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STPRRRRPTMADVAERAGVSRTLVSFILDGKPGASDETRRRVLAIADEIGYRPDSAARLLAQGRSRTLGV MTDVRQLFQAELVTHIYPAAERLGYEVLLSANLPDRTEATVVDSLLSHRCGALILLGPTGDQSFLEKLAQ RAPVVVACRRLTGLNQQTPLATVRTNDAKGIRQAVDYLVGLGHRRIHHVDGGRDPGSADRSRAYKAAMRA HGLAEEIEVIPGAHNEDAGAAAARAMLAAPTLPTAVLAGNDRCALGILDVFTRAGVDVPAQVSLMGYDDT RLSENPRIDLSTIHQDAAEIARHAVQLAVQMLVEGPPHAMDVVLEPTLVVRGTTAPPRGGPAARSGIADT IEG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0385 | - | - | 100% (354) | periplasmic binding protein/LacI transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2545 | - | 8e-27 | 30.41% (342) | periplasmic binding protein/LacI transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5317 | - | 3e-20 | 28.65% (370) | periplasmic binding protein/LacI transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3606c | - | 4e-19 | 27.91% (369) | transcriptional regulatory protein LacI-family |
| M. gilvum PYR-GCK | Mflv_1457 | - | 4e-20 | 28.73% (369) | periplasmic binding protein/LacI transcriptional regulator |
| M. tuberculosis H37Rv | Rv3575c | - | 4e-19 | 27.91% (369) | transcriptional regulatory protein LacI-family |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2023c | - | 8e-07 | 23.72% (333) | LacI family transcriptional regulator |
| M. marinum M | MMAR_5070 | - | 2e-21 | 28.92% (370) | PurR family transcriptional regulator |
| M. avium 104 | MAV_0585 | - | 4e-25 | 30.41% (365) | transcriptional regulator, LacI family protein |
| M. smegmatis MC2 155 | MSMEG_2954 | - | 1e-34 | 31.98% (344) | LacI-family protein transcriptional regulator |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4146 | - | 1e-20 | 28.65% (370) | PurR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0385|M.vanbaalenii_PYR-1 -MSTP-RRRRPTMADVAERAGVSRTLVSFILDGKPG--ASDETRRRVLAI
MSMEG_2954|M.smegmatis_MC2_155 -MTGPGRRRRPTLADVADIVGVDPSLVSRVLRNDPRGFASTRTRERIVAA
Mb3606c|M.bovis_AF2122/97 --MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQ--LSADLRERVLAT
Rv3575c|M.tuberculosis_H37Rv --MSPTPRRRATLASLAAELKVSRTTVSNAFNRPDQ--LSADLRERVLAT
MMAR_5070|M.marinum_M --MSPTPRRRATLASLAAELKVSRSTISNAFNRPDQ--LSAELRERVLAT
MUL_4146|M.ulcerans_Agy99 --MSPTPRRRATLASLAAELKVSRSTISNAFNRPDQ--LSVELRERVLAT
MAV_0585|M.avium_104 --MSPTPRRRATLASLADELKVSRTTVSNAFNRPDQ--LSADLRERVLAT
Mflv_1457|M.gilvum_PYR-GCK MSRSPTPRRRATLASLAAELKVSRTTVSNAYNRPDQ--LSAELRERVLST
MAB_2023c|M.abscessus_ATCC_199 -------------------MGLSKTTVADALGGSGR--VSEATREKTRLV
:. : :: * *.:
Mvan_0385|M.vanbaalenii_PYR-1 ADEIGYR-PDSAARLLAQGRSRTLGVMT-DVRQLFQA-----ELVTHIYP
MSMEG_2954|M.smegmatis_MC2_155 AEKIGYR-ANAAARGLRSSRTMALGLLLPGFTSPVYS-----AIVHGVEA
Mb3606c|M.bovis_AF2122/97 AKRLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVAGVAQ
Rv3575c|M.tuberculosis_H37Rv AKRLGYAGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVAGVAQ
MMAR_5070|M.marinum_M AKRMGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVTGVAQ
MUL_4146|M.ulcerans_Agy99 AKRMGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVTGVAQ
MAV_0585|M.avium_104 AKRLGYPGPDPVARSLRTRKAGAVGLVMAEPLTYFFSDPAARDFVTGVAQ
Mflv_1457|M.gilvum_PYR-GCK AKRLGYPGPDPVARSLRTRRAGAVGLVITEPLNYSFSDPAALDFVAGLAE
MAB_2023c|M.abscessus_ATCC_199 AERMGYV-SNRAARLLRRNETGALGLYIPGDVRNLSFY---MELAFGAAD
*..:** .: .** * .: ::*: :.
