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IPKQTVNMTDVARRSGVSIASVSRALRGESGVSAATRDRILSAARELAYVVSPEASRLSGGPTGRVGVIV PRVDAWFYSTILAGIADEFDTVGMDLILCTLPTSAARHRFFEALPLRRKVDAAVVVSLPLSARERTRLDQ LAVPTVFVGGHRTEDHRPWVGIDDERAAQQAVGHLLRIGHHDIAMIQAADDTDIPWATDQARIRGFHQTM QEAGLADPTVVTVKWSVDGGSHGMETLLSRSRPPTAVFCHSDEIALGALRTLRRSGISVPQQVSVIGVDD HPAAELSDLTTVAQPVREQGRIAARVVLGGLGDGDASGPPASVTTLPTRLVVRGSTAPPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2545 | - | - | 100% (341) | periplasmic binding protein/LacI transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0385 | - | 8e-27 | 30.41% (342) | periplasmic binding protein/LacI transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5317 | - | 2e-25 | 29.97% (367) | periplasmic binding protein/LacI transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3606c | - | 1e-24 | 29.64% (361) | transcriptional regulatory protein LacI-family |
| M. gilvum PYR-GCK | Mflv_1457 | - | 5e-26 | 29.86% (365) | periplasmic binding protein/LacI transcriptional regulator |
| M. tuberculosis H37Rv | Rv3575c | - | 1e-24 | 29.64% (361) | transcriptional regulatory protein LacI-family |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2023c | - | 8e-09 | 25.88% (340) | LacI family transcriptional regulator |
| M. marinum M | MMAR_5070 | - | 1e-23 | 28.81% (361) | PurR family transcriptional regulator |
| M. avium 104 | MAV_0585 | - | 7e-23 | 28.81% (361) | transcriptional regulator, LacI family protein |
| M. smegmatis MC2 155 | MSMEG_0491 | - | 5e-33 | 32.95% (349) | transcriptional regulator, LacI family protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4146 | - | 2e-23 | 28.53% (361) | PurR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2545|M.vanbaalenii_PYR-1 ----MIPKQTVNMTDVARRSGVSIASVSRALRGES--GVSAATRDRILSA
MSMEG_0491|M.smegmatis_MC2_155 ---------MGTLADVARAAGVSVSIASRALSGDTRARMSEATRARVLAA
Mb3606c|M.bovis_AF2122/97 --MSPTPRRRATLASLAAELKVSRTTVSNAFNRPD--QLSADLRERVLAT
Rv3575c|M.tuberculosis_H37Rv --MSPTPRRRATLASLAAELKVSRTTVSNAFNRPD--QLSADLRERVLAT
MMAR_5070|M.marinum_M --MSPTPRRRATLASLAAELKVSRSTISNAFNRPD--QLSAELRERVLAT
MUL_4146|M.ulcerans_Agy99 --MSPTPRRRATLASLAAELKVSRSTISNAFNRPD--QLSVELRERVLAT
MAV_0585|M.avium_104 --MSPTPRRRATLASLADELKVSRTTVSNAFNRPD--QLSADLRERVLAT
Mflv_1457|M.gilvum_PYR-GCK MSRSPTPRRRATLASLAAELKVSRTTVSNAYNRPD--QLSAELRERVLST
MAB_2023c|M.abscessus_ATCC_199 -------------------MGLSKTTVADALGGSG--RVSEATREKTRLV
:* : : * :* * : .
