M.vanbaalenii_PYR-1 DELTVDGNRVQLTAESLPPRTPVTLRVGVDVPTPPRAEVLWPHTWDRVLG
MSMEG_3062|M.smegmatis_MC2_155 D-LTVSGNTVRLQADNLEPRTPVTLRAGVDVPTPAQAELPWPYTWDPVLG
MMAR_0884|M.marinum_M VLGGDAGEATTYLPPELAATASGQDEDEQLAYSQAGENELLPVTGADEYG
* . *
Mb3420|M.bovis_AF2122/97 ------GTGGTGGAGGAAGWLYGSGGAGGAGGLNNAGGATGGTGGTGGAG
MUL_1721|M.ulcerans_Agy99 ------GNGGVGGAGGAG----AAGGAGAVGSTAQAG----GTGGDGGAG
Rv0746|M.tuberculosis_H37Rv NAGLLFGAGGTGGSGGAG--LGGDGGAGGAGGNTGVLFGNAGSGGTGGFG
Mflv_3732|M.gilvum_PYR-GCK -----QSVSGAVGVGALAVLLGAVALLWFRSVLEKPPGFPLQYAPPPGLG
Mvan_2685|M.vanbaalenii_PYR-1 -----RSVDGVAWMVGLTVAFGILALLWFRSVLERSPGFPLQYAPPPGLG
MSMEG_3062|M.smegmatis_MC2_155 -----RSVPRVVTTGVLTVLAALGALMWLRTTIEPSPGFPVQYAPPDGLG
MMAR_0884|M.marinum_M ----DYGPDDDEFADDYEDEAPAGTRLSSRSLLISNAVVAFAVIGFASLA
. . .
Mb3420|M.bovis_AF2122/97 GSGAWLYGNGGAA---GAGGNGGNNTSAGTGGVGASGGTGGNAGLIGAGG
MUL_1721|M.ulcerans_Agy99 GANRQLVS------------------------------------LFGAGG
Rv0746|M.tuberculosis_H37Rv DTDGGAGGAGGDAGWLGSGGVGGAGGFGETGDGGVGGAGGKAGLLIGNGG
Mflv_3732|M.gilvum_PYR-GCK PVQAEYIRTESVS------------------------KHGLTATLFYLAE
Mvan_2685|M.vanbaalenii_PYR-1 PVQAEYIRTESVS------------------------KHGLTATLFYLAE
MSMEG_3062|M.smegmatis_MC2_155 PVQLEFIRTEAVP------------------------SNGLTATLFHLAD
MMAR_0884|M.marinum_M VAVAVAIRPTASS---------------EPVEGHQNAQPGKFMPLLPTQQ
*:
Mb3420|M.bovis_AF2122/97 HGGAGGAGGNQTGGVGNGGAGGNGGAGGAGGQLYGNGGDGGNGGAG----
MUL_1721|M.ulcerans_Agy99 AGGADGAGG----------------LGGNGGDATGFGMTGGDGAMG----
Rv0746|M.tuberculosis_H37Rv AGGAGGQGAVTGGTGGAGGDGVLIGNGGNAG-IGGTGPTAGDTGAGGISG
Mflv_3732|M.gilvum_PYR-GCK QDLIRLRQV-----------------NDTHWKITSTAEPGRWGDVDPVS-
Mvan_2685|M.vanbaalenii_PYR-1 RDLVALRQV-----------------SDEHWEIKGIAEPGKWADVDPVS-
MSMEG_3062|M.smegmatis_MC2_155 RGLISLRQE-----------------SETRWSIRGMAAPAAWADADEVG-
MMAR_0884|M.marinum_M QAPVPPPPP-----------------DAPTAGFQGGTIPTVQGVVPRQAT
. .