Mvan_0385|M.vanbaalenii_PYR-1 AAERLGYEVLLSANLPDRTEATVVDSLLSHRCGALILLGPTGDQSFLEKL
MSMEG_2954|M.smegmatis_MC2_155 RAKEHGYGLVLGTHAAGDPHETMTSMLMHGSVDALLVASGRIEDQALRRL
Mb3606c|M.bovis_AF2122/97 SCEELGQGLQLVSVGSSRSLADGTAAVLGAGVDGFVVYSVGDDDPYLQVV
Rv3575c|M.tuberculosis_H37Rv SCEELGQGLQLVSVGSSRSLADGTAAVLGAGVDGFVVYSVGDDDPYLQVV
MMAR_5070|M.marinum_M SCEELGQGLLLVAVGASRSLEDGTAAVLNAGVDGFVVYSVRDDDPYLQVV
MUL_4146|M.ulcerans_Agy99 SCEELGQGLLLVAVGASRSLEDGTAAVLNAGVDGFVVYSVRDDDPYLQVV
MAV_0585|M.avium_104 SCEALGQGLLLVAVGPSRSLDEGTAAVLSAGVDGFVVYSVCDDDPYLQAV
Mflv_1457|M.gilvum_PYR-GCK SCEAVGQGLLLVAVGPNRSVAEGSAAVLAAGVDGFVVYSASDDDPYLPAV
MAB_2023c|M.abscessus_ATCC_199 ESAALGLDLTLIGR-----HLTGENRSRPPQVDGIIAVDPVPGDAALESL
. * : * ..:: . : * :
Mvan_0385|M.vanbaalenii_PYR-1 AQRAP--VVVAC-RRLTGLNQQTPLATVRTNDAKGIRQAVDYLVGLGHRR
MSMEG_2954|M.smegmatis_MC2_155 VQEVPQTVVLVN-RQVRGIS-----ASVVLRDADAAAVAVRHLVELGHRR
Mb3606c|M.bovis_AF2122/97 LQRRLPVVVVDQPKDLSGVS------RVGIDDRAAMRELAGYVLGLGHRE
Rv3575c|M.tuberculosis_H37Rv LQRRLPVVVVDQPKDLSGVS------RVGIDDRAAMRELAGYVLGLGHRE
MMAR_5070|M.marinum_M LQRRLPVVVVDQPKELAGVS------RVGIDDRAAMRKIADYVLGLGHRQ
MUL_4146|M.ulcerans_Agy99 LQRRLPVVVVDQPKELAGVS------RVGIDDRAAMRKIADYVLSLGHRQ
MAV_0585|M.avium_104 LQRRLPVVVVDQPKGLTGVS------RVGIDDRAAMRELADYVLGLGHRE
Mflv_1457|M.gilvum_PYR-GCK MERHLPVVVVDQPRDVPGAS------QVRIDDRAAMRSLAEHVIDLGHRE
MAB_2023c|M.abscessus_ATCC_199 LTSNVPIVTVGRILDKDVSHH---AAEIEIDHYRMVTLLLDAIRAAGGKR
*.: : . : * :.
Mvan_0385|M.vanbaalenii_PYR-1 IHHVDGGRDPG----------------------SADRSRAYKAAMRAHGL
MSMEG_2954|M.smegmatis_MC2_155 ICGVFGPATLD----------------------TMVRRRHGFATECAANG
Mb3606c|M.bovis_AF2122/97 LGLLTMRLGRDRRQD----LVDAERLRSPTFDVQRERIVGVWEAMTAAGV
Rv3575c|M.tuberculosis_H37Rv LGLLTMRLGRDRRQD----LVDAERLRSPTFDVQRERIVGVWEAMTAAGV
MMAR_5070|M.marinum_M IGLLTMRLGRDRRQD----LVDAERLKSPTFDVQRERITGVWEAMTAAGV
MUL_4146|M.ulcerans_Agy99 IGLLTMRLGRDRRQD----LVDAERLKSPTFDVQRERITGVWEAMTAAGV
MAV_0585|M.avium_104 IGLLTMRLGRDRRQG----LVDAERLRSPAFDVQRERITGVWEAMTAAGV
Mflv_1457|M.gilvum_PYR-GCK IGLLTMRLGRDWPHGPGPALADPERVRAPNFHVQCERIHGVYDAMTAAGL
MAB_2023c|M.abscessus_ATCC_199 PALAALDQGADS-------------------SYVFDVSRGYQEWCAKAGV
. .
