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GTLADVARAAGVSVSIASRALSGDTRARMSEATRARVLAAADELNYVPNARARALRHSRSGTIGLIVPDV NNAVFADMFSGVQMAASGHSTDVLLGQIDAPPRGTQQLSRLVSEGRVDGVLLQRREDFDDDMLAAVLEGV PAVTINSRVPGRVGSVILDDQKGGGIATEHLITLGHSRIAFISGTAIHDTAQRRKEGYLETLASAGLRSE AAWVVDAGWEADAGSAALNTLYRGANLGKPDGPTAVVVASVNAAVGALSTALRLGLRVPEDLSIVGINTT WVSDTVYPALTTVRLPLQRLGEVAADVLMEHLGGRALTDTVVTQPTPELLVRETTAPPTRD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0491 | - | - | 100% (342) | transcriptional regulator, LacI family protein |
| M. smegmatis MC2 155 | MSMEG_2954 | - | 3e-43 | 33.33% (339) | LacI-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_1708 | - | 8e-33 | 34.47% (351) | ribose operon repressor, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3606c | - | 9e-11 | 24.52% (367) | transcriptional regulatory protein LacI-family |
| M. gilvum PYR-GCK | Mflv_1457 | - | 4e-15 | 26.56% (369) | periplasmic binding protein/LacI transcriptional regulator |
| M. tuberculosis H37Rv | Rv3575c | - | 9e-11 | 24.52% (367) | transcriptional regulatory protein LacI-family |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2023c | - | 2e-09 | 25.14% (350) | LacI family transcriptional regulator |
| M. marinum M | MMAR_5070 | - | 2e-12 | 24.66% (365) | PurR family transcriptional regulator |
| M. avium 104 | MAV_5263 | - | 2e-14 | 28.66% (335) | transcriptional regulator, LacI family protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4146 | - | 6e-13 | 24.66% (365) | PurR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2545 | - | 4e-33 | 32.95% (349) | periplasmic binding protein/LacI transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5070|M.marinum_M ---------MSPTPRRRATLASLAAELKVSRSTISNAFNRPD--QLSAEL
MUL_4146|M.ulcerans_Agy99 ---------MSPTPRRRATLASLAAELKVSRSTISNAFNRPD--QLSVEL
Mb3606c|M.bovis_AF2122/97 ---------MSPTPRRRATLASLAAELKVSRTTVSNAFNRPD--QLSADL
Rv3575c|M.tuberculosis_H37Rv ---------MSPTPRRRATLASLAAELKVSRTTVSNAFNRPD--QLSADL
Mflv_1457|M.gilvum_PYR-GCK -------MSRSPTPRRRATLASLAAELKVSRTTVSNAYNRPD--QLSAEL
MSMEG_0491|M.smegmatis_MC2_155 ----------------MGTLADVARAAGVSVSIASRALSGDTRARMSEAT
Mvan_2545|M.vanbaalenii_PYR-1 -----------MIPKQTVNMTDVARRSGVSIASVSRALRGES--GVSAAT
MAV_5263|M.avium_104 MTGPQGNGNSSSNKAARPTTADVARLAGVSTATVSYVLNNARGRRISPDT
MAB_2023c|M.abscessus_ATCC_199 --------------------------MGLSKTTVADALGGSG--RVSEAT
:* : : . :*
MMAR_5070|M.marinum_M RERVLATAKRMGYPGPDPVARSLRTRKAGAVGLVMA-EPLTYFFSDPAAR
MUL_4146|M.ulcerans_Agy99 RERVLATAKRMGYPGPDPVARSLRTRKAGAVGLVMA-EPLTYFFSDPAAR
Mb3606c|M.bovis_AF2122/97 RERVLATAKRLGYAGPDPVARSLRTRKAGAVGLVMA-EPLTYFFSDPAAR
Rv3575c|M.tuberculosis_H37Rv RERVLATAKRLGYAGPDPVARSLRTRKAGAVGLVMA-EPLTYFFSDPAAR
Mflv_1457|M.gilvum_PYR-GCK RERVLSTAKRLGYPGPDPVARSLRTRRAGAVGLVIT-EPLNYSFSDPAAL
MSMEG_0491|M.smegmatis_MC2_155 RARVLAAADELNY-VPNARARALRHSRSGTIGLIVP-DVNNAVFAD----
Mvan_2545|M.vanbaalenii_PYR-1 RDRILSAARELAY-VVSPEASRLSGGPTGRVGVIVP-RVDAWFYST----
MAV_5263|M.avium_104 RDAVYRAAKLLGY-RPNLAARNLARGKSGVVLYVVP-HVAVGEMPMQ---
MAB_2023c|M.abscessus_ATCC_199 REKTRLVAERMGY-VSNRAARLLRRNETGALGLYIPGDVRNLSFYME---
* .* : * . * * :* : :.