Mvan_2545|M.vanbaalenii_PYR-1 ARELAY-VVSPEASRLSGGPTGRVGVIVPRVDAWFYST-----ILAGIAD
MSMEG_0491|M.smegmatis_MC2_155 ADELNY-VPNARARALRHSRSGTIGLIVPDVNNAVFAD-----MFSGVQM
Mb3606c|M.bovis_AF2122/97 AKRLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVAGVAQ
Rv3575c|M.tuberculosis_H37Rv AKRLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVAGVAQ
MMAR_5070|M.marinum_M AKRMGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVTGVAQ
MUL_4146|M.ulcerans_Agy99 AKRMGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVTGVAQ
MAV_0585|M.avium_104 AKRLGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVTGVAQ
Mflv_1457|M.gilvum_PYR-GCK AKRLGYPGPDPVARSLRTRRAGAVGLVITEPLNYSFSDPAALDFVAGLAE
MAB_2023c|M.abscessus_ATCC_199 AERMGY-VSNRAARLLRRNETGALGLYIPGDVRNLSFY---MELAFGAAD
* .: * . * * :* :*: :. : *
Mvan_2545|M.vanbaalenii_PYR-1 EFDTVGMDLILCTLPTSAARHRFFEALPLRRKVDAAVVVSLPLSARERTR
MSMEG_0491|M.smegmatis_MC2_155 AASGHSTDVLLGQIDAPPRGTQQLSRLVSEGRVDGVLLQRREDFDDDMLA
Mb3606c|M.bovis_AF2122/97 SCEELGQGLQLVSVGSSRSLADGTAAVLGAG-VDGFVVYSVGDDDPYLQV
Rv3575c|M.tuberculosis_H37Rv SCEELGQGLQLVSVGSSRSLADGTAAVLGAG-VDGFVVYSVGDDDPYLQV
MMAR_5070|M.marinum_M SCEELGQGLLLVAVGASRSLEDGTAAVLNAG-VDGFVVYSVRDDDPYLQV
MUL_4146|M.ulcerans_Agy99 SCEELGQGLLLVAVGASRSLEDGTAAVLNAG-VDGFVVYSVRDDDPYLQV
MAV_0585|M.avium_104 SCEALGQGLLLVAVGPSRSLDEGTAAVLSAG-VDGFVVYSVCDDDPYLQA
Mflv_1457|M.gilvum_PYR-GCK SCEAVGQGLLLVAVGPNRSVAEGSAAVLAAG-VDGFVVYSASDDDPYLPA
MAB_2023c|M.abscessus_ATCC_199 ESAALGLDLTLIGRHLTGENRS------RPPQVDGIIAVDPVPGDAALES
. .: * **. :
Mvan_2545|M.vanbaalenii_PYR-1 LDQLAVPTVFVGGHRTEDH---RPWVGIDDERAAQQAVGHLLRIGHHDIA
MSMEG_0491|M.smegmatis_MC2_155 AVLEGVPAVTIN-SRVPGR---VGSVILDDQKGGGIATEHLITLGHSRIA
Mb3606c|M.bovis_AF2122/97 VLQRRLPVVVVDQPKDLSG---VSRVGIDDRAAMRELAGYVLGLGHRELG
Rv3575c|M.tuberculosis_H37Rv VLQRRLPVVVVDQPKDLSG---VSRVGIDDRAAMRELAGYVLGLGHRELG
MMAR_5070|M.marinum_M VLQRRLPVVVVDQPKELAG---VSRVGIDDRAAMRKIADYVLGLGHRQIG
MUL_4146|M.ulcerans_Agy99 VLQRRLPVVVVDQPKELAG---VSRVGIDDRAAMRKIADYVLSLGHRQIG
MAV_0585|M.avium_104 VLQRRLPVVVVDQPKGLTG---VSRVGIDDRAAMRELADYVLGLGHREIG
Mflv_1457|M.gilvum_PYR-GCK VMERHLPVVVVDQPRDVPG---ASQVRIDDRAAMRSLAEHVIDLGHREIG
MAB_2023c|M.abscessus_ATCC_199 LLTSNVPIVTVGRILDKDVSHHAAEIEIDHYRMVTLLLDAIRAAGGKRPA
:* * :. : :*. : * .