Mvan_0385|M.vanbaalenii_PYR-1 AEEIEVIPG--AHNEDAGAAAARAMLAAPTLPTAVLAGNDRCALGILDVF
MSMEG_2954|M.smegmatis_MC2_155 VESSAIELP--ERNHAAGFEGAMRALERGNPPTAIVAATFPMAVGVLAAL
Mb3606c|M.bovis_AF2122/97 DPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTADILALSAMDYL
Rv3575c|M.tuberculosis_H37Rv DPDSLTVVESYEHLPTSGGTAAKVALQANPRLTALMCTADILALSAMDYL
MMAR_5070|M.marinum_M DPESLTVVESYEHLPTSGGDAAKVALEANPRITALMCTADILALSAMDYL
MUL_4146|M.ulcerans_Agy99 DPESLTVVESYEHLPTSGGDAAKVALEANPRITALMCTADILALSAMDYL
MAV_0585|M.avium_104 DPDSLTVVESYEHLPESGGAAAKVALEANPRITALMCTADILALSAMDYL
Mflv_1457|M.gilvum_PYR-GCK DPASLTLVESYEHLPTSGGAGADIALEANPRITALMCTADVLALSAMDHL
MAB_2023c|M.abscessus_ATCC_199 VP---LATRLSATPTDVELAQAIRGIVEHQGIDALVVGAQGLAARSLPVL
* : *:: * : :
Mvan_0385|M.vanbaalenii_PYR-1 TRAGVDVPAQVSLMGYDDTRLSENPRIDLSTIHQDAAEIARHAVQLAVQM
MSMEG_2954|M.smegmatis_MC2_155 HQRGIAVPSAMSVLALHDDNLASYLIPPLTAVSLPTERLGAEAVELAIAM
Mb3606c|M.bovis_AF2122/97 RAHGIYVPGQMTVTGFDG--VPEALSRGLTTVAQPSLHKGHRAGELLLKP
Rv3575c|M.tuberculosis_H37Rv RAHGIYVPGQMTVTGFDG--VPEALSRGLTTVAQPSLHKGHRAGELLLKP
MMAR_5070|M.marinum_M RGHGIYVPGQMTVTGFDG--VPEAISRGLTTVSQPSLQKGRRAGELLQNP
MUL_4146|M.ulcerans_Agy99 RGHGIYVPGQMTVTGFDG--VPEAISRGLTTVSQPSLQKGRRAGELLQNP
MAV_0585|M.avium_104 RAHGVYVPGQLTVTGFDG--VPDAISRGLTTVSQSSLHKGRRAGELLLKP
Mflv_1457|M.gilvum_PYR-GCK RAKGIYVPGQMTVTGFDG--VPEARQRGLTTVAQPGVEKGRRAGELLHNP
MAB_2023c|M.abscessus_ATCC_199 QSLGHEVGSNFHLGTLVGDPATELTNPDIHAVDLRPREFGHQAVTFLHDI
* * . . : . .. : :: . . .* :
Mvan_0385|M.vanbaalenii_PYR-1 LVEGPPHAMDVVLEPTLVVRGTTAPPRGGPAARSGIADTIEG
MSMEG_2954|M.smegmatis_MC2_155 VGGGQPRRVVVPDEPHIVLRGSTAAP----------------
Mb3606c|M.bovis_AF2122/97 PRSGLP---VIEVLDTELVRGRTAGPPA--------------
Rv3575c|M.tuberculosis_H37Rv PRSGLP---VIEVLDTELVRGRTAGPPA--------------
MMAR_5070|M.marinum_M PRSGLP---VVELLDTELIRGRTAGPPA--------------
MUL_4146|M.ulcerans_Agy99 PRSGLP---VVELLDTELIRGRTAGPPA--------------
MAV_0585|M.avium_104 ARSGLP---VVELLDTELIRGRTAGPPA--------------
Mflv_1457|M.gilvum_PYR-GCK PRSGLP---VVEVLDTEVIRGRTSGPPA--------------
MAB_2023c|M.abscessus_ATCC_199 IAGRASANDRRTHQARLKIAGVSSPPAIRRAMSD--------
. : * :: *