MMAR_5070|M.marinum_M DFVTGVAQSCEELGQGLLLVAVGASRSLEDGTAAVLNAG-VDGFVVYSVR
MUL_4146|M.ulcerans_Agy99 DFVTGVAQSCEELGQGLLLVAVGASRSLEDGTAAVLNAG-VDGFVVYSVR
Mb3606c|M.bovis_AF2122/97 DFVAGVAQSCEELGQGLQLVSVGSSRSLADGTAAVLGAG-VDGFVVYSVG
Rv3575c|M.tuberculosis_H37Rv DFVAGVAQSCEELGQGLQLVSVGSSRSLADGTAAVLGAG-VDGFVVYSVG
Mflv_1457|M.gilvum_PYR-GCK DFVAGLAESCEAVGQGLLLVAVGPNRSVAEGSAAVLAAG-VDGFVVYSAS
MSMEG_0491|M.smegmatis_MC2_155 -MFSGVQMAASGHSTDVLLGQIDAPPRGTQQLSRLVSEGRVDGVLLQRRE
Mvan_2545|M.vanbaalenii_PYR-1 -ILAGIADEFDTVGMDLILCTLPTSAARHRFFEALPLRRKVDAAVVVSLP
MAV_5263|M.avium_104 ---AGSRMTTALAREGLLQVQVFETDDDQHVVDAIANLDPVAVTSLFPLS
MAB_2023c|M.abscessus_ATCC_199 -LAFGAADESAALGLDLTLIGRHLTGENRS------RPPQVDGIIAVDPV
* .: *
MMAR_5070|M.marinum_M DDDPYLQVVLQRRLPVVVVDQPKELAG---VSRVGIDDRAAMRKIADYVL
MUL_4146|M.ulcerans_Agy99 DDDPYLQVVLQRRLPVVVVDQPKELAG---VSRVGIDDRAAMRKIADYVL
Mb3606c|M.bovis_AF2122/97 DDDPYLQVVLQRRLPVVVVDQPKDLSG---VSRVGIDDRAAMRELAGYVL
Rv3575c|M.tuberculosis_H37Rv DDDPYLQVVLQRRLPVVVVDQPKDLSG---VSRVGIDDRAAMRELAGYVL
Mflv_1457|M.gilvum_PYR-GCK DDDPYLPAVMERHLPVVVVDQPRDVPG---ASQVRIDDRAAMRSLAEHVI
MSMEG_0491|M.smegmatis_MC2_155 DFDDDMLAAVLEGVPAVTIN-SRVPGR---VGSVILDDQKGGGIATEHLI
Mvan_2545|M.vanbaalenii_PYR-1 LSARERTRLDQLAVPTVFVGGHRTEDH---RPWVGIDDERAAQQAVGHLL
MAV_5263|M.avium_104 --AAARRAVTEAGIPHIEIGTLPALN----DPHLSVGEMR-----IAHLV
MAB_2023c|M.abscessus_ATCC_199 PGDAALESLLTSNVPIVTVGRILDKDVSHHAAEIEIDHYRMVTLLLDAIR
:* : :. : :.. :
MMAR_5070|M.marinum_M GLGHRQIGLLTMRLGRDRRQD----LVDAERLKSPTFDVQRERITGVWEA
MUL_4146|M.ulcerans_Agy99 SLGHRQIGLLTMRLGRDRRQD----LVDAERLKSPTFDVQRERITGVWEA
Mb3606c|M.bovis_AF2122/97 GLGHRELGLLTMRLGRDRRQD----LVDAERLRSPTFDVQRERIVGVWEA
Rv3575c|M.tuberculosis_H37Rv GLGHRELGLLTMRLGRDRRQD----LVDAERLRSPTFDVQRERIVGVWEA
Mflv_1457|M.gilvum_PYR-GCK DLGHREIGLLTMRLGRDWPHGPGPALADPERVRAPNFHVQCERIHGVYDA
MSMEG_0491|M.smegmatis_MC2_155 TLGHSRIAFISGTAIHDT---------------------AQRRKEGYLET
Mvan_2545|M.vanbaalenii_PYR-1 RIGHHDIAMIQAADDTDIPWA-----------------TDQARIRGFHQT
MAV_5263|M.avium_104 ERGHRRIAFAYTGIARWRPLG-------------------DYWFEGVSRA
MAB_2023c|M.abscessus_ATCC_199 AAGGKRPALAALDQGADSSYV-------------------FDVSRGYQEW