Mb3420|M.bovis_AF2122/97 ----------------------------------------------GANI
MUL_1721|M.ulcerans_Agy99 ----------------------------------------------GAVT
Rv0746|M.tuberculosis_H37Rv LLLGADGFNTPASASPLHTLKQQALAAINAPTQTLTGRPLIGNGTPGAVG
Mflv_3732|M.gilvum_PYR-GCK ----------------------------------------------VAVA
Mvan_2685|M.vanbaalenii_PYR-1 ----------------------------------------------IAVA
MSMEG_3062|M.smegmatis_MC2_155 ----------------------------------------------IAVG
MMAR_0884|M.marinum_M P--------------------------------------------TVPAP
.
Mb3420|M.bovis_AF2122/97 AGGNGSDG-GAAGHGGAGGSARLIGAGGHGGDGGAGGNTAGRRADAIAGT
MUL_1721|M.ulcerans_Agy99 VPVN------FLAHAGS--------------DGGIG-------------T
Rv0746|M.tuberculosis_H37Rv SGATGAPGGWLLGDGGAGGSGAAGSGAPGGAGGAAGLWGTGGAGGAGGSS
Mflv_3732|M.gilvum_PYR-GCK SRLKIINRGSEFEAKKTAKSGEKLNKAKTDMAKAVESWALDSGLMVPRRK
Mvan_2685|M.vanbaalenii_PYR-1 SRLKVLNPGSEFDAKKTVKSGEKLNKAKADMAKAVEKWAVESGLLVPRKK
MSMEG_3062|M.smegmatis_MC2_155 AALKVMSPGATFRADGSVTAGKKLNRAKTDMADAVKKWAFDGGLMVRRRK
MMAR_0884|M.marinum_M VAPAPAPAPGVVPAPIPLPIPIIIPPWPNWSPGMPTPSTVTVTPTTPTTT
. .
Mb3420|M.bovis_AF2122/97 GGDGGNGGNGGLLSGNAGAGGHGGAGGSSTATT-TTGTPPTGATGGNGGN
MUL_1721|M.ulcerans_Agy99 GGNGGLGGNG-------GAGGHG------------------------GIN
Rv0746|M.tuberculosis_H37Rv AGGGGAGGAGGAGGWLLGDGGAGGIGGASTVLGGTGGGGGVGGLWGAGGA
Mflv_3732|M.gilvum_PYR-GCK ELWLRAANAVAFILMVCAFFRWG-FPATMWAVP-------FAVFFLLSAG
Mvan_2685|M.vanbaalenii_PYR-1 ELWLRAANVAAFVLMICGFFRWG-FPATMWALP-------FAAFFLFSAG
MSMEG_3062|M.smegmatis_MC2_155 ELWLRVANLFAFIAALAGFCLWFGISATMVGLP-------FAAFFAFSVG
MMAR_0884|M.marinum_M APSTVTPTTPTTTAPSTVTPTTPTTTAPSTLTPTTPTTTVPSTVITPTTT
Mb3420|M.bovis_AF2122/97 GGAGGTAGFTGSGGIGGNGGAG--------------GTG-----GNAGVA
MUL_1721|M.ulcerans_Agy99 TGTRGTA--SASGGTGGNGGAG--------------GNG-----GAPGAA
Rv0746|M.tuberculosis_H37Rv GGAGGTGLVGGDGGAGGAGGTGGLLAGLIGAGGGHGGTGGLSTNGDGGVG
Mflv_3732|M.gilvum_PYR-GCK SWRDGVGTRRTAAGRDLWSRVG----------------------GFHRLL
Mvan_2685|M.vanbaalenii_PYR-1 SWRDGVGTRRTAAGRELWSRAG----------------------GFHRML
MSMEG_3062|M.smegmatis_MC2_155 CWPAGLGTRRTPAGRQLWSRAG----------------------GFHRLL
MMAR_0884|M.marinum_M APITPTTVAPTTVNPTTVAPTTVAP-------------------TTQQTV
. . .