Mvan_2545|M.vanbaalenii_PYR-1 MIQAADDTDIPWA-----------------TDQARIRGFHQTMQEAGLAD
MSMEG_0491|M.smegmatis_MC2_155 FISGTAIHDT---------------------AQRRKEGYLETLASAGLRS
Mb3606c|M.bovis_AF2122/97 LLTMRLGRDRRQD----LVDAERLRSPTFDVQRERIVGVWEAMTAAGVDP
Rv3575c|M.tuberculosis_H37Rv LLTMRLGRDRRQD----LVDAERLRSPTFDVQRERIVGVWEAMTAAGVDP
MMAR_5070|M.marinum_M LLTMRLGRDRRQD----LVDAERLKSPTFDVQRERITGVWEAMTAAGVDP
MUL_4146|M.ulcerans_Agy99 LLTMRLGRDRRQD----LVDAERLKSPTFDVQRERITGVWEAMTAAGVDP
MAV_0585|M.avium_104 LLTMRLGRDRRQG----LVDAERLRSPAFDVQRERITGVWEAMTAAGVDP
Mflv_1457|M.gilvum_PYR-GCK LLTMRLGRDWPHGPGPALADPERVRAPNFHVQCERIHGVYDAMTAAGLDP
MAB_2023c|M.abscessus_ATCC_199 LAALDQGADSSYV-------------------FDVSRGYQEWCAKAGVVP
: * * : **:
Mvan_2545|M.vanbaalenii_PYR-1 PT--VVTVKWSVDGGSHGMETLLS-----RSRPPTAVFCHSDEIALGALR
MSMEG_0491|M.smegmatis_MC2_155 EAAWVVDAGWEADAGSAALNTLYRGANLGKPDGPTAVVVASVNAAVGALS
Mb3606c|M.bovis_AF2122/97 DSLTVVESYEHLPTSGGTAAKVALQAN----PRLTALMCTADILALSAMD
Rv3575c|M.tuberculosis_H37Rv DSLTVVESYEHLPTSGGTAAKVALQAN----PRLTALMCTADILALSAMD
MMAR_5070|M.marinum_M ESLTVVESYEHLPTSGGDAAKVALEAN----PRITALMCTADILALSAMD
MUL_4146|M.ulcerans_Agy99 ESLTVVESYEHLPTSGGDAAKVALEAN----PRITALMCTADILALSAMD
MAV_0585|M.avium_104 DSLTVVESYEHLPESGGAAAKVALEAN----PRITALMCTADILALSAMD
Mflv_1457|M.gilvum_PYR-GCK ASLTLVESYEHLPTSGGAGADIALEAN----PRITALMCTADVLALSAMD
MAB_2023c|M.abscessus_ATCC_199 LATRLSATPTDVELAQAIRGIVEHQG-------IDALVVGAQGLAARSLP
: : . : *:. : * ::
Mvan_2545|M.vanbaalenii_PYR-1 TLRRSGISVPQQVSVIGVDDHPAAELS--DLTTVAQPVREQGRIAARVVL
MSMEG_0491|M.smegmatis_MC2_155 TALRLGLRVPEDLSIVGINTTWVSDTVYPALTTVRLPLQRLGEVAADVLM
Mb3606c|M.bovis_AF2122/97 YLRAHGIYVPGQMTVTGFDG--VPEALSRGLTTVAQPSLHKGHRAGELLL
Rv3575c|M.tuberculosis_H37Rv YLRAHGIYVPGQMTVTGFDG--VPEALSRGLTTVAQPSLHKGHRAGELLL
MMAR_5070|M.marinum_M YLRGHGIYVPGQMTVTGFDG--VPEAISRGLTTVSQPSLQKGRRAGELLQ
MUL_4146|M.ulcerans_Agy99 YLRGHGIYVPGQMTVTGFDG--VPEAISRGLTTVSQPSLQKGRRAGELLQ
MAV_0585|M.avium_104 YLRAHGVYVPGQLTVTGFDG--VPDAISRGLTTVSQSSLHKGRRAGELLL
Mflv_1457|M.gilvum_PYR-GCK HLRAKGIYVPGQMTVTGFDG--VPEARQRGLTTVAQPGVEKGRRAGELLH
MAB_2023c|M.abscessus_ATCC_199 VLQSLGHEVGSNFHLGTLVGDPATELTNPDIHAVDLRPREFGHQAVTFLH
* * :. : . ..: : :* . *. * .:
Mvan_2545|M.vanbaalenii_PYR-1 GGLGDGDASGPPASVTTLPTRLVVRGSTAPPR-------
MSMEG_0491|M.smegmatis_MC2_155 EHLGG--RALTDTVVTQPTPELLVRETTAPPTRD-----
Mb3606c|M.bovis_AF2122/97 KPPRSG-----LPVIEVLDTELVRGRTAGPPA-------
Rv3575c|M.tuberculosis_H37Rv KPPRSG-----LPVIEVLDTELVRGRTAGPPA-------
MMAR_5070|M.marinum_M NPPRSG-----LPVVELLDTELIRGRTAGPPA-------
MUL_4146|M.ulcerans_Agy99 NPPRSG-----LPVVELLDTELIRGRTAGPPA-------
MAV_0585|M.avium_104 KPARSG-----LPVVELLDTELIRGRTAGPPA-------
Mflv_1457|M.gilvum_PYR-GCK NPPRSG-----LPVVEVLDTEVIRGRTSGPPA-------
MAB_2023c|M.abscessus_ATCC_199 DIIAGR---ASANDRRTHQARLKIAGVSSPPAIRRAMSD
. ..: :.**