* .: *
MMAR_5070|M.marinum_M MTAAGVDPESLTVVESYEHLPTSGGDAAKVALEAN----PRITALMCTAD
MUL_4146|M.ulcerans_Agy99 MTAAGVDPESLTVVESYEHLPTSGGDAAKVALEAN----PRITALMCTAD
Mb3606c|M.bovis_AF2122/97 MTAAGVDPDSLTVVESYEHLPTSGGTAAKVALQAN----PRLTALMCTAD
Rv3575c|M.tuberculosis_H37Rv MTAAGVDPDSLTVVESYEHLPTSGGTAAKVALQAN----PRLTALMCTAD
Mflv_1457|M.gilvum_PYR-GCK MTAAGLDPASLTLVESYEHLPTSGGAGADIALEAN----PRITALMCTAD
MSMEG_0491|M.smegmatis_MC2_155 LASAGLRSEAAWVVDAGWEADAGSAALNTLYRGANLGKPDGPTAVVVASV
Mvan_2545|M.vanbaalenii_PYR-1 MQEAGLADPT--VVTVKWSVDGGSHGMETLLS-----RSRPPTAVFCHSD
MAV_5263|M.avium_104 ARLRGLPPVRADEVILDTAASVVSAWVR-----------DGVTAVCAQSD
MAB_2023c|M.abscessus_ATCC_199 CAKAGVVPLATRLSATPTDVELAQAIRGIVEH-------QGIDALVVGAQ
*: *: :
MMAR_5070|M.marinum_M ILALSAMDYLRGHGIYVPGQMTVTGFDG--VPEAISRGLTTVSQPSLQKG
MUL_4146|M.ulcerans_Agy99 ILALSAMDYLRGHGIYVPGQMTVTGFDG--VPEAISRGLTTVSQPSLQKG
Mb3606c|M.bovis_AF2122/97 ILALSAMDYLRAHGIYVPGQMTVTGFDG--VPEALSRGLTTVAQPSLHKG
Rv3575c|M.tuberculosis_H37Rv ILALSAMDYLRAHGIYVPGQMTVTGFDG--VPEALSRGLTTVAQPSLHKG
Mflv_1457|M.gilvum_PYR-GCK VLALSAMDHLRAKGIYVPGQMTVTGFDG--VPEARQRGLTTVAQPGVEKG
MSMEG_0491|M.smegmatis_MC2_155 NAAVGALSTALRLGLRVPEDLSIVGINTTWVSDTVYPALTTVRLPLQRLG
Mvan_2545|M.vanbaalenii_PYR-1 EIALGALRTLRRSGISVPQQVSVIGVDDHPAAELS--DLTTVAQPVREQG
MAV_5263|M.avium_104 EIACLVLYGIHQAGLRCPGDLAVMGVDASPMGMVSTPPLTTVQFDPCAVA
MAB_2023c|M.abscessus_ATCC_199 GLAARSLPVLQSLGHEVGSNFHLGTLVGDPATELTNPDIHAVDLRPREFG
* : * :. : . : :* .
MMAR_5070|M.marinum_M RRAGELLQNPPRSG-----LPVVELLDTELIRGRTAGPPA-------
MUL_4146|M.ulcerans_Agy99 RRAGELLQNPPRSG-----LPVVELLDTELIRGRTAGPPA-------
Mb3606c|M.bovis_AF2122/97 HRAGELLLKPPRSG-----LPVIEVLDTELVRGRTAGPPA-------
Rv3575c|M.tuberculosis_H37Rv HRAGELLLKPPRSG-----LPVIEVLDTELVRGRTAGPPA-------
Mflv_1457|M.gilvum_PYR-GCK RRAGELLHNPPRSG-----LPVVEVLDTEVIRGRTSGPPA-------
MSMEG_0491|M.smegmatis_MC2_155 EVAADVLMEHLGG--RALTDTVVTQPTPELLVRETTAPPTRD-----
Mvan_2545|M.vanbaalenii_PYR-1 RIAARVVLGGLGDGDASGPPASVTTLPTRLVVRGSTAPPR-------
MAV_5263|M.avium_104 DAALAAVFERLGHAAP---PSPELTDIARLVVRSST-----------
MAB_2023c|M.abscessus_ATCC_199 HQAVTFLHDIIAGRAS---ANDRRTHQARLKIAGVSSPPAIRRAMSD
* : ..: :