Mb3420|M.bovis_AF2122/97 LSVGSTGGLGGNGGSGGLGGGGGSLFGNGGAGGVGATGGNAGSGIGPASV
MUL_1721|M.ulcerans_Agy99 NAIG------GQGGQGGIGGNGG----NGGNGGTASS-----SNTGPTPS
Rv0746|M.tuberculosis_H37Rv GAGGNAGMLAGPGGAGGAGGDGEN-LDTGGDGGAGGSAGLLFGSGGAGGA
Mflv_3732|M.gilvum_PYR-GCK STDSAESRFDFSARKDLYIAYVPFAVAAGVAAVWAQKYQDYTGSVAPQPE
Mvan_2685|M.vanbaalenii_PYR-1 ATDSAETRFDFSARKDLYTAYIPFAVAAGVAALWAKKYEAYTGAVAPQPD
MSMEG_3062|M.smegmatis_MC2_155 STDSAETRFDFAARKDLYVAYIPFAVAAGTAALWAKKYQASVGDIAPQPD
MMAR_0884|M.marinum_M VPQPTQETVAPLPTQQTVAPQPTIAPQPTQQAPEPPSGGSSGGSSGGGSS
. . . . .
Mb3420|M.bovis_AF2122/97 GGNGGKGGVGAAGGLA-GQIGNGGSGGSGGAGGNGGTGDTAGNG---GNG
MUL_1721|M.ulcerans_Agy99 AGTGG-GGTGGGG-------GGGGGGGGGGASASGAVGGTGGGG---GGG
Rv0746|M.tuberculosis_H37Rv GGFGFLGGDGGAGGNAGLLLSSGGAGGFGGFGTAGGVGGAGGNAGWLGFG
Mflv_3732|M.gilvum_PYR-GCK WYGSSHSSSSGTA-------FSGGAGGGDFDSFESALSSSIGAYTASQAS
Mvan_2685|M.vanbaalenii_PYR-1 WYGTSTSSSTSRG-------ISGG-GGADFDSFESALSSSIGAYTASQSS
MSMEG_3062|M.smegmatis_MC2_155 WYHS--SSDGGWK-------FSDGGGGTSFDSFESALSSSISAYTASQSS
MMAR_0884|M.marinum_M SGGGSSSGGGSSS-------GGGSSSGGGSSSGGGSSSGGGSSSGGGSSS
.. . ... .* . . .. .. . .
Mb3420|M.bovis_AF2122/97 GAGAVGGNAQLIGNGGNGGGGGNGGTGATPGTGGAGAAGGTGGTLFGAPG
MUL_1721|M.ulcerans_Agy99 GAGAAAG------TGAVGGGGGGAAPPAAP---------------VAPPE
Rv0746|M.tuberculosis_H37Rv GAGGVGGSAGLIGTGGNGGNGGTGANAGSPGTGGAG------GLLLGQNG
Mflv_3732|M.gilvum_PYR-GCK SSSSGGGSSSSSGGGGGGGGGGGGGSW-----------------------
Mvan_2685|M.vanbaalenii_PYR-1 SSSSSGGGSSSSGGGGGGGGGGGGGSW-----------------------
MSMEG_3062|M.smegmatis_MC2_155 SSSSSGGGGSS-GGGGGGGGGGGGGSW-----------------------
MMAR_0884|M.marinum_M GGGSSSGGGSSSGRGSSSGGSSSGGHSSGGGS------------------
.... .* *. .*... ..
Mb3420|M.bovis_AF2122/97 TTGADGT-
MUL_1721|M.ulcerans_Agy99 MEAREATP
Rv0746|M.tuberculosis_H37Rv LNGLP---
Mflv_3732|M.gilvum_PYR-GCK --------
Mvan_2685|M.vanbaalenii_PYR-1 --------
MSMEG_3062|M.smegmatis_MC2_155 --------
MMAR_0884|M.marinum_M --------